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HTiP: High-Throughput Immunomodulator Phenotypic Screening Platform
­ Application High Throughput Screening for identifying effective immuno-modulators. Key Benefits HT screening platform replicating complex immune medicated response to facilitate discovery of small molecule immunomodulatory agents. Simplicity and dual readouts of the design enable the screening of large chemical libraries to identify compounds...
Published: 5/17/2022       Contributor(s): Xiulei Mo, Haian Fu
Multifunctional Drug and Immune Modulator Delivery Nanoparticles for the Treatment of Cancer Patients with Comorbid Atherosclerosis
­ Application A multifunctional immuno-therapy nanoparticle (PD1Y-HANP/Avasimbe) that has ability of targeting and inhibiting immune checkpoint PDL-1 while producing therapeutic effects on tumors and atherosclerosis. Key Benefits Multifunctional immunotherapy for cancer patients with atherosclerosis. Shown to inhibit tumor growth and prevention...
Published: 5/13/2022       Contributor(s): Lily Yang, Lei Zhu
Using a Theranostic for Imaging and Treating Glioma
­ Application A small molecule imaging agent for imaging gliomas. Key Benefits Potentially increased specificity and sensitivity compared to existing imaging agents. Market Summary Glioma is a common type of tumor originating in the brain, comprising about 30 percent of all brain and central nervous system tumors. Current technologies for...
Published: 5/13/2022       Contributor(s): Mark Goodman, Lanny Liebeskind, Hui Mao, Gouthami Pashikanti
Mitigation of Negative Effects of Melphalan on Cardiomyocytes with N-acetyl-L-cysteine (NAC) Treatment
­ Application NAC (N-acetyl-L-cystine) as an antioxidant to reduce chemotherapy induced oxidative stress and cardiotoxicity. Key Benefits Mitigates cardiotoxic side effects of alkylating agent, melphalan in human cardiomyocytes. Market Summary Melphalan is a chemotherapeutic commonly used to treat various cancers including multiple myeloma,...
Published: 5/13/2022       Contributor(s): Chunhui Xu, Anant Mandawat, Rui Liu
Small Molecule Compound to Treat Neurological Diseases
­ Application Neurological disease treatment. Key Benefits Exemplary compound EU1180-490 is a potent and selective potentiator of GluN1/GluN3 NMDARs. The compound has excellent Lipinski drug-like properties including low molecular weight and cLogP, as well as water solubility. The initial studies have determined that the compound can penetrate...
Published: 5/13/2022       Contributor(s): Dennis Liotta, Stephen Traynelis, Hongjie Yuan, Matthew Epplin, Samantha Summer, David Menaldino, Leon Jacobs, Adam McCallum
SARS-CoV-2 Subgenomic Replicon (SARS2-Rn)
­ Application A series of SARS-CoV-2 sub-genomic replicons as artificial bacterial chromosomes for the screening of SARS-CoV-2 in studies such as drug discovery and inhibitors assay. Key Benefits Can be used at a lower biosafety level than non-artificial copies of SARS-CoV-2. Can be used for high throughput screening and characterization...
Published: 4/19/2022       Contributor(s): Stefan Sarafianos, Shuiyun Lan
Serological Test for SARS-CoV-2
­ Application Clinical assay for detecting SARS-CoV-2 neutralizing antibodies. Key Benefits Highly specific and sensitive. Fewer false positives than commercially available tests. Market Summary SARS-CoV-2 is currently causing a devastating pandemic and there is a pressing need to understand the dynamics, specificity, and neutralizing...
Published: 1/24/2022       Contributor(s): Rafi Ahmed, Mehul Suthar, John Roback, Jens Wrammert, Robert Kauffman
KRAS Mutant Protein-Protein Interaction Targets and Inhibitors for Cancer Therapy
­ Application Immunotherapeutic agent and biosensor for KRASG12V mutation in tumor cells. Key Benefits First in class, targeted immunotherapy for patients presented with KRASG12V mutation. Attenuates immune suppression associated with KRASG12V-positive cancers. Market Summary The KRASG12V mutation, representing 85% of all cancer mutations,...
Published: 1/7/2022       Contributor(s): Haian Fu, Cong Tang, Xiulei Mo
Small Molecule TrkB Agonist to Prevent Blindness from Eye Injuries
Application Small molecule HIOC derivatives as a therapeutic for preventing vision loss in traumatic eye injuries. Key Benefits Reduces blindness in a model of traumatic optical injury. May be administered systemically and penetrates tissues in and adjacent to the brain. This treatment method has potential for indications outside of retinal injury. Market...
Published: 5/5/2021       Contributor(s): Paul Iuvone, Frank Mcdonald, Christopher Walker
Engineering Tighter Binding Spherical Nucleic Acids
Application Method to enhance the affinity of spherical nucleic acids for their targets. Key Benefits Facile method for molecular printing on surface of NP. Massive improvement of SNA’s binding affinity to the target can provide strategies in applications for therapeutics and diagnostics. May maximize DNA density on the NP surface. Market...
Published: 11/2/2020       Contributor(s): Brendan Deal, Khalid Salaita
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