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Trimeric Immunogen for HIV-1 Vaccination
Application Trimeric gp120 immunogen that induces broadly cross-reactive V1V2-antibodies for HIV-1 vaccine. Key Benefits Possible oral administration. Broadly cross-reactive against HIV-1 panel. Promotes antibody responses as both a primary immunogen and boosting immunogen. Market Summary Antiretroviral therapy (ART) has dramatically prolonged...
Published: 8/26/2019       Inventor(s): Rama Amara, Andrew Jones, Raghavan Varadarajan, Sannula Kesavardhana
Antibody Therapy for Varicella Zoster Virus
Application Human monoclonal antibodies for the treatment of varicella zoster virus (VZV). Key Benefits Human monoclonal antibodies can limit the spread of VZV. gH-specific antibodies are complement-independent. Market Summary Varicella Zoster Virus (VZV) causes varicella, more commonly known as chickenpox. Once the illness resolves, the virus...
Published: 8/19/2019       Inventor(s): Rafi Ahmed, Nicole Sullivan
Antibody for the Treatment of Non-Alcoholic Steatohepatitis (NASH) and Liver Fibrosis
Application Repurposed monoclonal antibody (mAb) that blocks inflammatory CD4 T cell migration for the treatment of NASH and liver fibrosis. Key Benefits Therapy for treating NASH, NAFLD, and liver fibrosis. Potential reduced approval time due to existing clinical safety data for α4β7 mAb. Market Summary Non-alcoholic steatohepatitis (NASH)...
Published: 6/24/2019       Inventor(s): Frank Anania, Khalidur Rahman
Antibodies for Zika and Dengue Viruses
ApplicationsELISAWestern BlotImmunohistochemistrySpecificityHuman monoclonalTechnical SummaryZika Virus (ZIKV) is a mosquito borne filovirus responsible for a 2016-2017 epidemic in North and South America. ZIKV nonstructural protein 1 (NS1) is a pathogenicity factor implicated in virus replication, host interaction and immune invasion. The investigators...
Published: 5/9/2019       Inventor(s): Jens Wrammert, Mark Mulligan
Glycoprotein Tetramer for Identifying Antigen-specific B Cells
ApplicationEctodomain of viral glycoprotein tetramers detects antigen-specific memory B Cells.Key BenefitsViral glycoprotein tetramers detect antigen-specific memory B cells in the peripheral blood and tissues.Hepatitis C virus E2 protein triggers immune response, which may yield an effective vaccine against hepatitis C virus.Market SummaryHepatitis...
Published: 5/9/2019       Inventor(s): Arash Grakoui, Joseph Marcotrigiano
Human Monoclonal Antibodies Against Ebola Virus
ApplicationAntibodies that bind and neutralize Ebola virus glycoprotein (GP) for use in vaccination or treatment of Ebola virus disease.Key BenefitsHigher binding affinity for Ebola virus GP than closest competitor.Can be used prophylactically or for treatment of Ebola virus disease.Market SummaryThe Ebola virus is an RNA virus with a membrane composed...
Published: 3/26/2019       Inventor(s): Rafi Ahmed
Specialized Cell Culturing Media for Enhanced Antibody Secretion and Plasma Cell Survival
ApplicationCell culture media that promotes the survival of human plasma cells and enables immunoglobin (Ig) secretion from such plasma cells.Key BenefitsFacilitates the isolation of antibody-secreting cells (ASCs) found in blood after antigen exposure, which can be used to identify an active antigen or pathogen causing illness.Composed of factors secreted...
Published: 5/24/2018       Inventor(s): Frances Lee, Ignacio (Inaki) Sanz, Doan Nguyen
Antibodies for α-Synuclein Cleavage by Asparagine Endopeptidase (AEP) and Activated AEP
ApplicationELISAWestern BlotImmunohistochemistrySubtypeRabbit polyclonalTechnical SummaryParkinson's disease (PD) is a progressive neurodegenerative disorder that affects movement. It is characterized by the loss of predominately dopamine-producing neurons in a specific area of the brain called substantia nigra. α-Synuclein is a component of Lewy bodies,...
Published: 1/21/2018       Inventor(s): Keqiang Ye
Polyclonal Antibody Against Nematode Cyclase Associated Protein-2 (CAS-2)
ApplicationWestern blotSpecificityNematode CAS-2 C terminal halfSubtypeChicken PolyclonalImmunogenCAS-2 C terminal halfTechnical SummaryCAS-2 binds to both ATP-actin and ADP-actin and strongly promotes exchange of actin-bound nucleotides. Actin is a globular multi-functional protein that forms microfilaments and participates in many important cellular...
Published: 3/28/2017       Inventor(s): Shoichiro Ono
Antibodies that Bind to Amyloid Precursor Protein (APP) Peptides
Application ELISA Western Blot Immunohistochemistry Specificity Rabbit Polyclonal Technical Summary Alzheimer’s disease is the most common form of severe dementia; yet, there is no cure. Although it is known that Amyloid b (Ab) plaques contribute to the disease, additional research tools are necessary to determine how these plaques form. Researchers...
Published: 3/17/2016       Inventor(s): Keqiang Ye
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