http://emoryott.technologypublisher.comBe the first to know about the latest inventions and technologies available from Emory Universityen-USTue, 14 Apr 2026 00:26:29 GMTFri, 10 Apr 2026 12:15:37 GMThttp://blogs.law.harvard.edu/tech/rssemoryott@inteummail.comCopyright 2026, Emory University17042https://emoryott.technologypublisher.com/techcase/17042Application This technology delivers an objective, data‑driven PTSD assessment based on heart activity, addressing the absence of standardized physiological criteria and reducing dependence on subjective self‑reports. Key Benefits Uses measurable physiological signals rather than self-reported symptoms. Employs non-invasive electrocardiography or wearable sensors for heart activity data collection. Machine learning-based classifier enhances diagnostic reliability and long-term monitoring of illness severity. Market Summary PTSD affects millions of individuals globally, with particula...Fri, 10 Apr 2026 12:15:37 GMTemoryott@inteummail.comhttps://emoryott.technologypublisher.com/techcase/1704225215https://emoryott.technologypublisher.com/techcase/25215Mon, 23 Mar 2026 13:58:02 GMTemoryott@inteummail.comhttps://emoryott.technologypublisher.com/techcase/2521513140https://emoryott.technologypublisher.com/techcase/13140Application Web-based interface that provides advanced image processing and analytical tools for use in the treatment of cerebral aneurysms. Key Benefits Leverages large amounts of data and processing power in the cloud to deliver advanced software techniques in diagnosis. Facilitate the simulation of a wide range of clinical scenarios for more efficient planning of patient treatments. Market Summary Each year 30,000 people in the United States experience a ruptured cerebral aneurysm. About 60-70% of patients survive, but with permanent neurological deficits for half of these cases. O...Wed, 11 Mar 2026 11:41:37 GMTemoryott@inteummail.comhttps://emoryott.technologypublisher.com/techcase/1314023116https://emoryott.technologypublisher.com/techcase/23116Application Novel data learning framework for integrating radiology and pathology data for discovering prognostic biomarkers and predicting outcomes in head and neck cancer. Key Benefits Integrates radiology and pathology data to improve risk prediction for head and neck cancer and support more informed treatment decisions. Can analyze multiple high-resolution images to identify specific and detailed areas of high prognostic value. Concurrently processes radiology and pathology images to find associations at the micro- and macro- scales. Versatile software allows for integration of add...Tue, 10 Mar 2026 11:41:22 GMTemoryott@inteummail.comhttps://emoryott.technologypublisher.com/techcase/2311624038https://emoryott.technologypublisher.com/techcase/24038Application This AI-driven prognostic and predictive model aims to predict outcomes for muscle-invasive bladder cancer (MIBC) patients undergoing neoadjuvant chemo-immunotherapy, aiding in treatment decision-making and patient stratification. Key Benefits Harnesses nuclear morphology and architectural features for precise prognostication in MIBC patients. Offers predictive capability for pathologic downstaging, enhancing treatment planning. Provides personalized insights to identify non-responders to neoadjuvant chemo-immunotherapy, optimizing patient outcomes. Market Summary The mar...Mon, 02 Mar 2026 13:05:49 GMTemoryott@inteummail.comhttps://emoryott.technologypublisher.com/techcase/2403824034https://emoryott.technologypublisher.com/techcase/24034Application An artificial intelligence based prognostic model for early Biochemical recurrence (BCR) risk assessment of men post-radical prostatectomy. Key Benefits Identifies significant features, including tumor-infiltrating lymphocytes (TIL), in prostate cancer recurrence. Market Summary Prostate cancer is one of the most diagnosed cancers in the US, of which 1 in 8 US men will be diagnosed with prostate cancer at some point in their lives. Although prostatectomy is effective to remove cancerous tissue, biochemical recurrence (BCR) of prostate antigens post-surgery elevates risk for...Mon, 02 Mar 2026 13:05:46 GMTemoryott@inteummail.comhttps://emoryott.technologypublisher.com/techcase/2403420135https://emoryott.technologypublisher.com/techcase/20135Mon, 02 Mar 2026 13:05:31 GMTemoryott@inteummail.comhttps://emoryott.technologypublisher.com/techcase/2013519142https://emoryott.technologypublisher.com/techcase/19142Mon, 02 Mar 2026 13:05:23 GMTemoryott@inteummail.comhttps://emoryott.technologypublisher.com/techcase/1914225145https://emoryott.technologypublisher.com/techcase/25145Wed, 25 Feb 2026 08:06:31 GMTemoryott@inteummail.comhttps://emoryott.technologypublisher.com/techcase/2514523185https://emoryott.technologypublisher.com/techcase/23185Application Controlled substance inventory management software for pharmacies. Key Benefits Helps pharmacy personnel maintain accurate records of controlled substance transactions. User-friendly application that limits calculation errors and eliminates the reliance on potentially cumbersome handwritten logs. Designed to improve the workflow of controlled substance record keeping by maintaining complete, organized, and accurate records. Market Summary Maintaining organized, detailed, and accurate records for controlled substances is critical for pharmacies. All controlled substance re...Tue, 24 Feb 2026 11:50:35 GMTemoryott@inteummail.comhttps://emoryott.technologypublisher.com/techcase/2318525121https://emoryott.technologypublisher.com/techcase/25121Application A manufacturing approach for creating microfluidic devices used in disease modeling, diagnostics, and other lab on a chip applications. Key Benefits Supports high‑performance microfluidic workflows requiring strong, reliable, and reusable device assemblies. Compatible with complex device designs, enabling flexible integration of sensors, components, or multi‑material structures. Reduces fabrication costs and time, making microfluidic development more accessible for research and commercial use. Market Summary The microfluidics market continues to expand rapidly as research...Mon, 23 Feb 2026 12:15:26 GMTemoryott@inteummail.comhttps://emoryott.technologypublisher.com/techcase/2512124145https://emoryott.technologypublisher.com/techcase/24145Application An advanced gene therapy approach that improves therapeutic efficiency by protecting transgene expressing cells from host immune responses, through modulation of a key immune checkpoint pathway. Key Benefits Enhanced efficiency across viral and non-viral gene delivery systems, including AAV, lentivirus, LNPs, and electroporation. Enables immune modulation for a wide range of therapeutic applications, via expression of diverse immune checkpoint proteins or ligands. Market Summary The gene therapy market is rapidly expanding, driven by breakthroughs in genetic medicine, incr...Mon, 23 Feb 2026 12:15:17 GMTemoryott@inteummail.comhttps://emoryott.technologypublisher.com/techcase/2414525012https://emoryott.technologypublisher.com/techcase/25012Application A non-invasive molecular diagnostic tool that reliably predicts the tumor characteristics and risk of recurrence of meningiomas. Key Benefits Combines meningioma gene expression data, construction of a gene interaction network, and tumor histology data to diagnose and predict clinical outcomes. Complete analytical handling from specimen to result in less than 6 hours. Market Summary Meningiomas are the most common type of tumor that grows from membranes that surround the brain and spinal cord. They comprise approximately 39.7% of all central nervous system (CNS) tumors and...Wed, 28 Jan 2026 12:41:27 GMTemoryott@inteummail.comhttps://emoryott.technologypublisher.com/techcase/2501218009https://emoryott.technologypublisher.com/techcase/18009Application A simple, inexpensive mobile application-based tracker for early detection of abnormal labor progression adjusted for maternal body mass index (BMI). Key Benefits Generates electronic visualization of labor progress based on maternal BMI. Informed by dataset of 118k+ individual pregnant women. Limits premature dystocia diagnosis, unplanned cesarean delivery, and unnecessary intervention. Market Summary The U.S. labor and delivery market encompasses about 3.6 million births annually, with cesarean deliveries (C-sections) occurring in roughly a third of deliveries. 20-30% o...Mon, 26 Jan 2026 12:56:04 GMTemoryott@inteummail.comhttps://emoryott.technologypublisher.com/techcase/1800921065https://emoryott.technologypublisher.com/techcase/21065Application A mobile application to inform patients with cancer predisposition syndrome on the type and frequency of cancer screening and surveillance that they need. Key Benefits Focused on several cancer predisposition syndromes with an option to expand. Provides screening recommendations as per national guidelines, to hopefully allow for risk-reduction and early detection of cancer in patients with a genetic predisposition for cancer. Automates reminders matched to the expected scans and dates following national guidelines, with the option for individuals to customize the protocol to...Mon, 26 Jan 2026 12:21:49 GMTemoryott@inteummail.comhttps://emoryott.technologypublisher.com/techcase/2106525074https://emoryott.technologypublisher.com/techcase/25074Application A theranostic scaffold-derived protein that neutralizes candidalysin toxin. Key Benefits Different mechanism of action compared to current antifungal drugs, reducing the risk of resistance. Derived from human protein for lower immune response and produced cost-effectively in simple bacterial media. Small size improves tissue penetration and can also be used to help diagnose Candida infections. Market Summary Candida albicans is the most common human fungal pathogen, responsible for illnesses ranging from mild mucosal infections to severe systemic diseases with high mortal...Tue, 20 Jan 2026 13:08:22 GMTemoryott@inteummail.comhttps://emoryott.technologypublisher.com/techcase/2507425005https://emoryott.technologypublisher.com/techcase/25005Application A set of viral constructs that induce regulatable expression of methionine degrading enzyme for treatment of brain tumors. Key Benefits Built-in Tet-responsive element ensures precise regulation, preventing unwanted enzyme activity. IL-2 signal directs the enzyme for secretion, optimizing its therapeutic impact. Specific delivery to cancer cells, minimizing off-target effects. Can potentially be introduced into macrophages ex vivo and re-injected in vivo, allowing them to naturally migrate to the tumor environment. Market Summary Medulloblastoma (MB), a tumor of the cere...Tue, 09 Dec 2025 07:09:50 GMTemoryott@inteummail.comhttps://emoryott.technologypublisher.com/techcase/2500517062https://emoryott.technologypublisher.com/techcase/17062Application A portable, quiet and discrete device enables mothers to continuously collect breast milk within any environment. Key Benefits Noiseless, lightweight and discrete product for sterile extraction of breast milk throughout the workday. Bluetooth connectivity to a smartphone to easily control the device. Enables women to wear the pump comfortably all day and express milk discreetly without needing a private space or nursing area. A nursing pumping bra with a removable motor that can also be disguised/repurposed as a stylish scarf, bag or a breastfeeding cover. Market Summary ...Fri, 05 Dec 2025 11:15:15 GMTemoryott@inteummail.comhttps://emoryott.technologypublisher.com/techcase/1706224012https://emoryott.technologypublisher.com/techcase/24012Application This technology introduces small molecule inhibitors, ST80 and Z22, to disrupt the protein-protein interaction (PPI) between OTUD4 and CD73. These inhibitors enhance tumor immunogenicity by reducing CD73 stabilization, improving the immune response in triple-negative breast cancer (TNBC) and other immune-cold tumors. Key Benefits ST80 and Z22 uniquely target the OTUD4-CD73 interaction, reducing CD73 protein levels and overcoming immunosuppressive mechanisms. Enhance the efficacy of existing immunotherapies by restoring cytotoxic T-cell activity. Provide a novel treatment str...Thu, 13 Nov 2025 10:45:32 GMTemoryott@inteummail.comhttps://emoryott.technologypublisher.com/techcase/2401224178https://emoryott.technologypublisher.com/techcase/24178Application This technology enables targeted chemical correction of missense mutations in proteins using a modular heterotrifunctional molecule platform. Key Benefits Restores protein function by chemically mimicking healthy amino acid side chains. Modular toolkit allows rapid customization for diverse protein targets. Validated across multiple biochemical and cellular assays. Market Summary Missense mutations are a leading cause of many serious diseases, including cancer, cardiovascular and neurodegenerative disorders, and inherited conditions. These mutations often result in dysfun...Fri, 07 Nov 2025 12:54:11 GMTemoryott@inteummail.comhttps://emoryott.technologypublisher.com/techcase/2417825025https://emoryott.technologypublisher.com/techcase/25025Fri, 07 Nov 2025 11:57:46 GMTemoryott@inteummail.comhttps://emoryott.technologypublisher.com/techcase/2502525004https://emoryott.technologypublisher.com/techcase/25004Application Method for delivering gene-editing therapeutic in head and neck cancers. Key Benefits CRISPR/CAS9-based gene editing mechanism targeting novel disease-modifying gene. Liquid nanoparticle encapsulation permitting in vivo delivery. Market Summary Head and neck cancers (HNC) are the 7th most common global cancer, accounting for 3% of cancer diagnoses and 1.5% of cancer-related deaths in the United States. Recent innovations for treating advanced HNC have limited efficacy across patient subsets. With major pharmaceutical companies recently advancing HNC therapeutics into clini...Fri, 07 Nov 2025 11:57:44 GMTemoryott@inteummail.comhttps://emoryott.technologypublisher.com/techcase/2500425002https://emoryott.technologypublisher.com/techcase/25002Fri, 07 Nov 2025 11:57:42 GMTemoryott@inteummail.comhttps://emoryott.technologypublisher.com/techcase/2500222016https://emoryott.technologypublisher.com/techcase/22016Wed, 05 Nov 2025 11:53:24 GMTemoryott@inteummail.comhttps://emoryott.technologypublisher.com/techcase/2201623175https://emoryott.technologypublisher.com/techcase/23175Application An engineered protein for targeting disease-associated N-glycans. Key Benefits High affinity, pH insensitive, no cofactors required. Applications in anticancer and antiviral therapeutics and research. Can aid in manufacturing monoclonal antibodies with desired N-glycosylation properties. Market Summary Glycosylation involves post-translation addition of specific glycans to proteins or lipids. Abnormal glycosylation is an emerging biomarker of diverse cancer types (colorectal, pancreatic, ovarian, breast, prostate, and skin) and virus strains (including HIV, HSV-1, HCV, in...Mon, 03 Nov 2025 08:53:52 GMTemoryott@inteummail.comhttps://emoryott.technologypublisher.com/techcase/2317522168https://emoryott.technologypublisher.com/techcase/22168Application Cell line for efficient in vitro differentiation of rhesus macaque-specific T cells from hematopoietic stem and progenitor cells. Key Benefits Replaces need for primary rhesus macaque thymus tissue. Improves differentiation efficiency and reduces media requirements compared to existing methods. Yields CD4+ and CD8+ T cells, double-positive and double-negative thymocytes. Yields TCR selected CD4 and CD8 T cells. Market Summary Nonhuman primates serve as critical models for evaluating human disease pathogenesis and therapeutic interventions. In vitro systems for producing ...Mon, 03 Nov 2025 08:30:55 GMTemoryott@inteummail.comhttps://emoryott.technologypublisher.com/techcase/2216823122https://emoryott.technologypublisher.com/techcase/23122Application Antiviral therapeutic for multiple Dengue virus serotypes. Key Benefits Targets conserved regions of DENV genomes, enabling efficacy across serotypes. Mitigates lethal infections with a single lipid nanoparticle (LNP) based dose in mice. Minimal off-target effects. Market Summary Despite 390+ million annual DENV infections, there are no approved antiviral agents to prevent or treat any of the four prevalent DENV serotypes. Due to variability in viral strain and clinical pathology between infected patients, DENV imposes high diagnosis and treatment costs on affected countr...Thu, 30 Oct 2025 11:47:36 GMTemoryott@inteummail.comhttps://emoryott.technologypublisher.com/techcase/2312222060https://emoryott.technologypublisher.com/techcase/22060Wed, 29 Oct 2025 08:21:10 GMTemoryott@inteummail.comhttps://emoryott.technologypublisher.com/techcase/2206024139https://emoryott.technologypublisher.com/techcase/24139Application A combinatorial therapy to preserve muscle mass during semaglutide weight loss treatment. Key Benefits Preserves lean mass during semaglutide treatment in preclinical mouse models. Increases overall fat loss without affecting food/water intake during semaglutide treatment in preclinical mouse models. Market Summary The prevalence of obesity in adults exceeds 40% in the United States. 1.7% of the US population currently uses incretin therapies (such as semaglutide) for weight loss. Patients can lose 10% or more of their muscle mass during the first treatment year. With risi...Fri, 24 Oct 2025 11:58:14 GMTemoryott@inteummail.comhttps://emoryott.technologypublisher.com/techcase/2413924083https://emoryott.technologypublisher.com/techcase/24083Application Brief parent rating scale for researchers and clinicians to evaluate insomnia severity in children with autism spectrum disorder (ASD) age 3 to 12 years. Key Benefits Concise 21-question rating scale for caregivers of children with ASD. Internally consistent and reliable across severity levels. Highly correlated with existing tests. Usable for research and clinical trial inclusion. Market Summary 3.2% of children in the United States have autism spectrum disorder (ASD). 40-80% of children with ASD have persistent problems with insomnia compared to 20% of children in the ...Wed, 15 Oct 2025 13:01:33 GMTemoryott@inteummail.comhttps://emoryott.technologypublisher.com/techcase/2408318074https://emoryott.technologypublisher.com/techcase/18074Wed, 15 Oct 2025 12:59:59 GMTemoryott@inteummail.comhttps://emoryott.technologypublisher.com/techcase/1807425129https://emoryott.technologypublisher.com/techcase/25129Application A manualized intervention for the assessment and treatment of elopement for autistic youth. Key Benefits Provides clear step-by-step instructions/guidance for clinicians to coach caregivers. Employs specific strategies to reduce elopement incidents, minimize safety risks, and enforce readiness response. Parents and therapists find the manual easy to follow, beneficial, and implementable in real-world settings. Market Summary Elopement, in the context of individuals with disabilities, refers to the act of wandering or bolting away from supervision or a safe environment wit...Mon, 06 Oct 2025 09:04:52 GMTemoryott@inteummail.comhttps://emoryott.technologypublisher.com/techcase/2512924173https://emoryott.technologypublisher.com/techcase/24173Application Quantifiable protein biomarkers for Rett syndrome. Key Benefits Critical protein biomarkers of Rett syndrome identified in brain and cerebrospinal fluid. Quantifiable biochemical biomarkers of gene therapy effectiveness. Market Summary Rett syndrome is a progressive neurodevelopmental disorder that affects approximately one in 10,000 to 15,000 female births worldwide. It is caused by mutations on the X chromosome in the methyl-CpG-binding protein 2 (MECP2) gene, which modulates gene expression in neurons. Previous studies on Rett Syndrome have focused on either the defects...Fri, 03 Oct 2025 12:36:43 GMTemoryott@inteummail.comhttps://emoryott.technologypublisher.com/techcase/2417325106https://emoryott.technologypublisher.com/techcase/25106Application A therapeutic use for SGI-1027 in the treatment of Osimertinib-resistant non-small cell lung cancer (NSCLC). Key Benefits The MKK3/MYC protein-protein interaction inhibitor SGI-1027 effectively decreases MYC levels in Osimertinib-resistant NSCLC cell lines. The combination of SGI-1027 with Osimertinib offers synergistic benefits over either individual treatment. SGI-1027 combined with Osimertinib enhances apoptosis in resistant NSCLC cells. Market Summary Non-small cell lung cancer (NSCLC) accounts for about 85% of all lung cancer cases. Osimertinib is a third-generation ...Fri, 03 Oct 2025 12:19:43 GMTemoryott@inteummail.comhttps://emoryott.technologypublisher.com/techcase/2510624190https://emoryott.technologypublisher.com/techcase/24190Application An automated pipeline for digital phenotyping of brightfield bone biopsy images to generate feature maps for static histomorphometry. Key Benefits Combines automation with deep learning models to improve tissue delineation and quantify tissue and cellular components pertinent to static histomorphometric parameters. Incorporates Morphological Texture Analysis (MTA) that extracts and identifies unique structures in the bone tissue and associates them with normal or abnormal tissue states. Rapid generation of delineated tissue and cell maps in less than a minute. Market Summa...Fri, 03 Oct 2025 12:09:31 GMTemoryott@inteummail.comhttps://emoryott.technologypublisher.com/techcase/2419014118https://emoryott.technologypublisher.com/techcase/14118Application Use of neurokinin 3 receptor antagonist, osanetant, for the prevention and treatment of post-traumatic stress disorder (PTSD) and other anxiety disorders. Key Benefits Utilizes a repurposed drug that is safe for human use. Potential to treat specific PTSD symptoms better than antidepressants. Market Summary Post-traumatic stress disorder (PTSD) occurs in some individuals after witnessing or experiencing extreme traumatic events. Currently those suffering from PTSD are prescribed antidepressants, which have limited success in clinical trials. There are no treatments for sp...Fri, 30 May 2025 07:26:04 GMTemoryott@inteummail.comhttps://emoryott.technologypublisher.com/techcase/1411823198https://emoryott.technologypublisher.com/techcase/23198Application A brain organoid model for the human locus coeruleus to study its function and dysfunction in neurological diseases. Key Benefits Locus coeruleus region-specific neural organoid model for studying this deep region of the human brain. The organoid synthesizes norepinephrine, allowing for study of diseases related to these neurotransmitters. The organoid contains neuromelanin, enabling the analysis of how this pigment accumulates, affects neuronal activity and function, and contributes to neurodegeneration. Can help in identifying drug candidates for the prevention and treatm...Thu, 06 Mar 2025 11:44:11 GMTemoryott@inteummail.comhttps://emoryott.technologypublisher.com/techcase/2319823125https://emoryott.technologypublisher.com/techcase/23125Application Optimization heuristic for solving large-scale combinatorial problems. Key Benefits Efficient exploration of highly non-convex instances. Capable of handling large-scale problems. Reduces total computation time through massive parallelization. Especially designed for unconstrained binary problems. Market Summary The combinatorial optimization market is driven by the need to efficiently solve complex decision-making problems in industries including supply chain management, finance, machine learning, and advanced computing. Recent developments in artificial intelligence ar...Fri, 28 Feb 2025 12:18:28 GMTemoryott@inteummail.comhttps://emoryott.technologypublisher.com/techcase/2312522076https://emoryott.technologypublisher.com/techcase/22076Application A multi-sense deep learning platform and interview protocol used for detection and assessment of depression and schizophrenia. Key Benefits Automated and remote mental illness assessment without the need for self-reporting or clinical observation. Improved disease tracking for patients and clinicians. A more objective classifier and severity predictor model for depression than the standard (DSM). Cost-efficient approach towards mental illness management. Market Summary Depression and schizophrenia are mental illnesses with significant economic impacts on society. In the ...Fri, 19 Jul 2024 08:41:37 GMTemoryott@inteummail.comhttps://emoryott.technologypublisher.com/techcase/2207622100https://emoryott.technologypublisher.com/techcase/22100Application Diagnostic and automatic surveillance platform to identify RSV, Influenza A, and COVID-19 in real-time. Key Benefits Rapid smartphone-based detection of multiple respiratory viruses in nasal swab, breath condensate, and saliva. Requires few reagents and no expensive equipment. Limit of detection on par with PCR and rapid readout. Enables early detection, disease surveillance, and optimal treatment. Platform technology that can be used to detect other infectious diseases. Market Summary The respiratory disease diagnostic market is experiencing significant growth, driven ...Tue, 02 Jul 2024 07:00:34 GMTemoryott@inteummail.comhttps://emoryott.technologypublisher.com/techcase/2210020066https://emoryott.technologypublisher.com/techcase/20066Application Pre-clinical rodent model to study classic galactosemia disease. Key Benefits Identify striking differences in GALT-independent galactose metabolism among tissues and across post-natal time points. Study the relationship between galactose metabolite levels in blood and other tissues. Study the impact of rigorous galactose restriction diet. Identify biomarkers for classic galactosemia. Market Summary Classic galactosemia (CG) is a potentially lethal inborn error of galactose metabolism. Although newborn screening and rapid dietary restriction of galactose can prevent or r...Tue, 02 Jul 2024 07:00:27 GMTemoryott@inteummail.comhttps://emoryott.technologypublisher.com/techcase/2006620121https://emoryott.technologypublisher.com/techcase/20121Application Modified Vaccinia virus Ankara (MVA)- and deoxyribonucleic acid (DNA)-based vaccine for Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2). Key Benefits Safety profile is known. Demonstrated antiviral activity against related Coronaviruses. Single dose of vaccination was shown to be effective against related Coronaviruses in animal models. Induces both antibodies and killer T cells. Market Summary Coronavirus disease (COVID-19) is an infectious disease caused by a new virus, Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2). SARS-CoV-2 virus is a bet...Fri, 21 Jun 2024 11:22:10 GMTemoryott@inteummail.comhttps://emoryott.technologypublisher.com/techcase/2012198006https://emoryott.technologypublisher.com/techcase/98006Fri, 21 Jun 2024 11:20:41 GMTemoryott@inteummail.comhttps://emoryott.technologypublisher.com/techcase/9800622074https://emoryott.technologypublisher.com/techcase/22074Application A synthetic nanodisc (ND) scaffold for delivering antisense oligonucleotides (ASOs) for the treatment of disease. Key Benefits Improved cellular uptake and protein suppression using antisense oligos. Longer ASO half-life compared to other ASO delivery methods. Potential to overcome the delivery and efficacy challenges using ASOs for RNA and protein suppression. Market Summary Antisense oligonucleotides (ASOs) are short, synthetic strands of DNA/RNA that bind to a target mRNA molecule and modulate gene expression. They block the translation of the target mRNA into protein ...Thu, 11 Apr 2024 10:43:32 GMTemoryott@inteummail.comhttps://emoryott.technologypublisher.com/techcase/2207420201https://emoryott.technologypublisher.com/techcase/20201Thu, 11 Apr 2024 07:40:57 GMTemoryott@inteummail.comhttps://emoryott.technologypublisher.com/techcase/2020124010https://emoryott.technologypublisher.com/techcase/24010Application The developed protocol offers a reproducible and scalable method for generating lymphatic endothelial cells (LECs) from induced pluripotent stem cells (iPSCs), addressing critical challenges in the field of lymphatic-related therapies. Key Benefits Reproducible and scalable protocol for generating LECs from iPSCs. Utilizes specific culture conditions and molecules to enhance differentiation efficiency. Outperforms existing protocols, yielding a higher percentage of LECs from iPSCs. Market Summary The market for this therapeutic involves a wide range of potential diseases....Wed, 10 Apr 2024 12:40:32 GMTemoryott@inteummail.comhttps://emoryott.technologypublisher.com/techcase/2401014135https://emoryott.technologypublisher.com/techcase/14135Application The Electroconvulsive Cognitive Assessment (ECA) is a 10-minute cognitive exam designed for use during and after Electroconvulsive Therapy (ECT). It focuses on assessing memory deficits associated with ECT, offering a quick and targeted evaluation tool for healthcare professionals. Key Benefits Rapid cognitive assessment in under 10 minutes. Tailored evaluation of memory deficits caused by ECT. Incorporates seven memory components, including subjective and objective measures. Market Summary Electroconvulsive Therapy (ECT) has been a standard psychiatric procedure since th...Tue, 09 Apr 2024 13:11:37 GMTemoryott@inteummail.comhttps://emoryott.technologypublisher.com/techcase/1413523161https://emoryott.technologypublisher.com/techcase/23161Mon, 08 Apr 2024 11:55:25 GMTemoryott@inteummail.comhttps://emoryott.technologypublisher.com/techcase/2316111016https://emoryott.technologypublisher.com/techcase/11016Application A standardized series of questions for the assessment of vision related quality of life and visual function in children and adolescents. Key Benefits Provides age-appropriate questions for children from ages 8-18 as an improvement to using currently available assessments geared toward adults. Allows the subjective assessment of the impact of visual impairment. Questions specific to children with uveitis are in development. Market Summary Visual impairment in children is a significant problem in the U.S. Approximately 7% of children have a diagnosed vision problem and seve...Fri, 01 Mar 2024 10:39:06 GMTemoryott@inteummail.comhttps://emoryott.technologypublisher.com/techcase/1101615050https://emoryott.technologypublisher.com/techcase/15050Thu, 25 Jan 2024 12:52:07 GMTemoryott@inteummail.comhttps://emoryott.technologypublisher.com/techcase/1505024048https://emoryott.technologypublisher.com/techcase/24048Application Deep learning software for the automated detection and quantification of breast arterial calcifications in screening mammograms. Key Benefits Optimized image segmentation accuracy with improved generalizability towards mammograms with and without BAC presence. Robust ability to quantitate narrow or heavy BAC and/or partial depositions with integrated calcium scoring in real-time. Correlates BAC quantification to cardiovascular risk with potential to improve CVD risk stratification without additional cost and radiation exposure. Screens patients for CVD risk who would not no...Wed, 10 Jan 2024 08:37:42 GMTemoryott@inteummail.comhttps://emoryott.technologypublisher.com/techcase/2404822044https://emoryott.technologypublisher.com/techcase/22044Application A small molecule compound for the treatment of melanoma. Key Benefits Novel small molecule compound for the treatment of resistant melanoma. Well tolerated in vivo. Market Summary Malignant melanoma is a type of skin cancer that begins in melanocyte cells. Melanoma is the 19th most commonly occurring cancer. Exposure to UV radiation is a main contributing factor to developing melanoma, particularly in those who are genetically predisposed to the disease. Dependent on the stage of melanoma, treatment can include surgery, immunotherapy, targeted therapy, chemotherapy, and ra...Wed, 10 Jan 2024 08:36:53 GMTemoryott@inteummail.comhttps://emoryott.technologypublisher.com/techcase/2204423197https://emoryott.technologypublisher.com/techcase/23197Thu, 21 Dec 2023 08:02:39 GMTemoryott@inteummail.comhttps://emoryott.technologypublisher.com/techcase/2319723053https://emoryott.technologypublisher.com/techcase/23053Thu, 