Serotonin Transporter (SERT) Monoclonal Antibody
Applications
Immunohistochemistry
Specificity
Rat serotonin transporter - N-terminus
Subtype
Monoclonal Mouse IgG1
Technical Summary
The serotonin transporter (SERT) is a monoamine transporter protein, which works to recycle serotonin (5-HT) from the synaptic cleft thus regulating the 5-HT concentration in the synapse. SERT is the site of action of the selective serotonin reuptake inhibitors (SSRIs) class of antidepressants, which work by increasing 5-HT levels in the synapse through inhabitation of 5-HT reuptake. Additionally, SERT metabolism has been implicated in a host of phenomena ranging from alcoholism and clinical depression to obsessive compulsive disorder. These monoclonal antibodies have been generated against a rat SERT NH2-terminus/gluthionone S-transferase fusion protein and used extensively for immunohistochemical staining. They do not appear to be appropriate for western blotting or immunoprecipitation purposes.
Publications
Inazu et al. Neurochem Int, 2001. 39:39-49
Pickel et al. J Neurosci, 1999. 19:7356-7366
Schroeter et al. Mol Cell Neurosci, 1997. 9:170-184
Patent Information
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