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MVA and DNA Based SARS-CoV-2 Vaccines
Application
Modified Vaccinia virus Ankara (MVA)- and deoxyribonucleic acid (DNA)-based vaccine for Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2).
Key Benefits
Safety profile is known.
Demonstrated antiviral activity against related Coronaviruses.
Single dose of vaccination was shown to be effective against related Coronaviruses...
Published: 2/13/2025
Contributor(s): Rama Rao Amara, Sailaja Gangadhara
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Vaccines and Antibody Therapeutics for HPV-related Cancers
Application
Treatment and prevention of HPV-induced malignancies.
Key Benefits
Identification of a protein expressed in a large number of HPV-induced cancers.
Antibodies have been generated that bind to the protein and potentially elicit an immune response to the cancer cells.
The antibodies can be used to develop new treatments and vaccines...
Published: 3/28/2025
Contributor(s): Rafi Ahmed, Andreas Wieland
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A Predictive Marker and Treatment to Sensitize Multiple Myeloma Patients to Venetoclax (ABT-199)
Application
A marker that predicts Venetoclax (ABT-199) sensitivity that can also be targeted with a drug to help multiple myeloma patients.
Key Benefits
Marker that predicts if venetoclax will be an effective treatment in multiple myeloma patients.
A drug that targets venetoclax resistant multiple myeloma cells to improve treatment in patients.
Market...
Published: 2/28/2025
Contributor(s): Malathy (mala) Shanmugam, Richa Bajpai
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Photocaged Cytokines for Cancer Immunotherapy
Application
Light-responsive cytokine prodrugs with controlled activation for improved cancer immunotherapy.
Key Benefits
Spatiotemporal control of therapeutic cytokine activation leads to controlled local activation and reduces off-target toxicity.
Prolonged circulation means less frequent dosing is required.
Biased activity towards CD8+ T-cells...
Published: 3/28/2025
Contributor(s): Erik Dreaden, Lacey Perdue, Priscilla Do
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Live Attenuated Zika Virus Vaccines
Application
Yellow fever virus-based live attenuated Zika virus (ZIKV) vaccines.
Key Benefits
Reduces neurotropism from Zika virus.
High safety and immunogenicity of chimeric vaccines.
Market Summary
Zika virus (ZIKV) belongs to the flavivirus family of viruses, which include West Nile (WN), Japanese encephalitis (JE), yellow fever (YF), dengue...
Published: 2/13/2025
Contributor(s): Baek Kim
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Therapeutic Compounds Inhibiting DUSP5 and DUSP6 for Cardiomyocyte Proliferation and Cardiac Regeneration
Application
Therapeutics using siRNAs and small molecules to treat congenital heart defect and myocardial injuries.
Key Benefits
Reactivates cardiomyocyte (CM) cell replication, allowing regeneration of heart muscle after cardiac injuries.
Therapeutic compounds may be administered for transient regeneration/repair of heart muscle after cardiac...
Published: 2/13/2025
Contributor(s): Ahsan Husain, Nawazish Naqvi
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Combination Therapy for Increasing Venetoclax Sensitivity in Multiple Myeloma
Application
Marker and co-therapy that inhibits succinate dehydrogenase to increase patient response to venetoclax.
Key Benefits
Co-therapy increases MM sensitivity to venetoclax treatment.
Identifies patients who will respond to venetoclax therapy.
Market Summary
Multiple Myeloma (MM) is a cancer of plasma cells responsible for making antibody...
Published: 3/28/2025
Contributor(s): Malathy (mala) Shanmugam, Richa Bajpai
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Bacteria Strain in Probiotic Formulation for Weight Control
Application
Bacterial strain from Lactococcus lactis as a potential dietary supplement or therapeutic to help weight control and control gut inflammation.
Key Benefits
Provides anti-inflammatory effects in the intestine.
Improves weight control and protects against fatty liver disease in mice fed a high fat and high sugar Western-style diet.
This...
Published: 3/28/2025
Contributor(s): Rheinallt M. Jones, Trevor Darby
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IFN Gamma Prelicensing for Improved Mesenchymal Stromal Cell Function Post-Thaw
Application
Mesenchymal stromal cells (MSC) prelicensed with pro-inflammatory cytokines for improved survival and immunosuppressive properties following cryopreservation.
Key Benefits
Preserves the immunosuppressive function of MSCs following thawing.
Improves effectiveness of transplanted MSCs following cryopreservation.
Market Summary
Mesenchymal...
Published: 2/13/2025
Contributor(s): Jacques Galipeau, Raghavan Chinnadurai
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Biological Pacemakers as Alternatives/Adjuncts to Electronic Pacing Devices
Application
Non-viral gene delivery and a small molecule that converts heart muscle cells to pacemaker cells for the device-free treatment of slow heart rhythm.
Key Benefits
Minimally invasive procedure provides cardiac pacing without device implant.
Restores natural heart rhythm.
Eliminates or reduces significant complications such as repeat...
Published: 4/3/2025
Contributor(s): Hee Cheol Cho, Jun Li
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