07 Dec 2023 08:40:53 GMTemoryott@inteummail.comhttps://emoryott.technologypublisher.com/techcase/2305322185https://emoryott.technologypublisher.com/techcase/22185Application A humanized therapeutic L-asparaginase compound to treat acute lymphoblastic leukemia (ALL) and other cancers. Key Benefits Human‑aligned variants may reduce immunogenicity and systemic toxicity compared to current FDA‑approved asparaginase drugs. Opportunity to improve treatment outcomes by minimizing the severe hypersensitivity reactions and dose‑limiting toxicities common with existing therapies. Platform for developing humanized asparaginase‑based therapeutics for leukemia and other cancers. Market Summary Leukemias represent a significant global health burden, affect...Fri, 01 Dec 2023 10:55:57 GMTemoryott@inteummail.comhttps://emoryott.technologypublisher.com/techcase/2218521201https://emoryott.technologypublisher.com/techcase/21201Fri, 01 Dec 2023 10:55:48 GMTemoryott@inteummail.comhttps://emoryott.technologypublisher.com/techcase/2120121011https://emoryott.technologypublisher.com/techcase/21011Application Proteomic labeling (labeling of proteins). Key Benefits Method can be used to express TurboID in any cell type. The mouse line can be crossed with any existing Cre line and can be extended to any organ/tissue system. Detection of labeled biomarkers can be identified in biofluids as biomarkers of cell specific disease mechanisms. Can be used for defining proteomic signatures of tissues, labeling sub-cellular organelle proteins or exosomes, and labeling and detection of proteins in bio-fluids to identify cell-type specific biomarkers. Technical Summary Researchers at Emory...Fri, 01 Dec 2023 10:55:40 GMTemoryott@inteummail.comhttps://emoryott.technologypublisher.com/techcase/2101111138https://emoryott.technologypublisher.com/techcase/11138Application Test to detect NF-kB2 breaks to guide treatment with proteasome inhibitors and its use with other therapeutic agents. Key Benefits Improved the prediction model to determine which patients are more likely to respond to bortezomib treatment. Improved the efficacy of treatment for patients with multiple myeloma and lymphomas. Market Summary Multiple myeloma (MM) and lymphomas are late-stage B-cell malignancies. Novel agents targeting the proteasome (bortezomib) have shown promising results in relapsed and previously untreated patients. Existing technologies for predicting pa...Fri, 01 Dec 2023 10:53:53 GMTemoryott@inteummail.comhttps://emoryott.technologypublisher.com/techcase/1113821176https://emoryott.technologypublisher.com/techcase/21176Application A machine learning model to predict the need for ventriculoperitoneal shunt after posterior fossa tumor resection. Key Benefits Highly accurate prediction of post-surgical complications. Reducing healthcare costs by predicting prognoses and increasing efficiency of post-surgical treatment. Market Summary Neurosurgical procedures completed in the posterior fossa are usually well-tolerated. However, a well-known complication after resection of posterior fossa tumors (PFTs) is post-operative hydrocephalus (HCP). Post-operative HCP can necessitate long-term CSF diversion, whic...Mon, 27 Nov 2023 13:41:15 GMTemoryott@inteummail.comhttps://emoryott.technologypublisher.com/techcase/2117621078https://emoryott.technologypublisher.com/techcase/21078Application A cost-effective catalyst for industrial chemical applications as an alternative to expensive rhodium-dependent dirhodium catalysts. Key Benefits Alternative catalysts to dirhodium using a straightforward synthesis process. Preliminary data show the ability to self-assemble in a similar manner to dirhodium compounds. Significantly decreased cost compared to dirhodium compounds. Market Summary Dirhodium compounds are highly efficient catalysts for diverse reactions with broad use among many industries. They exhibit unique structural rigidity, ease of ligand exchange, open ...Mon, 27 Nov 2023 13:40:59 GMTemoryott@inteummail.comhttps://emoryott.technologypublisher.com/techcase/2107821021https://emoryott.technologypublisher.com/techcase/21021Mon, 27 Nov 2023 13:40:52 GMTemoryott@inteummail.comhttps://emoryott.technologypublisher.com/techcase/2102120015https://emoryott.technologypublisher.com/techcase/20015Mon, 27 Nov 2023 13:40:12 GMTemoryott@inteummail.comhttps://emoryott.technologypublisher.com/techcase/2001518226https://emoryott.technologypublisher.com/techcase/18226Mon, 27 Nov 2023 13:39:45 GMTemoryott@inteummail.comhttps://emoryott.technologypublisher.com/techcase/1822618070https://emoryott.technologypublisher.com/techcase/18070Application Treatment with combinations of FDA-approved antibodies targeting small drug-resistant cell populations for infectious disease. Key Benefits Specific combinations of existing drugs that target small subpopulations of bacterial cells resistant to many standard of care treatment regimens. Potential to overcome the drug resistance crisis leading to decreased morbidity and mortality. Applicable to a number of gram-negative and gram-positive antibiotic-resistant infections. Market Summary Antibiotic resistance is one of the most significant health-related challenges as it limit...Mon, 27 Nov 2023 13:39:36 GMTemoryott@inteummail.comhttps://emoryott.technologypublisher.com/techcase/1807018001https://emoryott.technologypublisher.com/techcase/18001Mon, 27 Nov 2023 13:39:29 GMTemoryott@inteummail.comhttps://emoryott.technologypublisher.com/techcase/1800122182https://emoryott.technologypublisher.com/techcase/22182Application A tool that measures cellular mechanical forces using flow cytometry. Key Benefits A fluorescently labeled approach based on the magnitude of molecular forces transmitted through cell adhesion receptors for evaluating mechanical forces in cells. A prototype has been developed showing proof -of-concept via the ability to determine mechanical forces between cells. Potential to improve the understanding of various diseases in basic research while promoting the development of new diagnostics and therapeutics. Market Summary Deformation-based flow cytometry characterizes the m...Mon, 06 Nov 2023 11:06:03 GMTemoryott@inteummail.comhttps://emoryott.technologypublisher.com/techcase/2218221186https://emoryott.technologypublisher.com/techcase/21186Application A life science tool for evaluating protein lysine methylation for drug discovery and disease research. Key Benefits Highly specific labeling method for post-translational methylated lysine. Potential to improve the understanding of protein lysine methylation and help develop new drugs to block its interactions across several disease indications. Analyzed using mass spectrometry and/or fluorescence. Market Summary Protein lysine methylation is a critical post-translational modification that regulates protein stability and function. The significance of the methylation facto...Tue, 17 Oct 2023 06:11:18 GMTemoryott@inteummail.comhttps://emoryott.technologypublisher.com/techcase/2118622114https://emoryott.technologypublisher.com/techcase/22114Application Improving diagnostic accuracy using hetero-multivalent DNA-functionalized materials for disease targets containing one or more genetic mutations. Key Benefits Tunable oligos increase specificity and cooperative binding to the disease target of interest. Distinguishes between cis- and trans mutations. Identifies different strains of viruses and avoids expensive and timely whole genome sequencing. Market Summary Molecular diagnostics are used to detect and diagnose diseases at the molecular level by analyzing nucleic acids (such as DNA or RNA) or proteins to identify diseas...Fri, 13 Oct 2023 13:45:47 GMTemoryott@inteummail.comhttps://emoryott.technologypublisher.com/techcase/2211422141https://emoryott.technologypublisher.com/techcase/22141Application Therapeutic monoclonal antibodies directed to Elongation Factor-Tu (EF-Tu) for the treatment of infections. Key Benefits An antibody that targets the protein EF-Tu, which is present on many types of bacteria involved in life-threatening infections. A research-grade antibody has been developed with animal data showing the ability to reduce bacterial infection in the lungs of mice. Potential to overcome resistance to many anti-infectives and provide a new treatment modality for many infectious diseases. Market Summary The global market for infectious disease treatments now ...Fri, 13 Oct 2023 13:18:35 GMTemoryott@inteummail.comhttps://emoryott.technologypublisher.com/techcase/2214122112https://emoryott.technologypublisher.com/techcase/22112Application Easy-to-use, short and long-term, minimally invasive, MR-safe approach for directly measuring the variation of intracranial pressure. Key Benefits A minimally invasive device that is compatible with MRI imaging for quantitatively measuring intracranial pressure. A prototype has been developed showing the ability to measure shunt pressure with ultrasound. Potential to improve the treatment of brain injury patients and reduce the high morbidity and mortality rates. Market Summary Current methods for measuring intracranial pressure are highly invasive and are limited to shor...Fri, 13 Oct 2023 13:18:34 GMTemoryott@inteummail.comhttps://emoryott.technologypublisher.com/techcase/2211217040https://emoryott.technologypublisher.com/techcase/17040Fri, 13 Oct 2023 13:18:27 GMTemoryott@inteummail.comhttps://emoryott.technologypublisher.com/techcase/1704023132https://emoryott.technologypublisher.com/techcase/23132Wed, 11 Oct 2023 13:07:02 GMTemoryott@inteummail.comhttps://emoryott.technologypublisher.com/techcase/2313222191https://emoryott.technologypublisher.com/techcase/22191Application A new class of vaccines targeting the viruses causing the common cold, rhinoviruses (RV). Key Benefits Capsid-chimeric strains for developing new RV vaccines. Preclinical data with a prototype show the ability to induce a robust capsid-specific immune response. Straightforward and inexpensive vaccine manufacturing process utilizing reverse-genetics technology. Market Summary Rhinoviruses (RV) are the most common cause of the common cold, accounting for up to 80% of all cases. Adults have an average of two to three colds per year, and even more frequent in children. Althou...Wed, 11 Oct 2023 13:07:01 GMTemoryott@inteummail.comhttps://emoryott.technologypublisher.com/techcase/2219123028https://emoryott.technologypublisher.com/techcase/23028Application Simple and economical method for isolating and storing RNA from biological samples at room temperatures. Key Benefits Alternative, low-cost extraction method suitable for extracting RNA from biological samples for molecular analysis and disease diagnosis. Eliminates the need for expensive proprietary materials, hazardous chemicals, or energy-consuming freezers. Ambient-temperature storage of the primary sample in lysis buffer for up to 7 days. Ambient-temperature storage and RNA stability for up to 35 days. Market Summary Ribonucleic acid (RNA) is central to protein synt...Wed, 11 Oct 2023 07:55:29 GMTemoryott@inteummail.comhttps://emoryott.technologypublisher.com/techcase/2302821178https://emoryott.technologypublisher.com/techcase/21178Application Set of interventional activity tools designed to incorporated faith-based principles to improve the quality of life of individuals living with or family members caring for persons with moderate to severe Alzheimer Disease or related dementias. Key Benefits Provides relief from anxiety. Reduced behavior disturbances. Improved quality of life for individuals living with dementia and their caregivers. Market Summary As described by the World Health Organization, dementia is a syndrome that leads to deterioration in cognitive function beyond what might be expected from the us...Tue, 10 Oct 2023 06:36:29 GMTemoryott@inteummail.comhttps://emoryott.technologypublisher.com/techcase/2117821177https://emoryott.technologypublisher.com/techcase/21177Application Religious (Christian) service videos available through a public online platform that are tailored to support the well-being of caregivers and family members of persons living with dementia (PLWD). Key Benefits Provides relief from anxiety. Reduced behavior disturbances. Improved quality of life for individuals living with dementia and their caregivers. Market Summary More than 5 million Americans over the age of 65 are living with some form of dementia. Dementia impairs cognitive function which is often accompanied by changes in mood, emotional control, behavior, or motiv...Tue, 10 Oct 2023 06:36:28 GMTemoryott@inteummail.comhttps://emoryott.technologypublisher.com/techcase/2117717157https://emoryott.technologypublisher.com/techcase/17157Application A class of drugs that inhibit molecules responsible for the severe nervous system complications associated with myotonic dystrophy. Key Benefits Potentially the first medication for treating the severe nervous system symptoms associated with myotonic dystrophy by targeting GABRG2. Transdermal and oral administration. May drive the development of new therapies that target GABRG2. Market Summary Myotonic dystrophy (DM) is considered a subgroup of myopathy and the most common type of muscular dystrophy. While DM commonly presents as an adult-onset multisystem degenerative di...Tue, 10 Oct 2023 06:36:25 GMTemoryott@inteummail.comhttps://emoryott.technologypublisher.com/techcase/1715722148https://emoryott.technologypublisher.com/techcase/22148Application Vaccine for Respiratory Syncytial Virus (RSV) in infants and children. Key Benefits A novel vaccine targeting both the F and G proteins of the respiratory syncytial virus (RSV), including its variants. Preliminary data in in mice show the vaccine induced the production of antibodies associated with preventing disease. Potential to prevent infection and its life-threatening complications. Market Summary Respiratory Syncytial Virus (RSV) is a leading cause of severe bronchiolitis in infants and young children and is responsible for 24.8 million acute respiratory tract infec...Thu, 05 Oct 2023 12:50:40 GMTemoryott@inteummail.comhttps://emoryott.technologypublisher.com/techcase/2214822192https://emoryott.technologypublisher.com/techcase/22192Application A real-time, non-invasive probe to determine the efficacy of cancer immunotherapies. Key Benefits Determines immunotherapy success in patients. CAR cells can be tested before putting it back in the patients. Simple diagnostic with readout in 30 minutes compared to 2-3 days. Market Summary Lymphoblastic leukemia is one of the most common types of childhood cancer that commences in the bone marrow. In lymphoblastic leukemia, the bone marrow makes too many immature white blood cells called lymphoblasts. These lymphoblasts crowd out healthy blood cells and can cause a number ...Thu, 05 Oct 2023 12:22:38 GMTemoryott@inteummail.comhttps://emoryott.technologypublisher.com/techcase/2219222012https://emoryott.technologypublisher.com/techcase/22012Application Salvianolic acid C for treating Fragile X Syndrome (FXS). Key Benefits New therapeutic drug candidate for the treatment of FXS. Preliminary data in the laboratory in organoids treated with the drug showed rescued cell phenotypes known to be associated with the disease in humans. Potential to treat other neurodevelopmental disorders. Market Summary Fragile X syndrome (FXS) is a genetic neurodevelopmental disorder caused by a mutation in the FMR1 gene and is the leading inherited cause of intellectual disability. The condition presents a broad range of symptoms, including i...Thu, 05 Oct 2023 12:22:36 GMTemoryott@inteummail.comhttps://emoryott.technologypublisher.com/techcase/2201217077https://emoryott.technologypublisher.com/techcase/17077Application Sleep stage classification algorithm and diagnostic platform. Key Benefits Real-time sleep classification using a single electrocardiogram sensor. Eliminates the need for multiple head, eye, skin, and heart sensors with current diagnostics. Preliminary results using human data demonstrate high accuracy in identifying different sleep stages. Potential to enter the $500 million sleep diagnostic market. Market Summary Sleep disorders are a significant public health problem, affecting over 50 million in the United States and leading to over $94 billion in healthcare-associat...Thu, 05 Oct 2023 09:01:22 GMTemoryott@inteummail.comhttps://emoryott.technologypublisher.com/techcase/1707715039https://emoryott.technologypublisher.com/techcase/15039Application A therapeutic technique to eliminate infection of patients suffering from chronic Hepatitis B Virus infection. Key Benefits May provide a cure for chronic HBV infection rather than just simple management. High efficiency of infection targeting may produce minimal side effects. May be used in combination with other HBV inhibitors. Market Summary Hepatitis B virus (HBV) is a major human pathogen that can cause serious liver complications. Current treatments for chronic HBV infections work to prevent viral spread by blocking viral replication or stimulating the host immune s...Thu, 31 Aug 2023 11:54:28 GMTemoryott@inteummail.comhttps://emoryott.technologypublisher.com/techcase/1503921165https://emoryott.technologypublisher.com/techcase/21165Application Immunotherapy for HER2+ and triple-negative breast cancer. Key Benefits Autologous vaccine comprising patient-specific tumor antigens and immune stimulatory components against aggressive breast cancers. Prepared outside of the body and then administered to patients. Preclinical data indicate treatment decreases tumor growth and improves survival in mice. Market Summary Breast cancer is the most common type of malignancy diagnosed in women, with over 260,000 new cases each year in the United States. Although treatment has significantly improved, some breast cancer patients...Tue, 06 Jun 2023 07:21:18 GMTemoryott@inteummail.comhttps://emoryott.technologypublisher.com/techcase/2116522132https://emoryott.technologypublisher.com/techcase/22132Application Assist in the diagnosis of hematologic disorders of bone marrow. Key Benefits Automated machine learning approach for performing bone marrow differential counts that accounts for all viable cells on the smear. Preliminary data generated by a prototype shows the system is fast and demonstrates precision compared to manual counting. Potential to be a rapid, automated approach for the diagnosis of many hematologic diseases, facilitating earlier and more efficacious treatment. Market Summary Bone marrow aspiration biopsy is performed on over half a million patients annually i...Mon, 05 Jun 2023 12:32:55 GMTemoryott@inteummail.comhttps://emoryott.technologypublisher.com/techcase/2213223068https://emoryott.technologypublisher.com/techcase/23068Application A small molecule showing cardioprotection from drug-induced and alcohol-induced cytotoxicity. Key Benefits Demonstrates broad impact with cardioprotective effects against multiple cardiotoxic agents, including alcohol and chemotherapeutic drugs like doxorubicin and bortezomib. Does not interfere with the proteasome inhibition activity and anticancer activity of carfilzomib, rather works in combination. Potential for broad application to patients of all ages. Market Summary Cardiotoxicity is one of the most common causes of drug withdrawal. Cardiotoxicity is a very much a ...Tue, 23 May 2023 06:32:12 GMTemoryott@inteummail.comhttps://emoryott.technologypublisher.com/techcase/2306822206https://emoryott.technologypublisher.com/techcase/22206Application A precision medicine algorithm that reduces mortality in sepsis patients by individualizing and targeting specific therapies to specific patients. Key Benefits An algorithm that uses bedside routine vital signs to optimize the precision treatment of sepsis. Clinical data show the ability of the algorithm to identify a subset of patients with improved mortality after treatment with balanced crystalloids. Simple, inexpensive, and can be easily integrated into hospital workflows. Market Summary Sepsis is a life-threatening condition that affects millions of people worldwide....Tue, 23 May 2023 06:32:06 GMTemoryott@inteummail.comhttps://emoryott.technologypublisher.com/techcase/2220622091https://emoryott.technologypublisher.com/techcase/22091Application A novel method to improve the effectiveness of marrow-mediated cartilage repair. Key Benefits Enhances the efficacy of the marrow stimulation procedure for cartilage repair. Priming the cartilage repair environment to enable subsequent healthy tissue growth. Potential to become a one-step, implementable, and effective treatment for focal cartilage injury. Market Summary Cartilage injuries are widespread, with an estimated 900,000 cases in the US annually. Most cartilage injuries occur in the knee in the weight-bearing areas of the joint. Unlike other tissues in the body, ...Tue, 16 May 2023 06:35:37 GMTemoryott@inteummail.comhttps://emoryott.technologypublisher.com/techcase/2209121073https://emoryott.technologypublisher.com/techcase/21073Application Diagnostic and automatic surveillance to identify COVID-19 via smartphone in real-time. Key Benefits Provides real-time, rapid results. Autonomous process. Device does not require RNA isolation or amplification for viral detection. Market Summary Coronavirus (COVID-19) is an infectious disease that causes severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The emergence of COVID-19 led to a global pandemic with more than 500 million infected and over 6 million deaths worldwide. One of the essential tools in combating COVID-19 and facilitating early treatment is ...Mon, 08 May 2023 13:18:45 GMTemoryott@inteummail.comhttps://emoryott.technologypublisher.com/techcase/2107322079https://emoryott.technologypublisher.com/techcase/22079Application A software application to educate and train healthcare professionals on addressing complex health-related needs of patients with frequent hospital visits after hospital discharge through virtual healthcare hotspotting. Key Benefits Remote learning without requiring colocation but achieving the same impact. Particularly useful in conditions like when a pandemic arises. Ability to involve larger groups of personnel to perform group exercises interactively in simulated environments beyond hospital walls. Interdisciplinary coordination and collaboration to achieve a comprehensiv...Wed, 05 Apr 2023 12:22:58 GMTemoryott@inteummail.comhttps://emoryott.technologypublisher.com/techcase/2207923006https://emoryott.technologypublisher.com/techcase/23006Application A repurposed therapeutic for the preventative and treatment of aneurysms. Key Benefits A repurposed cancer drug that targets cells known to be damaged during the progression of an aneurysm. The drug has been tested within an animal model of aortic aneurysms, where it prevented the severe complications of the disease and protected the vascular structures. Potential to be a non-invasive medicine to reduce the high mortality rate associated with aneurysms. Market Summary An aortic aneurysm is a bulge in the aorta wall, which carries blood from the heart to the rest of the bo...Wed, 05 Apr 2023 07:16:36 GMTemoryott@inteummail.comhttps://emoryott.technologypublisher.com/techcase/2300622069https://emoryott.technologypublisher.com/techcase/22069Application Therapeutic for treating age-associated lung fibrosis. Key Benefits Tecfidera (dimethyl fumarate - DMF) is an FDA approved therapy to treat multiple sclerosis via oral administration. A novel formulation for inhaled delivery demonstrated efficacy for a new indication: Idiopathic Pulmonary Fibrosis (IPF), where it promotes the reversal of age-dependent established lung fibrosis. FDA-approval via oral administration provides opportunities for expedited market availability. Market Summary Idiopathic pulmonary fibrosis (IPF), the most common type of lung fibrosis, is a seriou...Wed, 05 Apr 2023 07:16:19 GMTemoryott@inteummail.comhttps://emoryott.technologypublisher.com/techcase/2206922038https://emoryott.technologypublisher.com/techcase/22038Application Novel reagents for manufacturing of CAR T cells with improved characteristics. Key Benefits A multi-cytokine backpack particle that can be used during manufacturing process of CAR T treatments to improve their phenotype and efficacy. Preliminary data show the method can transduce primary healthy and patient T cells and promote CAR T cell efficacy against hematological and solid tumors. Potential to improve many of the CAR T cell -based therapies that are FDA-approved and those being used in clinical trials. Market Summary Immunotherapies, including CAR T cell treatments, ...Wed, 05 Apr 2023 07:16:16 GMTemoryott@inteummail.comhttps://emoryott.technologypublisher.com/techcase/2203821196https://emoryott.technologypublisher.com/techcase/21196Application A more reliable and accurate method for diagnosing SARS-CoV-2 infection based on the biochemical interactions between the spike trimer and ACE-2 protein. Key Benefits A fast, affordable, and easy-to-use SARS-Cov-2 diagnostic test for use in clinical settings. Market Summary SARS-CoV-2 has evolved significantly since the onset of the pandemic, and continues to impact lives acorss the globe. Currently, the CDC does not recommend antibody testing as a means to estimate COVID-19 immunity. While serology testing is available and inexpensive (around $70 per test), it is not as wi...Wed, 05 Apr 2023 07:16:12 GMTemoryott@inteummail.comhttps://emoryott.technologypublisher.com/techcase/2119621170https://emoryott.technologypublisher.com/techcase/21170Application An intra-articular alignment guide for ankle replacement system to treat ankle arthritis. Key Benefits Less invasive method that does not require drilling a hole through the heel for Inbone II tibial stem placement. More convenient to use compared to Inbone II frame and foot holder to find the correct alignment. Market Summary Approximately 1% of adults suffer from ankle arthritis. The condition is prevalent in the older population after a lifetime of ankle use and occasionally affects people under 40 years of age who have suffered an ankle injury in the past. About 18% of...Wed, 05 Apr 2023 07:16:06 GMTemoryott@inteummail.comhttps://emoryott.technologypublisher.com/techcase/21170NCS.25https://emoryott.technologypublisher.com/techcase/NCS.25Wed, 05 Apr 2023 07:10:38 GMTemoryott@inteummail.comhttps://emoryott.technologypublisher.com/techcase/NCS.2519114https://emoryott.technologypublisher.com/techcase/19114Application A blood-based biomarker test for the diagnosis of anxiety disorders. Key Benefits Gene panel of at least seven biomarkers that may predict anxiety in humans. Minimally invasive blood test. May identify different forms of anxiety leading to personalized treatment and improved clinical outcomes. Market Summary Anxiety disorders are the most common type of mental illness and fall under a number of classifications, including but not limited to separation anxiety and selective mutism, phobias, social anxiety, generalized anxiety, panic disorder, and agoraphobia. The WHO ranks ...Wed, 08 Feb 2023 14:14:20 GMTemoryott@inteummail.comhttps://emoryott.technologypublisher.com/techcase/19114NCS.28https://emoryott.technologypublisher.com/techcase/NCS.28Wed, 08 Feb 2023 14:12:57 GMTemoryott@inteummail.comhttps://emoryott.technologypublisher.com/techcase/NCS.2821101https://emoryott.technologypublisher.com/techcase/21101Application Diagnostic molecules for detecting bacterial infections using nuclear imaging. Key Benefits May improve the detection of infections within the body. Potentially facilitates earlier treatment and superior clinical outcomes compared to other diagnostic radiotracers. Market Summary The rising incidences of bacterial infections resistant to standard of care (SOC) antibiotics and antimicrobials has raised great health concerns worldwide. More than 2.8 million Americans will become infected with resistant infections leading to over 35,000 deaths. New solutions to help detect bac...Tue, 20 Dec 2022 11:46:20 GMTemoryott@inteummail.comhttps://emoryott.technologypublisher.com/techcase/2110120069https://emoryott.technologypublisher.com/techcase/20069Application Measurement device for detecting of single-cell dynamics under environment perturbations or drug treatment. Key Benefits Fast determination of drug sensitivity. Long-term continuous cell-fate tracking. Time-lapse analysis of cell proliferation. Cell community analysis: intra-species interactions, inter-species interactions. Market Summary The global market for microfluidic devices has been rapidly rising. The main reason behind this rise is the multifunctionality of microfluidic devices especially in the fields of life sciences and the pharmaceutical industry as well as ...Tue, 20 Dec 2022 11:45:59 GMTemoryott@inteummail.comhttps://emoryott.technologypublisher.com/techcase/2006922072https://emoryott.technologypublisher.com/techcase/22072Application Systems and methods for recording and recovering viable electrophysiological signals and during delivery of stimulation, including deep brain stimulation (DBS). Key Benefits Enables the recording of electrophysiology/neurophysiology during stimulation from the same stimulating contact and adjacent contacts. Enables the potential usage of these obtained biomarkers for improving and providing objective measures for the optimization of clinical therapy that involves neuromodulation therapies. Preserve oscillatory components within the electrophysiological signal, allowing the u...Tue, 06 Dec 2022 13:19:45 GMTemoryott@inteummail.comhttps://emoryott.technologypublisher.com/techcase/2207221037https://emoryott.technologypublisher.com/techcase/21037Application Home-based family psychoeducational intervention for low-income children with persistent asthma. Key Benefits Medical and psychosocial needs of patients and family members can be addressed simultaneously. Significantly improved asthma management and caregiver stress in randomized controlled clinical trial. Market Summary Asthma is a disease affecting the lungs and is prevalent in 7% of all children in the United States, and that number increases in children with lower annual household income. To address this, researchers at Emory University have developed a home-based fami...Tue, 06 Dec 2022 13:18:58 GMTemoryott@inteummail.comhttps://emoryott.technologypublisher.com/techcase/2103721032https://emoryott.technologypublisher.com/techcase/21032Tue, 06 Dec 2022 13:18:52 GMTemoryott@inteummail.comhttps://emoryott.technologypublisher.com/techcase/2103221189https://emoryott.technologypublisher.com/techcase/21189Application Highly transformative new strategy to enhance mesenchymal stromal cell consistency and efficacy for taking MSC therapies to clinical stage. Key Benefits Currently there is no method to determine if an MSC donor line will be therapeutically effective. Provides a point of use assay in the clinical setting which can determine MSC efficacy and rejuvenate the efficacy of the cells. Measurements can be utilized as real-time critical quality during large-scale MSC cell manufacturing. Market Summary The CDC estimates 1 in 4 Americans have some form of arthritis, with osteoarthrit...Fri, 29 Jul 2022 13:02:00 GMTemoryott@inteummail.comhttps://emoryott.technologypublisher.com/techcase/2118921033https://emoryott.technologypublisher.com/techcase/21033Application Antisense oligonucleotide (ASO) therapies for the treatment of rare diseases and cancer. Key Benefits Novel approach to ASO therapeutics that potentially improve tissue/cell targeting capabilities. Increases the efficacy of ASOs while decrease off-target toxicity. Potential to treat a variety of genetic diseases such as cancer, blood disorders, and rare conditions for which there are no viable treatment options. Market Summary Antisense oligonucleotides (ASOs) are an emerging therapeutic modality that allows for modulating specific RNA and subsequent protein translation f...Fri, 29 Jul 2022 12:57:54 GMTemoryott@inteummail.comhttps://emoryott.technologypublisher.com/techcase/2103320067https://emoryott.technologypublisher.com/techcase/20067Application Quinazolin-4(3H)-one derivatives as selective NOX-2 inhibitors to