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Smartphone Diagnostic for Rapid Respiratory Virus Detection
Application
Diagnostic and automatic surveillance platform to identify RSV, Influenza A, and COVID-19 in real-time.
Key Benefits
Rapid smartphone-based detection of multiple respiratory viruses in nasal swab, breath condensate, and saliva.
Requires few reagents and no expensive equipment.
Limit of detection on par with PCR and rapid readout.
Enables...
Published: 11/20/2024
Contributor(s): Selma Piranej, Khalid Salaita
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MVA and DNA Based SARS-CoV-2 Vaccines
Application
Modified Vaccinia virus Ankara (MVA)- and deoxyribonucleic acid (DNA)-based vaccine for Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2).
Key Benefits
Safety profile is known.
Demonstrated antiviral activity against related Coronaviruses.
Single dose of vaccination was shown to be effective against related Coronaviruses...
Published: 10/28/2024
Contributor(s): Rama Rao Amara, Sailaja Gangadhara
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Using Hetero-multivalent DNA-functionalized Materials to Detect Genetic Mutations
Application
Improving diagnostic accuracy using hetero-multivalent DNA-functionalized materials for disease targets containing one or more genetic mutations.
Key Benefits
Tunable oligos increase specificity and cooperative binding to the disease target of interest.
Distinguishes between cis- and trans mutations.
Identifies different strains of...
Published: 10/28/2024
Contributor(s): Brendan Deal, Khalid Salaita, Rong Ma, James Kindt
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Mobile Phone Diagnostic for COVID-19
Application
Diagnostic and automatic surveillance to identify COVID-19 via smartphone in real-time.
Key Benefits
Provides real-time, rapid results.
Autonomous process.
Device does not require RNA isolation or amplification for viral detection.
Market Summary
Coronavirus (COVID-19) is an infectious disease that causes severe acute respiratory...
Published: 11/20/2024
Contributor(s): Khalid Salaita, Alisina Bazrafshan, Selma Piranej
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Improved Clinical Diagnostic Method for SARS-CoV-2 Infection
Application
A more reliable and accurate method for diagnosing SARS-CoV-2 infection based on the biochemical interactions between the spike trimer and ACE-2 protein.
Key Benefits
A fast, affordable, and easy-to-use SARS-Cov-2 diagnostic test for use in clinical settings.
Market Summary
SARS-CoV-2 has evolved significantly since the onset of...
Published: 9/26/2024
Contributor(s): John Roback, Andrew Neish, Narayanaiah Cheedarla, Hans Verkerke, Huixia Wu, William Osick, Kaleb Mclendon, Sindhu Potlapalli
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SARS-CoV-2 Neutralizing Human Monoclonal Antibodies
Application
Monoclonal antibodies to SARS-CoV2 for use in COVID-19 diagnostics and therapeutics.
Key Benefits
Demonstrably neutralizing, important for therapeutic mAbs.
Most bind both RBG and stalk portion of spike protein, useful in case SARS-CoV2 strains develop variation in RBD.
Market Summary
Coronavirus (COVID-19) is an infectious...
Published: 10/17/2024
Contributor(s): Jens Wrammert, Carl Davis, Mehul Suthar, Robert Kauffman
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Extended Efficacy SARS-COV-2 Vaccine
Application
A vaccine for SARS-COV-2 that can be used to protect against infection by future forms of Variant-of-Concern (VOC) or other SARS-like coronaviruses.
Key Benefits
An approach to developing a vaccine that would be effective against future mutations of SARS-COV-2.
A vaccine that elicits an immune response to conserved portions...
Published: 11/20/2024
Contributor(s): Chinglai Yang, Ling Ye, Samuel Stampfer, Rui Jin
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SARS-CoV-2 Subgenomic Replicon (SARS2-Rn)
Application
A series of SARS-CoV-2 sub-genomic replicons as artificial bacterial chromosomes for the screening of SARS-CoV-2 in studies such as drug discovery and inhibitors assay.
Key Benefits
Can be used at a lower biosafety level than non-artificial copies of SARS-CoV-2.
Can be used for high throughput screening and characterization of SARS-CoV-2...
Published: 10/17/2024
Contributor(s): Stefan Sarafianos, Shuiyun Lan
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Yongshi: A Wild Boar Peptide with Anti-Viral Activity Targeting COVID-19
Application
An antiviral cathelicidin peptide from wild boar that exhibits antiviral properties against SARS-CoV-2.
Key Benefits
Pan-coronavirus inhibitor that may be effective for all future variants.
Functions as an inhibitor of ongoing infection.
Early data suggests it is safe to use in human tissue.
Market Summary
Coronavirus disease...
Published: 11/20/2024
Contributor(s): Joshy Jacob, Mehul Suthar, Troy Von Beck, Nikita Mullick, Abigail Vanderheiden, Jeffrey Skolnick
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Combination of Tetrahydrobiopterin and Arginine/ ± Arginase Inhibitors for the Treatment of COVID-19
Application
A novel drug combination to address acute arginine/BH4 dysregulation that develops with COVID-19 and MIS-C infection.
Key Benefits
Potential to improve outcomes of those infected with COVID-19 with few side effects.
Repurposing opportunity with the combination of two approved drugs (tetrahydrobiopterin and arginine).
Addresses...
Published: 7/30/2024
Contributor(s): Claudia Morris, Lou Ann Brown
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