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Extended Efficacy SARS-COV-2 Vaccine
Application
A vaccine for SARS-COV-2 that can be used to protect against infection by future forms of Variant-of-Concern (VOC) or other SARS-like coronaviruses.
Key Benefits
An approach to developing a vaccine that would be effective against future mutations of SARS-COV-2.
A vaccine that elicits an immune response to conserved portions...
Published: 5/13/2022
Contributor(s): Chinglai Yang, Ling Ye, Samuel Stampfer, Rui Jin
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SARS-CoV-2 Subgenomic Replicon (SARS2-Rn)
Application
A series of SARS-CoV-2 sub-genomic replicons as artificial bacterial chromosomes for the screening of SARS-CoV-2 in studies such as drug discovery and inhibitors assay.
Key Benefits
Can be used at a lower biosafety level than non-artificial copies of SARS-CoV-2.
Can be used for high throughput screening and characterization...
Published: 4/19/2022
Contributor(s): Stefan Sarafianos, Shuiyun Lan
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Yongshi: A Wild Boar Peptide with Anti-Viral Activity Targeting Covid-19
Application
An antiviral cathelicidin peptide from wild boar that exhibits antiviral properties against SARS-CoV-2.
Key Benefits
Pan-coronavirus inhibitor that may be effective for all future variants.
Functions as an inhibitor of ongoing infection.
Early data suggests it is safe to use in human tissue.
Market Summary
Coronavirus disease...
Published: 4/19/2022
Contributor(s): Joshy Jacob, Mehul Suthar, Troy Von Beck, Nikita Mullick, Abigail Vanderheiden, Jeffrey Skolnick
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Combination of Tetrahydrobiopterin and Arginine/ ± Arginase Inhibitors for the Treatment of COVID-19
Application
A novel drug combination to address acute arginine/BH4 dysregulation that develops with COVID-19 and MIS-C infection.
Key Benefits
Potential to improve outcomes of those infected with COVID-19 with few side effects.
Repurposing opportunity with the combination of two approved drugs (tetrahydrobiopterin and arginine).
Addresses...
Published: 3/16/2022
Contributor(s): Claudia Morris, Louann Brown
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Small Molecule Inhibitors for the Treatment of COVID-19 Infection
Application
Small molecule therapy to treat patients infected with COVID-19 virus.
Key Benefits
Current FDA-approved therapeutic can be repurposed to fight COVID-19 infection.
Treatment option for infected COVID-19 patients.
Market Summary
Coronavirus (COVID-19) is an infectious disease that causes severe acute respiratory syndrome coronavirus...
Published: 2/23/2022
Contributor(s): Jack Arbiser, Martijn van Hemert, Melissa Thaler
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Bag-Valve-Mask (BVM) Ventilator
Application
Simple, low-cost bag-valve-mask (ambu bag) ventilator for treating respiratory challenges associated with COVID-19 and acute respiratory distress syndrome.
Key Benefits
Enables ventilation of two patients simultaneously or allows alternating tidal volumes for a single patient.
Simple, low-cost design.
Technical Summary
Georgia Tech,...
Published: 2/23/2022
Contributor(s): Susan Margulies, Shannon Yee, Michael Adams, Kentez Craig, Connor Hart, James Hurley, Jordan Kocher, Maxwell Praniewicz, Leon Williams, Christopher (Chris) Saldana
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Serological Test for SARS-CoV-2
Application
Clinical assay for detecting SARS-CoV-2 neutralizing antibodies.
Key Benefits
Highly specific and sensitive.
Fewer false positives than commercially available tests.
Market Summary
SARS-CoV-2 is currently causing a devastating pandemic and there is a pressing need to understand the dynamics, specificity, and neutralizing...
Published: 1/24/2022
Contributor(s): Rafi Ahmed, Mehul Suthar, John Roback, Jens Wrammert, Robert Kauffman
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Infection Control System for Resuscitation and Airway Management
Application
Collapsible, single-use ‘pop-up tent’ system to prevent transmission of infectious disease during resuscitation and airway management.
Key Benefits
Provides protective barrier to prevent transmission of infectious disease.
Allows adequate access to the patient for airway management procedures.
Single-use to minimize infection...
Published: 9/15/2020
Contributor(s): Adam Klein, Russell Gore, David Wright
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C19Check: COVID-19 Severity Stratification Tool
Application
Algorithm for screening of individuals exhibiting coronavirus disease (COVID-19) symptoms.
Key Benefits
Allows mass screening of potential COVID-19 patients.
Alleviates burden on hospitals and doctors’ offices.
Reduces unnecessary interactions with individuals.
May be used in regions with low internet access.
Market Summary
Coronavirus...
Published: 4/8/2020
Contributor(s): Justin Schrager, Alexander Isakov, David Wright, Anna Yaffee, Arthur Kellermann
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Real-Time RT-PCR Assay for SARS-CoV-2
Application
Triplex, internally-controlled real-time RT-PCR for Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2).
Key Benefits
Two viral targets to confirm detection in a single sample.
Does not involve the performance of multiple reactions as are required for the majority of published assays.
May be performed using several different...
Published: 4/8/2020
Contributor(s): Jesse Waggoner
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Emory UniversityOffice of Technology Transfer