prevent oxidative damage. Key Benefits Small molecule NOX-2 specific inhibitor. Prevents excessive reactive oxygen species (ROS) generation rather than removing them. Selective NOX-2 inhibition offers significant advantages to development of an effective therapy against acute lung injury, chronic obstructive pulmonary disease (COPD), asthma, cystic fibrosis, and pulmonary hypertension, as well as CNS diseases and inflammatory diseases. Market Summary Oxidative stress is essential to many diseases, including...Fri, 29 Jul 2022 12:51:00 GMTemoryott@inteummail.comhttps://emoryott.technologypublisher.com/techcase/2006720008https://emoryott.technologypublisher.com/techcase/20008Application A small molecule compound to treat Malignant Glioblastoma multiforme. Key Benefits Dual inhibition of NQO1 and GSTP1 induces cell death in glioblastoma cells. Inhibition of NQO1 and GSTP1 by MNPC suppresses tumor growth and elongates the life span of the animals with GBM. Market Summary Approximately 30% of patients diagnosed with a brain or spinal cord tumor will survive more than five years. Glioblastoma multiforme (GBM) accounts for about 15% of all brain tumors and occurs in adults between the ages of 45 and 70 years. Effective treatments for brain cancer are limited b...Fri, 29 Jul 2022 12:49:00 GMTemoryott@inteummail.comhttps://emoryott.technologypublisher.com/techcase/2000821042https://emoryott.technologypublisher.com/techcase/21042Wed, 06 Jul 2022 13:21:39 GMTemoryott@inteummail.comhttps://emoryott.technologypublisher.com/techcase/2104220215https://emoryott.technologypublisher.com/techcase/20215Wed, 06 Jul 2022 13:21:04 GMTemoryott@inteummail.comhttps://emoryott.technologypublisher.com/techcase/2021520092https://emoryott.technologypublisher.com/techcase/20092Application An improved method for labeling and imagine RNA in live cells. Key Benefits Low background signal. Covalent binding suitable for time-resolved investigations. Photoactivatable for temporal control. Market Summary Ribonucleic acid (RNA) molecules are synthesized in cells through highly regulated biogenesis pathways, and when these molecules mature, they regulate the fundamental cellular processes in the body. In addition, they are involved many diseases and are a primary focus of biotechnology companies and academic researchers. Several tools have been developed to sequenc...Wed, 06 Jul 2022 13:20:23 GMTemoryott@inteummail.comhttps://emoryott.technologypublisher.com/techcase/2009220020https://emoryott.technologypublisher.com/techcase/20020Wed, 06 Jul 2022 13:19:44 GMTemoryott@inteummail.comhttps://emoryott.technologypublisher.com/techcase/2002019203https://emoryott.technologypublisher.com/techcase/19203Application Synthetic collagen-based biomaterials for therapeutic delivery or drug testing. Key Benefits Synthetic collagen substitute. Capable of formulating into various structures. Free of animal-based contaminants. Able to be spatially patterned. Market Summary Organ failure and tissue defects affect millions of Americans, resulting in significant healthcare-related expenses and morbidity. The lack of available organs and tissues for liver disease, renal failure, tissue grafts, and burns results in over 100,000 deaths yearly. Recently, tissue engineering has become a rapidly evo...Wed, 06 Jul 2022 13:19:09 GMTemoryott@inteummail.comhttps://emoryott.technologypublisher.com/techcase/1920318221https://emoryott.technologypublisher.com/techcase/18221Application A drug combination screening/testing platform for individualized cancer therapy. Key Benefits Rapid screening of effective drug combination. Integrated tumor microenvironment. Identifying personalized therapy for individual cancer patient. Market Summary Traditional two-dimensional (2D) in vitro culture models for drug development do not fully encompass all the features of human tissues, as they do not adequately simulate living tissue and their microenvironments. Although animal models can serve as translational methods to humans, they are expensive and can take months o...Wed, 06 Jul 2022 13:17:53 GMTemoryott@inteummail.comhttps://emoryott.technologypublisher.com/techcase/1822118082https://emoryott.technologypublisher.com/techcase/18082Wed, 06 Jul 2022 13:17:01 GMTemoryott@inteummail.comhttps://emoryott.technologypublisher.com/techcase/1808218014https://emoryott.technologypublisher.com/techcase/18014Application Therapeutic use of miR-483 mimic for treating aortic valve clarification. Key Benefits MiR-483 or mimics of miR-483 could be used as a therapeutic. Could also be a target for additional drug development toward a non-invasive therapy for aortic valve calcification. Market Summary Aortic stenosis (AS) is the most common type of heart valve disease in the elderly, affecting 4.6% of people over the age of 75. AS is often caused by aortic valve calcification (AVC), a degenerative disease of the heart that causes narrowing of the aortic valve. As the population ages, AS and AVC ...Wed, 06 Jul 2022 13:16:45 GMTemoryott@inteummail.comhttps://emoryott.technologypublisher.com/techcase/1801419249https://emoryott.technologypublisher.com/techcase/19249Wed, 18 May 2022 13:55:11 GMTemoryott@inteummail.comhttps://emoryott.technologypublisher.com/techcase/1924920070https://emoryott.technologypublisher.com/techcase/20070Wed, 18 May 2022 13:54:51 GMTemoryott@inteummail.comhttps://emoryott.technologypublisher.com/techcase/2007020045https://emoryott.technologypublisher.com/techcase/20045Tue, 17 May 2022 12:22:05 GMTemoryott@inteummail.comhttps://emoryott.technologypublisher.com/techcase/2004518240https://emoryott.technologypublisher.com/techcase/18240Tue, 17 May 2022 12:21:53 GMTemoryott@inteummail.comhttps://emoryott.technologypublisher.com/techcase/1824018225https://emoryott.technologypublisher.com/techcase/18225Tue, 17 May 2022 12:21:49 GMTemoryott@inteummail.comhttps://emoryott.technologypublisher.com/techcase/1822513144https://emoryott.technologypublisher.com/techcase/13144Tue, 17 May 2022 12:21:29 GMTemoryott@inteummail.comhttps://emoryott.technologypublisher.com/techcase/1314422095https://emoryott.technologypublisher.com/techcase/22095Application A multifunctional immuno-therapy nanoparticle (PD1Y-HANP/Avasimbe) that has ability of targeting and inhibiting immune checkpoint PDL-1 while producing therapeutic effects on tumors and atherosclerosis. Key Benefits Multifunctional immunotherapy for cancer patients with atherosclerosis. Shown to inhibit tumor growth and prevention of tumor recurrence. Shown to inhibit the progression of atherosclerotic plaques. Market Summary There is a close association between cancer and atherosclerosis, and patients with atherosclerosis have two-fold higher cancer incidence. There is a...Fri, 13 May 2022 11:45:51 GMTemoryott@inteummail.comhttps://emoryott.technologypublisher.com/techcase/2209522020https://emoryott.technologypublisher.com/techcase/22020Fri, 13 May 2022 11:45:16 GMTemoryott@inteummail.comhttps://emoryott.technologypublisher.com/techcase/2202021128https://emoryott.technologypublisher.com/techcase/21128Fri, 13 May 2022 11:44:24 GMTemoryott@inteummail.comhttps://emoryott.technologypublisher.com/techcase/2112821106https://emoryott.technologypublisher.com/techcase/21106Fri, 13 May 2022 11:44:16 GMTemoryott@inteummail.comhttps://emoryott.technologypublisher.com/techcase/2110621082https://emoryott.technologypublisher.com/techcase/21082Fri, 13 May 2022 11:44:07 GMTemoryott@inteummail.comhttps://emoryott.technologypublisher.com/techcase/2108220079https://emoryott.technologypublisher.com/techcase/20079Fri, 13 May 2022 11:42:30 GMTemoryott@inteummail.comhttps://emoryott.technologypublisher.com/techcase/2007920056https://emoryott.technologypublisher.com/techcase/20056Fri, 13 May 2022 11:42:16 GMTemoryott@inteummail.comhttps://emoryott.technologypublisher.com/techcase/2005621162https://emoryott.technologypublisher.com/techcase/21162Tue, 19 Apr 2022 09:10:30 GMTemoryott@inteummail.comhttps://emoryott.technologypublisher.com/techcase/2116221046https://emoryott.technologypublisher.com/techcase/21046Application A series of SARS-CoV-2 sub-genomic replicons as artificial bacterial chromosomes for the screening of SARS-CoV-2 in studies such as drug discovery and inhibitors assay. Key Benefits Can be used at a lower biosafety level than non-artificial copies of SARS-CoV-2. Can be used for high throughput screening and characterization of SARS-CoV-2 replicase inhibitors. Multiple replicons including mutants are available. Market Summary Coronavirus disease (COVID-19) is a deadly infectious disease caused by the new SARS-CoV-2 (Severe Acute Respiratory Syndrome Coronavirus 2) virus. S...Tue, 19 Apr 2022 09:09:49 GMTemoryott@inteummail.comhttps://emoryott.technologypublisher.com/techcase/2104621010https://emoryott.technologypublisher.com/techcase/21010Tue, 19 Apr 2022 09:09:34 GMTemoryott@inteummail.comhttps://emoryott.technologypublisher.com/techcase/2101021138https://emoryott.technologypublisher.com/techcase/21138Wed, 16 Mar 2022 12:57:18 GMTemoryott@inteummail.comhttps://emoryott.technologypublisher.com/techcase/2113820191https://emoryott.technologypublisher.com/techcase/20191Wed, 16 Mar 2022 12:56:36 GMTemoryott@inteummail.comhttps://emoryott.technologypublisher.com/techcase/2019122029https://emoryott.technologypublisher.com/techcase/22029Wed, 23 Feb 2022 11:39:03 GMTemoryott@inteummail.comhttps://emoryott.technologypublisher.com/techcase/2202921079https://emoryott.technologypublisher.com/techcase/21079Wed, 23 Feb 2022 11:38:10 GMTemoryott@inteummail.comhttps://emoryott.technologypublisher.com/techcase/2107921024https://emoryott.technologypublisher.com/techcase/21024Wed, 23 Feb 2022 11:37:51 GMTemoryott@inteummail.comhttps://emoryott.technologypublisher.com/techcase/2102417232https://emoryott.technologypublisher.com/techcase/17232Application A marker that predicts Venetoclax (ABT-199) sensitivity that can also be targeted with a drug to help multiple myeloma patients. Key Benefits Marker that predicts if venetoclax will be an effective treatment in multiple myeloma patients. A drug that targets venetoclax resistant multiple myeloma cells to improve treatment in patients. Market Summary Despite the use of next generation drug therapies, Multiple myeloma (MM) patients relapse and develop therapy resistance. Approximately 20% of patients succumb to this disease within a short period of time. Resistance is primari...Wed, 23 Feb 2022 11:33:14 GMTemoryott@inteummail.comhttps://emoryott.technologypublisher.com/techcase/1723220171https://emoryott.technologypublisher.com/techcase/20171Mon, 24 Jan 2022 14:29:29 GMTemoryott@inteummail.comhttps://emoryott.technologypublisher.com/techcase/2017119183https://emoryott.technologypublisher.com/techcase/19183Fri, 07 Jan 2022 11:25:30 GMTemoryott@inteummail.comhttps://emoryott.technologypublisher.com/techcase/1918321009https://emoryott.technologypublisher.com/techcase/21009Thu, 06 Jan 2022 14:01:38 GMTemoryott@inteummail.comhttps://emoryott.technologypublisher.com/techcase/2100920254https://emoryott.technologypublisher.com/techcase/20254Application A novel proton counting detector and accompanying methodology to characterize the dimensions of an artificial implant and human tissues. Key Benefits Provides an alternative way of counting protons utilizing most probable energy as a unit. Generates material maps of artificial implants and human tissues required for Monte Carlo (MC) dose calculation. Provides a secondary validation of material and density maps provided by metal artifact reduction (MAR) and multi-energy computed tomography (MECT) techniques. Market Summary Presence of metal implants in patients complicates...Thu, 06 Jan 2022 14:01:35 GMTemoryott@inteummail.comhttps://emoryott.technologypublisher.com/techcase/2025420153https://emoryott.technologypublisher.com/techcase/20153Application A therapeutic against B cell cancers developed using a novel screening method for rapid drug discovery. Key Benefits Screening approach can be used for future drug discovery. Therapeutic incorporates cytokine therapy with reduced risk of off-target toxicity. Therapeutic is of interest for the treatment of B cell cancers and autoimmune disease. Market Summary Acute lymphoblastic leukemia (ALL) is the most common type of cancer in children. A promising treatment strategy for leukemia and other cancers is immune cell redirection. This strategy focuses on manipulating anti-ca...Thu, 06 Jan 2022 07:01:16 GMTemoryott@inteummail.comhttps://emoryott.technologypublisher.com/techcase/2015319113https://emoryott.technologypublisher.com/techcase/19113Tue, 07 Dec 2021 06:49:15 GMTemoryott@inteummail.comhttps://emoryott.technologypublisher.com/techcase/1911320117https://emoryott.technologypublisher.com/techcase/20117Thu, 02 Dec 2021 06:04:30 GMTemoryott@inteummail.comhttps://emoryott.technologypublisher.com/techcase/2011716134https://emoryott.technologypublisher.com/techcase/16134Fri, 05 Nov 2021 13:08:01 GMTemoryott@inteummail.comhttps://emoryott.technologypublisher.com/techcase/1613417057https://emoryott.technologypublisher.com/techcase/17057Fri, 05 Nov 2021 12:05:55 GMTemoryott@inteummail.comhttps://emoryott.technologypublisher.com/techcase/1705718209https://emoryott.technologypublisher.com/techcase/18209Application This closed-loop platform monitors and maintains traditional cell culture and bioengineered tissues to automate standard and custom cell maintenance protocols, including stem cell differentiations, bioengineered tissue generation, and functional maturation of complex cell cultures. Key Benefits Automation of cell culture maintenance Integration with image analysis to determine reagent and media needs of cells in culture Compatibility with standard well plates Reusable after sterilization Cheaper and simpler than larger fluid handling systems Market Summary Current stand...Wed, 25 Aug 2021 14:13:22 GMTemoryott@inteummail.comhttps://emoryott.technologypublisher.com/techcase/1820915044https://emoryott.technologypublisher.com/techcase/15044Wed, 25 Aug 2021 14:01:42 GMTemoryott@inteummail.comhttps://emoryott.technologypublisher.com/techcase/15044NCS.27https://emoryott.technologypublisher.com/techcase/NCS.27Application MAST1 inhibitors to overcome resistance to platinum-based chemotherapy, exacerbated by dexamethasone co-administration. Key Benefits Co-administration of MAST1 inhibitor and MAST1-stabilizing protein inhibitor abrogates tumor resistance to cisplatin MAST1 inhibitor, lestaurtinib, has previously reached phase III clinical trials and proven safe in humans Hsp90B (MAST1 stabilizer) inhibitor, 17-AAG, has previously reached phase III clinical trials and proven safe in humans Market Summary Platinum-based drugs, including cisplatin, are regularly prescribed for the treatment o...Wed, 25 Aug 2021 13:20:26 GMTemoryott@inteummail.comhttps://emoryott.technologypublisher.com/techcase/NCS.2720040https://emoryott.technologypublisher.com/techcase/20040Application A new design of a modular hip implant with a rotational proximal junction in the femoral stem to minimize post-operative hip dislocation. Benefits Rotating femoral component alleviates torsional strain on implant, a primary cause of implant impingement and failure. Market Summary Peri-prosthetic hip dislocation is the number one cause for revision total hip arthroplasty, which is associated with high costs and long recovery periods. Though there have been several innovations to prevent post-operative hip dislocations, there is still an unmet need for a technology to solve t...Tue, 17 Aug 2021 05:12:31 GMTemoryott@inteummail.comhttps://emoryott.technologypublisher.com/techcase/2004020127https://emoryott.technologypublisher.com/techcase/20127Tue, 13 Jul 2021 07:44:56 GMTemoryott@inteummail.comhttps://emoryott.technologypublisher.com/techcase/2012711144https://emoryott.technologypublisher.com/techcase/11144Wed, 03 Feb 2021 13:41:11 GMTemoryott@inteummail.comhttps://emoryott.technologypublisher.com/techcase/1114420204https://emoryott.technologypublisher.com/techcase/20204Application Repurposed drug for transcriptomic-driven treatment of cocaine use disorder. Key Benefits FDA-approved drug. Outperformed current targets undergoing clinical trials for CUD at the mRNA level. Market Summary Cocaine abuse is associated with substantial morbidity and mortality, and there are no approved medications for the treatment of CUD. The current standard of treatment includes psychosocial treatments. Despite progress in the development of psychosocial approaches for CUD, many patients still do not respond to these treatments. Technical Summary Emory University inven...Sat, 23 Jan 2021 08:07:13 GMTemoryott@inteummail.comhttps://emoryott.technologypublisher.com/techcase/2020418047https://emoryott.technologypublisher.com/techcase/18047Application Multimodal learning test to assess naming and facial recognition in post-operative epilepsy patients. Key Benefits Provides non-invasive, age-appropriate neuropsychological testing. Allows clinicians to simultaneously assess multiple modalities. Market Summary Epilepsy is a chronic neurological disorder characterized by unpredictable, recurrent seizures and may affect people of all ages. These recurrent seizures and the surgical treatments often lead to cognitive dysfunction. Stereotaxic laser ablation is used to target specific areas of the temporal lobe and minimize coll...Thu, 10 Dec 2020 13:22:42 GMTemoryott@inteummail.comhttps://emoryott.technologypublisher.com/techcase/1804712224https://emoryott.technologypublisher.com/techcase/12224Application A CRISPR based gene silencing system using sequence specific RNA to repress expression of endogenous transcripts. Key Benefits Provides a platform to target specific mRNA transcripts in both prokaryotic and eukaryotic cells. Potential therapeutic strategy against pathogenic bacteria and viruses. Market Summary RNAi is an indispensable tool to study gene function and is extensively utilized in basic research as well as drug discovery. Due to the ability to specifically target a disease causing protein, RNAi offers the capability to develop personalized treatment. Use of RNA...Thu, 10 Dec 2020 13:22:37 GMTemoryott@inteummail.comhttps://emoryott.technologypublisher.com/techcase/1222418229https://emoryott.technologypublisher.com/techcase/18229Application Three-piece, partially biodegradable cannulated screw for use in syndesmosis ankle surgery. Key Benefits Implant removal is not necessary. Allows for both rigid initial fixation to allow syndesmotic healing and physiologic micro motion at the syndesmosis for long term support and function. Higher biomechanical strength than absorbable screws. Market Summary The ankle is made up of the tibia and fibula bones of the lower leg, and the tarsus bone of the foot held together by ligaments, which provide strength and stability during movement. The tibia and the fibula are held t...Tue, 08 Dec 2020 05:27:59 GMTemoryott@inteummail.comhttps://emoryott.technologypublisher.com/techcase/1822920088https://emoryott.technologypublisher.com/techcase/20088Application Mouse embryonic fibroblast (MEF) line deficient in caspase-3 that are reconstituted with constitutively expressed mutant versions of the protease. Key Benefits An immortalized caspase-3-deficient MEF cell line. Tool to study protease induced apoptosis. Technical Summary Emory inventors have discriminated a previously unknown role of the prodomain region of caspase-3. By reintroducing specific caspase mutations into an immortalized MEF cell line deficient in caspase-3 activity, investigators found a genomic region that rendered these cells more susceptible to death signals....Fri, 20 Nov 2020 12:35:59 GMTemoryott@inteummail.comhttps://emoryott.technologypublisher.com/techcase/2008820038https://emoryott.technologypublisher.com/techcase/20038Application Novel stabilized HIV-1 Clade C gp140 trimeric immunogen useful as a vaccine. Key Benefits Vaccine for HIV-1 infections. Induces both neutralizing and V1V2 scaffold directed antibody responses. V1V2 scaffold directed antibodies bind to multiple strains of HIV-1 from different clades including Clades B and C. Market Summary HIV-1 is a virus having nine different subtypes, or clades. While most HIV clinical studies have been conducted in populations where subtype B predominate, subtype C accounts for a larger share (50%) of all people living with the disease. Traditional the...Fri, 20 Nov 2020 06:28:36 GMTemoryott@inteummail.comhttps://emoryott.technologypublisher.com/techcase/2003820046https://emoryott.technologypublisher.com/techcase/20046Application Ligature resistant medical tubing for use in institutional facilities for the safe administration of IV medicine. Key Benefits Reduces financial burden associated with constant supervision of psychiatric, suicidal, or incarcerated patients needing IV administrations. Minimizes risk of psychiatric patients utilizing medical tubing for harmful purposes. Market Summary Psychiatric patients with co-morbidities are especially expensive to care for because they have a high demand for individual staff supervision and treatment management. Supervision is required because there is ...Wed, 18 Nov 2020 11:17:26 GMTemoryott@inteummail.comhttps://emoryott.technologypublisher.com/techcase/2004620062https://emoryott.technologypublisher.com/techcase/20062Tue, 17 Nov 2020 15:39:42 GMTemoryott@inteummail.comhttps://emoryott.technologypublisher.com/techcase/2006220064https://emoryott.technologypublisher.com/techcase/20064 Application Method to enhance the affinity of spherical nucleic acids for their targets. Key Benefits Facile method for molecular printing on surface of NP. Massive improvement of SNA’s binding affinity to the target can provide strategies in applications for therapeutics and diagnostics. May maximize DNA density on the NP surface. Market Summary Spherical nucleic acids (SNAs) are a type of DNA nanostructure comprised of a dense arrangement of ...]]>Mon, 02 Nov 2020 07:17:06 GMTemoryott@inteummail.comhttps://emoryott.technologypublisher.com/techcase/2006420133https://emoryott.technologypublisher.com/techcase/20133Application Software to automatically measure muscle fiber types and sizes. Key Benefits Accurately identify and characterize different muscle fiber types within a sample. Market Summary Despite generations of technological advancements in disease interpretation and testing technologies, accurate diagnosis of myopathy remains a challenge. Myopathy, a muscle fibers dysfunction disease, is typically diagnosed with a variety of tests including muscle biopsy which involves collecting a small amount of muscle tissue samples and analyzing the sample via histology. The physician then identifi...Mon, 02 Nov 2020 07:07:45 GMTemoryott@inteummail.comhttps://emoryott.technologypublisher.com/techcase/2013319256https://emoryott.technologypublisher.com/techcase/19256Mon, 02 Nov 2020 07:07:23 GMTemoryott@inteummail.comhttps://emoryott.technologypublisher.com/techcase/1925619248https://emoryott.technologypublisher.com/techcase/19248Mon, 02 Nov 2020 07:07:20 GMTemoryott@inteummail.comhttps://emoryott.technologypublisher.com/techcase/1924819229https://emoryott.technologypublisher.com/techcase/19229Application Small molecules to treat cystic fibrosis and other pulmonary diseases. Key Benefits Rescue rare variants of CFTR gene. Serve as PDE4 inhibitors with strong anti-inflammatory effects. Market Summary Cystic fibrosis (CF) is a progressive, genetic disorder that arises from mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene, resulting in dysfunction at the plasma membrane. Wild type CFTR acts as an ion channel in epithelial cells, and regulates fluid transport in lung, pancreas, and other organs. Since CF has an autosomal recessive inheritance pat...Mon, 02 Nov 2020 07:07:17 GMTemoryott@inteummail.comhttps://emoryott.technologypublisher.com/techcase/1922919210https://emoryott.technologypublisher.com/techcase/19210Application New class of fluorine-18 labeled amino acid-derived radiotracer compounds for positron emission tomography (PET) cancer imaging. Key Benefits Next generation of cancer imaging agents. Enhanced sensitivity to detect glioblastoma, prostate cancer and other cancers. Market Summary PET imaging is a type of nuclear medicine procedure which relies on radioactive tracers to show the metabolic activity of cells in the body. The most commonly used radiopharmaceutical is 18F-FDG (fludeoxyglucose), whose level is greatly elevated in rapidly growing malignant tumors. PET radiotracers ...Mon, 02 Nov 2020 07:07:12 GMTemoryott@inteummail.comhttps://emoryott.technologypublisher.com/techcase/1921019185https://emoryott.technologypublisher.com/techcase/19185Application Light-responsive cytokine prodrugs with controlled activation for improved cancer immunotherapy. Key Benefits Spatiotemporal control of therapeutic cytokine activation leads to controlled local activation and reduces off-target toxicity. Prolonged circulation means less frequent dosing is required. Biased activity towards CD8+ T-cells and biased immune cell-selectivity. Market Summary While recombinant cytokines hold great potential for cancer immunotherapy, their clinical use has greatly declined in recent years. Their off-target toxicity/pleiotropic effects and poor cir...Mon, 02 Nov 2020 07:07:00 GMTemoryott@inteummail.comhttps://emoryott.technologypublisher.com/techcase/1918519122https://emoryott.technologypublisher.com/techcase/19122Mon, 02 Nov 2020 07:06:53 GMTemoryott@inteummail.comhttps://emoryott.technologypublisher.com/techcase/1912216129https://emoryott.technologypublisher.com/techcase/16129Application Yellow fever virus-based live attenuated Zika virus (ZIKV) vaccines. Key Benefits Reduces neurotropism from Zika virus. High safety and immunogenicity of chimeric vaccines. Market Summary Zika virus (ZIKV) belongs to the flavivirus family of viruses, which include West Nile (WN), Japanese encephalitis (JE), yellow fever (YF), dengue (DEN) and tick-borne encephalitis (TBE) viruses. Mostly, it is spread by the bite of an infected mosquito, but it can also spread through sexual contact. In addition, Zika can be passed from a pregnant woman to her fetus and infection during pr...Mon, 02 Nov 2020 07:06:13 GMTemoryott@inteummail.comhttps://emoryott.technologypublisher.com/techcase/1612915176https://emoryott.technologypublisher.com/techcase/15176Application Magnetic theranostic nano-toxin for imaging and drug delivery applications in cancer therapy. Key Benefits Induces tumor cell death via a different biological mechanism, compared to current chemotherapeutics, to overcome drug resistance mechanisms in tumor cells. Delivers high levels of therapeutic agents into metastatic tumors, while reducing systemic toxicity. Enables molecular optical and MR imaging to monitor drug delivery, therapeutic responses and intraoperative optical imaging to remove drug resistant tumor lesions. Market Summary Cancer patients with metastatic di...Mon, 02 Nov 2020 07:06:04 GMTemoryott@inteummail.comhttps://emoryott.technologypublisher.com/techcase/1517618091https://emoryott.technologypublisher.com/techcase/18091Application Anti-human Galectin-9-directed chimeric antigen receptor (CAR) T-cells for treatment of hematological malignancies (B-ALL, T-ALL, and DLBCL) in normal, overweight, and obese patients. Key Benefits Can be used as a stand-alone or in-combination product to treat patients with hematological malignancies, particularly overweight and obese patients. Market Summary Pediatric acute lymphoblastic leukemia (ALL) is a type of cancer in which the bone marrow makes too many immature white blood cells, and diffuse large B-cell lymphoma (DLBCL) occurs from the accumulation of B-cells (no...Tue, 13 Oct 2020 05:31:47 GMTemoryott@inteummail.comhttps://emoryott.technologypublisher.com/techcase/1809119171https://emoryott.technologypublisher.com/techcase/19171Application Combination product co-targeting PDH and GLUT1 to inhibit lung cancer metastasis. Key Benefits Combination of drugs exhibits greater synergism in cancer cell lines (H1299, 4T1, H1792). Has potential to prevent metastasis in a variety of cancers. Decreases both cell viability and invasive area. Repurposed drugs. Market Summary Metastatic disease is the primary cause of cancer patient death. Numerous studies show that it is not a single metastatic cell but rather collective packs of invasive cells, that can be further divided into leaders and followers. Compared to followe...Thu, 01 Oct 2020 12:14:45 GMTemoryott@inteummail.comhttps://emoryott.technologypublisher.com/techcase/1917120137https://emoryott.technologypublisher.com/techcase/20137Tue, 15 Sep 2020 08:56:35 GMTemoryott@inteummail.comhttps://emoryott.technologypublisher.com/techcase/2013712226https://emoryott.technologypublisher.com/techcase/12226Thu, 23 Jul 2020 10:00:39 GMTemoryott@inteummail.comhttps://emoryott.technologypublisher.com/techcase/1222619137https://emoryott.technologypublisher.com/techcase/19137Application Tool to precisely and reproducibly implant electrode and other instrumentation into the mouse brain for neurophysiology studies. Key Benefits Inexpensive, rapid and efficient reproduction of headplates. Allows consistent and quick surgical implantation. Capable of recording or stimulating multiple sites in the mouse brain. Market Summary Mouse models are crucial to understanding neurophysiology and neural networks. One of the major limitations using mouse models is the difficulty of instrumenting mice. Surgical procedures for instrumentation are often prolonged, up to sev...Thu, 21 May 2020 13:53:26 GMTemoryott@inteummail.comhttps://emoryott.technologypublisher.com/techcase/1913718157https://emoryott.technologypublisher.com/techcase/18157Application Vaccine formulation of an activator of the stimulator of interferon genes (STING) pathway and saponin adjuvant for enhanced protection of aged population. Key Benefits Significantly improved protective immunity of vaccine in the aged. More efficient than the current methods of influenza vaccination of population 65 years of age or older without the need of additional dosing. Simple in preparation. Market Summary There is an urgent need to improve protective responses to vaccination in the elderly population, which is at especially high risk for adverse outcomes from infec...Fri, 24 Apr 2020 05:39:49 GMTemoryott@inteummail.comhttps://emoryott.technologypublisher.com/techcase/1815719152https://emoryott.technologypublisher.com/techcase/19152Application Antibiotic-free method to prevent the growth of cells that fail to express high levels of a non-essential protein (target protein). Key Benefits Prevents the use of antibiotics and markers that promote resistance. Facilitates the deployment of recombinant bacteria in uncontrolled environments. Stabilizes heterologous expression of a non-essential protein at high levels. Can be applied to any transformable organism. Market Summary Recombinant protein expression systems allow you to obtain large amounts of commercially and/or pharmaceutically relevant protein such as Human...Wed, 22 Apr 2020 06:45:48 GMTemoryott@inteummail.comhttps://emoryott.technologypublisher.com/techcase/19152NCS.26https://emoryott.technologypublisher.com/techcase/NCS.26Application Therapeutics using siRNAs and small molecules to treat congenital heart defect and myocardial injuries. Key Benefits Reactivates cardiomyocyte (CM) cell replication, allowing regeneration of heart muscle after cardiac injuries. Therapeutic compounds may be administered for transient regeneration/repair of heart muscle after cardiac injuries. Market Summary Approximately 50% of people who develop congestive heart failure will die within 5 years of diagnosis, a death rate similar to some cancers. Because adult humans fail to regenerate heart tissue, a cure for heart failure ...Wed, 22 Apr 2020 04:04:21 GMTemoryott@inteummail.comhttps://emoryott.technologypublisher.com/techcase/NCS.2617032https://emoryott.technologypublisher.com/techcase/17032Fri, 17 Apr 2020 13:36:37 GMTemoryott@inteummail.comhttps://emoryott.technologypublisher.com/techcase/1703220132https://emoryott.technologypublisher.com/techcase/20132Application Triplex, internally-controlled