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BG505 SOSIP Vaccine Elicited Neutralizing Monoclonal Antibodies for HIV
­ Application ELISA Western Blot Immunohistochemistry Specficity HIV-1 BG505 Env protein (clone name: YRK01, YRK02). Subtype Monoclonal antibody. Immunogen HIV-1 BG505 SOSIP Env trimer. Technical Summary HIV-1 envelope glycoprotein (Env) is a membrane protein complex involved in receptor recognition and viral fusion with CD4+ T cells...
Published: 5/17/2022       Contributor(s): Cynthia Derdeyn, Tysheena Charles
Using Antibodies to inhibit Glycoprotein Ib-IX mediated Platelet Signaling and Clearance for the treatment of Thrombocytopenia
­ Application A therapeutic agent to treat thrombocytopenia, the lack of sufficient platelets which can lead to excessive bleeding. Key Benefits This molecule modulates platelet signaling without blocking its ligand binding domain. Its mechanism of action targets a different part of the platelet life cycle from currently available therapeutics. RAM.1...
Published: 5/13/2022       Contributor(s): Renhao Li, Francois Lanza, Wenchun Chen, Moriah Wilson
Additives that Increase Storage and Shelf Life of Platelets
Application Monoclonal antibody additive that inhibits ectodomain shedding of a platelet glycoprotein to improve platelet storage. Key Benefits Current storage techniques allows for limited storage times (5-7 days). New additive may enable platelet storage at 4°C, increase platelet storage time, and improve quality of stored platelets. Inhibits...
Published: 11/2/2020       Contributor(s): Renhao Li
Galectin-9 Directed CAR T-cells for Overcoming Resistance to Chemotherapy in Hematological Malignancies
Application Anti-human Galectin-9-directed chimeric antigen receptor (CAR) T-cells for treatment of hematological malignancies (B-ALL, T-ALL, and DLBCL) in normal, overweight, and obese patients. Key Benefits Can be used as a stand-alone or in-combination product to treat patients with hematological malignancies, particularly overweight and obese...
Published: 10/13/2020       Contributor(s): Curtis Henry, Miyoung (Mi-Young) Lee, Sunil Raikar, Jamie Hamilton, Anthony Ross
Trimeric Immunogen for HIV-1 Vaccination
Application Trimeric gp120 immunogen that induces broadly cross-reactive V1V2-antibodies for HIV-1 vaccine. Key Benefits Possible oral administration. Broadly cross-reactive against HIV-1 panel. Promotes antibody responses as both a primary immunogen and boosting immunogen. Market Summary Antiretroviral therapy (ART) has dramatically prolonged...
Published: 8/26/2019       Contributor(s): Rama Amara, Andrew Jones, Raghavan Varadarajan, Sannula Kesavardhana
Antibody Therapy for Varicella Zoster Virus
Application Human monoclonal antibodies for the treatment of varicella zoster virus (VZV). Key Benefits Human monoclonal antibodies can limit the spread of VZV. gH-specific antibodies are complement-independent. Market Summary Varicella Zoster Virus (VZV) causes varicella, more commonly known as chickenpox. Once the illness resolves, the virus...
Published: 8/19/2019       Contributor(s): Rafi Ahmed, Nicole Sullivan
Antibody for the Treatment of Non-Alcoholic Steatohepatitis (NASH) and Liver Fibrosis
Application Repurposed monoclonal antibody (mAb) that blocks inflammatory CD4 T cell migration for the treatment of NASH and liver fibrosis. Key Benefits Therapy for treating NASH, NAFLD, and liver fibrosis. Potential reduced approval time due to existing clinical safety data for α4β7 mAb. Market Summary Non-alcoholic steatohepatitis...
Published: 6/24/2019       Contributor(s): Frank Anania, Khalidur Rahman
Antibodies for Zika and Dengue Viruses
ApplicationsELISAWestern BlotImmunohistochemistrySpecificityHuman monoclonalTechnical SummaryZika Virus (ZIKV) is a mosquito borne filovirus responsible for a 2016-2017 epidemic in North and South America. ZIKV nonstructural protein 1 (NS1) is a pathogenicity factor implicated in virus replication, host interaction and immune invasion. The investigators...
Published: 5/9/2019       Contributor(s): Jens Wrammert, Mark Mulligan
Glycoprotein Tetramer for Identifying Antigen-specific B Cells
ApplicationEctodomain of viral glycoprotein tetramers detects antigen-specific memory B Cells.Key BenefitsViral glycoprotein tetramers detect antigen-specific memory B cells in the peripheral blood and tissues.Hepatitis C virus E2 protein triggers immune response, which may yield an effective vaccine against hepatitis C virus.Market SummaryHepatitis...
Published: 5/9/2019       Contributor(s): Arash Grakoui, Joseph Marcotrigiano
Human Monoclonal Antibodies Against Ebola Virus
ApplicationAntibodies that bind and neutralize Ebola virus glycoprotein (GP) for use in vaccination or treatment of Ebola virus disease.Key BenefitsHigher binding affinity for Ebola virus GP than closest competitor.Can be used prophylactically or for treatment of Ebola virus disease.Market SummaryThe Ebola virus is an RNA virus with a membrane composed...
Published: 3/26/2019       Contributor(s): Rafi Ahmed
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