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Therapeutic for Potential Elimination of Chronic Hepatitis B
Application
A therapeutic technique to eliminate infection of patients suffering from chronic Hepatitis B Virus infection.
Key Benefits
May provide a cure for chronic HBV infection rather than just simple management.
High efficiency of infection targeting may produce minimal side effects.
May be used in combination with other HBV inhibitors.
Market...
Published: 2/13/2025
Contributor(s): Raymond Schinazi, Leda Bassit, Ting Nie
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CRISPR Based System for Targeted Reduction of Gene Expression
Application
A CRISPR based gene silencing system using sequence specific RNA to repress expression of endogenous transcripts.
Key Benefits
Provides a platform to target specific mRNA transcripts in both prokaryotic and eukaryotic cells.
Potential therapeutic strategy against pathogenic bacteria and viruses.
Market Summary
RNAi is an indispensable...
Published: 2/13/2025
Contributor(s): David Weiss, Timothy Sampson
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Cas9 Controlled Gene Activation
Application
Flexible system using Cas9 to modulate gene expression.
Key Benefits
Edits genes by cleaving DNA as well as inhibiting transcription.
No need to transfect cells with additional Cas9.
Market Summary
The CRISPR-Cas9 system is a bacterial adaptive immune system that has been appropriated for genetic engineering. The CRISPR-Cas9 system...
Published: 2/13/2025
Contributor(s): David Weiss, Hannah Ratner
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DNAzyme Nanoparticles for the Cleavage of RNA
Application
Site-selective RNA splicing nanozyme for cleaving and ligating RNA.
Key Benefits
Can cleave virtually any RNA stem loop.
Removes a 19 nucleotide segment from a 67 nucleotide RNA loop with up to 66% efficiency.
Technical Summary
Modulating RNA can be useful for studying RNA biology, gene knockdown, and regulating RNA splicing. Scientists...
Published: 2/13/2025
Contributor(s): Jessica Petree, Kevin Yehl, Khalid Salaita
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Microfluidic Device for Increased Viral Transduction Efficiency
Application
Microfluidic chip device for facilitating high throughput viral transduction for gene therapy applications.
Key Benefits
Improves surface-to-volume ratio, allowing more efficient contact between lentiviruses and cells
Increases efficiency while maintaining cell viability of traditional methods.
Enables gene transfer for non-adherent...
Published: 2/13/2025
Contributor(s): Reginald Tran, Wilbur Lam, David Myers, Christopher Doering, H. (Harold) Trent Spencer
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Nanoparticle Carrying siRNA DNA Cassette to Target Survival Genes in Cancer Treatment
Application
Tumor receptor-targeted nanoparticle containing a siRNA DNA cassette for the knockdown of survival genes and treating cancer.
Key Benefits
Nanoparticles are targeted directly to tumors for treatment and/or diagnostic imaging.
siRNA encoded by a DNA cassette has increased stability and more effective gene depletion.
siRNA knockdown...
Published: 2/13/2025
Contributor(s): Lily Yang
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Therapeutic DNAzyme-Nanoparticle Conjugates for Gene Regulation
Application
Catalytic DNA molecules (DNAzymes) conjugated to gold nanoparticles for use as therapeutics to treat cancers, infections or other applications of gene therapy.
Key Benefits
DNAzyme-gold nanoparticles regulate gene expression through an RNAi independent mechanism.
Each DNAzyme-gold nanoparticle is more catalytically active than a free...
Published: 2/13/2025
Contributor(s): Khalid Salaita, Kevin Yehl
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