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HTiP: High-Throughput Immunomodulator Phenotypic Screening Platform
Application
High Throughput Screening for identifying effective immuno-modulators.
Key Benefits
HT screening platform replicating complex immune medicated response to facilitate discovery of small molecule immunomodulatory agents.
Simplicity and dual readouts of the design enable the screening of large chemical libraries to identify compounds...
Published: 5/17/2022
Contributor(s): Xiulei Mo, Haian Fu
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Multifunctional Drug and Immune Modulator Delivery Nanoparticles for the Treatment of Cancer Patients with Comorbid Atherosclerosis
Application
A multifunctional immuno-therapy nanoparticle (PD1Y-HANP/Avasimbe) that has ability of targeting and inhibiting immune checkpoint PDL-1 while producing therapeutic effects on tumors and atherosclerosis.
Key Benefits
Multifunctional immunotherapy for cancer patients with atherosclerosis.
Shown to inhibit tumor growth and prevention...
Published: 5/13/2022
Contributor(s): Lily Yang, Lei Zhu
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Using a Theranostic for Imaging and Treating Glioma
Application
A small molecule imaging agent for imaging gliomas.
Key Benefits
Potentially increased specificity and sensitivity compared to existing imaging agents.
Market Summary
Glioma is a common type of tumor originating in the brain, comprising about 30 percent of all brain and central nervous system tumors. Current technologies for...
Published: 5/13/2022
Contributor(s): Mark Goodman, Lanny Liebeskind, Hui Mao, Gouthami Pashikanti
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Mitigation of Negative Effects of Melphalan on Cardiomyocytes with N-acetyl-L-cysteine (NAC) Treatment
Application
NAC (N-acetyl-L-cystine) as an antioxidant to reduce chemotherapy induced oxidative stress and cardiotoxicity.
Key Benefits
Mitigates cardiotoxic side effects of alkylating agent, melphalan in human cardiomyocytes.
Market Summary
Melphalan is a chemotherapeutic commonly used to treat various cancers including multiple myeloma,...
Published: 5/13/2022
Contributor(s): Chunhui Xu, Anant Mandawat, Rui Liu
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Small Molecule Compound to Treat Neurological Diseases
Application
Neurological disease treatment.
Key Benefits
Exemplary compound EU1180-490 is a potent and selective potentiator of GluN1/GluN3 NMDARs.
The compound has excellent Lipinski drug-like properties including low molecular weight and cLogP, as well as water solubility.
The initial studies have determined that the compound can penetrate...
Published: 5/13/2022
Contributor(s): Dennis Liotta, Stephen Traynelis, Hongjie Yuan, Matthew Epplin, Samantha Summer, David Menaldino, Leon Jacobs, Adam McCallum
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SARS-CoV-2 Subgenomic Replicon (SARS2-Rn)
Application
A series of SARS-CoV-2 sub-genomic replicons as artificial bacterial chromosomes for the screening of SARS-CoV-2 in studies such as drug discovery and inhibitors assay.
Key Benefits
Can be used at a lower biosafety level than non-artificial copies of SARS-CoV-2.
Can be used for high throughput screening and characterization...
Published: 4/19/2022
Contributor(s): Stefan Sarafianos, Shuiyun Lan
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Serological Test for SARS-CoV-2
Application
Clinical assay for detecting SARS-CoV-2 neutralizing antibodies.
Key Benefits
Highly specific and sensitive.
Fewer false positives than commercially available tests.
Market Summary
SARS-CoV-2 is currently causing a devastating pandemic and there is a pressing need to understand the dynamics, specificity, and neutralizing...
Published: 1/24/2022
Contributor(s): Rafi Ahmed, Mehul Suthar, John Roback, Jens Wrammert, Robert Kauffman
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KRAS Mutant Protein-Protein Interaction Targets and Inhibitors for Cancer Therapy
Application
Immunotherapeutic agent and biosensor for KRASG12V mutation in tumor cells.
Key Benefits
First in class, targeted immunotherapy for patients presented with KRASG12V mutation.
Attenuates immune suppression associated with KRASG12V-positive cancers.
Market Summary
The KRASG12V mutation, representing 85% of all cancer mutations,...
Published: 1/7/2022
Contributor(s): Haian Fu, Cong Tang, Xiulei Mo
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Small Molecule TrkB Agonist to Prevent Blindness from Eye Injuries
Application
Small molecule HIOC derivatives as a therapeutic for preventing vision loss in traumatic eye injuries.
Key Benefits
Reduces blindness in a model of traumatic optical injury.
May be administered systemically and penetrates tissues in and adjacent to the brain.
This treatment method has potential for indications outside of retinal injury.
Market...
Published: 5/5/2021
Contributor(s): Paul Iuvone, Frank Mcdonald, Christopher Walker
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Engineering Tighter Binding Spherical Nucleic Acids
Application
Method to enhance the affinity of spherical nucleic acids for their targets.
Key Benefits
Facile method for molecular printing on surface of NP.
Massive improvement of SNA’s binding affinity to the target can provide strategies in applications for therapeutics and diagnostics.
May maximize DNA density on the NP surface.
Market...
Published: 11/2/2020
Contributor(s): Brendan Deal, Khalid Salaita
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Emory UniversityOffice of Technology Transfer