real-time RT-PCR for Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2). Key Benefits Two viral targets to confirm detection in a single sample. Does not involve the performance of multiple reactions as are required for the majority of published assays. May be performed using several different human specimens. Highly specific. Market Summary Coronavirus disease (COVID-19) is an infectious disease caused by a new virus, Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2). SARS-CoV-2 is a betacoronavirus, similar to MERS-Co...Wed, 08 Apr 2020 12:05:04 GMTemoryott@inteummail.comhttps://emoryott.technologypublisher.com/techcase/2013219116https://emoryott.technologypublisher.com/techcase/19116Application Autonomical control of the formation of WMNs to enable node density control, frequency diversity and cooperative, multi-domain software-defined networking (SDN) on large-scale wireless mesh networks. Key Benefits Enhanced capacity of wireless mesh networks. Robust to changes in nodes (new nodes going up, old nodes going down, etc.). Enables multi-domain centralized network management strategies such as software-defined networking. Market Summary A wireless mesh network (WMN) is a communications network composed of nodes that provide access to the network (e.g. routers) or...Wed, 11 Mar 2020 07:39:50 GMTemoryott@inteummail.comhttps://emoryott.technologypublisher.com/techcase/1911619163https://emoryott.technologypublisher.com/techcase/19163Application A molecular probe that stores and integrates short-lived cellular mechanical events over time. Key Benefits Quantitative method of measuring short-lived interactions between cells. Ideal for immunology-based assays Fluorescence-based and amenable as a drug screening research tool. Market Summary Studying the interplay between mechanical forces and chemical signaling in living cells is challenging. This is, in part, because it involves the transmission of forces which are often weak, infrequent, and short lived, and hence difficult to study. Such rare mechanical events are...Thu, 27 Feb 2020 11:04:27 GMTemoryott@inteummail.comhttps://emoryott.technologypublisher.com/techcase/1916319209https://emoryott.technologypublisher.com/techcase/19209Application Torque device for one-handed manipulation of guidewire during endovascular, interventional and catheterization lab procedures. Key Benefits Enables single-person, one-handed use. Prevents ejection of guidewire during torque device removal. Allows placement of torque device anywhere on the wire. Market Summary Interventional procedures, endovascular procedures, and cardiac catheterization labs (cath lab) all involve the use of tiny instruments for minimally invasive treatment, diagnosis, or surgery. Guidewires are used to navigate wires during procedures and act as guides ...Tue, 28 Jan 2020 13:09:44 GMTemoryott@inteummail.comhttps://emoryott.technologypublisher.com/techcase/1920919135https://emoryott.technologypublisher.com/techcase/19135Application System for quickly and efficiently obtaining therapeutic levels of transduction. Key Benefits Uses less viral vector to achieve high gene transfer. Shortens transduction time. Produces clinically relevant gene modified cell numbers. Market Summary Information relay at the molecular level, such as the transcription of RNA into proteins, is an essential process. It is challenging to impart this type of complex dynamic behavior at a synthetic molecular level. DNA self-assembly is the current approach, however the current systems typically exhibit simple dynamic behaviors tha...Thu, 23 Jan 2020 12:16:57 GMTemoryott@inteummail.comhttps://emoryott.technologypublisher.com/techcase/1913520022https://emoryott.technologypublisher.com/techcase/20022Application Color-coded decal to provide accurate and specific instructions for proper body positioning during radiology imaging. Key Benefits Saves time with each procedure. Reduces patient exposure to unwanted radiation. Can be used in all exams that are requested in the upright position. Eliminate costly and time-consuming re-takes. Relies on visual aids and audible instructions instead of physically moving the patient. Market Summary In a modern healthcare environment, almost all in- and outpatients are likely to undergo one or more radiological studies. Proper body position du...Thu, 23 Jan 2020 05:10:24 GMTemoryott@inteummail.comhttps://emoryott.technologypublisher.com/techcase/2002219238https://emoryott.technologypublisher.com/techcase/19238Wed, 22 Jan 2020 05:15:51 GMTemoryott@inteummail.comhttps://emoryott.technologypublisher.com/techcase/1923819186https://emoryott.technologypublisher.com/techcase/19186Application Antibiotic use of sodium deoxycholate for preventing colonization with Streptococcus pneumoniae and treating pneumococcal infection. Key Benefits Effective against antibiotic-resistant pneumococcus. FDA-approved for use in humans. Safety already demonstrated in FDA trials for subcutaneous injection to dissolve fat deposits in humans. Market Summary Pneumococcus colonize children and the elderly and can cause several different illnesses, including pneumonia, ear infections, sinus infections, meningitis, and bacteremia. Some pneumococcal infections are invasive, starting in...Wed, 22 Jan 2020 05:15:48 GMTemoryott@inteummail.comhttps://emoryott.technologypublisher.com/techcase/1918618064https://emoryott.technologypublisher.com/techcase/18064Wed, 22 Jan 2020 05:15:21 GMTemoryott@inteummail.comhttps://emoryott.technologypublisher.com/techcase/1806419024https://emoryott.technologypublisher.com/techcase/19024Application Virus-like particle (VLP) vaccine candidate(s) to prevent respiratory syncytial virus (RSV) infection. Key Benefits Candidates may have the most effective anti-viral and anti-inflammatory response. Potentially protects elderly and immunocompromised patients from re-infection with the RSV virus. Efficient, tunable and stable production system for VLP vaccines for RSV. Market Summary Respiratory syncytial virus (RSV) is the leading cause of severe bronchiolitis in infants and young children, with nearly all children experiencing infection by two years of age. RSV infection ...Wed, 15 Jan 2020 13:06:53 GMTemoryott@inteummail.comhttps://emoryott.technologypublisher.com/techcase/1902419149https://emoryott.technologypublisher.com/techcase/19149Application Small molecule agonist for treating cancers involving KRAS mutations. Key Benefits Specifically targets mutant KRAS in non-small-cell lung carcinoma (NSCLC). Selective for mutant KRAS lung cancer cells over normal cells. Non-toxic to normal cells. Market Summary Lung cancer patients with KRAS mutation(s) have a poor prognosis due in part to the development of resistance to currently available therapeutic interventions. Currently, there are no effective targeted therapies for patients with the KRAS mutation. Developing a specific anti-KRAS agent is very challenging. This p...Tue, 14 Jan 2020 10:56:15 GMTemoryott@inteummail.comhttps://emoryott.technologypublisher.com/techcase/1914918180https://emoryott.technologypublisher.com/techcase/18180Application Linguistic software to predict and diagnose psychosis. Key Benefits New method of diagnosing psychosis. Very high accuracy rate (86.7%). Market Summary Psychotic disorders are mental illnesses characterized by delusions, hallucinations, and disorganized thinking and speaking. Schizophrenia is an example of a psychotic disorder. Such disorders cause a detachment from reality. Despite years of research, the biological causes of psychotic disorders and methods of diagnosing or predicting these disorders are unknown. The language of patients with psychosis has been known to co...Tue, 14 Jan 2020 08:31:00 GMTemoryott@inteummail.comhttps://emoryott.technologypublisher.com/techcase/1818019112https://emoryott.technologypublisher.com/techcase/19112Application Mobile application to encourage healthy eating habits. Key Benefits Less effort than traditional calorie-counting apps. Focuses on how food makes the user feel rather than on specific foods to avoid or max calorie counts. Free app. Market Summary In the United States, nearly 40 percent of adults and 20 percent of children and adolescents suffer from obesity. Obesity increases the likelihood of heart disease, stroke, type 2 diabetes and certain cancers. Healthy eating and active living are important to curbing medical conditions including obesity. While mobile applications...Mon, 13 Jan 2020 12:23:12 GMTemoryott@inteummail.comhttps://emoryott.technologypublisher.com/techcase/1911219102https://emoryott.technologypublisher.com/techcase/19102Application Post-processing algorithm to correct field inhomogeneity in MR spectroscopy. Key Benefits Subvoxel field inhomogeneity correction enables CEST magnetic resonance imaging (MRI) Z-spectrum from body tissues where shimming is challenging. Intravoxel field inhomogeneity correction enables MR spectroscopy (MRS) and MR spectroscopy imaging (MRSI) in tissues experiencing magnetic field inhomogeneity. Market Summary MR spectroscopy (MRS) is a non-invasive technique to detect metabolic changes in the tissues of the human body. It has been used to assist in the diagnosis of diseases...Mon, 13 Jan 2020 12:23:11 GMTemoryott@inteummail.comhttps://emoryott.technologypublisher.com/techcase/1910218096https://emoryott.technologypublisher.com/techcase/18096Fri, 10 Jan 2020 12:10:54 GMTemoryott@inteummail.comhttps://emoryott.technologypublisher.com/techcase/1809619090https://emoryott.technologypublisher.com/techcase/19090Application Kit to efficiently identify and enrich adenosine-to-inosine (A-to-I) editing in RNA molecules. Key Benefits Robust and facile method for enriching A-to-I edited transcripts. Overcomes the low efficiency and accuracy of transcriptome-wide RNA-seq. Market Summary A-to-I RNA editing by adenosine deaminases is a common RNA modification of double-stranded RNA. RNA editing plays critical roles in RNA metabolism, and may also be involved in cancer, aging and/or autoimmune diseases. Accurate identification and effective editing rate are necessary to understanding the effect of A-t...Tue, 03 Dec 2019 11:56:12 GMTemoryott@inteummail.comhttps://emoryott.technologypublisher.com/techcase/1909018015https://emoryott.technologypublisher.com/techcase/18015Application Small molecules that inhibit oral bacteria growth to treat gum disease and prevent tooth decay. Key Benefits Inhibits S. mutans biofilm formation. Reduces the number of bacteria by working in a bactericidal, as opposed to bacteriostatic, manner. Market Summary Periodontitis is a gum infection in which gums become inflamed due to a bacterial biofilm. This can ultimately lead to caries/cavities and tooth loss. Treatment is usually cleaning, planning and/or topical or oral antibiotics. If the disease is advanced, surgery may be required. Complications from periodontitis can e...Mon, 02 Dec 2019 13:24:18 GMTemoryott@inteummail.comhttps://emoryott.technologypublisher.com/techcase/1801519126https://emoryott.technologypublisher.com/techcase/19126Application Educational tool, STEM initiative, and mobile app to stimulate critical thinking in K-12 students. Key Benefits Curriculum is based primarily upon utilizing and understanding Big Data in K-12 schools. Can be used as a STEM educational tool and curriculum at schools, events, and community outreach programs. Increases diversity in STEM by encouraging under-represented individuals and populations to pursue STEM careers. Provides a platform to collect and analyze data, based on citizen science. Technical Summary Emory researchers have developed several curricula, academies, ...Fri, 22 Nov 2019 07:02:41 GMTemoryott@inteummail.comhttps://emoryott.technologypublisher.com/techcase/1912618168https://emoryott.technologypublisher.com/techcase/18168Application Machine learning software for brain-machine interface and neuro-stimulation device-controlling. Key Benefits Significantly improves machine learning performance by minimizing overfitting. Market Summary In machine learning (ML), autoencoder, a type of unsupervised artificial neural network, attempts to learn efficient data coding. It has emerged as a powerful tool in understanding complex neural activities, and brain-machine interface is gaining interest potentially as a life changing technology. Improving performance of such neural networks to uncover complex structures, c...Fri, 22 Nov 2019 07:02:31 GMTemoryott@inteummail.comhttps://emoryott.technologypublisher.com/techcase/1816818215https://emoryott.technologypublisher.com/techcase/18215Fri, 11 Oct 2019 12:15:30 GMTemoryott@inteummail.comhttps://emoryott.technologypublisher.com/techcase/1821519029https://emoryott.technologypublisher.com/techcase/19029Application Hybrid proton-photon inverse optimization method that synergizes proton and photon therapy with improved total optimization objectives for robust cancer treatment delivery. Key Benefits Improved planning target volume coverage and organ at risk sparing. Reduced overall optimization values. Less expensive treatment than proton therapy alone. Market Summary Of all cancer treatment methods, radiation therapy (RT) is one of the more cost-effective cancer treatment modalities throughout the world. Approximately 50 percent of all cancer patients can benefit from RT in the manag...Fri, 11 Oct 2019 11:27:58 GMTemoryott@inteummail.comhttps://emoryott.technologypublisher.com/techcase/1902917006https://emoryott.technologypublisher.com/techcase/17006Fri, 20 Sep 2019 05:38:45 GMTemoryott@inteummail.comhttps://emoryott.technologypublisher.com/techcase/1700618042https://emoryott.technologypublisher.com/techcase/18042Application A drug-carrying nanoparticle that selectively targets cancer cells. Key Benefits Incorporates an already proven anti-cancer therapeutic. Increases deliverability. Targets cancer cells. Market Summary Tris DBA palladium has been shown to have anti-cancer activity against melanoma and pancreatic cancer. However, Tris DBA has not been optimized for delivery to solid tumors. Emory researchers have demonstrated effective targeting in a highly aggressive model of melanoma, which expresses the tumor stem cell marker CD44. By effectively depleting CD44 positive cells, this drug s...Mon, 09 Sep 2019 06:47:01 GMTemoryott@inteummail.comhttps://emoryott.technologypublisher.com/techcase/1804218022https://emoryott.technologypublisher.com/techcase/18022Application Site-selective RNA splicing nanozyme for cleaving and ligating RNA. Key Benefits Can cleave virtually any RNA stem loop. Removes a 19 nucleotide segment from a 67 nucleotide RNA loop with up to 66% efficiency. Technical Summary Modulating RNA can be useful for studying RNA biology, gene knockdown, and regulating RNA splicing. Scientists at Emory University have developed a new DNAzyme nanoparticle for cleaving and ligating RNA. This technology encompasses a composite nanoparticle designed to cleave and ligate RNA targets. The composite NP is comprised of 4 pieces: a gold n...Thu, 05 Sep 2019 13:09:54 GMTemoryott@inteummail.comhttps://emoryott.technologypublisher.com/techcase/1802219010https://emoryott.technologypublisher.com/techcase/19010Thu, 29 Aug 2019 14:23:15 GMTemoryott@inteummail.comhttps://emoryott.technologypublisher.com/techcase/1901018058https://emoryott.technologypublisher.com/techcase/18058Mon, 26 Aug 2019 08:25:44 GMTemoryott@inteummail.comhttps://emoryott.technologypublisher.com/techcase/1805817220https://emoryott.technologypublisher.com/techcase/17220Application Trimeric gp120 immunogen that induces broadly cross-reactive V1V2-antibodies for HIV-1 vaccine. Key Benefits Possible oral administration. Broadly cross-reactive against HIV-1 panel. Promotes antibody responses as both a primary immunogen and boosting immunogen. Market Summary Antiretroviral therapy (ART) has dramatically prolonged the lives of patients suffering from HIV. While antiretroviral therapy (ART) can suppress viral replication, it does not eliminate the viral reservoir. A recent study determined a major correlate of protection to be non-neutralizing antibodies ...Mon, 26 Aug 2019 08:23:05 GMTemoryott@inteummail.comhttps://emoryott.technologypublisher.com/techcase/1722018123https://emoryott.technologypublisher.com/techcase/18123Application Human monoclonal antibodies for the treatment of varicella zoster virus (VZV). Key Benefits Human monoclonal antibodies can limit the spread of VZV. gH-specific antibodies are complement-independent. Market Summary Varicella Zoster Virus (VZV) causes varicella, more commonly known as chickenpox. Once the illness resolves, the virus remains dormant and can later become reactive causing herpes zoster, or shingles. Immunity can protect against this reactivation. However, as the immune response to VZV wanes, either in the immunocompromised or with age, reactivation can occur. ...Mon, 19 Aug 2019 09:55:58 GMTemoryott@inteummail.comhttps://emoryott.technologypublisher.com/techcase/1812319054https://emoryott.technologypublisher.com/techcase/19054ApplicationKnockout mouse models for adhesion G protein-coupled receptors B3, brain-specific angiogenesis inhibitor-3 (ADGRB3/BAI3) gene study.Technical SummaryEmory University researchers have developed a knockout mouse model for the ADGRB3/BAI3 gene. Mice were generated by CRISP/cas9 technology on C57Bl6 background. These mice can be used to study the effects of losing BAI3 expression throughout the whole mouse body. BAI3 has roles in neuroscience, behavior, pathogen phagocytosis, myogenesis, and cancer.Developmental StageModel is available for license.Publication: Bhattacharya, D. et al. (2...Tue, 09 Jul 2019 05:37:47 GMTemoryott@inteummail.comhttps://emoryott.technologypublisher.com/techcase/1905418178https://emoryott.technologypublisher.com/techcase/18178ApplicationScale/survey instrument for measuring anxiety in children with autism based upon a parent report.Key BenefitsIncludes 25-item measure for anxiety.Tested in a large-scale survey and clinical setting.Market SummaryAutism spectrum disorder (ASD) is a neurodevelopmental disorder characterized by social communication deficits and repetitive behavior. It is estimated that 40% of youth with ASD have at least one anxiety disorder, such as separation anxiety, specific phobias, generalized anxiety disorder, or social anxiety disorder. This is the first tool specifically designed to assess anx...Mon, 08 Jul 2019 13:34:51 GMTemoryott@inteummail.comhttps://emoryott.technologypublisher.com/techcase/1817817149https://emoryott.technologypublisher.com/techcase/17149Application Expandable cervical pessary device to treat cervical incompetence. Key Benefits Inflatable device can adapt to any size. Eliminates need for sutures or cervical tape, reducing risk of cervical trauma. Market Summary Cervical incompetence is a premature dilation and effacement (cervical ripening) during the second trimester of pregnancy and often leads to miscarriage or preterm birth. It accounts for 9% of all preterm births and 3% of infant deaths in the U.S. Pessaries are medical devices inserted into the vagina to aid in supporting the cervix, treat cervical incompetence...Mon, 08 Jul 2019 13:34:43 GMTemoryott@inteummail.comhttps://emoryott.technologypublisher.com/techcase/1714918109https://emoryott.technologypublisher.com/techcase/18109Tue, 02 Jul 2019 14:24:40 GMTemoryott@inteummail.comhttps://emoryott.technologypublisher.com/techcase/1810917233https://emoryott.technologypublisher.com/techcase/17233Application Marker and co-therapy that inhibits succinate dehydrogenase to increase patient response to venetoclax. Key Benefits Co-therapy increases MM sensitivity to venetoclax treatment. Identifies patients who will respond to venetoclax therapy. Market Summary Multiple Myeloma (MM) is a cancer of plasma cells responsible for making antibody and fighting infection. It is the second most common blood cancer. Current treatments include immunomodulatory drugs, proteasome inhibitors and newer targeted therapies. Chemo-resistant MM is common, with approximately 20% of patients succumbin...Tue, 18 Jun 2019 13:52:27 GMTemoryott@inteummail.comhttps://emoryott.technologypublisher.com/techcase/1723315005https://emoryott.technologypublisher.com/techcase/15005Tue, 18 Jun 2019 12:58:00 GMTemoryott@inteummail.comhttps://emoryott.technologypublisher.com/techcase/1500514152https://emoryott.technologypublisher.com/techcase/14152Application Self-reported numeric rating scale for determining the severity of itch. Key Benefits Incorporates cartoons, making assessment easier to administer. May determine severity of itchiness in pediatric population. Market Summary Itch (also known as pruritus) is an uncomfortable, irritating condition that involves any part of the body and creates the urge to scratch. Itchiness can have a wide variety of causes, including psychiatric diseases, allergic reactions, and skin conditions such as eczema, psoriasis, or dry skin (xerosis). Numeric scales are used in adult patients to de...Mon, 03 Jun 2019 08:38:43 GMTemoryott@inteummail.comhttps://emoryott.technologypublisher.com/techcase/1415217191https://emoryott.technologypublisher.com/techcase/17191Application Small molecule inhibitors of NOX4 signaling with a wide array of therapeutic potential. Key Benefits Small molecule inhibitors of NOX4 signaling. Low cytotoxicity. Market Summary The NADPH oxidase 4 (NOX4) has gained considerable and growing attention during the past years because of its potential key involvement in a variety of diseases, some of which have high unmet medical needs. Currently the few known NOX4 inhibitors that are in clinical trials are non-specific molecules. Finding a new class of small molecule inhibitors has substantial advantages in drug development, ...Mon, 13 May 2019 13:33:57 GMTemoryott@inteummail.comhttps://emoryott.technologypublisher.com/techcase/1719118012https://emoryott.technologypublisher.com/techcase/18012Applications ELISA Western Blot Immunohistochemistry Specificity Human monoclonal Technical Summary Zika Virus (ZIKV) is a mosquito borne filovirus responsible for a 2016-2017 epidemic in North and South America. ZIKV nonstructural protein 1 (NS1) is a pathogenicity factor implicated in virus replication, host interaction and immune invasion. The investigators have isolated and characterized monoclonal antibodies from patients infected with ZIKV that bind the ZIKV NS1 protein. Some of the mAbs display cross-reactivity with Dengue virus (DENV) NS1 and could potentially be used as f...Thu, 09 May 2019 08:58:35 GMTemoryott@inteummail.comhttps://emoryott.technologypublisher.com/techcase/1801217017https://emoryott.technologypublisher.com/techcase/17017Application Ectodomain of viral glycoprotein tetramers detects antigen-specific memory B Cells. Key Benefits Viral glycoprotein tetramers detect antigen-specific memory B cells in the peripheral blood and tissues. Hepatitis C virus E2 protein triggers immune response, which may yield an effective vaccine against hepatitis C virus. Market Summary Hepatitis C (HCV) is a viral infectious disease that invades the liver, specifically. Available treatments to manage and cure HCV include interferons, ribavirin, and direct acting antivirals. However, current treatments lack a vaccine that spe...Thu, 09 May 2019 08:49:29 GMTemoryott@inteummail.comhttps://emoryott.technologypublisher.com/techcase/1701718083https://emoryott.technologypublisher.com/techcase/18083ApplicationMobile app and desktop application for management of research studies involving human patients.Key BenefitsSupports a variety of study formats.Combines management of all parts of study in one place.Automatically reminds patients and research staff of upcoming appointments and tasks.Improves communication between study admin and study participants.Market SummaryResearch studies involving human patients are a necessary part of developing novel interventions for many diseases. These studies are complex and involve regular communication between patients, project coordinators, and other ...Wed, 08 May 2019 12:12:26 GMTemoryott@inteummail.comhttps://emoryott.technologypublisher.com/techcase/1808318239https://emoryott.technologypublisher.com/techcase/18239Application Small molecule therapeutic specifically targeting invasive cancer cells for treatment of lung cancer. Key Benefits Inhibits cancer cell invasion. Utilizes a novel mechanism of action. Market Summary One of the main barriers in developing new treatment strategies is the vast diversity between and within cancers. The cells within a tumor can vary from one another in many ways such as by cellular morphology, gene expression, metabolism, motility, proliferation, and metastatic potential. The ability of cancer cells to invade adjacent tissues and to stimulate neovascularization...Fri, 12 Apr 2019 07:41:37 GMTemoryott@inteummail.comhttps://emoryott.technologypublisher.com/techcase/1823917207https://emoryott.technologypublisher.com/techcase/17207ApplicationStandalone smartphone app to increase vaccinations and improve vaccine knowledge for providers, pharmacists, and the general public.Key BenefitsProvides detailed information about a variety of vaccines and diseases. Sends out alerts and updates. Market SummaryVaccines prevent millions of cases of infectious diseases each year; however, many parents are now refusing to have their children vaccinated. The decline in vaccination rate has contributed to outbreaks of preventable diseases in the developed world. Due to false information found on websites, message boards, and blogs, many p...Tue, 02 Apr 2019 13:48:43 GMTemoryott@inteummail.comhttps://emoryott.technologypublisher.com/techcase/1720717192https://emoryott.technologypublisher.com/techcase/17192Fri, 29 Mar 2019 08:33:56 GMTemoryott@inteummail.comhttps://emoryott.technologypublisher.com/techcase/1719218202https://emoryott.technologypublisher.com/techcase/18202ApplicationSterile sticky labels for specimen labeling during surgery.Key BenefitsEasy and hygienic specimen labeling in the operating room.Miniature design maintained with labelling accuracy.Market SummarySpecimen labeling practices are critical components of effective and accurate patient identification. Errors in specimen labeling can lead to results of no clinical value or adverse outcomes for the patient. Improvement of specimen labeling quality brings the opportunity for continuous cycle of quality improvement (CQI). Particularly, specimen labeling in the operating room needs to be user ...Wed, 27 Mar 2019 06:52:51 GMTemoryott@inteummail.comhttps://emoryott.technologypublisher.com/techcase/1820216124https://emoryott.technologypublisher.com/techcase/16124Tue, 26 Mar 2019 08:32:16 GMTemoryott@inteummail.comhttps://emoryott.technologypublisher.com/techcase/1612416008https://emoryott.technologypublisher.com/techcase/16008ApplicationAntibodies that bind and neutralize Ebola virus glycoprotein (GP) for use in vaccination or treatment of Ebola virus disease.Key BenefitsHigher binding affinity for Ebola virus GP than closest competitor.Can be used prophylactically or for treatment of Ebola virus disease.Market SummaryThe Ebola virus is an RNA virus with a membrane composed of host cell-derived membrane studded with an imbedded viral expressed glycoprotein (GP). Ebola virus GP allow the virus to breach the host cell membrane and are critical in the infection process. Ebola virus disease is a highly infectious illne...Tue, 26 Mar 2019 08:32:11 GMTemoryott@inteummail.comhttps://emoryott.technologypublisher.com/techcase/1600818080https://emoryott.technologypublisher.com/techcase/18080Application Questionnaire to assess self-reported adherence to medication for patients of all literacy levels. Key Benefits Increases patient adherence to medication prescription. ARMS-D (diabetes-specific) identifies barriers to adherence. Market Summary Taking medication on time is crucial for the successful management of chronic illness, but only 50%-70% of patients adhere to the medications they are prescribed. Illiteracy increases the difficulty of adherence to medications, as illiterate patients are less likely to identify their medications, drug indications and side effects. In...Wed, 23 Jan 2019 08:35:56 GMTemoryott@inteummail.comhttps://emoryott.technologypublisher.com/techcase/1808016077https://emoryott.technologypublisher.com/techcase/16077Application Mesenchymal stromal cells (MSC) prelicensed with pro-inflammatory cytokines for improved survival and immunosuppressive properties following cryopreservation. Key Benefits Preserves the immunosuppressive function of MSCs following thawing. Improves effectiveness of transplanted MSCs following cryopreservation. Market Summary Mesenchymal stromal cells are adult multipotent stem cells derived from bone marrow and other tissues. MSCs are used in clinical settings for anti-inflammatory and regenerative medicine applications. In most instances, the MSCs are cryobanked prior to ...Tue, 22 Jan 2019 14:44:40 GMTemoryott@inteummail.comhttps://emoryott.technologypublisher.com/techcase/1607719052https://emoryott.technologypublisher.com/techcase/19052Application Hypoxia/Hypoxia-inducible factor 1 (HIF-1) inducible luciferase/LacZ reporter cell lines. Key Benefit Expression of luciferase and beta-galactosidase in response to hypoxia treatment. Technical Summary Emory University researcher, Erwin Van Meir, has made HIF/hypoxia reporter cell lines by stably transfecting the cells with pBIGL-V6R-HRE-Luc/LacZ reporter construct. The cell lines can be used to monitor transcriptional activity of the reporter in response to hypoxia or HIF transcriptional activity. The reporter activates both luciferase and b-galactosidase expression. LN229...Tue, 22 Jan 2019 14:37:24 GMTemoryott@inteummail.comhttps://emoryott.technologypublisher.com/techcase/1905219051https://emoryott.technologypublisher.com/techcase/19051ApplicationADGRB3/BAI3 expressing human brain tumor cell lines.Technical SummaryAdhesion G protein coupled receptor B3 (ADGRB3), also called Brain-specific angiogenesis inhibitor 3 (BAI3) is a protein that in humans is encoded by the ADGRB3 gene. Emory University researcher Erwin Van Meir has developed medulloblastoma cell lines DAOY, UW288-1 and PFSK1, stably expressing BAI3 with pLenti-GIII-CMV lentiviral vector and selected with puromycin. BAI3 protein is being investigated in neuroscience, behavior, phagocytosis, myogenesis and cancer.Developmental StageCell lines are developed and availab...Tue, 22 Jan 2019 14:37:23 GMTemoryott@inteummail.comhttps://emoryott.technologypublisher.com/techcase/1905116127https://emoryott.technologypublisher.com/techcase/16127Application Granulin proteins (GRNs) as potential therapeutics for multiple neurodegenerative disorders caused by lysosome dysfunction and inflammation. Key Benefits Novel pathway and target provides new route for treatment. Granulins shown to rescue lysosomal defects in cell culture models. Market Summary Granulins are small proteins that are derived by proteolysis from full-length progranulin (PGRN). PGRN is cleaved into several granulin proteins, which are implicated in development, inflammation, cell proliferation and protein homeostasis. Previously, most investigators believed th...Tue, 18 Dec 2018 14:57:40 GMTemoryott@inteummail.comhttps://emoryott.technologypublisher.com/techcase/1612715073https://emoryott.technologypublisher.com/techcase/15073Application Glutamate dehydrogenase (GDH1) inhibitors targeting cancer cell metabolic pathways. Key Benefits Targets tricarboxylic acid (TCA) cycle/mitochondrial metabolism utilized by several cancer cell types for cell growth and survival. Reduces cell proliferation and viability in several tumor derived cell lines as well as in xenograft tumor models. Limited effects on cell toxicity and proliferation rates observed in non-tumor derived cell lines or in tissues from mice treated with GDH1 inhibitors. Market Summary Advances in oncology have relied on targeted therapies that destroy...Thu, 06 Dec 2018 13:00:35 GMTemoryott@inteummail.comhttps://emoryott.technologypublisher.com/techcase/1507318245https://emoryott.technologypublisher.com/techcase/18245Application Web-based application for visualizing and