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Using a Theranostic for Imaging and Treating Glioma

Application A small molecule imaging agent for imaging gliomas. Key Benefits Potentially increased specificity and sensitivity compared to existing imaging agents. Market Summary Glioma is a common type of tumor originating in the brain, comprising about 30 percent of all brain and central nervous system tumors. Current technologies for...

Published: 5/13/2022 Contributor(s): Mark Goodman, Lanny Liebeskind, Hui Mao, Gouthami Pashikanti

Amino Acid-Derived Radiotracer Compounds for PET Cancer Imaging

Application New class of fluorine-18 labeled amino acid-derived radiotracer compounds for positron emission tomography (PET) cancer imaging. Key Benefits Next generation of cancer imaging agents. Enhanced sensitivity to detect glioblastoma, prostate cancer and other cancers. Market Summary PET imaging is a type of nuclear medicine procedure...

Published: 11/2/2020 Contributor(s): Mark Goodman, Lanny Liebeskind, Thomas Pickel

Dual Purpose Radiotracer for Renal Imaging

ApplicationRadioactive tracer with improved plasma clearance for use as either a planar or positron emission tomography (PET) renal imaging agent.Key BenefitsRapid renal excretion.Minimal localization at other body sites.More rapid blood clearance than current standard.Can be adapted for either standard planar or positron emission tomography (PET) imaging.Market...

Published: 6/20/2017 Contributor(s): Jeffrey Klenc, Malgorzata Lipowska, Andrew Taylor

LED Emitting Silica Nanoparticles

Application LED dye-linked silica nanoparticles with tunable size for imaging applications. Key Benefits Incorporation of a naphthalimide derivative greatly enhances photostability and increases pH tolerance. Large size range and easily tunable. Excited by visual light, 450-495 nm (blue) & emits visual wavelength, 545 nm (green). Particle can...

Published: 7/15/2013 Contributor(s): George Beck, Jr., Mervyn Neale Weitzmann, Shin Woo Ha, Jin-Kyu Lee, Hak-Sung Jung

Ubiquitin and Ubiquitin-Like Proteins (UBLs)-Derived Probes to Study Enzymatic Functions of Ubiquitination Proteins

Application Two series of probes that are derived from ubiquitin and UBLs to serve as research tools to identify and detect biological functions of ubiquitination/de-ubiquitination enzymes. Key Benefits Can monitor enzymatic activities of multiple deubiquitinating enzymes (DUBs) simultaneously. Able to identify novel ubiquitination/de-ubiquitination...

Published: 7/1/2013 Contributor(s): Keith Wilkinson

Real Time Imaging of HIV with a PET/CT Total Body Scan

Application PET-based imaging of HIV anatomical reservoir locations for health monitoring and determination of therapy effectiveness. Key Benefits The only in vivo method for visualizing sites of HIV. Compatible with existing PET/CT imaging system. Market Summary AIDS is a worldwide pandemic, with over 35 million people carrying active HIV infections....

Published: 6/21/2013 Contributor(s): Philip Santangelo, Francois Villinger

CRF-1 Receptor Antagonists for PET Imaging or as Potential Therapeutics

ApplicationSmall molecule corticotrophin releasing factor 1 (CRF-1) antagonists, for use as PET imaging agents or potential therapeutics for treating generalized anxiety disorder. Key BenefitsCan image CRF-1 receptor density and distribution via PET Potential antagonist and therapeutics for psychological disorders including anxiety and depression Technical...

Published: 9/6/2011 Contributor(s): Jeffrey Stehouwer, Mark Goodman, Clint Kilts, Charles Nemeroff

Tc-99m Nitrilotriacetic Acid (Tc-99m-NTA) for Renal Imaging and Measurement of Tubular Function

Application Diagnostic imaging of the kidneys for the determination of renal function. Key Benefits Renal tracer for measuring the effective renal plasma flow. 99mTc-labeled small molecule has renal clearance characteristics that are superior to currently available tracers. First-in-man studies have been performed with resulting image quality and...

Published: 4/29/2009 Contributor(s): Malgorzata Lipowska, Andrew Taylor, Luigi Marzilli

Polymer Coated SERS Nanoparticle Tags

Application Nanoparticle for in vivo tumor targeting and detection. Key Benefits Large optical enhancements were achieved under in vivo conditions in live animals. Conjugated nanoparticles were able to target tumor biomarkers on human cancer cells and in xenograft tumor models. Functionalized nanoparticles can be used as a diagnostic or therapeutic...

Published: 2/24/2009 Contributor(s): Ximei Qian, Dominic Ansari, Shuming Nie

A Potentially Imageable Fluorinated Anticancer Alkaloid

Application Synthesis of noscapine analogs and their use as cancer treatments, including drug resistant cancers. Key BenefitsEfficient, high yielding synthesis of noscapine derivatives. Selective for cancer cells over normal human cells.Technical Summary The effectiveness of microtubule-targeting drugs as treatments for cancer has been validated through...

Published: 2/24/2009 Contributor(s): Harish Joshi, Ritu Aneja

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