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Artificial Neural Network for Prediction of Clinical Outcomes
Application
A machine learning model to predict the need for ventriculoperitoneal shunt after posterior fossa tumor resection.
Key Benefits
Highly accurate prediction of post-surgical complications.
Reducing healthcare costs by predicting prognoses and increasing efficiency of post-surgical treatment.
Market Summary
Neurosurgical procedures...
Published: 7/30/2024
Contributor(s): Kimberly Hoang, Ali Alawieh, David Bray
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Multiple Organ Localization and Segmentation for Automatic Treatment Planning
Application
A software for automatic detecting and segmenting tumors and Organs at Risk (OAR) in medical images.
Key Benefits
Automatically detect and segment tumors and OARs.
Can detect multiple organs and generate their contour maps.
Market Summary
Radiation therapy (RT) is one of the most common treatment modalities for cancer and...
Published: 7/30/2024
Contributor(s): Xiaofeng Yang, Yang Lei, Tian Liu
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Novel Piperidine-Amide Derivatives as CXCR4 Modulators
Application
A new class of CXCR4 modulators for metastasis and inflammation.
Key Benefits
Selective for only one allosteric site on CXCR4.
Lower adverse effects.
Market Summary
Activation of the CXCR4 receptor triggers multiple signaling pathways that orchestrate cell migration, hematopoiesis and cell homing, and retention in the bone...
Published: 7/30/2024
Contributor(s): Hyunsuk Shim, Yoon Hyeun Oum
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An Algorithm for Optimized Patient-Specific Phase Selection During Stereotactic Body Radiation Therapy (SBRT)
Application
An algorithm for optimizing SBRT tumor targeting.
Key Benefits
Reduction in motion errors
Faster treatment planning
Applicable on different treatment modalities such as IMRT and VMAT
Minimize dose delivery to surrounding organs-at-risk
Does not rely on a physician’s subjective judgment
Market Summary
SBRT is a radiation...
Published: 10/17/2024
Contributor(s): Mohammad Khan, Jerome Carl Landry, Lei Zhu
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Combination Therapy to Overcome Resistance to Platinum-Based Chemotherapy
Application
MAST1 inhibitors to overcome resistance to platinum-based chemotherapy, exacerbated by dexamethasone co-administration.
Key Benefits
Co-administration of MAST1 inhibitor and MAST1-stabilizing protein inhibitor abrogates tumor resistance to cisplatin
MAST1 inhibitor, lestaurtinib, has previously reached phase III clinical trials and...
Published: 7/30/2024
Contributor(s): Sumin Kang, Jing Chen
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Drug Combination to Treat Lung Cancer Metastasis
Application
Combination product co-targeting PDH and GLUT1 to inhibit lung cancer metastasis.
Key Benefits
Combination of drugs exhibits greater synergism in cancer cell lines (H1299, 4T1, H1792).
Has potential to prevent metastasis in a variety of cancers.
Decreases both cell viability and invasive area.
Repurposed drugs.
Market Summary
Metastatic...
Published: 7/30/2024
Contributor(s): Malathy (mala) Shanmugam, Adam Marcus
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Strategy to Identify miRNAs for Disease Diagnosis
Application
Method to measure precursor and mature miRNA specifically.
Key Benefits
Unique primers can specifically identify miRNAs and precursor miRNAs by standard qRT-PCR without the requirement for an additional detection probe.
Allows for amplification and quantification of both mature miRNA and precursor miRNAs.
Potential technology to evaluate...
Published: 9/26/2024
Contributor(s): Wenming Li
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Hybrid Proton-Photon Inverse Optimization to Deliver Radiation Therapy
Application
Hybrid proton-photon inverse optimization method that synergizes proton and photon therapy with improved total optimization objectives for robust cancer treatment delivery.
Key Benefits
Improved planning target volume coverage and organ at risk sparing.
Reduced overall optimization values.
Less expensive treatment than proton therapy...
Published: 7/30/2024
Contributor(s): Hao Gao
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ADGRB3/BAI3 Knockout Mouse
ApplicationKnockout mouse models for adhesion G protein-coupled receptors B3, brain-specific angiogenesis inhibitor-3 (ADGRB3/BAI3) gene study.Technical SummaryEmory University researchers have developed a knockout mouse model for the ADGRB3/BAI3 gene. Mice were generated by CRISP/cas9 technology on C57Bl6 background. These mice can be used to study...
Published: 10/28/2024
Contributor(s): Erwin Van Meir
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Small Molecule Inhibitors of NADPH Oxidase 4 (NOX4) Signaling
Application
Small molecule inhibitors of NOX4 signaling with a wide array of therapeutic potential.
Key Benefits
Small molecule inhibitors of NOX4 signaling.
Low cytotoxicity.
Market Summary
The NADPH oxidase 4 (NOX4) has gained considerable and growing attention during the past years because of its potential key involvement in a variety of...
Published: 10/28/2024
Contributor(s): Bernard Lassegue, Kathy Griendling, David Brown, Qian Xu, Osman Guner, J. Phillip Bowen, Amol Kulkarni, E. Blake Watkins
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