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Multiple Organ Localization and Segmentation for Automatic Treatment Planning
­ Application A software for automatic detecting and segmenting tumors and Organs at Risk (OAR) in medical images. Key Benefits Automatically detect and segment tumors and OARs. Can detect multiple organs and generate their contour maps. Market Summary The National Cancer Institute estimates that in 2019 there were 53,000 new head and...
Published: 5/18/2022       Contributor(s): Xiaofeng Yang, Yang Lei, Tian Liu
Tumor Specific CD8 T Cell TCR Sequences of HPV-Positive Head and Neck Tumors
­ Application HPV-specific CD8 TCR sequences for the treatment of HPV-positive head and neck cancer by adoptive cell therapy. Key Benefits HPV tumor antigen set is specific for HPV-positive head and neck cancer. Targeting of ‘non-classical’ HPV antigens E2 and E5. Potential to synergize and complement HPV E6/7-specific TCR therapies...
Published: 5/18/2022       Contributor(s): Rafi Ahmed, Christiane Eberhardt, Andreas Wieland
CBCT-Guided Adaptive Photon and Proton Radiotherapy
­ Application Generating synthetic MRI images from CBCT images with deep learning. Key Benefits Generate high contrast MRI images from cone-beam CT images. High quality, high contrast images to enable precise radiation treatment. Market Summary Cone-beam computed tomography (CBCT) is an imaging method that produces 3D images of tissues...
Published: 5/18/2022       Contributor(s): Xiaofeng Yang, Yang Lei, Tian Liu, Jun Zhou
Method and Procedure to use 3D Skin Ultrasound to Enhance Cancer and Dermatology Procedures
­ Application A method for generating 3D ultrasound images of skin lesions to improve radiation and dermatology procedures. Key Benefits Generation of high-resolution 3D images of small skin lesions. Ability to work with a variety of high-frequency US probes. Provides guidance to surgeons performing dermatologic procedures. Provides guidance...
Published: 5/18/2022       Contributor(s): Mohammad Khan, Xiaofeng Yang, (Jiwoong) Jason Jeong
Novel Piperidine-Amide Derivatives as CXCR4 Modulators
­ Application A new class of CXCR4 modulators for metastasis and inflammation. Key Benefits Selective for only one allosteric site on CXCR4. Lower adverse effects. Market Summary Multiple myeloma, acute myeloid leukemia, HIV, and rheumatoid arthritis all involve the G-protein receptor CXCR4. Currently, there is only one FDA approved CXCR4...
Published: 5/17/2022       Contributor(s): Hyunsuk Shim, Yoon Oum
HTiP: High-Throughput Immunomodulator Phenotypic Screening Platform
­ Application High Throughput Screening for identifying effective immuno-modulators. Key Benefits HT screening platform replicating complex immune medicated response to facilitate discovery of small molecule immunomodulatory agents. Simplicity and dual readouts of the design enable the screening of large chemical libraries to identify compounds...
Published: 5/17/2022       Contributor(s): Xiulei Mo, Haian Fu
Multifunctional Drug and Immune Modulator Delivery Nanoparticles for the Treatment of Cancer Patients with Comorbid Atherosclerosis
­ Application A multifunctional immuno-therapy nanoparticle (PD1Y-HANP/Avasimbe) that has ability of targeting and inhibiting immune checkpoint PDL-1 while producing therapeutic effects on tumors and atherosclerosis. Key Benefits Multifunctional immunotherapy for cancer patients with atherosclerosis. Shown to inhibit tumor growth and prevention...
Published: 5/13/2022       Contributor(s): Lily Yang, Lei Zhu
Patient-Specific Replan Probability Prediction for Radiotherapy Treatment
­ Application A replan-probability-constrained optimization algorithm for patient-specific treatment plan optimization to reduce replan rates in radiation therapy. Key Benefits Ability to predict if a head and neck cancer patient will need a re-plan. Determines the statistical significance of dosimetry and clinical features. Market Summary Worldwide,...
Published: 5/13/2022       Contributor(s): Jun Zhou, Mark McDonald, Tian Liu, Chih-Wei Chang, Duncan Bohannon
Using a Theranostic for Imaging and Treating Glioma
­ Application A small molecule imaging agent for imaging gliomas. Key Benefits Potentially increased specificity and sensitivity compared to existing imaging agents. Market Summary Glioma is a common type of tumor originating in the brain, comprising about 30 percent of all brain and central nervous system tumors. Current technologies for...
Published: 5/13/2022       Contributor(s): Mark Goodman, Lanny Liebeskind, Hui Mao, Gouthami Pashikanti
Targeting SREBP1 for Managing Acquired Resistance to Osimertinib/AZD9291 and Other EGFR Inhibitors for Non-small Cell Lung Cancer Treatment
­ Application Small molecule combination therapy (adjuvant, sensitizing agent) for Osimertinib (to treat non-small cell lung cancer with common EGFR activating mutations and T790M resistant mutation). Key Benefits Therapy against EGFR-TKI resistant tumors with mutant EGFR (e.g., T790M). Market Summary Non-small cell lung cancer (NSCLC)...
Published: 5/13/2022       Contributor(s): Shi-Yong Sun, Zhen Chen
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