Serotonin Transporter (SERT) Monoclonal Antibody




Rat serotonin transporter - N-terminus


Monoclonal Mouse IgG1

Technical Summary

The serotonin transporter (SERT) is a monoamine transporter protein, which works to recycle serotonin (5-HT) from the synaptic cleft thus regulating the 5-HT concentration in the synapse. SERT is the site of action of the selective serotonin reuptake inhibitors (SSRIs) class of antidepressants, which work by increasing 5-HT levels in the synapse through inhabitation of 5-HT reuptake. Additionally, SERT metabolism has been implicated in a host of phenomena ranging from alcoholism and clinical depression to obsessive compulsive disorder. These monoclonal antibodies have been generated against a rat SERT NH2-terminus/gluthionone S-transferase fusion protein and used extensively for immunohistochemical staining. They do not appear to be appropriate for western blotting or immunoprecipitation purposes.


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Patent Information

Tech ID: RT002
Published: 4/9/2013