21 Results

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Functionalized Collagen Biochips with Core-Shell Structures and Collagen-Mimetic Peptide Nanotubes Application Synthetic collagen-based biomaterials for therapeutic delivery or drug testing. Key Benefits Synthetic collagen substitute. Capable of formulating into various structures. Free of animal-based contaminants. Able to be spatially patterned. Market Summary Organ failure and tissue defects affect millions of Americans, resulting in... Published: 3/28/2025       Contributor(s): Vincent Conticello, Andrea Merg, Gavin Touponse

KRAS Mutant Protein-Protein Interaction Targets and Inhibitors for Cancer Therapy Application Immunotherapeutic agent and biosensor for KRASG12V mutation in tumor cells. Key Benefits First in class, targeted immunotherapy for patients presented with KRASG12V mutation. Attenuates immune suppression associated with KRASG12V-positive cancers. Market Summary The KRASG12V mutation, representing 85% of all cancer mutations, is... Published: 3/28/2025       Contributor(s): Haian Fu, Cong Tang, Xiulei Mo

Caspase-3 Deficient MEFs with Mutant Caspase-3 Re-Introduced Application Mouse embryonic fibroblast (MEF) line deficient in caspase-3 that are reconstituted with constitutively expressed mutant versions of the protease. Key Benefits An immortalized caspase-3-deficient MEF cell line. Tool to study protease induced apoptosis. Technical Summary Emory inventors have discriminated a previously unknown role... Published: 2/13/2025       Contributor(s): Lawrence Boise, Katelyn Ponder

Photocaged Cytokines for Cancer Immunotherapy Application Light-responsive cytokine prodrugs with controlled activation for improved cancer immunotherapy. Key Benefits Spatiotemporal control of therapeutic cytokine activation leads to controlled local activation and reduces off-target toxicity. Prolonged circulation means less frequent dosing is required. Biased activity towards CD8+ T-cells... Published: 3/28/2025       Contributor(s): Erik Dreaden, Lacey Perdue, Priscilla Do

Ribosome Pegging: An Antibiotic-free System to Produce Recombinant Proteins Application Antibiotic-free method to prevent the growth of cells that fail to express high levels of a non-essential protein (target protein). Key Benefits Prevents the use of antibiotics and markers that promote resistance. Facilitates the deployment of recombinant bacteria in uncontrolled environments. Stabilizes heterologous expression of... Published: 2/13/2025       Contributor(s): Ichiro Matsumura

Selective Enrichment of A-To-I Edited Transcripts from Cellular RNA Using Endonuclease V Application Kit to efficiently identify and enrich adenosine-to-inosine (A-to-I) editing in RNA molecules. Key Benefits Robust and facile method for enriching A-to-I edited transcripts. Overcomes the low efficiency and accuracy of transcriptome-wide RNA-seq. Market Summary A-to-I RNA editing by adenosine deaminases is a common RNA modification... Published: 2/13/2025       Contributor(s): Steven Knutson, Jennifer Heemstra

DNAzyme Nanoparticles for the Cleavage of RNA Application Site-selective RNA splicing nanozyme for cleaving and ligating RNA. Key Benefits Can cleave virtually any RNA stem loop. Removes a 19 nucleotide segment from a 67 nucleotide RNA loop with up to 66% efficiency. Technical Summary Modulating RNA can be useful for studying RNA biology, gene knockdown, and regulating RNA splicing. Scientists... Published: 3/6/2025       Contributor(s): Jessica Petree, Kevin Yehl, Khalid Salaita

Trimeric Immunogen for HIV-1 Vaccination Application Trimeric gp120 immunogen that induces broadly cross-reactive V1V2-antibodies for HIV-1 vaccine. Key Benefits Possible oral administration. Broadly cross-reactive against HIV-1 panel. Promotes antibody responses as both a primary immunogen and boosting immunogen. Market Summary Antiretroviral therapy (ART) has dramatically prolonged... Published: 2/28/2025       Contributor(s): Rama Rao Amara, Andrew Jones, Raghavan Varadarajan, Sannula Kesavardhana

IFN Gamma Prelicensing for Improved Mesenchymal Stromal Cell Function Post-Thaw Application Mesenchymal stromal cells (MSC) prelicensed with pro-inflammatory cytokines for improved survival and immunosuppressive properties following cryopreservation. Key Benefits Preserves the immunosuppressive function of MSCs following thawing. Improves effectiveness of transplanted MSCs following cryopreservation. Market Summary Mesenchymal... Published: 2/13/2025       Contributor(s): Jacques Galipeau, Raghavan Chinnadurai

GeneRegs: Nanoparticles for Treatment of Severe Asthma Application Gold nanoparticles coated with enzyme which specifically targets and degrades asthma-associated inflammation molecules. Key Benefits Specifically suppresses asthma associated inflammation. Easy self-administration by inhalation. Market Summary Asthma is defined as a chronic inflammatory lung disease with significant worldwide morbidity.... Published: 2/28/2025       Contributor(s): Khalid Salaita, Cherry Wongtrakool, Kornelia Galior

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