An efficient and economic catalytic process for forming amide and peptide compounds.
- Uses more inexpensive reagents compared to other methods.
- Amide/peptide bond is generated in high yield at or near ambient temperature.
- Mild reaction conditions prevent generation of impurities.
Peptide and amide linkages are important in organic chemical manufacturing, plastics and resin manufacturing, synthetic biology, pharmaceuticals and peptide therapeutics, catalysts and catalysis regeneration, as well as active pharmaceuticals. The current methods for producing amide and peptide linkages are inefficient. Some syntheses of amide and peptide linkages take place at high temperatures (>200°C), which lowers production efficiency by damaging the reactant molecules. Others require costly reagents to produce these linkages, form undesirable side products, and are consumed during the reaction. There is a growing need for more efficient and cost-effective methods for producing amide and peptide linkages.
Emory inventors have designed a novel, generalized method of synthesizing peptide and amide linkages. This process offers a simple and efficient means of activating a carboxylic acid group through catalytic redox dehydration. The activated carboxylic acid reacts with amines in open air. This method can be modified to generate many different types of peptide and amide linkages. The method uses inexpensive reagents. This synthesis method also utilizes mild reaction conditions, producing fewer side products that must otherwise be removed by extensive purification.
This method has been tested in small scale production of compounds.