Polymer Coated SERS Nanoparticle Tags
Application
Nanoparticle for in vivo tumor targeting and detection.
Key Benefits
- Large optical enhancements were achieved under in vivo conditions in live animals.
- Conjugated nanoparticles were able to target tumor biomarkers on human cancer cells and in xenograft tumor models.
- Functionalized nanoparticles can be used as a diagnostic or therapeutic tool.
Technical Summary
Dr. Shuming Nie and his team have developed biocompatible and nontoxic nanoparticles for in vivo tumor targeting and detection based on pegylated gold particles and surface-enhanced Raman scattering (SERS). These SERS nanoparticles are significantly brighter than semiconductor quantum dots with light emission in the near infrared spectrum. Nanoparticles in this size range (~70 nm) are advantageous compared to more traditional technology because the large surface area of the particle allows for conjugation of multiple diagnostic (e.g., optical, radioisotopic, or magnetic) and therapeutic agents.
Patent Information
| App Type |
Country |
Serial No. |
Patent No. |
File Date |
Issued Date |
Patent Status |
| EP Registered Country |
United Kingdom |
08744924.5 |
2134642 |
4/2/2008 |
2/24/2016 |
Issued |
| Continuation |
United States |
13/680,524 |
10,137,208 |
11/19/2012 |
11/27/2018 |
Issued |
|
|
