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Small Molecule Inhibitors of the p38/MK2 Protein Interaction
Application
New class of small molecule inhibitors with therapeutic potential for inflammatory diseases through disruption of the p38/MK2 protein-protein interaction.
Key Benefits
Therapeutic potential and utility for various inflammatory diseases.
May have potentially fewer off-target effects and dose-limiting toxicities.
May serve as a foundation...
Published: 7/10/2026
Contributor(s): Andrey Ivanov, Haian Fu
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New Treatment for Pain
Application
Veragranine A analogs with improved synthetic efficiency and enhanced potency for the treatment of pain.
Key Benefits
Increased synthetic efficiency of Veragranine A analogs, helping address supply limitations.
Synthetic analogs demonstrate greater potency than Veragranine A and may offer improved pharmacological response.
The analogs...
Published: 7/9/2026
Contributor(s): Mingji Dai, Donghui Ma, Reem Al-Ahmad, Rajesh Khanna
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Automated Deep Brain Stimulation Programming
Application
A program to optimize parameters for deep brain stimulation.
Key Benefits
Can provide patient-specific deep brain stimulation parameters.
May reduce the frequency of programming clinic visits
May improve clinical outcomes by selecting optimal stimulation parameters.
Market Summary
Deep brain stimulation (DBS) is currently approved...
Published: 3/10/2026
Contributor(s): Svjetlana Miocinovic, Babak Mahmoudi
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c‑Abl Modulators for Neurodegenerative Disease Treatment
Application
Small‑molecule c‑Abl inhibitors designed to treat neurodegenerative diseases such as Parkinson’s and Alzheimer’s.
Key Benefits
Targets c‑Abl, a key regulator linked to neurodegeneration, oxidative stress, and loss of dopaminergic neurons.
Provides new small‑molecule scaffolds with potential for improved safety profiles...
Published: 3/2/2026
Contributor(s): Thomas Kaiser, Zackery Dentmon, Christopher Dalloul, Dennis Liotta
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Molecules Targeting Inflammatory Signaling
Application
A group of small molecules for treating central and peripheral diseases associated with inflammation.
Key Benefits
Applicable to a wide variety of central nervous system and peripheral diseases.
Can bypass side effects of existing therapeutics targeting similar inflammatory pathways.
High target selectivity and aqueous solubility.
Capability...
Published: 5/22/2026
Contributor(s): Raymond (Ray) Dingledine, Radhika Amaradhi, Shabber Mohammed, Thota Ganesh
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Repurposed Receptor Blocker for the Treatment of PTSD
Application
Use of neurokinin 3 receptor antagonist, osanetant, for the prevention and treatment of post-traumatic stress disorder (PTSD) and other anxiety disorders.
Key Benefits
Utilizes a repurposed drug that is safe for human use.
Potential to treat specific PTSD symptoms better than antidepressants.
Market Summary
Post-traumatic stress...
Published: 1/20/2026
Contributor(s): Kerry Ressler, Raul Andero Gali
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A 3D In Vitro Model of the Human Locus Coeruleus
Application
A brain organoid model for the human locus coeruleus to study its function and dysfunction in neurological diseases.
Key Benefits
Locus coeruleus region-specific neural organoid model for studying this deep region of the human brain.
The organoid synthesizes norepinephrine, allowing for study of diseases related to these neurotransmitters.
The...
Published: 2/25/2026
Contributor(s): Fikri Birey, David Weinshenker
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Multi-Modal Sensing Platform for Diagnosing Depression and Schizophrenia
Application
A multi-sense deep learning platform and interview protocol used for detection and assessment of depression and schizophrenia.
Key Benefits
Automated and remote mental illness assessment without the need for self-reporting or clinical observation.
Improved disease tracking for patients and clinicians.
A more objective classifier and...
Published: 5/22/2026
Contributor(s): Gari Clifford, Robert Cotes, Mina Boazak, Zifan Jiang, Seyed Salman Seyedi, Ali Bahrami Rad
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Technology for Assessment in Enhancing Memory Measurement in ECT Therapy
Application
The Electroconvulsive Cognitive Assessment (ECA) is a 10-minute cognitive exam designed for use during and after Electroconvulsive Therapy (ECT). It focuses on assessing memory deficits associated with ECT, offering a quick and targeted evaluation tool for healthcare professionals.
Key Benefits
Rapid cognitive assessment in under 10...
Published: 4/3/2025
Contributor(s): Adriana Hermida
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The CaRE Course: CaREgiving While Black
Application
The CaRE Course is a curriculum to develop caregiving mastery of people living with dementias (PLWD) while understanding, acknowledging, and addressing the influence of race, culture, and disparities on caregivers’ mental health, medical, spiritual, and safety needs during the COVID-19 pandemic.
Key Benefits
Augments caregiver's...
Published: 5/22/2026
Contributor(s): Fayron Epps, Kenneth Hepburn, Carolyn Clevenger, Stephanie Bennett
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