Presenillin 1 C-Terminal Monoclonal Antibody
Applications
- Immunoblotting
- Immunohistochemistry
Specificity
Human Presenilin-1 C-terminal
Subtypes
Mouse Monoclonal
Technical Summary
By immunoblotting applications the antibody recognizes a predominant 32 kDa polypeptide in a varitety of samples including PC12 cells transfected with human PS1, complimentary DNA brain biopsy specimens from dementia patients and postmortem Alzheimer's disease patients. PS1 is expressed primarily in neurons, with the protein localizing in the soma and dendritic processes. In contrast, in sporadic Alzheimer's disease cases PS1 immunoreactivity is present in the neuritic component of senile plaques as well as in neurofibrillary tangles. Localization of PS1 immunoreactivity heterogeneous forms of the disease share a common pathophysiology involving PS1 protein.
Publications
Chyung JH, et al., J. Biol. Chem. 280: 6, 4383-4392. (2004).
Ribaut-Barassin C, et al., Synapse. 35: 96-110 (2000).
Lee MK, et al., Nature Medicine. 3: 756-760 (1997)
Patent Information
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