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Chemotherapy Dose Calculator
Application Software to calculate doses for more effective and safe clinical trial design. Key Benefits Intuitive, user-friendly software design. Flexible parameter inputs and easily interpreted results. Provides simulations to estimate recommended maximum tolerated dose (MTD). Market Summary Before entry to commercial market, novel therapeutics...
Published: 2/20/2020       Inventor(s): Zhengjia (nelson) Chen, Youyun Zheng, Michael (Mike) Kutner
Combination Therapy to Treat Pediatric Brain Tumor
Application Combination therapy (inhibition of STAT3 and YB-1) to treat medulloblastoma. Key Benefits Drug combination targets cancer stem cells. Increased apoptosis of cancer cells compared to current chemotherapeutic agents. Market Summary Medulloblastoma (MB) is the most common cancerous brain tumor that affects children and survival rates...
Published: 1/28/2020       Inventor(s): Tobey MacDonald, Anna Kenney, James Felker, Abhinav Dey
Strategy to Identify miRNAs for Disease Diagnosis
Application Method to measure precursor and mature miRNA specifically. Key Benefits Unique primers can specifically identify miRNAs and precursor miRNAs by standard qRT-PCR without the requirement for an additional detection probe. Allows for amplification and quantification of both mature miRNA and precursor miRNAs. Potential technology to evaluate...
Published: 1/22/2020       Inventor(s): Wenming Li
Small Molecule for Treatment-Resistant Lung Cancer
Application Small molecule agonist for treating cancers involving KRAS mutations. Key Benefits Specifically targets mutant KRAS in non-small-cell lung carcinoma (NSCLC). Selective for mutant KRAS lung cancer cells over normal cells. Non-toxic to normal cells. Market Summary Lung cancer is the leading cause of cancer death in the US. Lung cancer...
Published: 1/14/2020       Inventor(s): Xingming Deng
High-Resolution Field Inhomogeneity Correction for Magnetic Resonance Spectroscopy
Application Post-processing algorithm to correct field inhomogeneity in MR spectroscopy. Key Benefits Subvoxel field inhomogeneity correction enables CEST magnetic resonance imaging (MRI) Z-spectrum from body tissues where shimming is challenging. Intravoxel field inhomogeneity correction enables MR spectroscopy (MRS) and MR spectroscopy imaging...
Published: 1/13/2020       Inventor(s): Phillip Zhe Sun
Combination Therapy Using Small Molecule Conjugation to Reovirus for TNBC Treatment
ApplicationSmall molecule inhibitor doxorubicin hydrochloride (Dox) conjugated to reovirus for targeted combination therapy of triple-negative breast cancer (TNBC).Key BenefitsTargeted treatment that directly infects and kills breast cancer cells.Increased cytopathicity, cytotoxicity and faster induction of cell death than virus alone.Enhanced selective...
Published: 10/11/2019       Inventor(s): Bernardo Mainou, Roxana Rodriguez, Angela Berger
Hybrid Proton-Photon Inverse Optimization to Deliver Radiation Therapy
Application Hybrid proton-photon inverse optimization method that synergizes proton and photon therapy with improved total optimization objectives for robust cancer treatment delivery. Key Benefits Improved planning target volume coverage and organ at risk sparing. Reduced overall optimization values. Less expensive treatment than proton therapy...
Published: 10/11/2019       Inventor(s): Hao Gao
Targeted Anti-Cancer Nanoparticle Therapy
Application A drug-carrying nanoparticle that selectively targets cancer cells. Key Benefits Incorporates an already proven anti-cancer therapeutic. Increases deliverability. Targets cancer cells. Market Summary Tris DBA palladium has been shown to have anti-cancer activity against melanoma and pancreatic cancer. However, Tris DBA has not...
Published: 9/9/2019       Inventor(s): Jack Arbiser, Lily Yang
Beta Blocker Isomers as Angiogenesis Inhibitors
Application β-blocker inactive form of propranolol for treatment of angiogenic disease. Key Benefits Reduced side-effects, such as low blood pressure and low blood sugar. Increased anti-angiogenic activity compared to the active isoform. Market Summary Angiogenesis is the growth of blood vessels from the existing vasculature. While it is a...
Published: 7/29/2019       Inventor(s): Jack Arbiser
ADGRB3/BAI3 Knockout Mouse
ApplicationKnockout mouse models for adhesion G protein-coupled receptors B3, brain-specific angiogenesis inhibitor-3 (ADGRB3/BAI3) gene study.Technical SummaryEmory University researchers have developed a knockout mouse model for the ADGRB3/BAI3 gene. Mice were generated by CRISP/cas9 technology on C57Bl6 background. These mice can be used to study...
Published: 7/9/2019       Inventor(s): Erwin Van Meir
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