DNAzyme Nanoparticles for the Cleavage of RNA
Application
Site-selective RNA splicing nanozyme for cleaving and ligating RNA.
Key Benefits
- Can cleave virtually any RNA stem loop.
- Removes a 19 nucleotide segment from a 67 nucleotide RNA loop with up to 66% efficiency.
Technical Summary
Modulating RNA can be useful for studying RNA biology, gene knockdown, and regulating RNA splicing. Scientists at Emory University have developed a new DNAzyme nanoparticle for cleaving and ligating RNA. This technology encompasses a composite nanoparticle designed to cleave and ligate RNA targets. The composite NP is comprised of 4 pieces: a gold nanoparticle, two 10-23 DNAzymes that cut pre-mRNA at a certain purine/pyrimidine junction, and an RNA ligase that pastes RNA fragments back together.
Developmental Stage
Technology is available for license.
Publication: Petree, J. R. et al. (2018). ACS Chem. Biol, 13(1), 215-224.
Patent Information
| App Type |
Country |
Serial No. |
Patent No. |
File Date |
Issued Date |
Patent Status |
| Utility (parent) |
United States |
16/180,786 |
11,136,595 |
11/5/2018 |
10/5/2021 |
Issued |
|
|
