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Repurposing a Potent MDM2 Inhibitor for Leukemia Treatment
Application
VERU-111, also known as sabizabulin, is a potent microtubule inhibitor and, notably, an MDM2 inhibitor. This repurposed compound demonstrates remarkable efficacy in the treatment of Acute Myeloid Leukemia (AML).
Key Benefits
Unique dual-action functionality as a microtubule and MDM2 inhibitor.
Successful inhibition of MDM2, an oncogene...
Published: 2/13/2025
Contributor(s): Deborah DeRyckere, Muxiang Zhou, Lu Bing Gu, Douglas Graham, Tao Liu
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Caspase-3 Deficient MEFs with Mutant Caspase-3 Re-Introduced
Application
Mouse embryonic fibroblast (MEF) line deficient in caspase-3 that are reconstituted with constitutively expressed mutant versions of the protease.
Key Benefits
An immortalized caspase-3-deficient MEF cell line.
Tool to study protease induced apoptosis.
Technical Summary
Emory inventors have discriminated a previously unknown role...
Published: 2/13/2025
Contributor(s): Lawrence Boise, Katelyn Ponder
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HIF/Hypoxia-Reporter Cell Lines
Application
Hypoxia/Hypoxia-inducible factor 1 (HIF-1) inducible luciferase/LacZ reporter cell lines.
Key Benefit
Expression of luciferase and beta-galactosidase in response to hypoxia treatment.
Technical Summary
Emory University researcher, Erwin Van Meir, has made HIF/hypoxia reporter cell lines by stably transfecting the cells with pBIGL-V6R-HRE-Luc/LacZ...
Published: 2/13/2025
Contributor(s): Erwin Van Meir
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ADGRB3/BAI3-Expressing Cell Lines
ApplicationADGRB3/BAI3 expressing human brain tumor cell lines.Technical SummaryAdhesion G protein coupled receptor B3 (ADGRB3), also called Brain-specific angiogenesis inhibitor 3 (BAI3) is a protein that in humans is encoded by the ADGRB3 gene. Emory University researcher Erwin Van Meir has developed medulloblastoma cell lines DAOY, UW288-1 and PFSK1,...
Published: 2/13/2025
Contributor(s): Erwin Van Meir
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Spatiotemporal Genomic Analysis to Identify and Extract Rare Cancer Cells
Application
Isolation and analysis of phenotype and genome of rare cell types within a tumor for research and potential diagnostics.
Key Benefits
Allows the identification of a single cell or group of cells within a tumor sample using phenotypic criteria.
Enables both phenotypic and genetic analysis of the same rare cells within a tumor.
Market...
Published: 2/13/2025
Contributor(s): Adam Marcus, Jessica Konen
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Immortalized Mouse Aortic Endothelial Cell Lines
Application
Immortalized (using polyoma middle T-antigen) mouse aortic endothelial primary cell lines for studying vascular biology and pathophysiology, including cardiovascular research.
Key Benefits
Immortalized from mouse artery endothelial cells using polyoma middle T-antigen.
Validated retention of primary endothelial markers and structural...
Published: 2/13/2025
Contributor(s): Hanjoong Jo, Chih-Wen Ni, Sandeep Kumar
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Chemically Induced Pluripotent Stem (CiPS) Cells
Application
Generation of pluripotent stem cells from adult somatic cells for medical use.
Key Benefits
No exogenous genetic manipulations, which minimize oncogenic effects, were observed in current methods.
Peripheral blood can be used as a source of parent cell instead of fibroblasts or keratinocytes.
Market Summary
The economic and psychological...
Published: 2/13/2025
Contributor(s): Young-Sup Yoon, Ji Woong (Jay) Han, Xiaodong Cheng, Antonello Mai
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A Cellular Model for Huntington's Disease
Applications
Diagnosis and treatment of Huntington's disease.
Technical Summary
Huntington's disease (HD) is a genetically inherited disease that leads to
progressive neurodegeneration, resulting in motor disturbances, loss of memory
and cognition, and psychiatric manifestations. The underlying molecular and
biochemical basis of HD are not...
Published: 2/13/2025
Contributor(s): Xiao-Jiang Li, Shi Hua (Shihua) Li
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