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Implanted Passive Pressure Sensor Interrogated with (Ultra)-Sound (iPPSIS)
Application
Easy-to-use, short and long-term, minimally invasive, MR-safe approach for directly measuring the variation of intracranial pressure.
Key Benefits
A minimally invasive device that is compatible with MRI imaging for quantitatively measuring intracranial pressure.
A prototype has been developed showing the ability to measure shunt pressure...
Published: 2/13/2025
Contributor(s): David Myers, Nicholas Au Yong, Brooks Lindsey, Cecilia Alessandra Luna, Saeyoung (Sunny) Kim, Bowen Jing
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Antisense Restoration of ELAVL3 for Neurological Diseases
Application
Antisense therapeutics targeting ELAVL3 expression for neurodegenerative disorders.
Key Benefits
Antisense approach for restoring protein levels and function of ELAVL3 and TDP-43.
Preclinical data show the ability of several ELAVL3-targeting ASOs to restore protein expression via in vitro experiments.
Potential to be a new medicine...
Published: 2/13/2025
Contributor(s): Zachary X McEachin
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Latent Variable Modeling for Developing Neuroprosthetic Devices
Application
A high-performing neural decoder that reconstructs spiking data from local field potentials to analyze neural recordings for developing neuro-prosthetic devices.
Key Benefits
Capable of augmenting local field potential to overcome perturbations in data.
Improved decoding stability with high accuracy.
Potential to lead to the development...
Published: 2/13/2025
Contributor(s): Brianna Karpowicz, Chethan Pandarinath, Yahia Ali, Marc Slutzky, Robert Flint, Bareesh Bhaduri
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Faith-based Home Activity Toolbox (HAT)
Application
Set of interventional activity tools designed to incorporated faith-based principles to improve the quality of life of individuals living with or family members caring for persons with moderate to severe Alzheimer Disease or related dementias.
Key Benefits
Provides relief from anxiety.
Reduced behavior disturbances.
Improved quality...
Published: 2/13/2025
Contributor(s): Fayron Epps
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Flumazenil for Treatment of CNS Symptoms in Myotonic Dystrophy
Application
A class of drugs that inhibit molecules responsible for the severe nervous system complications associated with myotonic dystrophy.
Key Benefits
Potentially the first medication for treating the severe nervous system symptoms associated with myotonic dystrophy by targeting GABRG2.
Transdermal and oral administration.
May drive the...
Published: 2/13/2025
Contributor(s): Gary Bassell, Andrew Jenkins, David Rye, Eric Wang, Maurice Swanson, Lyndon Lien
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Novel Therapeutic Target for Fragile X Syndrome and Neurodevelopmental Disorders
Application
Salvianolic acid C for treating Fragile X Syndrome (FXS).
Key Benefits
New therapeutic drug candidate for the treatment of FXS.
Preliminary data in the laboratory in organoids treated with the drug showed rescued cell phenotypes known to be associated with the disease in humans.
Potential to treat other neurodevelopmental disorders.
Market...
Published: 2/13/2025
Contributor(s): Peng Jin, Chuan He, Zhongyu Zou
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Machine Learning for Neurodegenerative Disease Diagnosis and Monitoring
Application
A machine learning classification model incorporating biomarkers for detecting Parkinson's disease.
Key Benefits
The image processing methods are simple to use, and the processing pipeline is fully automated.
The method is novel and customized to address the practical requirements of clinical and research imaging.
Market Summary
Parkinson’s...
Published: 2/13/2025
Contributor(s): Daniel Huddleston, Babak Mahmoudi
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Blood-based Diagnostic Test for Anxiety
Application
A blood-based biomarker test for the diagnosis of anxiety disorders.
Key Benefits
Gene panel of at least seven biomarkers that may predict anxiety in humans.
Minimally invasive blood test.
May identify different forms of anxiety leading to personalized treatment and improved clinical outcomes.
Market Summary
Anxiety disorders are...
Published: 2/13/2025
Contributor(s): Reid Alisch, Pankaj Chopra
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Method and System for Recording and Recovery of Electrophysiology During Stimulation
Application
Systems and methods for recording and recovering viable electrophysiological signals and during delivery of stimulation, including deep brain stimulation (DBS).
Key Benefits
Enables the recording of electrophysiology/neurophysiology during stimulation from the same stimulating contact and adjacent contacts.
Enables the potential usage...
Published: 2/13/2025
Contributor(s): Enrico Opri, Svjetlana Miocinovic
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Repurposed Treatment for Cocaine Use Disorder
Application
Repurposed drug for transcriptomic-driven treatment of cocaine use disorder.
Key Benefits
FDA-approved drug.
Outperformed current targets undergoing clinical trials for CUD at the mRNA level.
Market Summary
Cocaine abuse is associated with substantial morbidity and mortality, and there are no approved medications for the treatment...
Published: 2/13/2025
Contributor(s): Rohan Palmer, Spencer Huggett
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