analyzing spectroscopic MRI data (sMRI, MRSI) in diagnosing, treatment planning, and monitoring of neuropathologies such as tumor. Key Benefits Enables the analysis of multiple diagnostic images simultaneously. Generates a heat map of metabolite (e.g., CHO/NAA) levels to better diagnose malignancies. Incorporates filters to eliminate visual artifacts for proper quality control and improve image quality. Allows for detailed analyses of spectra in specific regions of the brain. Generate radiation treatment target volume for better th...Fri, 30 Nov 2018 12:45:34 GMTemoryott@inteummail.comhttps://emoryott.technologypublisher.com/techcase/1824508054https://emoryott.technologypublisher.com/techcase/08054ApplicationSoftware program providing a real-time display of actionable, patient-specific data to be used by care givers in a particular care unit.Key BenefitsEasy-to- use, color coded display of patient specific data. Improves quality of care by identifying those patients within a unit not receiving a particular key care measure. Tracks key quality of care metrics for a unit. Compatible with other common healthcare software programs.Technical SummaryImproving healthcare through the use of information technology (IT) solutions is an expanding segment of the heathcare industry, expected to grow...Fri, 30 Nov 2018 12:45:15 GMTemoryott@inteummail.comhttps://emoryott.technologypublisher.com/techcase/0805416164https://emoryott.technologypublisher.com/techcase/16164ApplicationA cell based assay to quantify the titer of circulating Ebola glycoprotein (GP) antibodies that trigger antibody-dependent cell-mediated cytotoxicity (ADCC).Key BenefitsSpecific for detection of ADCC activity of Ebola virus antibodies or antisera.Applicable to all pathogenic strains of Ebola virus.Ebola GP-specific stable reporter cells eliminate need for handling viruses or for transfections.Validated standard operating procedure reduces optimization cost.Market SummaryEbola virus disease (EVD) is an acute illness with a fatality rate of approximately 50%. There are no available tr...Mon, 26 Nov 2018 12:12:44 GMTemoryott@inteummail.comhttps://emoryott.technologypublisher.com/techcase/1616416098https://emoryott.technologypublisher.com/techcase/16098Application Non-viral gene delivery and a small molecule that converts heart muscle cells to pacemaker cells for the device-free treatment of slow heart rhythm. Key Benefits Minimally invasive procedure provides cardiac pacing without device implant. Restores natural heart rhythm. Eliminates or reduces significant complications such as repeat surgeries for device exchange or infected indwelling devices. Provides alternative treatment for pediatric patients. Market Summary Cardiac arrhythmia is an irregular beating of the heart. Changes from the normal sequence of electrical impulses...Fri, 16 Nov 2018 05:26:24 GMTemoryott@inteummail.comhttps://emoryott.technologypublisher.com/techcase/1609813081https://emoryott.technologypublisher.com/techcase/13081Application Conditional epigenetic mutation in CD8+ memory T cells as potential cell therapy for chronic viral infection and personalized cancer treatment. Key Benefits Blocks DNA methylation in T cells, prolonging the life and enhancing the function of these cells. Results in faster CD62L re-expression during effector to memory cell conversion. Delays or eliminates T cell exhaustion. Reduces side effects of currently approved treatments by patient specific autologous cell-based therapy. Market Summary Infectious diseases are a leading cause of death worldwide and pose an increasing...Wed, 14 Nov 2018 13:23:16 GMTemoryott@inteummail.comhttps://emoryott.technologypublisher.com/techcase/1308117132https://emoryott.technologypublisher.com/techcase/17132Tue, 16 Oct 2018 09:04:48 GMTemoryott@inteummail.comhttps://emoryott.technologypublisher.com/techcase/1713215113https://emoryott.technologypublisher.com/techcase/15113Application Strain of respiratory syncytial virus (RSV) for vaccine and therapeutic research and development. Key Benefits Higher early viral load. Induces greater necrotic airway damage and neurophil infiltration. Market Summary RSV is a highly contagious and ubiquitous virus that causes respiratory tract infections in individuals of all ages, particularly young children and the elderly. Worldwide the virus is also responsible for 160,000 deaths per year. Currently, no effective vaccine against RSV exists and treatment is limited to a non-vaccine prophylactic medication and supportiv...Tue, 16 Oct 2018 09:02:31 GMTemoryott@inteummail.comhttps://emoryott.technologypublisher.com/techcase/1511318008https://emoryott.technologypublisher.com/techcase/18008ApplicationSoftware program to help physicians streamline peer-review for radiotherapy patients during chart rounds.Key BenefitsIncreases efficiency and reduces time for reviewing patient chart records.Enables faster detection of errors and deviations.Provides standardized treatment for all patients.Improves quality and safety of cancer patient treatment.Market SummaryRadiation therapy is the application of high energy radiation to kill cancer cells and shrink tumors. Any deviation from appropriate use of radiation therapy can create a risk for the patient and potential lawsuit against the hea...Thu, 27 Sep 2018 11:54:10 GMTemoryott@inteummail.comhttps://emoryott.technologypublisher.com/techcase/1800818020https://emoryott.technologypublisher.com/techcase/18020ApplicationConditional knock-in mouse mimicking Oculopharyngeal muscular dystrophy.Technical SummaryOculopharyngeal muscular dystrophy (OPMD) is rare genetic disease caused by a mutation in the PABPN1 gene. In this mutation, the number of GCG trinucleotide repeats at the 5' end of PABPN1 are increased, which leads to an expansion of an alanine repeat region. Emory University researchers have created a conditional genetic mouse model of PABPN1 using a combination of cre-lox and FLP recombinase technology. Seven additional copies of GCG are inserted to the 5' end of exon1 the Pabpn1 gene in thes...Thu, 27 Sep 2018 05:03:29 GMTemoryott@inteummail.comhttps://emoryott.technologypublisher.com/techcase/1802018163https://emoryott.technologypublisher.com/techcase/18163ApplicationMouse lines expressing isoforms a, b, and c of the Human Osteopontin (OPN) protein for cancer research.Technical SummaryThe murine OPN is not subject to splicing and therefore does not express different isoforms. Human cancers express splice variants. Emory researchers developed these mouse models to express each isoform independently from the murine promotor to allow for studies for specific indications where the a, b, or c isoform is implicated. Each strain is a knock-in mutant of the individual isoform coding cDNA expressed with a Myc/DDK tag at the c-terminus and also flanked by...Wed, 26 Sep 2018 08:16:12 GMTemoryott@inteummail.comhttps://emoryott.technologypublisher.com/techcase/1816317222https://emoryott.technologypublisher.com/techcase/17222Thu, 23 Aug 2018 12:59:18 GMTemoryott@inteummail.comhttps://emoryott.technologypublisher.com/techcase/1722217208https://emoryott.technologypublisher.com/techcase/17208Tue, 10 Jul 2018 13:20:09 GMTemoryott@inteummail.comhttps://emoryott.technologypublisher.com/techcase/1720818160https://emoryott.technologypublisher.com/techcase/18160Key BenefitsTissue-specific knockout mouse, allowing PAR1 to be inactivated in specific cell types in certain tissue.Inducible knockout mouse, allowing PAR1 to be temporally suppressed at a given time-point in embryonic, post-natal or adult animals.Eliminates drawbacks and side effects of traditional knockout processes that eliminate genes from the entire body.Technical SummaryProtease-activated receptor 1 (PAR1) is a G protein-coupled receptor (GPCR) that was first identified as the thrombin receptor. Although PAR1 is best known for its role in platelet activation and hemostasis, it also is e...Tue, 26 Jun 2018 11:23:31 GMTemoryott@inteummail.comhttps://emoryott.technologypublisher.com/techcase/18160NCS.24https://emoryott.technologypublisher.com/techcase/NCS.24Application Cell culture media that promotes the survival of human plasma cells and enables immunoglobin (Ig) secretion from such plasma cells. Key Benefits Facilitates the isolation of antibody-secreting cells (ASCs) found in blood after antigen exposure, which can be used to identify an active antigen or pathogen causing illness. Composed of factors secreted by mesenchymal stromal cells, which dramatically increases plasma cell survival time in tissue culture. Allows the screening for and identification of novel therapeutic antibodies. Applicable for selection of myeloma chemotherapy...Thu, 24 May 2018 09:01:22 GMTemoryott@inteummail.comhttps://emoryott.technologypublisher.com/techcase/NCS.2417171https://emoryott.technologypublisher.com/techcase/17171ApplicationDiagnostic for identifying Streptococcus pneumonia serotypes.Key BenefitsAllows for rapid detection and serotype identification of Streptococcus pneumonia infections.Market SummaryStreptococcus pneumonia (Spn) is a gram-positive bacteria and significant human pathogen responsible for most pneumonia cases. Typically, Spn resides asymptomatically in healthy carriers while colonizing the respiratory tract, sinuses, and nasal cavity. However, in susceptible individuals with weaker immune systems, such as the elderly and young children, it may become pathogenic leading to cases of pneumo...Mon, 16 Apr 2018 08:22:40 GMTemoryott@inteummail.comhttps://emoryott.technologypublisher.com/techcase/1717117164https://emoryott.technologypublisher.com/techcase/17164ApplicationBooklet/card to help patients with low literacy care for wounds and track wound healing.Key BenefitsAvailable in English and Spanish.Includes pictures for patients with low literacy and low health literacy.Built in ruler and record space helps patients track wound size for easy reporting to clinician.Market SummaryWound care management is an important aspect of patient health; however, many patients do not know how to care for wounds properly, or accurately track wound healing and related symptoms. This is especially difficult for patients with low literacy. Comprehensive materials ...Mon, 09 Apr 2018 07:59:13 GMTemoryott@inteummail.comhttps://emoryott.technologypublisher.com/techcase/1716417210https://emoryott.technologypublisher.com/techcase/17210ApplicationHuman induced pluripotent stem cells useful for human stem cell biology, Lesch-Nyhan disease or DYT1 dystonia.Technical SummaryLesch-Nyhan syndrome (juvenile gout) is a rare, inherited disorder caused by deficiency in hypoxanthine-guanine phosphoribosyltransferase (HGPRT). The disease causes overproduction of uric acid often leading to gout and kidney problems. It also causes intellectual and neurological disability. Treatment is symptom-focused and may include use of allopurinol to control overproduction of uric acid as well as extracorporeal shock wave lithotripsy for kidney stone...Mon, 26 Mar 2018 10:36:02 GMTemoryott@inteummail.comhttps://emoryott.technologypublisher.com/techcase/1721016139https://emoryott.technologypublisher.com/techcase/16139ApplicationPeriostin as a therapeutic target for liver disease.Key BenefitsNew therapeutic target for preventing fibrosis from entering cirrhosis stage.Therapeutic target may be used for identifying new therapy for fibrosis.Market SummaryCirrhosis is a condition in which the liver is unable to function normally due to chronic, or long lasting, injury. Scar tissue replaces healthy liver tissue causing fibrosis leading to partial blocks to the flow of blood through the liver. A liver transplant is recommended when a person's liver no longer functions adequately enough to keep them alive. There i...Fri, 23 Mar 2018 07:04:19 GMTemoryott@inteummail.comhttps://emoryott.technologypublisher.com/techcase/1613917126https://emoryott.technologypublisher.com/techcase/17126ApplicationTargeting peptide molecule for image-based diagnosis of myocarditis.Key BenefitsEnables noninvasive diagnosis of myocarditis.Targets and binds to biomarker of myocarditis.Market SummaryMyocarditis is an inflammation of the heart muscle (myocardium). Myocarditis can affect your heart muscle and your heart's electrical system, reducing the heart's ability to pump and causing rapid or abnormal heart rhythms. Myocarditis is one of the most challenging diagnosis in cardiology and has led to the under-diagnosis of the condition. The gold standard for diagnosis, endomyocardial biopsy, is i...Wed, 07 Feb 2018 08:09:06 GMTemoryott@inteummail.comhttps://emoryott.technologypublisher.com/techcase/1712617217https://emoryott.technologypublisher.com/techcase/17217Sun, 21 Jan 2018 19:06:10 GMTemoryott@inteummail.comhttps://emoryott.technologypublisher.com/techcase/1721717145https://emoryott.technologypublisher.com/techcase/17145Sun, 21 Jan 2018 19:06:09 GMTemoryott@inteummail.comhttps://emoryott.technologypublisher.com/techcase/1714517100https://emoryott.technologypublisher.com/techcase/17100Wed, 03 Jan 2018 10:29:53 GMTemoryott@inteummail.comhttps://emoryott.technologypublisher.com/techcase/1710017019https://emoryott.technologypublisher.com/techcase/17019Application Use of nanoscale vanadium containing compounds for the treatment of cancers. Key Benefits Potent anti-cancer compound is effective against many drug-resistant types of cancers. Anti-cancer mechanism inhibits tumor growth with almost no organ toxicity. Compound can be synthesized at low cost. Market Summary Cancer is the leading cause of death in the U.S. and around the world. Nanomedicine has emerged as a new avenue to tackle the challenge of disease treatment. Several nanomedicines are FDA-approved and even more are in clinical trial. The emergence of drug resistant canc...Mon, 04 Dec 2017 16:51:50 GMTemoryott@inteummail.comhttps://emoryott.technologypublisher.com/techcase/1701916148https://emoryott.technologypublisher.com/techcase/16148ApplicationMobile application and program to remotely identify and assess severity of tenderness and abdominal pain.Key BenefitsAllows physician to replicate physical abdominal exam remotely.Eliminates distance barrier, increasing access to medical service.Potentially reduces need for in-person visits and costs.Market SummaryAbdominal (or stomach) pains vary in their durations and severity. Though there are many potential causes, the most common causes are not serious and include indigestion, gas, or a pulled muscle. Ten percent of all physician visits are due to abdominal pain, which can only...Mon, 04 Dec 2017 16:51:41 GMTemoryott@inteummail.comhttps://emoryott.technologypublisher.com/techcase/1614816116https://emoryott.technologypublisher.com/techcase/16116Application Gold nanoparticles coated with enzyme which specifically targets and degrades asthma-associated inflammation molecules. Key Benefits Specifically suppresses asthma associated inflammation. Easy self-administration by inhalation. Market Summary Asthma is defined as a chronic inflammatory lung disease with significant worldwide morbidity. Currently, inhaled corticosteroids are one of the essential long-term maintenance therapies for all patients with persistent asthma. In general, oral corticosteroids suppress the immune response to control asthma symptoms and asthma exacerb...Mon, 04 Dec 2017 16:51:32 GMTemoryott@inteummail.comhttps://emoryott.technologypublisher.com/techcase/1611613135https://emoryott.technologypublisher.com/techcase/13135Application Triphenylmethane small molecules inhibiting NADPH oxidase (NOX) for the anti-proliferation of melanoma tumor cells. Key Benefits Modifies molecular interactions with cellular proteins, reducing cell tumor growth. Compounds are capable of inhibiting cell proliferation to a greater extent than current competing NOX inhibitors for melanoma cells. Market Summary Skin cancer accounts for approximately one third of all cancers in the U.S. In over 60% of cases, Melanomas express a mutation, leading to uncontrolled cell growth. In cases with the mutation, late stage melanoma patie...Mon, 04 Dec 2017 16:47:54 GMTemoryott@inteummail.comhttps://emoryott.technologypublisher.com/techcase/1313516067https://emoryott.technologypublisher.com/techcase/16067Application Hypolipidemic dehydroacetic acid (DHAA) treatment to prevent growth of BRAF V600E positive tumors. Key Benefits Treatment with slows BRAF V600E-positive tumor growth. Repurposed compound may speed FDA approval. May be used in combination with other therapies. Market Summary Up to 50% of melanoma cases harbor the BRAF V600E mutation, which is also a contributing factor in other cancer types such as, colorectal cancer, hairy cell leukemia, and multiple myeloma. Treatment strategies for melanoma include surgical removal of the tumor and surrounding area followed by chemother...Thu, 26 Oct 2017 14:38:15 GMTemoryott@inteummail.comhttps://emoryott.technologypublisher.com/techcase/1606716055https://emoryott.technologypublisher.com/techcase/16055ApplicationFusion protein for non-invasive assessment of chloride fluctuations in neuronal processes.Key BenefitsEnables a non-invasive method of imaging chloride in animals.Offers high signal-to-noise ratio compared to fluorescent light.Market SummaryNeuronal chloride (Cl-) is involved in many normal neurophysiological activities, including synaptic inhibition, pH and volume regulation. Changes in Cl- have been implicated in mechanisms underlying neurological diseases such as stroke, pain and epilepsy. Various indicator proteins have been developed, enabling functional imaging for active intr...Tue, 26 Sep 2017 06:50:57 GMTemoryott@inteummail.comhttps://emoryott.technologypublisher.com/techcase/1605517018https://emoryott.technologypublisher.com/techcase/17018Application An interview score system to quantify the level of treatment resistance in patients with post-traumatic stress disorder (PTSD). Key Benefits Enables quantification of the degree of treatment resistance. Delivers a comprehensive assessment of prior PTSD treatments. Provides a standard measurement for the level of treatment resistance. Market Summary Several evidence-based psychotherapies and medications are available to treat posttraumatic stress disorder (PTSD). However, many patients do not respond to these treatments, placing them at risk for developing a chronic course...Fri, 22 Sep 2017 12:27:07 GMTemoryott@inteummail.comhttps://emoryott.technologypublisher.com/techcase/1701815212https://emoryott.technologypublisher.com/techcase/15212Mon, 17 Jul 2017 14:39:03 GMTemoryott@inteummail.comhttps://emoryott.technologypublisher.com/techcase/1521214176https://emoryott.technologypublisher.com/techcase/14176Application Isolation and analysis of phenotype and genome of rare cell types within a tumor for research and potential diagnostics. Key Benefits Allows the identification of a single cell or group of cells within a tumor sample using phenotypic criteria. Enables both phenotypic and genetic analysis of the same rare cells within a tumor. Market Summary For many years, tumors were thought to be homogeneous, made up of a single proliferative cancer cell type. Today, tumors are thought to be comprised of a variety of cell types. Cells within a tumor can vary across cellular morphology, g...Thu, 13 Jul 2017 10:08:26 GMTemoryott@inteummail.comhttps://emoryott.technologypublisher.com/techcase/1417616106https://emoryott.technologypublisher.com/techcase/16106ApplicationA mobile app that facilitates liver transplant referrals.Key BenefitsSecurely facilitates liver transplant referrals to patients through mobile app or web portal.Provides community providers with information about Liver Transplant Center physicians, clinical trials, outcomes and news.Conveniently provides a MELD Calculator to estimate severity of liver disease.Market SummaryUtilizing healthcare apps offers many benefits, including the potential to improve communication between clinicians and patients. While many liver transplant centers currently utilize mobile apps allowing patient...Mon, 03 Jul 2017 10:37:19 GMTemoryott@inteummail.comhttps://emoryott.technologypublisher.com/techcase/1610616111https://emoryott.technologypublisher.com/techcase/16111ApplicationTransgenic mice expressing floxed mitochondrial antiviral-signaling protein (MAVS) for study of cell-type and tissue-specific immunity.Key BenefitsStudy cell-type and tissue-specific immunity.Can be crossed using CRE-recombinase system.Technical SummaryMitochondrial antiviral-signaling protein (MAVS) is a protein in humans that is encoded by the MAVS gene. It is the central adaptor protein for the RIG-I signaling pathway and promotes induction of type I interferon and other antiviral responses. Emory inventors have created homozygous floxed MAVS mice in a C57BL/6N background. These ...Mon, 26 Jun 2017 16:21:02 GMTemoryott@inteummail.comhttps://emoryott.technologypublisher.com/techcase/1611116085https://emoryott.technologypublisher.com/techcase/16085Application Mechanically induced catalytic amplification reaction (MCR) as an assay for high throughput screening of drugs which target cellular mechanics and mechanical phenotyping of live cells. Key Benefits Adaptable for high throughput screening of drugs that impair cell mechanics. Enables characterization of different cells types based on their traction forces. Assay can be performed using a conventional fluorescence plate reader. Allows detection of weak and transient cellular forces. Market Summary High Throughput Screening (HTS) is a drug-discovery process widely used in the...Mon, 26 Jun 2017 16:20:55 GMTemoryott@inteummail.comhttps://emoryott.technologypublisher.com/techcase/1608516002https://emoryott.technologypublisher.com/techcase/16002ApplicationProtein tyrosine kinase inhibitor (imatinib) used as a treatment to prevent multiple drug-resistant tuberculosis lethality and latent reactivation.Key BenefitsEffective against drug resistant strains of tuberculosis.May be used in combination with current first-line treatments of TB.Market SummaryTuberculosis (TB) is a chronic infectious disease which primarily affects lungs and often co-infects individuals with HIV. Although curable, TB still continues to be a global health problem as one of the most common cause of death from an infectious disease. According to the World Health Or...Tue, 20 Jun 2017 14:36:43 GMTemoryott@inteummail.comhttps://emoryott.technologypublisher.com/techcase/1600215068https://emoryott.technologypublisher.com/techcase/15068Application Radioactive tracer with improved plasma clearance for use as either a planar or positron emission tomography (PET) renal imaging agent. Key Benefits Rapid renal excretion. Minimal localization at other body sites. More rapid blood clearance than current standard. Can be adapted for either standard planar or positron emission tomography (PET) imaging. Market Summary Renal nuclear scans are performed to investigate kidney function and structure. Following an intravenous injection, a renal radioactive tracer flows through the blood to the kidneys where it is extracted by th...Tue, 20 Jun 2017 14:34:04 GMTemoryott@inteummail.comhttps://emoryott.technologypublisher.com/techcase/1506813197https://emoryott.technologypublisher.com/techcase/13197Wed, 07 Jun 2017 08:57:31 GMTemoryott@inteummail.comhttps://emoryott.technologypublisher.com/techcase/1319715178https://emoryott.technologypublisher.com/techcase/15178Thu, 25 May 2017 07:18:03 GMTemoryott@inteummail.comhttps://emoryott.technologypublisher.com/techcase/1517811014https://emoryott.technologypublisher.com/techcase/11014Application Small molecules containing either the piperidine or piperazine core which act as antagonists to C-X-C chemokine receptor type 4 (CXCR4) and may be orally administered. Key Benefits Orally administered CXCR4 antagonists with diverse clinical applications in oncology. Mobilize white blood cells in mice in a dose-dependent manner. Cause apoptosis-cell death in CXCR4 expressing breast cancer cells. Non-toxic to normal immune cells (T-cells, macrophages). Market Summary The CXCR4 receptor is expressed in more than 20 types of cancers, making it the most prevalent chemokine re...Thu, 27 Apr 2017 12:02:29 GMTemoryott@inteummail.comhttps://emoryott.technologypublisher.com/techcase/1101416021https://emoryott.technologypublisher.com/techcase/16021Application Amide derivatives as chemokine receptor type 4 (CXCR4) modulators for the treatment of inflammation or prevention of cancer cell metastasis. Key Benefits Excellent binding affinity, compared to currently available compounds targeting CXCR4 receptor. Stability in plasma compared to protein/peptide agonists of CXCR4, these amide derivatives can be cost effective, and easier to handle and store. Compounds show reduced cytotoxicity issues and no mobilization of stem cells/tumors. Market Summary CXCR4 receptors play a crucial role in recruitment of inflammatory cells to inflam...Mon, 24 Apr 2017 06:53:10 GMTemoryott@inteummail.comhttps://emoryott.technologypublisher.com/techcase/1602115100https://emoryott.technologypublisher.com/techcase/15100Application Amine derivatives as chemokine receptor type 4 (CXCR4) modulators to treat breast cancer and block tumor metastasis. Key Benefits New class of anti-cancer drugs targeting CXCR4 instead of COX pathway. Partial antagonists are safer for use because they do not mobilize stem cells. Market Summary CXC chemokine receptor 4 (CXCR4) and stromal cell-derived factor 1 (SDF-1, also known as CXCL12) are a chemokine receptor and chemokine pair that play a critical role in cancer metastasis and inflammation. Expression of CXCR4 is increased in many types of cancer such as breast, pancr...Mon, 10 Apr 2017 06:54:54 GMTemoryott@inteummail.comhttps://emoryott.technologypublisher.com/techcase/1510016017https://emoryott.technologypublisher.com/techcase/16017Application A multifunctional polymer that captures and degrades chemical threats in the environment. Key Benefits Forms a gel that entraps toxic materials within seconds of contact. Visible color change of gel confirms neutralization of toxic substance. Modifiable structure allows for functional use against chemical entity of choice. Market Summary Toxic chemicals and materials are manufactured, stored, transported, and used in large quantities throughout the United States. In industrial environments, many people may be in close proximity to potentially dangerous chemicals in solid,...Wed, 29 Mar 2017 06:20:03 GMTemoryott@inteummail.comhttps://emoryott.technologypublisher.com/techcase/1601715121https://emoryott.technologypublisher.com/techcase/15121Tue, 07 Mar 2017 13:54:35 GMTemoryott@inteummail.comhttps://emoryott.technologypublisher.com/techcase/1512109004https://emoryott.technologypublisher.com/techcase/09004Application Small molecules that selectively potentiate N-methyl-D-aspartate (NMDA) receptor subunits GluN2C/GluN2D for the treatment of neurological conditions. Key Benefits Selective potentiation of only NMDA receptor that contain GluN2C or GluN2D subunits will likely reduce adverse side effects. Selective potentiation of only NMDA receptor that contain GluN2C or GluN2D subunits may yield better pharmacological and pharmacokinetic properties versus global NMDA receptor antagonists. Market Summary Impaired NMDA receptor function has been suggested in a wide range of neurological cond...Tue, 21 Feb 2017 11:20:07 GMTemoryott@inteummail.comhttps://emoryott.technologypublisher.com/techcase/0900415095https://emoryott.technologypublisher.com/techcase/15095Application Fibrinogen-coated micron-sized drug vehicles for targeted treatment of unregulated blood clotting. Key Benefits Facilitates targeted release of drugs specifically for blood clotting disorders. Drug delivery vehicle can be used with newly discovered or known therapeutics on the market. Site specific biological mechanism may help increase drug efficacy and avoid side effects. Market Summary Life threatening occurrences of unregulated blood clotting such as Hemophilia A/B or Deep Vein Thrombosis can result in severe blood loss or unwanted blood clotting, respectively. In cas...Mon, 20 Feb 2017 14:23:15 GMTemoryott@inteummail.comhttps://emoryott.technologypublisher.com/techcase/1509516113https://emoryott.technologypublisher.com/techcase/16113Sun, 19 Feb 2017 12:20:24 GMTemoryott@inteummail.comhttps://emoryott.technologypublisher.com/techcase/1611317002https://emoryott.technologypublisher.com/techcase/17002ApplicationPlasmids rescuing recombinant syncytial virus for RSV research and vaccine development.Key BenefitsAllow expression and recombination in vero cells.Optimized for human codon bios to increase expression in mammalian cells.Market SummaryRespiratory syncytial virus (RSV) is the major cause of acute lower respiratory tract infections in infants and young children. Infections often lead to hospitalizations and, in rare cases or underdeveloped countries, can result in death. RSV-related illnesses amongst the elderly are also on the rise. Currently, there are no effective therapeutics or v...Thu, 16 Feb 2017 10:21:06 GMTemoryott@inteummail.comhttps://emoryott.technologypublisher.com/techcase/1700214170https://emoryott.technologypublisher.com/techcase/14170Application Microfluidic chip device for facilitating high throughput viral transduction for gene therapy applications. Key Benefits Improves surface-to-volume ratio, allowing more efficient contact between lentiviruses and cells Increases efficiency while maintaining cell viability of traditional methods. Enables gene transfer for non-adherent cells. Compatible with syringe pump. Market Summary Lentiviral vector gene therapy is one of the predominant methods used for gene transfer during gene therapy applications. Although lentiviral vectors are very effective mechanism for gene tr...Tue, 07 Feb 2017 08:39:36 GMTemoryott@inteummail.comhttps://emoryott.technologypublisher.com/techcase/1417015145https://emoryott.technologypublisher.com/techcase/15145Application Cell-based assay for sensitive and specific detection of undifferentiated cells in stem cell-related research and development. Key Benefits Nanotechnology-based assay can detect residual undifferentiated cells and characterize cultures that may be tumorigenic. Technology is potentially more sensitive method compared to current methods. Market Summary Human pluripotent stem cells (hPSCs) have emerged as a potentially invaluable resource for cell therapy and regenerative medicine. A major concern is the potential risk for residual undifferentiated stem cells in preparations ...Fri, 16 Dec 2016 13:39:49 GMTemoryott@inteummail.comhttps://emoryott.technologypublisher.com/techcase/1514516049https://emoryott.technologypublisher.com/techcase/16049Application Tumor-targeted nanoparticles for the delivery of anti-PD-L1 peptides for treatment of cancers. Key Benefits Nanoparticles loaded with a variety of drugs and/or peptides for prolonged therapeutic delivery to tumor sites. Targeted delivery to tumor sites can reduce level of dosing and side effects. Market Summary PD-L1 is expressed in tumor cells and tumor associated stromal cells to suppress function of cytotoxic T cells. Anti PD-L1 antibodies or peptide blockers are a highly active area of oncology research for pharmaceutical companies. Problems still exist in many tumor t...Mon, 05 Dec 2016 12:27:19 GMTemoryott@inteummail.comhttps://emoryott.technologypublisher.com/techcase/16049RT011https://emoryott.technologypublisher.com/techcase/RT011Applications Bacterial artificial chromosome (BAC) plasmid containing the antigenomic sequence A2-BAG-BAF derived from multiple strains of RSV. Key Benefits Viral DNA is contained in a BAC, allowing for efficient mutagenesis and recombineering of viral DNA. BAC is stable and can be used for cloning in common bacteria types like E. coli. Provides powerful tool for use in engineering potential RSV vaccines. Market Summary Human Respiratory syncytial virus (RSV) RSV is a leading cause of respiratory infections. Beyond infants, RSV-related illnesses in the elderly are on the rise. As the...Tue, 29 Nov 2016 11:11:06 GMTemoryott@inteummail.comhttps://emoryott.technologypublisher.com/techcase/RT01114099https://emoryott.technologypublisher.com/techcase/14099Application