|
Methioninase Inducing Virus for Anti-Cancer Therapy
Application
A set of viral constructs that induce regulatable expression of methionine degrading enzyme for treatment of brain tumors.
Key Benefits
Built-in Tet-responsive element ensures precise regulation, preventing unwanted enzyme activity.
IL-2 signal directs the enzyme for secretion, optimizing its therapeutic impact.
Specific delivery...
Published: 1/20/2026
Contributor(s): Timothy R. Gershon, Leon McSwain, Andrey Tikunov
|
|
Precision Protein Repair Platform for Missense Mutations
Application
This technology enables targeted chemical correction of missense mutations in proteins using a modular heterotrifunctional molecule platform.
Key Benefits
Restores protein function by chemically mimicking healthy amino acid side chains.
Modular toolkit allows rapid customization for diverse protein targets.
Validated across multiple...
Published: 11/12/2025
Contributor(s): Monika Raj
|
|
Anticancer Agent with N-Glycan Specificity
Application
An engineered protein for targeting disease-associated N-glycans.
Key Benefits
High affinity, pH insensitive, no cofactors required.
Applications in anticancer and antiviral therapeutics and research.
Can aid in manufacturing monoclonal antibodies with desired N-glycosylation properties.
Market Summary
Glycosylation involves post-translation...
Published: 1/20/2026
Contributor(s): Eric J. Sundberg, Diego Sastre, Maros Huliciak
|
|
Functionalized Collagen Biochips with Core-Shell Structures and Collagen-Mimetic Peptide Nanotubes
Application
Synthetic collagen-based biomaterials for therapeutic delivery or drug testing.
Key Benefits
Synthetic collagen substitute.
Capable of formulating into various structures.
Free of animal-based contaminants.
Able to be spatially patterned.
Market Summary
Organ failure and tissue defects affect millions of Americans, resulting in...
Published: 1/20/2026
Contributor(s): Vincent Conticello, Andrea Merg, Gavin Touponse
|
|
Targeted Immunotherapy for KRAS-Driven Cancers
Application
Targeted immunotherapy and companion biosensing approach for cancers harboring the KRASG12V mutation.
Key Benefits
First-in-class therapeutic strategy specifically designed for KRASG12V-positive cancers.
Addresses a significant unmet need in oncology where no approved KRASG12V-targeted therapies currently exist.
Restores the body’s...
Published: 1/21/2026
Contributor(s): Haian Fu, Cong Tang, Xiulei Mo
|
|
Caspase-3 Deficient MEFs with Mutant Caspase-3 Re-Introduced
Application
Mouse embryonic fibroblast (MEF) line deficient in caspase-3 that are reconstituted with constitutively expressed mutant versions of the protease.
Key Benefits
An immortalized caspase-3-deficient MEF cell line.
Tool to study protease induced apoptosis.
Technical Summary
Emory inventors have discriminated a previously unknown role...
Published: 1/20/2026
Contributor(s): Lawrence Boise, Katelyn Ponder
|
|
Photocaged Cytokines for Cancer Immunotherapy
Application
Light-responsive cytokine prodrugs with controlled activation for improved cancer immunotherapy.
Key Benefits
Spatiotemporal control of therapeutic cytokine activation leads to controlled local activation and reduces off-target toxicity.
Prolonged circulation means less frequent dosing is required.
Biased activity towards CD8+ T-cells...
Published: 9/3/2025
Contributor(s): Erik Dreaden, Lacey Perdue, Priscilla Do
|
|
Ribosome Pegging: An Antibiotic-free System to Produce Recombinant Proteins
Application
Antibiotic-free method to prevent the growth of cells that fail to express high levels of a non-essential protein (target protein).
Key Benefits
Prevents the use of antibiotics and markers that promote resistance.
Facilitates the deployment of recombinant bacteria in uncontrolled environments.
Stabilizes heterologous expression of...
Published: 2/13/2025
Contributor(s): Ichiro Matsumura
|
|
Selective Enrichment of A-To-I Edited Transcripts from Cellular RNA Using Endonuclease V
Application
Kit to efficiently identify and enrich adenosine-to-inosine (A-to-I) editing in RNA molecules.
Key Benefits
Robust and facile method for enriching A-to-I edited transcripts.
Overcomes the low efficiency and accuracy of transcriptome-wide RNA-seq.
Market Summary
A-to-I RNA editing by adenosine deaminases is a common RNA modification...
Published: 1/26/2026
Contributor(s): Steven Knutson, Jennifer Heemstra
|
|
DNAzyme Nanoparticles for the Cleavage of RNA
Application
Site-selective RNA splicing nanozyme for cleaving and ligating RNA.
Key Benefits
Can cleave virtually any RNA stem loop.
Removes a 19 nucleotide segment from a 67 nucleotide RNA loop with up to 66% efficiency.
Technical Summary
Modulating RNA can be useful for studying RNA biology, gene knockdown, and regulating RNA splicing. Scientists...
Published: 1/20/2026
Contributor(s): Jessica Petree, Kevin Yehl, Khalid Salaita
|
