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Artificial Neural Network for Prediction of Clinical Outcomes
Application
A machine learning model to predict the need for ventriculoperitoneal shunt after posterior fossa tumor resection.
Key Benefits
Highly accurate prediction of post-surgical complications.
Reducing healthcare costs by predicting prognoses and increasing efficiency of post-surgical treatment.
Market Summary
Neurosurgical procedures...
Published: 7/30/2024
Contributor(s): Kimberly Hoang, Ali Alawieh, David Bray
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Combination Therapy to Overcome Resistance to Platinum-Based Chemotherapy
Application
MAST1 inhibitors to overcome resistance to platinum-based chemotherapy, exacerbated by dexamethasone co-administration.
Key Benefits
Co-administration of MAST1 inhibitor and MAST1-stabilizing protein inhibitor abrogates tumor resistance to cisplatin
MAST1 inhibitor, lestaurtinib, has previously reached phase III clinical trials and...
Published: 7/30/2024
Contributor(s): Sumin Kang, Jing Chen
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Strategy to Identify miRNAs for Disease Diagnosis
Application
Method to measure precursor and mature miRNA specifically.
Key Benefits
Unique primers can specifically identify miRNAs and precursor miRNAs by standard qRT-PCR without the requirement for an additional detection probe.
Allows for amplification and quantification of both mature miRNA and precursor miRNAs.
Potential technology to evaluate...
Published: 9/26/2024
Contributor(s): Wenming Li
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Hybrid Proton-Photon Inverse Optimization to Deliver Radiation Therapy
Application
Hybrid proton-photon inverse optimization method that synergizes proton and photon therapy with improved total optimization objectives for robust cancer treatment delivery.
Key Benefits
Improved planning target volume coverage and organ at risk sparing.
Reduced overall optimization values.
Less expensive treatment than proton therapy...
Published: 7/30/2024
Contributor(s): Hao Gao
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ADGRB3/BAI3 Knockout Mouse
ApplicationKnockout mouse models for adhesion G protein-coupled receptors B3, brain-specific angiogenesis inhibitor-3 (ADGRB3/BAI3) gene study.Technical SummaryEmory University researchers have developed a knockout mouse model for the ADGRB3/BAI3 gene. Mice were generated by CRISP/cas9 technology on C57Bl6 background. These mice can be used to study...
Published: 10/28/2024
Contributor(s): Erwin Van Meir
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Software for Reviewing Patients in Radiotherapy Chart Rounds
ApplicationSoftware program to help physicians streamline peer-review for radiotherapy patients during chart rounds.Key BenefitsIncreases efficiency and reduces time for reviewing patient chart records.Enables faster detection of errors and deviations.Provides standardized treatment for all patients.Improves quality and safety of cancer patient treatment.Market...
Published: 7/30/2024
Contributor(s): Eduard Schreibmann, Natia Esiashvili
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Human Osteopontin Knock-in Mouse Line
ApplicationMouse lines expressing isoforms a, b, and c of the Human Osteopontin (OPN) protein for cancer research.Technical SummaryThe murine OPN is not subject to splicing and therefore does not express different isoforms. Human cancers express splice variants. Emory researchers developed these mouse models to express each isoform independently from...
Published: 9/26/2024
Contributor(s): Alicia Lyle
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Small Molecule NOX Inhibitors of Human Melanoma Cell Proliferation
Application
Triphenylmethane small molecules inhibiting NADPH oxidase (NOX) for the anti-proliferation of melanoma tumor cells.
Key Benefits
Modifies molecular interactions with cellular proteins, reducing cell tumor growth.
Compounds are capable of inhibiting cell proliferation to a greater extent than current competing NOX inhibitors for melanoma...
Published: 9/26/2024
Contributor(s): Jack Arbiser
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PI3Kα Inhibitors for the Treatment of Cancer
Application
Compounds that inhibit the kinase activity of phospoinostidie 3-kinase (PI3Kα) for the treatment of cancer.
Key Benefits
Potential therapeutic targeted to pathway without a clinically approved inhibitor.
Provides a useful pharmacological probe for research purposes.
Market Summary
In order to grow, cancer cells must have the...
Published: 11/20/2024
Contributor(s): Qi Shi, Thomas Kaiser, Dennis Liotta, James Snyder, Zackery Dentmon, John Diraddo
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Imaging Software for Individualized Treatment with Radiotherapy
Application
Predictive mathematical modeling to individualize radiation treatment margins for prostate cancer patients treated with image-guided radiation therapy (IGRT).
Key Benefits
Predicts patient specific prostate motion for treatment planning with multi-fractionated intensity modulated radiotherapy (IMRT).
More accurate than conventional...
Published: 10/17/2024
Contributor(s): Mohammad Khan, Michael Howard, Laurence Miller
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