Modified recombinant syncytial virus (RSV) strain expressing a bioluminescent reporter protein for high throughput screening and vaccine development. Key Benefits Provides a new high throughput screening tool for RSV vaccine development and drug discovery. Firefly luciferase based assays show better signal-to-noise than fluorescence-based assays. Market Summary RSV is a major cause of respiratory illness, especially in young children and the elderly. In the United States, nearly all children have been infected with RSV by age two. Currently, no vaccine or small molecule tr...Mon, 14 Nov 2016 10:43:06 GMTemoryott@inteummail.comhttps://emoryott.technologypublisher.com/techcase/1409916093https://emoryott.technologypublisher.com/techcase/16093Sat, 29 Oct 2016 10:42:06 GMTemoryott@inteummail.comhttps://emoryott.technologypublisher.com/techcase/1609311128https://emoryott.technologypublisher.com/techcase/11128Mon, 17 Oct 2016 11:38:46 GMTemoryott@inteummail.comhttps://emoryott.technologypublisher.com/techcase/1112814150https://emoryott.technologypublisher.com/techcase/14150Application Fibroblasts reprogrammed into tissue-like patch including functional cardiomyocyte, endothelial, smooth muscle and pericyte cells for treatment of cardiac diseases. Key Benefits Enables simultaneous reprogramming of multi-lineage cells including cardiomyocytes and endothelial cells Increases expression of cardioprotective paracrine factors. Provides cardiac functionality, with demonstrated muscle contractility. Market Summary Ischemic heart disease or coronary artery disease is the single leading cause of death and disability worldwide. Mycoardial function is sensitive to...Tue, 19 Jul 2016 06:54:09 GMTemoryott@inteummail.comhttps://emoryott.technologypublisher.com/techcase/1415015156https://emoryott.technologypublisher.com/techcase/15156Wed, 01 Jun 2016 11:47:16 GMTemoryott@inteummail.comhttps://emoryott.technologypublisher.com/techcase/1515615148https://emoryott.technologypublisher.com/techcase/15148Application Plasmids to produce the catalytic domain of human PRDM9 or mouse Prdm9 protein, a robust methyltransferase generating trimethylation of histone H3 lysine 4 (H3K4me3). Technical Summary PRDM9 specifically trimethylates lysine 4 of histone H3, but does not have the ability to mono- and dimethylate lysine 4 of histone H3. H3K4 methylation represents a specific tag for epigenetic transcriptional activation during early meiotic prophase and is essential for proper meiotic progression. Recombinant, purified catalytic domains of human PRDM9 (aa 194-414) and mouse Prdm9 (aa 195-368) can...Wed, 01 Jun 2016 11:47:15 GMTemoryott@inteummail.comhttps://emoryott.technologypublisher.com/techcase/1514814216https://emoryott.technologypublisher.com/techcase/14216Application GIFT4 anchored to virus-like particles (VLPs) as a prophylactic vaccine adjuvant to prevent chronic viral infections including HIV, HBV, HPV and influenza. Key Benefits GIFT4-containing VLPs induce higher antibody response than non-adjuvanted VLPs. Effectively induce strong mucosal immune response. Market Summary Currently, there is no vaccine to prevent HIV infection. Although there has been an overall decrease in the number of new infections and AIDS-related deaths due to antiretroviral therapies in the past decade, the number of people living with HIV grows steadily wor...Wed, 01 Jun 2016 11:47:10 GMTemoryott@inteummail.comhttps://emoryott.technologypublisher.com/techcase/1421615088https://emoryott.technologypublisher.com/techcase/15088Tue, 26 Apr 2016 06:37:10 GMTemoryott@inteummail.comhttps://emoryott.technologypublisher.com/techcase/15088NCS.20https://emoryott.technologypublisher.com/techcase/NCS.20Application Repurposed small molecules for use as a bone forming therapeutic during treatment of diseases requiring local bone formation such as fracture repair, spinal fusion, and large segmental bone defects. Key Benefits Current treatments require high concentrations of bone morphogenetic protein (BMP) which results in high costs, adverse side effects, and creates a barrier for routine clinical use. These novel small molecules modulate a part of the signaling pathway for BMP and can be administered locally to promote bone growth and healing. These repurposed therapeutics are already ...Thu, 14 Apr 2016 09:42:55 GMTemoryott@inteummail.comhttps://emoryott.technologypublisher.com/techcase/NCS.20NCS.19https://emoryott.technologypublisher.com/techcase/NCS.19Application Multiple series of small molecules that selectivity potentiate NMDA receptors composed of specific subunits including GluN2B, GluN2C, GluN2B/GluN2C/GluN2D, and GluN2C/GluN2D. Key Benefits Small molecule potentiators enhance endogenous signals without exogenous activation. Subunit selectivity allows targeting of specific subtypes of NMDA receptors. Class of molecules are highly brain penetrant. Market Summary The NMDA receptor is a complex ligand-gated ion channel that has been viewed as a therapeutic target for multiple diseases and disorders for over 30 years. Reduced NM...Thu, 14 Apr 2016 09:42:53 GMTemoryott@inteummail.comhttps://emoryott.technologypublisher.com/techcase/NCS.1915107https://emoryott.technologypublisher.com/techcase/15107Mon, 28 Mar 2016 09:12:14 GMTemoryott@inteummail.comhttps://emoryott.technologypublisher.com/techcase/1510715096https://emoryott.technologypublisher.com/techcase/15096Application Immortalized (using polyoma middle T-antigen) mouse aortic endothelial primary cell lines for studying vascular biology and pathophysiology, including cardiovascular research. Key Benefits Immortalized from mouse artery endothelial cells using polyoma middle T-antigen. Validated retention of primary endothelial markers and structural phenotype in cell culture. Wild-type, p47phox-/-, eNOS-/-, and caveolin-1-/- knockout aortic endothelial cell llines. Technical Summary A lack of primary mouse aortic endothelial cells for cell culture remains a hindrance in endothelial cel...Fri, 25 Mar 2016 10:31:30 GMTemoryott@inteummail.comhttps://emoryott.technologypublisher.com/techcase/1509614212https://emoryott.technologypublisher.com/techcase/14212Application A vaccine that provides protection from a broad spectrum of human rhinovirus serotypes. Key Benefits Targets numerous, specific human rhinovirus (HRV) serotypes and provides broad neutralizing antibodies. Engineered bacterial artificial chromosome (BAC) expression of HRV to reproducibly express specific serotypes. BAC system allows for genetic manipulation of HRV to produce recombinant strains of virus potentially improving vaccine effectiveness. Market Summary Human rhinovirus (HRV) is the most common virus infecting humans, primarily impacting the nose, throat (pharynx...Wed, 16 Mar 2016 05:04:18 GMTemoryott@inteummail.comhttps://emoryott.technologypublisher.com/techcase/1421215055https://emoryott.technologypublisher.com/techcase/15055Applications Mouse model that utilizes a BAC to express human dopamine beta-hydroxylase in the brain. Key Benefits In vivo approach to dissect role of single genes in the nervous system. May be used in the study of how human variants of dopamine beta-hydroxylase affect norepinephrine signaling in the brain. Technical Summary Dopamine beta-hydroxylase is encoded by the DBH gene and converts dopamine to norepinephrine. These signaling molecules are involved in a variety of processes important in Parkinson disease, drug dependence, and mental illness. Researchers at Emory have developed ...Tue, 09 Feb 2016 06:26:52 GMTemoryott@inteummail.comhttps://emoryott.technologypublisher.com/techcase/1505514158https://emoryott.technologypublisher.com/techcase/14158Application Small molecule inhibitor of CHFR to increase taxane efficacy in cancer treatment. Key Benefits Combination treatment, potentially effective against cancers resistant to taxane treatment. Market Summary Microtubular-targeted chemotherapy agents such as taxanes are among the most widely prescribed first- and second- line chemotherapy choices for patients with the most common malignancies including lung-, breast-, and prostate cancer. Unfortunately, primary resistance to taxanes is a common clinical problem. CHFR protein levels and CHFR promoter methylation are highly predictive ...Mon, 08 Feb 2016 07:17:48 GMTemoryott@inteummail.comhttps://emoryott.technologypublisher.com/techcase/1415815117https://emoryott.technologypublisher.com/techcase/15117Application Recombinant respiratory syncytial virus (RSV) strains expressing the G and F Proteins from RSV strains as well as renilla luciferase for use in drug and vaccine screening. Key Benefits Provides new and needed tool for screening potential RSV therapies, ensuring they are broadly effective against multiple, distinct strains of the virus. Expresses renilla luciferase for easy screening. Market Summary RSV is a common respiratory virus infecting most of the population at some point during their life and a major cause of lower respiratory tract infections in infants, children,...Tue, 19 Jan 2016 10:05:55 GMTemoryott@inteummail.comhttps://emoryott.technologypublisher.com/techcase/1511715114https://emoryott.technologypublisher.com/techcase/15114Tue, 19 Jan 2016 10:05:53 GMTemoryott@inteummail.comhttps://emoryott.technologypublisher.com/techcase/1511415080https://emoryott.technologypublisher.com/techcase/15080Application DNA-based machines that roll rather than walk and can be used for single nucleotide polymorphism (SNP) analysis. Key Benefits Unique "rolling" cogwheel-like mechanism allows directional motion without a track or external guidance. Micron-sized cargo travels large distances; can be visualized using a smartphone camera equipped with an inexpensive lens. Moves up to 1,000 times faster than conventional DNA-based motors. Market Summary Single Nucleotide Polymorphism (SNP) genotyping is the screening and analysis of genetic variations of SNPs in the genome of various species...Tue, 19 Jan 2016 10:05:42 GMTemoryott@inteummail.comhttps://emoryott.technologypublisher.com/techcase/1508014127https://emoryott.technologypublisher.com/techcase/14127Fri, 08 Jan 2016 11:37:41 GMTemoryott@inteummail.comhttps://emoryott.technologypublisher.com/techcase/1412713118https://emoryott.technologypublisher.com/techcase/13118Tue, 22 Dec 2015 11:31:23 GMTemoryott@inteummail.comhttps://emoryott.technologypublisher.com/techcase/13118NCS.18https://emoryott.technologypublisher.com/techcase/NCS.18Application DETECT is a computerized system for diagnosing mild traumatic brain injury (mTBI) in diverse and austere environments. Key Benefits Heads up display and immersive platform eliminate the need for controlled testing environments, allowing for neuropsychological testing in locations closer to point of injury (e.g. sports sidelines or battlefield). Allows for rapid administration (10-15 min) of sensitive neuropsychological tests to identify mTBI shortly after injury. Market Summary Millions of people suffer TBI each year in the U.S. Of them, approximately 75% are considered mi...Tue, 22 Dec 2015 11:31:15 GMTemoryott@inteummail.comhttps://emoryott.technologypublisher.com/techcase/NCS.1815218https://emoryott.technologypublisher.com/techcase/15218Mon, 26 Oct 2015 17:55:55 GMTemoryott@inteummail.comhttps://emoryott.technologypublisher.com/techcase/1521815217https://emoryott.technologypublisher.com/techcase/15217Mon, 26 Oct 2015 17:55:51 GMTemoryott@inteummail.comhttps://emoryott.technologypublisher.com/techcase/1521715216https://emoryott.technologypublisher.com/techcase/15216Applications Western Blot Immunoprecipitation Specificity Human Subtype Rabbit Polyclonal Technical Summary Calcium is responsible for regulating various cellular processes. The elevation of intracellular calcium regulates the activity of Na+/H+ exchanger 3 (NHE3). Emory inventors have identified a polyclonal antibody which cross reacts with inositol triphosphate (IP3) receptor-binding protein (IRBIT). IRBIT is released with IP3, binds NHE3 and activates NHE3 activity in response to calcium. The interaction of IRBIT is necessary for the stimulation of NHE3 activity. Publication: H...Mon, 26 Oct 2015 17:55:45 GMTemoryott@inteummail.comhttps://emoryott.technologypublisher.com/techcase/1521604005https://emoryott.technologypublisher.com/techcase/04005ApplicationOral lozenges (and other oral therapies) for the maintenance of oral health and treatment of mucositis associated with chemotherapy/radiation treatment.Key BenefitsCurrent approaches to the treatment of mucositis associated with cancer therapy have not proven to be efficacious. An over the counter (OTC) supplement involving glutathione, an antioxidant, reduced mucositis symptoms by 70% in an animal model.Technical SummaryMucositis (inflammation of the oral mucosa) is a common, painful, and often dose-limiting side effect associated with chemotherapy and/or radiation therapy for canc...Tue, 01 Sep 2015 06:15:15 GMTemoryott@inteummail.comhttps://emoryott.technologypublisher.com/techcase/0400514112https://emoryott.technologypublisher.com/techcase/14112Application Biomarkers to diagnose active and latent tuberculosis infection and monitor treatment regimen. Key Benefits Three biomarkers accurately distinguish active tuberculosis (TB) from latent TB infections with 100% specificity and greater than 96% sensitivity. Faster and more accurate test to monitor treatment response among active tuberculosis patients. Uses blood samples instead of sputum samples that are more difficult to obtain in some patient population. Market Summary Tuberculosis (TB) remains a serious global health problem. Current diagnostic tests rely on direct smear ...Mon, 01 Jun 2015 12:37:51 GMTemoryott@inteummail.comhttps://emoryott.technologypublisher.com/techcase/14112NCS.15https://emoryott.technologypublisher.com/techcase/NCS.15Application The use of progesterone to treat patients with traumatic brain injury (TBI) via a tapered administration protocol. Key Benefits Early administration of progesterone reduces cerebral edema and neural loss, and improves behavioral recovery from traumatic brain injury (TBI) in pre-clinical animal models. Tapered progesterone withdrawal enhances recovery after TBI compared to acute withdrawal. Progesterone reduces mortality by 50% and improves functional outcomes in patients with TBI in phase II clinical trials. Tested in phase II and phase III clinical trials and has an accept...Mon, 01 Jun 2015 12:37:49 GMTemoryott@inteummail.comhttps://emoryott.technologypublisher.com/techcase/NCS.1513080https://emoryott.technologypublisher.com/techcase/13080ApplicationSmall molecule therapeutic that can be delivered locally to enhance TGF-beta activity and promote cartilage growth.Key BenefitsIncreases production of protease inhibitors, simultaneously stimulating production and blocking degradation of extracellular matrix (ECM). Potentially reduces or eliminates need for joint replacements by regenerating articular cartilage Market SummaryEach year, there are approximately one million knee and hip replacements performed in the United States, often due to osteoarthritis (OA), a joint disease that results from the breakdown of joint cartilage and u...Mon, 01 Jun 2015 08:21:31 GMTemoryott@inteummail.comhttps://emoryott.technologypublisher.com/techcase/1308015091https://emoryott.technologypublisher.com/techcase/15091Application Survey for identifying patterns of social networking and cyber bullying among adolescents. Key Benefits Identifies specific behaviors and experiences to provide a more detailed analysis of cyber bullying. Survey is anonymous and requires no protected health information. Market Summary Internet usage among adolescents has increased tremendously in the last decade, resulting in an increase in unsupervised access to various forms of media and electronic content. A study by the Kaiser Foundation found that internet use among 8-18 year olds has increased from 47 to 85 percent i...Thu, 30 Apr 2015 13:40:34 GMTemoryott@inteummail.comhttps://emoryott.technologypublisher.com/techcase/1509112019https://emoryott.technologypublisher.com/techcase/12019Application Heart stabilization device for use in minimally invasive cardiac bypass surgeries. Key Benefits Shorter and thinner articulating arm allows for smaller incisions and less crowding of the work field. Flexible articulating arm accommodates variations in patient anatomy. V-shaped stabilizing arms are much less bulky than those for currently available devices. Market Summary Coronary artery bypass surgery is one of the most commonly performed surgeries in the United States. Minimally invasive techniques in this surgery have become increasingly common. Additionally, bypass sur...Tue, 28 Apr 2015 10:20:34 GMTemoryott@inteummail.comhttps://emoryott.technologypublisher.com/techcase/1201914033https://emoryott.technologypublisher.com/techcase/14033Mon, 27 Apr 2015 09:13:17 GMTemoryott@inteummail.comhttps://emoryott.technologypublisher.com/techcase/1403312092https://emoryott.technologypublisher.com/techcase/12092Thu, 16 Apr 2015 08:20:40 GMTemoryott@inteummail.comhttps://emoryott.technologypublisher.com/techcase/1209214094https://emoryott.technologypublisher.com/techcase/14094Application Registration software for higher accuracy in magnetic resonance (MR) and transrectal ultrasound (TRUS) imaging. Key Benefits Increased accuracy of prostate radiotherapy by combining two imaging modalities that include identifying patient-specific prostate variations. Market Summary Current methods for the treatment of prostate cancer include magnetic resonance (MR) and transrectal ultrasound (TRUS) guided radiotherapy; however, available software does not adequately merge the MR and TRUS images for successful image-guided prostate radiation therapy. MR-TRUS image registration ...Tue, 31 Mar 2015 12:44:46 GMTemoryott@inteummail.comhttps://emoryott.technologypublisher.com/techcase/1409415026https://emoryott.technologypublisher.com/techcase/15026ApplicationRecombinant RSV Strains Expressing the G and F Proteins from various geographically distributed RSV strains for use in drug and vaccine screeningKey BenefitsProvides new and needed tool for screening potential RSV therapies, ensuring they are broadly effective against multiple, geographically distinct strains of the virus Expresses the red fluorescent protein mKate2 for easy screening Market SummaryRSV is a common respiratory virus infecting most of the population at some point during their life and a major cause of lower respiratory tract infections in infants, children, and the el...Thu, 26 Mar 2015 12:52:26 GMTemoryott@inteummail.comhttps://emoryott.technologypublisher.com/techcase/1502614006https://emoryott.technologypublisher.com/techcase/14006Application ReliefLink is a mobile companion app for suicide prevention. Key Benefits A companion app that includes mood tracking, reminders and safety plans. Location aware for finding the nearest hospitals and mental health treatment centers. Includes personalized coping mechanisms and assistance for finding therapists and support groups. Market Summary Suicide is the 10th leading cause of death in the U.S. It is important to understand that deaths due to suicide are only a leading indicator of the individuals at risk. It is estimated that 11 attempted suicides occur per suicide de...Thu, 26 Mar 2015 12:52:23 GMTemoryott@inteummail.comhttps://emoryott.technologypublisher.com/techcase/1400614013https://emoryott.technologypublisher.com/techcase/14013Tue, 24 Mar 2015 09:07:02 GMTemoryott@inteummail.comhttps://emoryott.technologypublisher.com/techcase/1401312208https://emoryott.technologypublisher.com/techcase/12208Application Cell culture system that acts as an in vitro model for infection and stress-induced airway inflammation; used for research and drug discovery/screening. Key Benefits Improved structure of system offers natural path for neutrophil transepithelial migration, unlike current systems. More accurately models pathological environment due to integration of airway fluid from patients. Could be used to model other tissues (e.g. gut) beyond small airways. Market Summary Human small airway epithelial cells (SAECs) are a subset of general respiratory epithelial cells isolated from n...Thu, 12 Mar 2015 13:34:11 GMTemoryott@inteummail.comhttps://emoryott.technologypublisher.com/techcase/1220813099https://emoryott.technologypublisher.com/techcase/13099Tue, 17 Feb 2015 10:29:25 GMTemoryott@inteummail.comhttps://emoryott.technologypublisher.com/techcase/13099NCS.11https://emoryott.technologypublisher.com/techcase/NCS.11Application Combined antigen-adjuvant virus-like particle (VLP) vaccine platform for enhanced immune response. Key Benefits Chimeric VLPs (cVLPs) contain both antigen and adjuvant, thereby enhancing both cellular and humoral responses. cVLPs are safer than live replicating vectored vaccines because of their lack of infectivity. The cVLP manufacturing process is much shorter than current vaccine production. Market Summary Traditional vaccines are generally composed of dead or attenuated microbes that have lost their disease-causing properties, its toxins or one or more of its surface ...Tue, 17 Feb 2015 10:00:22 GMTemoryott@inteummail.comhttps://emoryott.technologypublisher.com/techcase/NCS.11NCS.10https://emoryott.technologypublisher.com/techcase/NCS.10Tue, 10 Feb 2015 09:03:14 GMTemoryott@inteummail.comhttps://emoryott.technologypublisher.com/techcase/NCS.10NCS.09https://emoryott.technologypublisher.com/techcase/NCS.09Application Antisense oligonucleotide inhibitors of microRNA-miR712/miR205 to prevent or treat atherosclerosis and aortic aneurysm. Key Benefits 80% reduction on the expression of their microRNA targets. Reduces atheroma plaque formation in a mouse model of atherosclerosis. Provides potential non-surgical treatment for aortic aneurysm. Market Summary Atherosclerosis is a chronic inflammatory disease that involves the accumulation of fat on the artery walls over time and thickening of the artery walls, which leads to heart attack or stroke. Current therapies for atherosclerosis includ...Mon, 09 Feb 2015 08:26:01 GMTemoryott@inteummail.comhttps://emoryott.technologypublisher.com/techcase/NCS.0914220https://emoryott.technologypublisher.com/techcase/14220Wed, 28 Jan 2015 09:19:51 GMTemoryott@inteummail.comhttps://emoryott.technologypublisher.com/techcase/1422014148https://emoryott.technologypublisher.com/techcase/14148Application A mobile app for iOS to capture and communicate joint pain and arthritic parameters to healthcare providers, particularly in children. Key Benefits Designed specifically for children to use. Employs a user friendly game and reward based system to collect data. Accurately captures disease data for diagnosis, management and surveillance. Market Summary Juvenile arthritis is one of the most common childhood diseases in the U.S. Children and parents need to be able to report subjective levels of joint pain, swelling, and joint mobility in order to facilitate timely and accura...Wed, 28 Jan 2015 09:19:47 GMTemoryott@inteummail.comhttps://emoryott.technologypublisher.com/techcase/1414814115https://emoryott.technologypublisher.com/techcase/14115ApplicationMRI-compatible device that enables precise delivery of therapeutic or cells to specific locations in the spinal cord. Key BenefitsCompatible with real-time MRI imaging systems allowing for the targeting and delivery of therapies concurrent with imaging. Can precisely guide and deliver a multitude of therapies (small molecules, biologics or stem cells) to a specific location in the spinal cord. Market SummarySpinal cord injuries and diseases are complex, difficult to treat, and usually have a poor prognosis, resulting in a range of symptoms from pain and weakness to paralysis and inc...Wed, 28 Jan 2015 09:19:42 GMTemoryott@inteummail.comhttps://emoryott.technologypublisher.com/techcase/1411513173https://emoryott.technologypublisher.com/techcase/13173Application Two-dimensional sheets composed of collagen-mimetic peptides on the nanoscale that are highly-ordered and self-assembling. Key Benefits Thermal stability, sheet thickness, and sheet dimensions can be controlled through the peptide sequence and preparative conditions. Market Summary Collagens are used in a number of consumer and biomedical products including cosmetics, tissue repair, wound management, burn treatment, drug delivery, sutures, tissue engineering, and vasculature and valve replacements. Currently, collagen derivatives for medical applications originate primarily...Wed, 07 May 2014 14:52:46 GMTemoryott@inteummail.comhttps://emoryott.technologypublisher.com/techcase/1317313004https://emoryott.technologypublisher.com/techcase/13004Application Predictive mathematical modeling to individualize radiation treatment margins for prostate cancer patients treated with image-guided radiation therapy (IGRT). Key Benefits Predicts patient specific prostate motion for treatment planning with multi-fractionated intensity modulated radiotherapy (IMRT). More accurate than conventional fixed treatment margin approaches which may over treat or undertreat some patients Potentially decreases toxicity by reducing radiation dose to the bladder and rectum. Market Summary Prostate cancer is the most common cancer in American men. Re...Wed, 07 May 2014 14:51:47 GMTemoryott@inteummail.comhttps://emoryott.technologypublisher.com/techcase/1300413188https://emoryott.technologypublisher.com/techcase/13188Application An image processing algorithm that differentiates between malignant and non-malignant cells in a hyperspectral image. Key Benefits Able to detect head and neck cancer in hyperspectral images with higher than 95% accuracy and sensitivity. Allows for the identification of head and neck caner without an invasive procedure or expensive contrast agents. Market Summary The healthcare industry is undergoing a shift towards non-invasive diagnostics and therapeutic procedures. Technologies such as optical imaging have the potential to revolutionize clinical diagnostic safety. This ...Tue, 29 Apr 2014 13:33:14 GMTemoryott@inteummail.comhttps://emoryott.technologypublisher.com/techcase/1318813105https://emoryott.technologypublisher.com/techcase/13105Tue, 29 Apr 2014 13:33:12 GMTemoryott@inteummail.comhttps://emoryott.technologypublisher.com/techcase/1310514022https://emoryott.technologypublisher.com/techcase/14022Fri, 11 Apr 2014 11:26:49 GMTemoryott@inteummail.comhttps://emoryott.technologypublisher.com/techcase/1402213023https://emoryott.technologypublisher.com/techcase/13023Application Prophylactic administration of an antifibrinolytic agent, epsilon aminocaproic acid (EACA), to prevent bleeding in patients with thrombocytopenia from hematological malignancies. Key Benefits Orally bioavailable, repurposed drug. Commonly used and FDA approved to manage hemorrhage in patients with congenital bleeding. Cheaper and easier to administer to patients compared to platelet replacement therapy. Results from retrospective human study suggest it is safe and effective for patients with very severe and chronic thrombocytopenia. Market Summary Individuals with leu...Wed, 09 Apr 2014 12:47:58 GMTemoryott@inteummail.comhttps://emoryott.technologypublisher.com/techcase/1302313165https://emoryott.technologypublisher.com/techcase/13165Application Platform that creates conjugates of self-assembling peptides and cell signaling molecules as a potential therapeutic for the treatment and repair of tissue. Key Benefits Hydrogels form at physiological pH and osmolarity. Produces cells that display characteristics of adult cardiac muscle cells. Additional molecules (pro-growth or pro-repair) could be incorporated into the hydrogel and delivered to the body. Market Summary Ischemic heart disease, which includes myocardial infarction and angina, is the leading cause of death in the U.S. Drugs for ischemic heart disease addr...Tue, 08 Apr 2014 13:13:37 GMTemoryott@inteummail.comhttps://emoryott.technologypublisher.com/techcase/1316513126https://emoryott.technologypublisher.com/techcase/13126Application Repurposed, small molecule kinase inhibitors, such as epidermal growth factor receptor (EGFR) inhibitors, as topical vaccine adjuvants. Key Benefits Improves immune response and efficacy of vaccines and vaccine candidates. Employs compounds that are already approved for human use. Market Summary In order to create long lasting protection from infection, many vaccines require the use of an adjuvant. Adjuvants for vaccines work to enhance the immune response particularly in cases where the vaccine alone is incapable of eliciting a sufficient response. Currently, there is gro...Tue, 08 Apr 2014 13:13:35 GMTemoryott@inteummail.comhttps://emoryott.technologypublisher.com/techcase/1312613213https://emoryott.technologypublisher.com/techcase/13213Application Software application to connect clinicians and caregivers for the monitoring and collection of health data of infants with congenital heart defects. Key Benefits Mobile platform makes key health information easily accessible for caregivers. Allows remote monitoring of health data by clinical staff. Provides easier communication between caregiver and clinical staff. Market Summary The increased success rate in initial treatment of congenital heart defects (CHD) has led to an increase in the number of infants with CHD that are released from the hospital to non-medical care...Tue, 25 Feb 2014 11:54:55 GMTemoryott@inteummail.comhttps://emoryott.technologypublisher.com/techcase/1321313196https://emoryott.technologypublisher.com/techcase/13196Application A ligand-protease fusion peptide that cuts through the tumor stromal barrier and provides enhanced tumor targeting and delivery efficiency for therapeutic agents. Key Benefits The protease activity of the fusion peptide enables breaking of the stromal matrix and allows migration into stroma-rich tumor tissues. Can be attached to nanoparticles or other imaging and drug delivery carriers for the enhanced tumor targeting and efficient therapeutic delivery By digesting the surrounding extracellular matrix this fusion peptide improves intratumoral distribution of the therapeutics...Tue, 25 Feb 2014 11:54:52 GMTemoryott@inteummail.comhttps://emoryott.technologypublisher.com/techcase/1319612098https://emoryott.technologypublisher.com/techcase/12098Fri, 03 Jan 2014 10:55:51 GMTemoryott@inteummail.comhttps://emoryott.technologypublisher.com/techcase/1209813089https://emoryott.technologypublisher.com/techcase/13089Application A glycopeptide inhibitor of p-selectin for the treatment of sickle cell disease. Key Benefits Blocks the activity of P-selectin with nM affinity. Potential treatment for vaso-occlusive crisis associated with sickle cell disease. Inhibits the earliest stage of leukocyte activation helping to prevent immune response. Market Summary Sickle cell anemia, a serious disorder in which the body makes sickle-shaped red blood cells, affects thousands of Americans and a majority of these are African Americans. The most common clinical manifestation of sickle cell disease is vaso-occl...Wed, 04 Dec 2013 14:01:24 GMTemoryott@inteummail.comhttps://emoryott.technologypublisher.com/techcase/1308913016https://emoryott.technologypublisher.com/techcase/13016Application PC and mobile applications designed for the creation and sharing of radiology case images for teaching and testing purposes. Key Benefits Allows for the creation of annotated medical image files for teaching. Facilitates effortless sharing of medical images to handheld devices for mobile teaching and testing. Market Summary In an academic setting, radiologists often spend time educating students and medical staff using a collection of medical images. These images are often stored on hospital workstations, carried on USB thumb drives, or emailed to facilitate the sharing of...Wed, 04 Dec 2013 14:01:22 GMTemoryott@inteummail.comhttps://emoryott.technologypublisher.com/techcase/1301612090https://emoryott.technologypublisher.com/techcase/12090Thu, 07 Nov 2013 13:09:12 GMTemoryott@inteummail.comhttps://emoryott.technologypublisher.com/techcase/1209008081https://emoryott.technologypublisher.com/techcase/08081Application