Technology Listings


Desulfitative Redox Catalysis Method for Production of Amide and Peptide Linkages

Application

An efficient and economic catalytic process for forming amide and peptide compounds.

Key Benefits
  • Uses more inexpensive reagents compared to other methods.
  • Amide/peptide bond is generated in high yield at or near ambient temperature.
  • Mild reaction conditions prevent generation of impurities.
Market Summary

Peptide and amide linkages are important in organic chemical manufacturing, plastics and resin manufacturing, synthetic biology, pharmaceuticals and peptide therapeutics, catalysts and catalysis regeneration, as well as active pharmaceuticals. The current methods for producing amide and peptide linkages are inefficient. Some syntheses of amide and peptide linkages take place at high temperatures (>200°C), which lowers production efficiency by damaging the reactant molecules. Others require costly reagents to produce these linkages, form undesirable side products, and are consumed during the reaction. There is a growing need for more efficient and cost-effective methods for producing amide and peptide linkages.

Technical Summary

Emory inventors have designed a novel, generalized method of synthesizing peptide and amide linkages. This process offers a simple and efficient means of activating a carboxylic acid group through catalytic redox dehydration. The activated carboxylic acid reacts with amines in open air. This method can be modified to generate many different types of peptide and amide linkages. The method uses inexpensive reagents. This synthesis method also utilizes mild reaction conditions, producing fewer side products that must otherwise be removed by extensive purification.

Developmental Stage

This method has been tested in small scale production of compounds.

Patent Information
App Type Country Serial No. Patent No. File Date Issued Date Expire Date Patent Status
Nationalized PCT - United States United States 15/028,205 9,700,881 4/8/2016 7/11/2017 10/8/2034 Issued
Tech ID: 14014
Published: 11/16/2017
Category
Non-Therapeutics
Drug Discovery

Contact
Hyeon (Sean) Kim
Licensing Associate
Emory University
404-727-7218
hkim70@emory.edu

Inventor(s)
Lanny Liebeskind
Matthew Lindale

Keywords
Chemistry
Enzyme/Protein