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Multiple Organ Localization and Segmentation for Automatic Treatment Planning
Application
A software for automatic detecting and segmenting tumors and Organs at Risk (OAR) in medical images.
Key Benefits
Automatically detect and segment tumors and OARs.
Can detect multiple organs and generate their contour maps.
Market Summary
The National Cancer Institute estimates that in 2019 there were 53,000 new head and...
Published: 5/18/2022
Contributor(s): Xiaofeng Yang, Yang Lei, Tian Liu
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Tumor Specific CD8 T Cell TCR Sequences of HPV-Positive Head and Neck Tumors
Application
HPV-specific CD8 TCR sequences for the treatment of HPV-positive head and neck cancer by adoptive cell therapy.
Key Benefits
HPV tumor antigen set is specific for HPV-positive head and neck cancer.
Targeting of ‘non-classical’ HPV antigens E2 and E5.
Potential to synergize and complement HPV E6/7-specific TCR therapies...
Published: 5/18/2022
Contributor(s): Rafi Ahmed, Christiane Eberhardt, Andreas Wieland
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CBCT-Guided Adaptive Photon and Proton Radiotherapy
Application
Generating synthetic MRI images from CBCT images with deep learning.
Key Benefits
Generate high contrast MRI images from cone-beam CT images.
High quality, high contrast images to enable precise radiation treatment.
Market Summary
Cone-beam computed tomography (CBCT) is an imaging method that produces 3D images of tissues...
Published: 5/18/2022
Contributor(s): Xiaofeng Yang, Yang Lei, Tian Liu, Jun Zhou
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Method and Procedure to use 3D Skin Ultrasound to Enhance Cancer and Dermatology Procedures
Application
A method for generating 3D ultrasound images of skin lesions to improve radiation and dermatology procedures.
Key Benefits
Generation of high-resolution 3D images of small skin lesions.
Ability to work with a variety of high-frequency US probes.
Provides guidance to surgeons performing dermatologic procedures.
Provides guidance...
Published: 5/18/2022
Contributor(s): Mohammad Khan, Xiaofeng Yang, (Jiwoong) Jason Jeong
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Novel Piperidine-Amide Derivatives as CXCR4 Modulators
Application
A new class of CXCR4 modulators for metastasis and inflammation.
Key Benefits
Selective for only one allosteric site on CXCR4.
Lower adverse effects.
Market Summary
Multiple myeloma, acute myeloid leukemia, HIV, and rheumatoid arthritis all involve the G-protein receptor CXCR4. Currently, there is only one FDA approved CXCR4...
Published: 5/17/2022
Contributor(s): Hyunsuk Shim, Yoon Oum
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HTiP: High-Throughput Immunomodulator Phenotypic Screening Platform
Application
High Throughput Screening for identifying effective immuno-modulators.
Key Benefits
HT screening platform replicating complex immune medicated response to facilitate discovery of small molecule immunomodulatory agents.
Simplicity and dual readouts of the design enable the screening of large chemical libraries to identify compounds...
Published: 5/17/2022
Contributor(s): Xiulei Mo, Haian Fu
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Multifunctional Drug and Immune Modulator Delivery Nanoparticles for the Treatment of Cancer Patients with Comorbid Atherosclerosis
Application
A multifunctional immuno-therapy nanoparticle (PD1Y-HANP/Avasimbe) that has ability of targeting and inhibiting immune checkpoint PDL-1 while producing therapeutic effects on tumors and atherosclerosis.
Key Benefits
Multifunctional immunotherapy for cancer patients with atherosclerosis.
Shown to inhibit tumor growth and prevention...
Published: 5/13/2022
Contributor(s): Lily Yang, Lei Zhu
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Patient-Specific Replan Probability Prediction for Radiotherapy Treatment
Application
A replan-probability-constrained optimization algorithm for patient-specific treatment plan optimization to reduce replan rates in radiation therapy.
Key Benefits
Ability to predict if a head and neck cancer patient will need a re-plan.
Determines the statistical significance of dosimetry and clinical features.
Market Summary
Worldwide,...
Published: 5/13/2022
Contributor(s): Jun Zhou, Mark McDonald, Tian Liu, Chih-Wei Chang, Duncan Bohannon
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Using a Theranostic for Imaging and Treating Glioma
Application
A small molecule imaging agent for imaging gliomas.
Key Benefits
Potentially increased specificity and sensitivity compared to existing imaging agents.
Market Summary
Glioma is a common type of tumor originating in the brain, comprising about 30 percent of all brain and central nervous system tumors. Current technologies for...
Published: 5/13/2022
Contributor(s): Mark Goodman, Lanny Liebeskind, Hui Mao, Gouthami Pashikanti
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Targeting SREBP1 for Managing Acquired Resistance to Osimertinib/AZD9291 and Other EGFR Inhibitors for Non-small Cell Lung Cancer Treatment
Application
Small molecule combination therapy (adjuvant, sensitizing agent) for Osimertinib (to treat non-small cell lung cancer with common EGFR activating mutations and T790M resistant mutation).
Key Benefits
Therapy against EGFR-TKI resistant tumors with mutant EGFR (e.g., T790M).
Market Summary
Non-small cell lung cancer (NSCLC)...
Published: 5/13/2022
Contributor(s): Shi-Yong Sun, Zhen Chen
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Emory UniversityOffice of Technology Transfer