Acid-sensitive polyketal nanoparticles for biodegradable drug delivery. Key Benefits Can be engineered to a variety of sizes and shapes to facilitate the delivery of hydrophobic small molecules, proteins, or nucleic acids. Provides a vehicle for delivering therapeutics to acidic environments found in tumors, inflammatory tissues, and phagosomes. Market Summary A major challenge in drug therapy is the delivery of an exact therapeutic dose in a variety of microenvironments. The use of nanoparticles has circumvented some of these hurdles by precisely delivering therapeutics, ...Sun, 03 Nov 2013 13:26:31 GMTemoryott@inteummail.comhttps://emoryott.technologypublisher.com/techcase/0808113046https://emoryott.technologypublisher.com/techcase/13046Sun, 03 Nov 2013 13:26:22 GMTemoryott@inteummail.comhttps://emoryott.technologypublisher.com/techcase/13046NCS.07https://emoryott.technologypublisher.com/techcase/NCS.07Sun, 03 Nov 2013 13:26:14 GMTemoryott@inteummail.comhttps://emoryott.technologypublisher.com/techcase/NCS.0713001https://emoryott.technologypublisher.com/techcase/13001Application Live bacteria-based vaccine that is delivered by oral route and stimulates the body's immune system to produce mucosal antibodies against HIV. Key Benefits Provides better vaccine scheme via mucosal immune response as a primary vaccine compared to other primary vaccines that are administered parenterally. Generates both antibody and T-cell responses. First-in-class treatment that could be combined with other approaches as well. Does not need refrigeration and is inexpensive to produce. Good safety profile already exists concerning human oral ingestion of L. lactis. M...Wed, 04 Sep 2013 07:56:59 GMTemoryott@inteummail.comhttps://emoryott.technologypublisher.com/techcase/1300108144https://emoryott.technologypublisher.com/techcase/08144Application Biotherapeutic activation of toll-like receptor 5 (TLR5) to treat graft-versus-host disease (GvHD). Key Benefits Administration of flagellin reduces both acute and chronic GvHD. Contrary to immunosuppressive drugs, flagellin enhances immunity and protects patients from opportunistic infections. Market Summary Transplant recipients are prone to rejecting the newly transplanted tissue, and 50% of recipients develop graft-versus-host disease in which the new donor cells destroy tissues in the host body. To prevent GvHD, patients are administered immunosuppressive drugs prophy...Fri, 26 Jul 2013 05:19:16 GMTemoryott@inteummail.comhttps://emoryott.technologypublisher.com/techcase/0814413117https://emoryott.technologypublisher.com/techcase/13117ApplicationSmall molecule analogs of the naturally-occurring compound solenopsin for the treatment of various cancers including melanoma and angiosarcoma.Key BenefitsAnalogs derived from a naturally-occurring alkaloid. Potential treatment of cancers for which there is a poor prognosis or low survival rate. Market SummaryPhosphoinositol-3 kinase (PI3K) and its downstream effector Akt, play a major regulatory role in control of apoptosis, proliferation, and angiogenesis. Many cancers show an overexpression of PI3K and Akt. For example, PI3K and Akt are amplified or overexpressed in sarcomas, ova...Fri, 19 Jul 2013 11:44:32 GMTemoryott@inteummail.comhttps://emoryott.technologypublisher.com/techcase/1311713021https://emoryott.technologypublisher.com/techcase/13021Application Universal clamp to mount objects to an operating table. Key Benefits Provides a low profile and pitch accommodation on the operating table and general ease of use in the OR. Designed to mate with standard OR table railings, allowing for widespread use in any type of hospital and with any type of surgery. Universal design decreases storage space and maintenance required for multiple OR clamps. Market Summary There is currently no universal clamp for operating tables available. There are instead many different clamps that are used to mount objects to the operating table. Al...Mon, 01 Jul 2013 11:13:36 GMTemoryott@inteummail.comhttps://emoryott.technologypublisher.com/techcase/1302113077https://emoryott.technologypublisher.com/techcase/13077Application Mounting and video system for video recording in the operating room. Key Benefits Can be used as a component of an overall intra-operative video system as well as a standalone product. Simple design is easy to manufacture and easy for the surgeon to operate. Allow devices to be mounted directly on the edge of the sterile field. Can streamline some of the equipment necessary in the room. Market Summary Operating room (OR) video recording has increased in recent years. Visual documentation of each surgery provides documentation for medical litigation, visual components to ...Mon, 01 Jul 2013 11:13:34 GMTemoryott@inteummail.comhttps://emoryott.technologypublisher.com/techcase/1307713067https://emoryott.technologypublisher.com/techcase/13067Application PET-based imaging of HIV anatomical reservoir locations for health monitoring and determination of therapy effectiveness. Key Benefits The only in vivo method for visualizing sites of HIV. Compatible with existing PET/CT imaging system. Market Summary The first line of therapy for AIDS is administering anti-HIV drug cocktails to slow the progression of the disease; however, retroviruses quickly adapt to the regime and become resistant. With over 30% patients resistant to conventional drugs, an aggressive treatment strategy warrants continuous monitoring. Currently, drug tr...Fri, 21 Jun 2013 09:29:44 GMTemoryott@inteummail.comhttps://emoryott.technologypublisher.com/techcase/1306711158https://emoryott.technologypublisher.com/techcase/11158Application A web-based information management application for data tracking and sharing during the discovery and development of new small molecule therapeutics. Key Benefits Can be used to register compounds and display information about chemical structures and calculations. Easily customizable and has a ticket system to allow administrators to restrict and keep track of user access and updates that have been made to the database. Accessible from any personal computer, tablet, or smartphone device. Market Summary Although there are many applications that can store large amounts of...Fri, 21 Jun 2013 09:29:36 GMTemoryott@inteummail.comhttps://emoryott.technologypublisher.com/techcase/1115812101https://emoryott.technologypublisher.com/techcase/12101Application Animal inventory database software that combines animal tracking, usage requests, and animal allocation into one program through a web-based user interface. Highlights Streamlines colony management by using one program instead of separate programs for tracking, allocation, and usage requests. Built on open source software to allow easy customization to the specific needs of each institution. Market Summary The allocation of research animals is a time consuming process for research centers as animal status, upcoming research projects, and researcher requests are often mai...Fri, 21 Jun 2013 09:29:32 GMTemoryott@inteummail.comhttps://emoryott.technologypublisher.com/techcase/1210105012https://emoryott.technologypublisher.com/techcase/05012Application Western blot Immunoprecipitation Specificity Peptide sequences conserved within several human 14-3-3 protein subspecies Subtype Rabbit polyclonal Technical Summary Two rabbit sera identified as p81 and Q97 were made against synthetically synthesized peptides of 14-3-3 protein. The two antibodies are more specifically a beta-zeta 14-3-3 polyclonal antibody (p81) and a zeta-gamma ETA 14-3-3 polyclonal antibody (Q97). Polyclonal rabbit serum was raised against the pep-tide ELVQKAKLAEQA synthesized on a polylysine core (MAP resin). The identical sequence is found in several...Fri, 21 Jun 2013 09:29:25 GMTemoryott@inteummail.comhttps://emoryott.technologypublisher.com/techcase/0501213115https://emoryott.technologypublisher.com/techcase/13115Application Software to register and fuse TRUS and CT images for use in high-dose-rate brachytherapy procedures. Key Benefits Integrates intra-operative ultrasound-based prostate volume into treatment planning. Improves prostate delineation and enables accurate dose planning and delivery which may improve outcomes from high dose rate brachytherapy treatments. Market Summary Prostate cancer is the second leading cause of cancer in men in the United States. One treatment option for prostate cancer patients is high-dose-rate (HDR) brachytherapy which uses small catheters inserted into t...Fri, 14 Jun 2013 12:43:07 GMTemoryott@inteummail.comhttps://emoryott.technologypublisher.com/techcase/13115RT006https://emoryott.technologypublisher.com/techcase/RT006Application Highly malignant and metastatic prostate cancer cell line. Key Benefits Prostate cancer cell line with reduced Epithelial Protein Lost In Neoplasm (EPLIN) expression. Cell line exhibits morphology characteristics of malignant cell lines and increased chemoresistance, migration, and invasion. Market Summary Although the survival rates for prostate cancer have improved due to improvements in cancer detection and increased awareness, survival rates for metastatic prostate cancer remain quite low. To further improve prostate cancer survival rates, there is a large research foc...Tue, 28 May 2013 09:06:44 GMTemoryott@inteummail.comhttps://emoryott.technologypublisher.com/techcase/RT00612177https://emoryott.technologypublisher.com/techcase/12177Application Cancer cell line derived from a pediatric patient with early B-cell precursor (Pre-B) acute lymphoblastic leukemia with myeloid phenotype. Key Benefits Does not express p53 and expresses wild-type MDM2. Expresses wild-type Bax, over-expresses Bcl-xl, and does not express Bcl-2. Can be used as a tool for gene transfection assays in leukemia studies. Technical Summary p53 is a tumor suppressor protein that in humans is encoded by the TP53 gene. p53 regulates the cell cycle and thereby functions as a tumor suppressor that is involved in preventing cancer. Mutation or inactiv...Fri, 24 May 2013 10:13:35 GMTemoryott@inteummail.comhttps://emoryott.technologypublisher.com/techcase/1217712176https://emoryott.technologypublisher.com/techcase/12176Fri, 24 May 2013 10:02:43 GMTemoryott@inteummail.comhttps://emoryott.technologypublisher.com/techcase/1217612178https://emoryott.technologypublisher.com/techcase/12178Application Cancer cell line derived from a relapsed pediatric patient with early B-cell precursor (Pre-B) acute lymphoblastic leukemia. Key Benefits Well-characterized to have a point mutation of the p53 gene at codon 273. Expresses wild-type Bax, Bcl-xl, and Bcl-2. Well used tool for p53 studies in leukemia. Technical Summary p53 is a tumor suppressor protein that in humans is encoded by the TP53 gene. p53 regulates the cell cycle and thereby functions as a tumor suppressor that is involved in preventing cancer. Mutation or inactivation of the p53 gene has been implicated in a wide...Fri, 24 May 2013 10:02:27 GMTemoryott@inteummail.comhttps://emoryott.technologypublisher.com/techcase/12178RT002https://emoryott.technologypublisher.com/techcase/RT002Tue, 09 Apr 2013 12:23:36 GMTemoryott@inteummail.comhttps://emoryott.technologypublisher.com/techcase/RT00211137https://emoryott.technologypublisher.com/techcase/11137Application Tumor receptor-targeted nanoparticle containing a siRNA DNA cassette for the knockdown of survival genes and treating cancer. Key Benefits Nanoparticles are targeted directly to tumors for treatment and/or diagnostic imaging. siRNA encoded by a DNA cassette has increased stability and more effective gene depletion. siRNA knockdown of survival genes increases susceptibility to chemotherapy. Can be used alone or combined/incorporated with chemotherapeutics. Market Summary Although survival rates from cancer have been increasing, there are still challenges with one-size-fit...Wed, 27 Mar 2013 09:28:00 GMTemoryott@inteummail.comhttps://emoryott.technologypublisher.com/techcase/1113712147https://emoryott.technologypublisher.com/techcase/12147Application Dual-labeled antisense oligonucleotide probes for fluorescent activated cell sorting (FACS) of pluripotent stem cells. Key Benefits Allows for the purification of a homogeneous cell population compared to currently available techniques which can only produce heterogeneous mixtures. Binds intracellular RNA using standard delivery techniques eliminating the need for known surface markers to be present within the cell population. Specific probes can be generated for different cell types. Market Summary Flow cytometry sorting techniques have previously used a mitochondrial dy...Wed, 27 Mar 2013 09:27:38 GMTemoryott@inteummail.comhttps://emoryott.technologypublisher.com/techcase/1214713072https://emoryott.technologypublisher.com/techcase/13072Mon, 04 Mar 2013 09:16:36 GMTemoryott@inteummail.comhttps://emoryott.technologypublisher.com/techcase/1307212140https://emoryott.technologypublisher.com/techcase/12140Fri, 15 Feb 2013 10:51:56 GMTemoryott@inteummail.comhttps://emoryott.technologypublisher.com/techcase/1214010012https://emoryott.technologypublisher.com/techcase/10012Thu, 14 Feb 2013 11:44:22 GMTemoryott@inteummail.comhttps://emoryott.technologypublisher.com/techcase/1001208050https://emoryott.technologypublisher.com/techcase/08050Application Quality of life instrument administered to the patient that enables healthcare providers to assess the quality of life of patients with irregular heart rhythm atrial fibrillation. Key Benefits Allows healthcare provider to evaluate the effects of atrial fibrillation and treatments on a patient more reliably. Examines physical, emotional, psychological, and social functioning of patient and is sensitive to changes in patient quality of life. Can be used during treatment, clinical trials, and other professional organizations involved in the care of patients with atrial fibri...Thu, 07 Feb 2013 11:17:06 GMTemoryott@inteummail.comhttps://emoryott.technologypublisher.com/techcase/0805013073https://emoryott.technologypublisher.com/techcase/13073Thu, 07 Feb 2013 11:15:10 GMTemoryott@inteummail.comhttps://emoryott.technologypublisher.com/techcase/1307312134https://emoryott.technologypublisher.com/techcase/12134Mon, 28 Jan 2013 11:05:52 GMTemoryott@inteummail.comhttps://emoryott.technologypublisher.com/techcase/1213412108https://emoryott.technologypublisher.com/techcase/12108Application Web software and mobile app for interpreting and qualifying newborn pulse oximetry data. Key Benefits Reduces interpretation of pulse oximetry data. Provides decision support type feedback. Based upon algorithm endorsed by the American Academy of Pediatrics and the American Heart Association. Market Summary The use of pulse oximetry as a tool for monitoring the health of patients has continued to grow. With regards to mobile applications, medical application lags other segments such as gaming, entertainment, social networking, and navigation, however in general medical ap...Tue, 08 Jan 2013 11:10:20 GMTemoryott@inteummail.comhttps://emoryott.technologypublisher.com/techcase/1210812066https://emoryott.technologypublisher.com/techcase/12066Application A recombinant fusion cytokine that activates host immune responses for the treatment of cancer or infectious diseases and the development of adjuvant vaccines. Key Benefits Retains the immune stimulatory properties of both its parental molecules. Displays novel functions such as direct activation of B cells leading to anti-cancer and vaccine adjuvant activity. Technical Summary Cytokines are small cell-signaling proteins with immuno-modulatory properties. GM-CSF and IL-4 are two important cytokines with immuno-stimulatory activities, GM-CSF affects adaptive immunity by pro...Tue, 08 Jan 2013 11:10:14 GMTemoryott@inteummail.comhttps://emoryott.technologypublisher.com/techcase/1206612135https://emoryott.technologypublisher.com/techcase/12135Tue, 27 Nov 2012 08:08:12 GMTemoryott@inteummail.comhttps://emoryott.technologypublisher.com/techcase/1213510161https://emoryott.technologypublisher.com/techcase/10161Application Fast and efficient method for quality assurance of deformable registration of images from PET or CT scans, particularly for adaptive radiotherapy. Key Benefits Quantitative metrics of registration quality designed for routine use that are algorithm-independent, labor-efficient, and accurate. Increased usability and accuracy in detecting unrealistic warping over classical registration assessment methods. Market Summary Image guided radiation therapy (IGRT) is a relatively new approach in imaging before and after treatment visualizes anatomical changes. This image-guided th...Tue, 16 Oct 2012 07:44:13 GMTemoryott@inteummail.comhttps://emoryott.technologypublisher.com/techcase/1016109116https://emoryott.technologypublisher.com/techcase/09116Application Normalization procedure that allows for the direct comparison of high-throughput liquid chromatography/mass spectrometry (LC/MS) metabolomic data gathered from different individuals at different times. Key Benefits Samples used can be collected at different times and/or analyzed by different mass spectrometers. Cumulative datasets can be compiled and datasets can be compared to each other. Useful for clinical diagnostics and research. Market Summary Metabolomic analyses are used in clinical diagnostics for a number of disorders including metabolic, hematologic, and endocr...Tue, 18 Sep 2012 13:17:34 GMTemoryott@inteummail.comhttps://emoryott.technologypublisher.com/techcase/0911612057https://emoryott.technologypublisher.com/techcase/12057Wed, 22 Aug 2012 12:12:26 GMTemoryott@inteummail.comhttps://emoryott.technologypublisher.com/techcase/1205711212https://emoryott.technologypublisher.com/techcase/11212Application Catalytic DNA molecules (DNAzymes) conjugated to gold nanoparticles for use as therapeutics to treat cancers, infections or other applications of gene therapy. Key Benefits DNAzyme-gold nanoparticles regulate gene expression through an RNAi independent mechanism. Each DNAzyme-gold nanoparticle is more catalytically active than a free DNAzyme molecule. Gold nanoparticle conjugation protects DNAzymes against nuclease degradation and extends their half-life and activity. DNAzyme gold nanoparticles are non-toxic and readily enter cells without transfection agent. DNAzyme-gold ...Wed, 22 Aug 2012 12:12:25 GMTemoryott@inteummail.comhttps://emoryott.technologypublisher.com/techcase/1121206134https://emoryott.technologypublisher.com/techcase/06134Application Nonpeptidic molecules that block the chemokine receptor, CXCR4, for treatment of proliferative disorders including inhibition of cancer metastasis. Key Benefits Modulate CXCR4 receptor activity by interfering with SDF-1 ligand binding. Inhibit migration of metastatic cancer cells by blocking chemokine receptor signaling. Show increased bioavailability and efficacy over known CXCR4 antagonists. Market Summary Most cancer deaths are attributed to metastasis, the migration of cancerous cells from primary tumor origin. Although several strategies have been developed to preven...Fri, 17 Aug 2012 06:07:39 GMTemoryott@inteummail.comhttps://emoryott.technologypublisher.com/techcase/0613411227https://emoryott.technologypublisher.com/techcase/11227Application Software that automatically integrates both PET/CT and 3D ultrasound imaging for a molecular image-targeted prostate biopsy in real time. Key Benefits Incorporates both PET/CT imaging and 3D ultrasound imaging for improved accuracy of biopsy sampling and staging of prostate cancer. Useful for image-targeted biopsy, brachytherapy, radiofrequency thermal ablation, cryotherapy, and interstitial photodynamic therapy. The fusion software of PET/CT and ultrasound is also useful for prostate, ovarian, liver, and breast cancer detection. Market Summary Millions of prostate biopsi...Tue, 07 Aug 2012 13:56:56 GMTemoryott@inteummail.comhttps://emoryott.technologypublisher.com/techcase/1122711229https://emoryott.technologypublisher.com/techcase/11229Application An invertebrate animal model of nemaline myopathy using Caenorhabditis elegans. Key Benefits C. elegans with pathological mutations of tropomyosin that cause nemaline myopathy. Technical Summary Nemaline myopathy, or rod myopathy, is a congenital and hereditary neuromuscular disorder that causes muscle weakness of varying severity. It can even be life-threatening in severe cases, but no effective therapy for nemaline myopathy has been developed. Tropomyosin, an actin-binding protein that stabilizes actin filament dynamics, has been identified as a nemaline myopathy gene that ...Tue, 31 Jul 2012 12:13:02 GMTemoryott@inteummail.comhttps://emoryott.technologypublisher.com/techcase/1122911191https://emoryott.technologypublisher.com/techcase/11191Application Cancer cell lines (specifically non-small cell lung cancer) with depleted levels of LKB1 protein. Key Benefits Multiple cancer cell lines are available. Produced with lentiviral LKB1 short hairpin RNA constructs. Technical Summary LKB1 is a serine/threonine kinase gene located on chromosome 19p13.3 and inactivation of LKB1 is present in approximately 30% of non-small cell lung cancer primary tumors and cell lines. LKB1 suppresses tumors, opposite to Akt, by negatively regulating the mammalian target of rapamycin through the activation of AMP-activated protein kinase and th...Tue, 31 Jul 2012 12:13:00 GMTemoryott@inteummail.comhttps://emoryott.technologypublisher.com/techcase/1119112118https://emoryott.technologypublisher.com/techcase/12118Mon, 30 Jul 2012 08:43:20 GMTemoryott@inteummail.comhttps://emoryott.technologypublisher.com/techcase/1211811234https://emoryott.technologypublisher.com/techcase/11234Application Microfluidic slide with individual cell holders for use in microinjection procedures. Key Benefits Open system - compatible with other microinjection technologies and existing research instrumentation. Compatible with both adherent and non-adherent cells. Enables high-throughput and high-precision delivery of substances into cells, specifically the nucleus if needed. Potentially low-cost and disposable. Market Summary The efficient capture and retention of individual cells for precise delivery of therapeutic agents remains a great challenge in microinjection procedure...Thu, 12 Jul 2012 12:53:45 GMTemoryott@inteummail.comhttps://emoryott.technologypublisher.com/techcase/1123412073https://emoryott.technologypublisher.com/techcase/12073Fri, 06 Jul 2012 12:12:14 GMTemoryott@inteummail.comhttps://emoryott.technologypublisher.com/techcase/1207311010https://emoryott.technologypublisher.com/techcase/11010Application Device that enhances the tissue mechanical strength of the heart apex allowing access to the cardiac chambers. Key Benefits Reduces procedural time and risks such as apical rupture and bleeding for transapical heart surgery. Improves tissue mechanical stability by enhancing tissue strength, particularly apex tissue which may be weakened in some patients. Facilitates easier and safer access to the interior structures of the heart during surgical procedures involving repair and replacement. Less risk of bleed complications compared to conventional suturing of the access site....Fri, 08 Jun 2012 06:17:33 GMTemoryott@inteummail.comhttps://emoryott.technologypublisher.com/techcase/1101011051https://emoryott.technologypublisher.com/techcase/11051Application MitraSurg is a simple device for surgical correction of mitral valve lesions, which can be implanted using minimally invasive and robotic surgical techniques. Key Benefits Simple, collapsible design to enable delivery to the mitral valve via small incisions or ports. Does not require suturing to the valve, which reduces the time and risk associated with the procedure and improves patient quality of life. Enables free flow of blood through the valve, without the danger of valvular thrombosis or stenosis. Market Summary Mitral annuloplasty is the current standard of care to...Fri, 08 Jun 2012 06:17:19 GMTemoryott@inteummail.comhttps://emoryott.technologypublisher.com/techcase/1105110131https://emoryott.technologypublisher.com/techcase/10131Application Automatic 3D segmentation method based on image registration and filters to determine edges and textures of prostate images for use in the diagnosis and assessment of prostate cancer. Key Benefits Provides an automatic segmentation method that does not require initialization, unlike currently available methods. Uses an image database and filters to train a statistical classification machine to segment novel images of prostate tissue. Market Summary Millions of prostate biopsies are performed on men each year. To date, 2D transrectal ultrasound (TRUS) image segmentation has...Tue, 29 May 2012 11:52:07 GMTemoryott@inteummail.comhttps://emoryott.technologypublisher.com/techcase/1013105077https://emoryott.technologypublisher.com/techcase/05077Application Western Blot Specificity Human, Mouse, Rat Subtype Rabbit Polyclonal Immunogen KLH-Linked Peptide Technical Summary mMob3 also called Phocein (and was called mMob1 - see publication below) is a mammalian class II homolog of yeast MOB1 that appears to be a substrate for PP2A. In S. cerevisiae, MOB1 is an essential gene that is required for exit from mitosis, maintenance of cell ploidy, and possibly mitotic spindle pole body duplication. In mammalian cells, mMob3 forms complexes with members of the striatin family and PP2A and may be involved in vesicular trafficking and cel...Thu, 17 May 2012 08:00:10 GMTemoryott@inteummail.comhttps://emoryott.technologypublisher.com/techcase/0507710102https://emoryott.technologypublisher.com/techcase/10102Tue, 10 Apr 2012 14:17:51 GMTemoryott@inteummail.comhttps://emoryott.technologypublisher.com/techcase/1010212022https://emoryott.technologypublisher.com/techcase/12022Application Generation of pluripotent stem cells from adult somatic cells for medical use. Key Benefits No exogenous genetic manipulations, which minimize oncogenic effects, were observed in current methods. Peripheral blood can be used as a source of parent cell instead of fibroblasts or keratinocytes. Market Summary The economic and psychological tolls of chronic, degenerative, and acute diseases in the United States are enormous.Stem cell medicine has been identified as an emerging potential for the treatment of such conditions, however, obtaining embryonic tissues and isolating re...Thu, 29 Mar 2012 10:14:53 GMTemoryott@inteummail.comhttps://emoryott.technologypublisher.com/techcase/1202211071https://emoryott.technologypublisher.com/techcase/11071Application Bone forming therapeutic for use in spinal fusion devices and treatment of systemic bone diseases and disorders. Key Benefits Current devices for bone grafting procedures require high concentrations of bone morphogenetic protein (BMP) which results in a high cost and create a barrier for routine clinical use. Small molecule therapeutics that modulate Jab1 (part of the signaling pathway for BMP) have been identified and could be used locally or systemically to promote bone formation. Market Summary Millions of bone grafting procedures are performed worldwide each year. For ...Tue, 27 Mar 2012 07:49:29 GMTemoryott@inteummail.comhttps://emoryott.technologypublisher.com/techcase/1107111070https://emoryott.technologypublisher.com/techcase/11070Application Bone forming therapeutic for use in spinal fusion devices and treatment of systemic bone diseases and disorders. Key Benefits Current devices for bone grafting procedures require high concentrations of bone morphogenetic protein (BMP) which results in a high cost and create a barrier for routine clinical use. Small molecule therapeutics that inhibit noggin (an extracellular inhibitor of BMP) have been identified and could be used locally to promote bone formation. Market Summary Millions of bone grafting procedures are performed worldwide each year. For spinal fusions the ...Tue, 27 Mar 2012 07:49:28 GMTemoryott@inteummail.comhttps://emoryott.technologypublisher.com/techcase/1107010164https://emoryott.technologypublisher.com/techcase/10164Application Bone forming therapeutic for use in spinal fusion devices and treatment of systemic bone diseases and disorders. Key Benefits Current devices for bone grafting procedures require high concentrations of bone morphogenic protein (BMP) which results in a high cost and create a barrier for routine clinical use. Commercially available small molecule therapeutics that modulate Smurf1 (part of the signaling pathway for BMP) have been identified and these compounds induce bone formation. Lead compound is a major metabolite of a currently marketed, FDA-approved anti-microbial drug wi...Wed, 15 Feb 2012 11:57:31 GMTemoryott@inteummail.comhttps://emoryott.technologypublisher.com/techcase/1016412013https://emoryott.technologypublisher.com/techcase/12013Application Small molecule measles virus RNA Dependent RNA Polymerase (RDRP) inhibitors. Key Benefits Potent (nM) non-nucleoside small molecule inhibitors of the measles virus RDRP protein. No current drug therapy for measles. Market Summary The target market for this therapeutic agent is in the developing world where measles has been known to kill as many as one out of four people. In underdeveloped nations with high rates of malnutrition and poor healthcare, fatality rates have been as high as 28%. For immunocompromised patients (e.g., people with AIDS) with limited response to vacc...Fri, 27 Jan 2012 10:30:37 GMTemoryott@inteummail.comhttps://emoryott.technologypublisher.com/techcase/1201310096https://emoryott.technologypublisher.com/techcase/10096ApplicationSmall molecules that can be used in the treatment of neuropathic pain. Key BenefitsCyclopropylamines have shown reduced side effects compared to other SNRIs for the treatment of neuropathic pain. Cyclopropylamine derivatives are more potent than other SNRI medication. Technical SummaryNeuropathic pain is a chronic/persistent state resulting from nerve damage due to trauma, disease, or chemical injury. Recent studies and surveys have suggested that up to 30% of adults in the US report suffering from chronic pain, with one third of those identifying their pain as moderate to severe in...Thu, 06 Oct 2011 11:00:15 GMTemoryott@inteummail.comhttps://emoryott.technologypublisher.com/techcase/1009609156https://emoryott.technologypublisher.com/techcase/09156Applications Western Blot Immunofluorescence Immunoprecipitation Specificity Human Subtype Polyclonal Immunogen (DP63/DP64) corresponding to residues 450-477 and 1152-1173 of Human Flightless I homolog Technical Summary Protein flightless-1 homolog (Flightless 1) is a member of the gelsolin family of actin-remodeling proteins. It interacts with various other proteins such as ACTL6A, NCOA2, CARM1, LRRFIP1 and LRRFIP2.The cytoskeletal actin remodeling process in Flightless 1 involves severing filaments, capping filament ends, and nucleating actin assembly . It is a nuclear recept...Fri, 30 Sep 2011 12:40:43 GMTemoryott@inteummail.comhttps://emoryott.technologypublisher.com/techcase/0915611064https://emoryott.technologypublisher.com/techcase/11064Applications Bacterial artificial choromosome (BAC) plasmid containing the antigenomic sequence of RSV that can be used for directed mutations of the virus and thus vaccine generation. Key BenefitsViral DNA is contained in a BAC, Allowing for efficient mutagenesis and recombineering of viral DNA. BAC is stable, can be used for cloning in common bacteria types like E. Coli. Provides powerful tool for vaccine developers to use in engineering potential RSV vaccines. Technical SummaryHuman RSV is a leading cause of respiratory infections in the US leading to over 100,000 infant hospitalizations an...Wed, 14 Sep 2011 13:22:35 GMTemoryott@inteummail.comhttps://emoryott.technologypublisher.com/techcase/1106408061https://emoryott.technologypublisher.com/techcase/08061Application Adjuvant, capable of boosting the immunogenicity and effectiveness of DNA or MVA-based vaccines. Key Benefits Stimulates CD8+ (cytotoxic) T cells directly, which boosts the immune system response against infected cells. Bypasses the need for CD4+ (helper) T cells to help raise functional CD8+ T cells. Offers