Polymer Coated SERS Nanoparticle Tags


Nanoparticle for in vivo tumor targeting and detection.

Key Benefits

  • Large optical enhancements were achieved under in vivo conditions in live animals.
  • Conjugated nanoparticles were able to target tumor biomarkers on human cancer cells and in xenograft tumor models.
  • Functionalized nanoparticles can be used as a diagnostic or therapeutic tool.

Technical Summary

Dr. Shuming Nie and his team have developed biocompatible and nontoxic nanoparticles for in vivo tumor targeting and detection based on pegylated gold particles and surface-enhanced Raman scattering (SERS). These SERS nanoparticles are significantly brighter than semiconductor quantum dots with light emission in the near infrared spectrum. Nanoparticles in this size range (~70 nm) are advantageous compared to more traditional technology because the large surface area of the particle allows for conjugation of multiple diagnostic (e.g., optical, radioisotopic, or magnetic) and therapeutic agents.

Patent Information

App Type Country Serial No. Patent No. File Date Issued Date Patent Status
EP Registered Country United Kingdom 08744924.5 2134642 10/1/2009 2/24/2016 Issued
Continuation United States 13/680,524 10,137,208 11/19/2012 11/27/2018 Issued
Tech ID: 08025
Published: 2/24/2009