Technology Listings


Granulin for Treatment of Neurodegeneration

Application

Granulin proteins (GRNs) as potential therapeutics for multiple neurodegenerative disorders caused by lysosome dysfunction and inflammation.

Key Benefits
  • Novel pathway and target provides new route for treatment.
  • Granulins shown to rescue lysosomal defects in cell culture models.
Market Summary

Granulins are small proteins that are derived by proteolysis from full-length progranulin (PGRN). PGRN is cleaved into several granulin proteins, which are implicated in development, inflammation, cell proliferation and protein homeostasis. Previously, most investigators believed that PGRN acts in the extracellular space by activating signaling receptors on the neuronal surface or modulating inflammation (i.e. suppress excessive activation of microglia). Therefore, many therapeutic strategies to replace PGRN have focused on increasing the extracellular levels of PGRN. Though the precise functions of PGRN and granulins remain unclear, they are known to be linked to neurodegenerative diseases.

Technical Summary

The inventor recently discovered PGRN is intracellularly routed to the lysosome and processed into stable, functional granulins. Dr. Kukar’s data suggest that granulins play a critical role in the normal function and homeostasis of the lysosome and, when decreased or absent, cause disease. The researcher is developing novel compositions of granulin as a therapy for individuals that harbor genetic variants or mutations in the GRN gene that decrease levels of PGRN/granulins. These novel granulins also have therapeutic potential in other neurodegenerative diseases with low PGRN/granulin levels or are caused by lysosomal dysfunction. This small protein has therapeutic potential against neurodegenerative diseases, including frontotemporal dementia, Alzheimer’s disease, and Parkinson’s disease, through a novel target and pathway.

Developmental Stage
  • Animal data is available – recombinant human PGRN is processed into mature granulins in mouse cells and brains. Novel recombinant granulins can directly rescue lysosome dysfunction.
  • Further experiments are underway.

Publication: Holler, C. J. et al. (2017). eNeuro. 4(4).

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Patent Information
App Type Country Serial No. Patent No. File Date Issued Date Expire Date Patent Status
Nationalized PCT - United States United States 16/317,731 1/14/2019     Pending
Tech ID: 16127
Published: 12/18/2018
Category
Therapeutics
Diagnostics

Contact
Hyeon (Sean) Kim
Licensing Associate
Emory University
404-727-7218
hkim70@emory.edu

Inventor(s)
Thomas Kukar

Keywords
Biologic
Enzyme/Protein
Neuroscience/Pain