new therapeutic option for creating vaccines against otherwise untreatable diseases. Technical Summary The lack of success of DNA or MVA-based vaccines in human clinical trials has refocused researchers on vaccine approaches, capable of increasing both cellular and hu...Wed, 14 Sep 2011 11:45:40 GMTemoryott@inteummail.comhttps://emoryott.technologypublisher.com/techcase/0806109017https://emoryott.technologypublisher.com/techcase/09017Tue, 06 Sep 2011 11:55:04 GMTemoryott@inteummail.comhttps://emoryott.technologypublisher.com/techcase/09017RT005https://emoryott.technologypublisher.com/techcase/RT005Tue, 26 Jul 2011 13:29:34 GMTemoryott@inteummail.comhttps://emoryott.technologypublisher.com/techcase/RT00511119https://emoryott.technologypublisher.com/techcase/11119Applications Therapeutic use of Glial Cell Line-Derived Neurotrophic Factor (GDNF) to treat obesity. Potential drug target for further therapeutic development. Key Benefits Growth Factor expression in the brain causes a reduction in high fat diet-induced obesity. Fat level reduction has been shown in both mouse and human cells. Reducing obesity can lower risk of coronary heart disease and type-II diabetes. Technical Summary Obesity is a growing problem, both in the United States and internationally. The US has the highest rate of obesity in the world, with over 30% of adults co...Thu, 30 Jun 2011 11:05:22 GMTemoryott@inteummail.comhttps://emoryott.technologypublisher.com/techcase/1111911151https://emoryott.technologypublisher.com/techcase/11151Application Catalysis of highly enantioselective cyclopropanations, tandem cyclopropanation/Cope rearrangements and combined C-H functionalization/Cope rearrangement reactions. Key Benefits Exhibits good tolerance to large ester groups for electron-withdrawing in high asymmetric induction. Efficient reactions in dichlormethane allowing broader range of substrates than other enantioselective catalyst. Technical Summary Researchers have sought a chiral dirhodium catalyst for use in reactions involving diazo compounds; these reactions rely heavily on the ability of a catalyst to drive t...Thu, 30 Jun 2011 11:05:19 GMTemoryott@inteummail.comhttps://emoryott.technologypublisher.com/techcase/1115108042https://emoryott.technologypublisher.com/techcase/08042Application Therapeutic treatment of traumatic brain injury and other uses of progesterone where composition of matter intellectual property are required. Key Benefits 20 fold increase in solubility relative to the hormone progesterone. Synthetic analogues are as effective as progesterone in reducing cerebral edema following traumatic brain injury. Technical Summary Traumatic brain injury (TBI) occurs in 1.4 million members of the U.S. population per year, resulting in more than 50,000 deaths annually and significant long-term neuronal damage in many of those affected. To date, prog...Wed, 08 Jun 2011 07:22:26 GMTemoryott@inteummail.comhttps://emoryott.technologypublisher.com/techcase/0804206012https://emoryott.technologypublisher.com/techcase/06012Thu, 19 May 2011 15:49:38 GMTemoryott@inteummail.comhttps://emoryott.technologypublisher.com/techcase/0601210146https://emoryott.technologypublisher.com/techcase/10146Application Small RNA molecules for the treatment of stomach and lung cancer. Key Benefits Reduces growth survival or proliferation of neoplastic cells. Enhances the efficacy of anti-cancer drugs. Technical Summary Uncontrolled cell growth and proliferation is a distinctive feature of cancer. As critical molecules in cell-cycle regulation, small, endogenous inhibitory molecules known as microRNAs (miRNAs) play an important role in regulating cell development and programmed cell death. MiRNAs are short, functional RNA molecules that regulate expression by binding to target nucleotide ...Thu, 21 Apr 2011 11:43:43 GMTemoryott@inteummail.comhttps://emoryott.technologypublisher.com/techcase/1014610150https://emoryott.technologypublisher.com/techcase/10150Tue, 22 Mar 2011 08:47:04 GMTemoryott@inteummail.comhttps://emoryott.technologypublisher.com/techcase/1015011045https://emoryott.technologypublisher.com/techcase/11045Application Potent small molecule inhibitors of RNA viruses that cause many highly contagious and dangerous diseases such as canine distemper, RSV, influenza, and measles. Key Benefits Inhibits measles, canine distemper, human parainfluenza, and influenza A viruses. May be used for the management of a disease and for rapid control of possible outbreaks. Molecules are directed against host factors that are involved in viral reproduction thus reducing the possibility of viral resistance. Provides a therapeutic and an improved alternative to current vaccinations. Technical Summary This...Mon, 21 Mar 2011 11:35:20 GMTemoryott@inteummail.comhttps://emoryott.technologypublisher.com/techcase/1104510069https://emoryott.technologypublisher.com/techcase/10069ApplicationTreatment for neuroblastoma and other tumors in the central nervous system.Key BenefitsInduces cell death in tumor cells while having no negative effects on surrounding neurons. Slows the rate of neuroblastoma tumor growth. Technical SummaryEmory researchers have shown that progesterone caused significant cell death in tumor cells while remaining absolutely safe in primary cortical neurons. After a single treatment of progesterone a significant decrease in cell survival on human neuroblastoma was observed in vitro. Cell death of human neuroblastoma and glioblastoma cells increased a...Wed, 24 Nov 2010 10:06:52 GMTemoryott@inteummail.comhttps://emoryott.technologypublisher.com/techcase/1006910050https://emoryott.technologypublisher.com/techcase/10050Mon, 11 Oct 2010 05:48:35 GMTemoryott@inteummail.comhttps://emoryott.technologypublisher.com/techcase/1005010076https://emoryott.technologypublisher.com/techcase/10076Application Clinical assay to predict therapeutic outcomes based on kinase or phostphatase activity. Key Benefits Eliminates inconsistencies stemming from variable baseline activity. Selective measurement of specific enzymatic activity within a heterogeneous sample. Technical Summary Researchers at Emory University have developed assays to selectively measure the activity of a specific phosphate modifying enzyme within a heterogeneous samples. Unlike existing detection methods, which rely upon the incorporation or removal of radiolabelled phosphate, this novel assay measures the bindi...Thu, 22 Apr 2010 08:19:02 GMTemoryott@inteummail.comhttps://emoryott.technologypublisher.com/techcase/10076RT004https://emoryott.technologypublisher.com/techcase/RT004Thu, 15 Apr 2010 13:37:51 GMTemoryott@inteummail.comhttps://emoryott.technologypublisher.com/techcase/RT004RT003https://emoryott.technologypublisher.com/techcase/RT003Thu, 15 Apr 2010 13:37:50 GMTemoryott@inteummail.comhttps://emoryott.technologypublisher.com/techcase/RT003RT001https://emoryott.technologypublisher.com/techcase/RT001Thu, 15 Apr 2010 13:37:50 GMTemoryott@inteummail.comhttps://emoryott.technologypublisher.com/techcase/RT00102020https://emoryott.technologypublisher.com/techcase/02020ApplicationGenetically modified cell line which inhibits O-linked glycosylation and produces glycoproteins containing N-linked modifications.Key BenefitsModel system represents epimerase deficiency galactosemia, a variant form of galactosemia.Provides a means to study differing functional mechanisms of N- and O-linked glycosylation.Market SummaryGalactosemia, a rare genetic metabolic disorder, is characterized as deficiency of enzymes involved in the metabolization of dietary galactose. For instance, UDP-galactose 4-epimerase (GALE) is one of the key enzymes needed for glycosylation, the proce...Thu, 15 Apr 2010 13:24:19 GMTemoryott@inteummail.comhttps://emoryott.technologypublisher.com/techcase/0202096064https://emoryott.technologypublisher.com/techcase/96064Applications Cloning and studying of the norepinephrine transporter. Technical Summary This invention is the first cDNA clone encoding a norepinephrine transporter. The cDNA allows high-level expression of the transporter in non-neuronal eukaryotic and prokaryotic systems suitable for isolation of the protein. This invention has applications in the research and drug development regarding behavioral disorders and makes it possible to perform high-level structure analysis of norepinephrine uptake. This will allow for a precise study of the manner by which anti-depressants, cocain...Thu, 15 Apr 2010 13:24:17 GMTemoryott@inteummail.comhttps://emoryott.technologypublisher.com/techcase/9606410091https://emoryott.technologypublisher.com/techcase/10091Application Biodegradable polymer for use in medical implants. Key Benefits Ability to tailor mechanical properties to desired medical application. Easily adjustable biodegradation profile. Technical Summary Studies into the properties of methyl methacrylate (MMA) networks have led Emory University scientists to develop biodegradable polymers that can be tailored to a wide array of precise medical uses. Unlike the formulation of existing biomedical polymers, the ability to alter the ratio of acrylate compounds within the polymer permits wide variation in elastic modulus, tensile stren...Wed, 24 Mar 2010 08:56:14 GMTemoryott@inteummail.comhttps://emoryott.technologypublisher.com/techcase/1009110082https://emoryott.technologypublisher.com/techcase/10082Application Antibiotic protein with the ability to target pathogens expressing the blood group B antigen. Key Benefits Naturally occurring factors produced by humans. Induces rapid cell death in bacteria expressing the blood group B antigen. Does not harm commensal bacteria. Technical Summary Emory University scientists have successfully demonstrated in vivo that two Galectin family members, Galectin-4 and -8, possess antibiotic properties that effectively treat pathogenic E. coli infections. Galectin interaction with cell surface antigens resembling blood group B provides a means ...Tue, 23 Mar 2010 12:38:04 GMTemoryott@inteummail.comhttps://emoryott.technologypublisher.com/techcase/1008209049https://emoryott.technologypublisher.com/techcase/09049Tue, 23 Mar 2010 12:37:53 GMTemoryott@inteummail.comhttps://emoryott.technologypublisher.com/techcase/0904908147https://emoryott.technologypublisher.com/techcase/08147Application Browser mouse monitoring algorithms for improved targeting of web advertisement to client needs. Key Benefits Novel integration of client side instrumentation and server side information. Detects misleading information that otherwise misclassifies client intent. Technical Summary Software has been developed that combines a novel algorithm with the integration of user side instrumentation and server side information that is capable of picking up on the subtleties of internet user activities translating into more accurate measurement and categorization o...Mon, 11 May 2009 12:50:14 GMTemoryott@inteummail.comhttps://emoryott.technologypublisher.com/techcase/0814706105https://emoryott.technologypublisher.com/techcase/06105Application Fetal and postnatal enteric neuronal cell lines for use in studying the enteric nervous system. Technical Summary We have developed fetal (IM-FEN) and postnatal (IM-PEN) enteric neuronal cell lines with features similar to primary enteric neurons. The IM-FEN and IM-PEN have been passaged 40 times since their isolation and have shown no major changes in their cell growth characteristics, morphology, neuronal properties, or GDNF sensitivity. This homogeneity suggests that the lines will tend to remain phenotypically and biologically stable in vitro for many generations. We have s...Mon, 11 May 2009 12:50:06 GMTemoryott@inteummail.comhttps://emoryott.technologypublisher.com/techcase/0610505083https://emoryott.technologypublisher.com/techcase/05083Application Antidepressant drug screening for depression studies. Technical Summary We have developed different lines of rats by behavioral testing and then selective breeding of those showing desired characteristics in attempting to rat models for study of affective disorders. The lines were directed at possibly improving both drug screens (i.e., improved sensitivity and selectivity of detection of antidepressant drugs) and "homologous" models of depression (i.e., rats that show characteristics seen in human depression). While simply measuring baseline home-cage ambulatory activity of a ...Mon, 11 May 2009 12:50:03 GMTemoryott@inteummail.comhttps://emoryott.technologypublisher.com/techcase/0508308152https://emoryott.technologypublisher.com/techcase/08152Wed, 29 Apr 2009 12:18:58 GMTemoryott@inteummail.comhttps://emoryott.technologypublisher.com/techcase/0815207083https://emoryott.technologypublisher.com/techcase/07083Application Expression vectors and recombinant proteins for use in 14-3-3 based bioassays and a variety of research applications. Technical Summary 14-3-3 proteins are a family of phosphoserine/threonine recognition proteins that play important roles in diverse cellular processes, including cell proliferation, cell cycle progression, and apoptosis control. There are seven isoforms of the 14-3-3 genes from different chromosomes. 14-3-3 proteins function in cells primarily through their binding to diverse family of client proteins. These interactions are mediated by the recognition of phospho...Wed, 29 Apr 2009 12:18:56 GMTemoryott@inteummail.comhttps://emoryott.technologypublisher.com/techcase/0708308097https://emoryott.technologypublisher.com/techcase/08097Application Diagnostic imaging of the kidneys for the determination of renal function. Key Benefits Renal tracer for measuring the effective renal plasma flow. 99mTc-labeled small molecule has renal clearance characteristics that are superior to currently available tracers. First-in-man studies have been performed with resulting image quality and renogram parameters comparable to 131I-OIH, the gold standard radiolabeled renal tracer. Technical Summary In the U.S., approximately eight million adults have kidney disease. In order to diagnose and treat renal diseases and disorders, it...Wed, 29 Apr 2009 07:29:02 GMTemoryott@inteummail.comhttps://emoryott.technologypublisher.com/techcase/0809706067https://emoryott.technologypublisher.com/techcase/06067Application Diagnostic test for predicting the onset of atrial fibrillation (AF). Key Benefits Potential diagnostic test to predict susceptibility to arrhythmia. Extensive (100kb) of SCN5A promoter sequence has been identified. Technical Summary The invention provides oxidative stress blood markers for use in predicting the onset of atrial fibrillation (AF). The markers may also have utility in predicting complications of AF. Identification of the markers in this invention resulted from a study of human patients with persistent or permanent AF that revealed increases in certain oxidat...Wed, 29 Apr 2009 07:29:01 GMTemoryott@inteummail.comhttps://emoryott.technologypublisher.com/techcase/0606706097https://emoryott.technologypublisher.com/techcase/06097Application Western blot Immunoprecipitation Immunocytochemistry Specificity Human junctional adhesion molecule (JAM-A). No detectable cross reactivity to other proteins by Western blot. Subtype Mouse IgG1 Technical Summary Junctional adhesion molecule A (JAM-A) is a transmembrane structural component of intercellular junctions implicated in the regulation of platelet aggregation, cellular adhesion, leukocyte transmigration/inflammation, and in the regulation of paracellular permeability at the level of epithelial and endothelial tight junctions. These monoclonal antibodies (J3F.1,...Thu, 26 Mar 2009 15:49:48 GMTemoryott@inteummail.comhttps://emoryott.technologypublisher.com/techcase/0609706083https://emoryott.technologypublisher.com/techcase/06083Thu, 26 Mar 2009 15:49:48 GMTemoryott@inteummail.comhttps://emoryott.technologypublisher.com/techcase/0608306082https://emoryott.technologypublisher.com/techcase/06082Thu, 26 Mar 2009 15:49:47 GMTemoryott@inteummail.comhttps://emoryott.technologypublisher.com/techcase/0608205067https://emoryott.technologypublisher.com/techcase/05067Thu, 26 Mar 2009 15:49:47 GMTemoryott@inteummail.comhttps://emoryott.technologypublisher.com/techcase/0506704038https://emoryott.technologypublisher.com/techcase/04038Thu, 26 Mar 2009 15:49:46 GMTemoryott@inteummail.comhttps://emoryott.technologypublisher.com/techcase/0403804017https://emoryott.technologypublisher.com/techcase/04017Thu, 26 Mar 2009 15:49:45 GMTemoryott@inteummail.comhttps://emoryott.technologypublisher.com/techcase/0401794023https://emoryott.technologypublisher.com/techcase/94023Applications Immunohistochemistry Western blotting Specificity m2 muscarinic acetylcholine receptor Subtype Rat Monoclonal Technical Summary The m2 muscarinic acetylcholine receptor is a membrane bound G-protein coupled receptor highly expressed throughout the basal forebrain, as well as in cardiac tissue. These monoclonal antibodies were generated in rats and are specific to the m2 muscarinic acetylcholine receptor, showing no cross reactivity with other receptor subtypes. These antibodies are appropriate for immunofluorescence and immunoblotting applications; however do not work w...Thu, 26 Mar 2009 15:49:38 GMTemoryott@inteummail.comhttps://emoryott.technologypublisher.com/techcase/9402309006https://emoryott.technologypublisher.com/techcase/09006Application Compositions and methods for treating cancer and inflammatory disease using noscapine and noscapine analogues conjugated to targeting molecules. Key Benefits Noscapine is a plant-derived alkaloid with a long-history of human use as an anti-cough agent. Noscapine is currently in phase I clinical trials for the treatment of cancer. Noscapine conjugate (Targetin) retains the parent compound microtubule binding and resulting microtubule dynamics attenuating activities. Since activated macrophages also over express receptors for Targetin, it can be...Tue, 24 Feb 2009 14:05:36 GMTemoryott@inteummail.comhttps://emoryott.technologypublisher.com/techcase/0900608058https://emoryott.technologypublisher.com/techcase/08058Application Simultaneous assessment of lipid and iron content of the liver. Highlights A non-invasive, MRS-based method for rapidly (within 15 seconds) and accurately measuring both liver lipid and iron levels simultaneously. A technique that eliminates the need for invasive, risky and painful liver biopsies to assess hepatic lipid and iron levels. Technical Summary Abnormal elevation of liver lipid (fat) levels is becoming the most important liver disorder in the U.S. and in other industrialized and developing countries. Currently, the standard diagnostic tool for measuring liver lip...Tue, 24 Feb 2009 14:05:07 GMTemoryott@inteummail.comhttps://emoryott.technologypublisher.com/techcase/0805808025https://emoryott.technologypublisher.com/techcase/08025Application Nanoparticle for in vivo tumor targeting and detection. Key Benefits Large optical enhancements were achieved under in vivo conditions in live animals. Conjugated nanoparticles were able to target tumor biomarkers on human cancer cells and in xenograft tumor models. Functionalized nanoparticles can be used as a diagnostic or therapeutic tool. Technical Summary Dr. Shuming Nie and his team have developed biocompatible and nontoxic nanoparticles for in vivo tumor targeting and detection based on pegylated gold particles and surface-enhanced Raman scattering (SERS). These SE...Tue, 24 Feb 2009 14:04:59 GMTemoryott@inteummail.comhttps://emoryott.technologypublisher.com/techcase/0802507127https://emoryott.technologypublisher.com/techcase/07127Application A visual analog scale (VAS) used in clinical trials to determine self-perceived change in dyspnea (breathlessness). Highlights Defines a scale for measuring self-perceived change in dyspnea that has been used with heart failure patients. Improved accuracy over standards set for VAS used in measurement of dyspnea in asthma patients. Technical Summary Dyspnea is a common symptom that is presented by heart failure patients admitted into the emergency departments. During an evaluation of heart failure patients, physicians often gauge the severity of the illness and response to...Tue, 24 Feb 2009 14:04:48 GMTemoryott@inteummail.comhttps://emoryott.technologypublisher.com/techcase/0712706107https://emoryott.technologypublisher.com/techcase/06107Tue, 24 Feb 2009 14:04:13 GMTemoryott@inteummail.comhttps://emoryott.technologypublisher.com/techcase/0610706085https://emoryott.technologypublisher.com/techcase/06085Tue, 24 Feb 2009 14:04:08 GMTemoryott@inteummail.comhttps://emoryott.technologypublisher.com/techcase/0608506071https://emoryott.technologypublisher.com/techcase/06071Application Synthesis of noscapine analogs and their use as cancer treatments, including drug resistant cancers. Key BenefitsEfficient, high yielding synthesis of noscapine derivatives. Selective for cancer cells over normal human cells.Technical Summary The effectiveness of microtubule-targeting drugs as treatments for cancer has been validated through the extensive clinical use of vinca alkaloids and taxanes. Though useful, the success of the currently used microtubule drugs is limited due to their insolubility in water, emergence of drug resistance, and associated toxicities. Noscapine, whi...Tue, 24 Feb 2009 14:04:05 GMTemoryott@inteummail.comhttps://emoryott.technologypublisher.com/techcase/0607106054https://emoryott.technologypublisher.com/techcase/06054Tue, 24 Feb 2009 14:04:01 GMTemoryott@inteummail.comhttps://emoryott.technologypublisher.com/techcase/0605405031https://emoryott.technologypublisher.com/techcase/05031ApplicationA lipase-based platform technology that can be used in the production of fine chemicals, detergents, and pharmaceuticals.Key BenefitsEnhanced thermostability, activity, and enantioselectivity of enantiopure compounds including bulky substrates. Can be used at a concentration 100x less than that of other enzymes. Technical SummaryLipases are a group of specialized enzymes that are also important biocatalysts for the chiral synthesis of the active ingredients of pharmaceuticals and specialty chemicals. Among the most commonly used biocatalysts is lipase B from Candida Antarctica (CALB...Tue, 24 Feb 2009 14:03:32 GMTemoryott@inteummail.comhttps://emoryott.technologypublisher.com/techcase/0503102041https://emoryott.technologypublisher.com/techcase/02041Application This invention provides methods that can be used to directly translate DNA strands, or genes, into different synthetic polymers. Technical Summary In typical biological systems, polymerization reactions are driven along a template using a catalyst to specifically read sequence-specific and chain-length-specific information. Typically, the set of structural components involved in these in vivo reactions is limited to the four base pairs that comprise DNA. Additionally, the resulting polymers are limited to structures having phosphate-based backbones. Despite these limitations,...Tue, 24 Feb 2009 14:02:49 GMTemoryott@inteummail.comhttps://emoryott.technologypublisher.com/techcase/0204101094https://emoryott.technologypublisher.com/techcase/01094Application This antibody detects PME-1 in cell lysates and immunoprecipitates native protein. Technical Summary Dr. Pallas has made a polyclonal antibody to yeast PME-1, a protein methylesterase for which PP2A (protein phosphatase 2A) is a substrate. This antibody is raised against a PME-1 peptide. At this point there are no similar antibodies available commercially. This antibody can be used for immunoblotting and immunoprecipitation. It has not been tested on immunofluorescence or histochemistry. Tue, 24 Feb 2009 14:02:43 GMTemoryott@inteummail.comhttps://emoryott.technologypublisher.com/techcase/0109401090https://emoryott.technologypublisher.com/techcase/01090Applications Immunoprecipitation Immunofluorescence Immunoblotting Specificity A polyclonal antibody to striatin Subtype Anti-rabbit Technical Summary The inventor has made polyclonal antibodies to a striatin peptide. Striatin is a calmodulin (CaM)-binding proteins that forms a stable complex with PP2A A and PP2A C heterodimers. While this antibody is polyclonal, it was made to a specific peptide and is highly specific and can be used for multiple applications. This antibody can be used for Western blotting and immunofluorescence. The antibody also immunoprecipitates native...Tue, 24 Feb 2009 14:02:42 GMTemoryott@inteummail.comhttps://emoryott.technologypublisher.com/techcase/0109001089https://emoryott.technologypublisher.com/techcase/01089Applications Immunoblotting Immunofluorescence Histochemistry Specificity Monoclonal and polyclonal antibodies that recognize the PP2A A subunit Subtype Anti-mouse Technical Summary The inventor has made monoclonal (4G7) and polyclonal (R39) antibodies to the PP2A A subunit peptide (DP32). Most A subunit antibodies available are polyclonal antibodies. This hybridoma provides a continuous source of monoclonal antibody that will help provide consistency of results better than with polyclonal antibodies. May be useful for detecting A alpha or A beta mutants or expression changes that ...Tue, 24 Feb 2009 14:02:42 GMTemoryott@inteummail.comhttps://emoryott.technologypublisher.com/techcase/0108901087https://emoryott.technologypublisher.com/techcase/01087Applications Immunoprecipitation Immunofluorescence Immunoblotting Specificity Monoclonal and polyclonal antibodies to SG2NA Subtype Anti-rabbit Technical Summary SG2NA is a calmodulin-binding proteins that form stable complexes with PP2A A and PP2C heterodimers. The inventor has made monoclonal and polyclonal antibodies to an SG2NA peptide. The hybridoma provides a continuous source of monoclonal antibody that will provide consistency of results and can be used in multiple applications. The polyclonal antibody is also of very high quality. They both work in Western blottin...Tue, 24 Feb 2009 14:02:41 GMTemoryott@inteummail.comhttps://emoryott.technologypublisher.com/techcase/0108700051https://emoryott.technologypublisher.com/techcase/00051Applications Can be used as a target for drug discovery, gene therapy and, to create a diagnostic tool. These applications are relevant to conditions involving inappropriate cell proliferation (e.g., cancer, atherosclerosis), angiogenesis, and tissue damage associated with inflammatory diseases. Technical Summary Reactive oxygen species (ROS) include superoxide and hydrogen peroxide. ROS are increasingly being recognized as playing a central role in diverse physiologic and pathologic processes. When produced in high amounts, for example by specific immune cells, ROS are chemically reactive,...Tue, 24 Feb 2009 14:02:25 GMTemoryott@inteummail.comhttps://emoryott.technologypublisher.com/techcase/0005100033https://emoryott.technologypublisher.com/techcase/00033Application Small molecule therapeutics for the treatment of inflammation and autoimmune disorders. Key Benefits Decreased toxicity compared to the natural product triptolide. Improved aqueous solubility compared to triptolide. Market Summary Inflammation is known to be a component in a wide range of disease states including arthritis, asthma, and many types of cancer. Current treatment for arthritis and related joint disease include non-steroidal anti-inflammatory drugs (NSAIDs), corticosteroids, disease-modifying anti-rheumatic drugs (DMARDs), and biologics. However, most of these d...Tue, 24 Feb 2009 14:02:23 GMTemoryott@inteummail.comhttps://emoryott.technologypublisher.com/techcase/0003300005https://emoryott.technologypublisher.com/techcase/00005Applications Immunoblo Immunoblotting Immunoprecipitation Immunofluorescence Histochemistry Specificity Monoclonal antibodies specific for the PP2A catalytic subunit. Subtype Anti-Mouse Technical Summary The inventor has developed an anti-PP2A C-terminal peptide monoclonal antibodies, specific for the PP2A C subunit, 1d6, 4b7, and 4e1. These antibodies almost exclusively recognize the PP2A catalytic subunit in its unmethylated state. The antibodies are inhibited by methylation of PP2A and are therefore useful for assaying the PP2A methylation state in a quantitative manner. While...Tue, 24 Feb 2009 14:02:18 GMTemoryott@inteummail.comhttps://emoryott.technologypublisher.com/techcase/0000500004https://emoryott.technologypublisher.com/techcase/00004ApplicationsAn antibody to detect mammalian PME-1 that can be used for immunoblotting and immunoflorescence and possibly histochemistryTechnical SummaryDr. Pallas has developed a polyclonal antibody to PME-1, a protein methylesterase for which PP2A (protein phosphatase 2A) is a substrate. PP2A is a highly conserved serine/threonine phosphatase involved in the regulation of a wide variety of enzymes, signal transduction pathways, and other cellular events. In accordance with these diverse roles, PP2A has been found localized to the nucleus, cytoplasm, cytoskeleton, and membranes. This antibody ...Tue, 24 Feb 2009 14:02:17 GMTemoryott@inteummail.comhttps://emoryott.technologypublisher.com/techcase/0000497053https://emoryott.technologypublisher.com/techcase/97053Applications Can be used in assays to search for drugs that modulate protein phosphatase 2A (PP2A) methylesterase activity or to make recombinant protein to be used in assays. Such derivatives have potential application as anti-cancer and Alzheimer's treatment drugs. Technical Summary Protein phosphatase 2A (PP2A) is involved in the regulation of a wide variety of enzymes, signal transduction pathways, and cellular events. Therefore, it is not surprising that PP2A is highly regulated. This invention describes the cloning of a modulating enzyme for human PP2A, named Protein Phosphatase Methyles...Tue, 24 Feb 2009 14:02:13 GMTemoryott@inteummail.comhttps://emoryott.technologypublisher.com/techcase/9705395027https://emoryott.technologypublisher.com/techcase/95027Applications Screening method for drug discovery and investigating protein-protein interactions. Technical Summary Drug discovery is typically dependant on screening methods that involve negative selection, or the death of cell cultures when exposed to a specific drug. This invention, a cytoxicity-based genetic selection method (TOXSEL), introduces a new screening method for drug discovery and protein-protein interactions in which the selection method is dependant on cell survival. The technology utilizes a construct containing a segment of the diphtheria toxic (DT) gene causing cell d...Tue, 24 Feb 2009 14:02:09 GMTemoryott@inteummail.comhttps://emoryott.technologypublisher.com/techcase/9502795033https://emoryott.technologypublisher.com/techcase/95033Tue, 24 Feb 2009 14:01:36 GMTemoryott@inteummail.comhttps://emoryott.technologypublisher.com/techcase/9503392028https://emoryott.technologypublisher.com/techcase/92028Application Cloning and studying the serotonin transporter. Technical Summary This invention is the first cDNA clone encoding a serotonin transporter. The cDNA allows high-level expression of the transporter in non-neuronal eukaryotic and prokaryotic systems suitable for isolation of the protein. This invention has applications in the research and drug development regarding behavioral disorders and makes it possible to perform high-level structure analysis of serotonin uptake. This will allow for a precise study of the manner by which anti-depressants, cocaine, and amphetamin...Tue, 24 Feb 2009 14:01:35 GMTemoryott@inteummail.comhttps://emoryott.technologypublisher.com/techcase/9202899043https://emoryott.technologypublisher.com/techcase/99043Applications Diagnosis and treatment of Huntington's disease. Technical Summary Huntington's disease (HD) is a genetically inherited disease that leads to progressive neurodegeneration, resulting in motor disturbances, loss of memory and cognition, and psychiatric manifestations. The underlying molecular and biochemical basis of HD are not fully understood, and consequently there is no treatment effective in delaying or preventing the onset and progression of this devastating disorder. HD cell models are useful tools in elucidating the mechanistic basis of HD. However, most o...Tue, 24 Feb 2009 14:01:27 GMTemoryott@inteummail.comhttps://emoryott.technologypublisher.com/techcase/99043