SARS-CoV-2 Neutralizing Human Monoclonal Antibodies

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Application

Monoclonal antibodies to SARS-CoV2 for use in COVID-19 diagnostics and therapeutics.

Key Benefits

  • Demonstrably neutralizing, important for therapeutic mAbs.
  • Most bind both RBG and stalk portion of spike protein, useful in case SARS-CoV2 strains develop variation in RBD.

Market Summary

Coronavirus (COVID-19) is an infectious disease that causes severe acute respiratory syndrome and led to millions of deaths. Most people infected with the SARS-CoV-2 virus experience mild to moderate respiratory illness and recover without special treatment. However, the elderly and those immunocompromised are substantially more likely to develop severe infections leading to death. Although several FDA-authorized preventative vaccines are on the market, there are limited treatments for those already infected with COVID-19. There is a significant unmet need to rapidly develop therapeutics that help treat the millions of people infected with this deadly virus and its variants.

Technical Summary

The invention consists of a novel method for the generation of monoclonal antibodies (mAb) for the purpose of being administered to SARS-CoV2 patients. During SARS-CoV2 infection mAb has the potential to neutralize the virus by blocking its receptor binding domain. Researchers generated a panel of 4 mAb from patients who were currently infected by or recovering from SARS-CoV2. The researchers then tested the mAB for their binding affinity to SARS-CoV2 spike proteins and their ability to neutralize the virus in vitro. All 4 mAB demonstrated successful binding ability to SARS-CoV2 spike proteins and its receptor binding domain. Furthermore, 3 of the mAb demonstrated neutralizing capacity.

Patent Information

App Type Country Serial No. Patent No. File Date Issued Date Patent Status
PCT PCT PCT/US2022/020322   3/15/2022   Pending
Tech ID: 21003
Published: 7/6/2022
Category
Diagnostics
Therapeutics

Contact
Jessica Beach
Marketing Specialist
Emory, OTT
(404) 727-1899
OTT-Market@emory.edu

Inventor(s)
Jens Wrammert
Carl Davis
Mehul Suthar
Robert Kauffman

Keyword(s)
Antibody
COVID19
Microbiology/Infectious Diseases