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Small Molecule TrkB Agonist to Prevent Blindness from Eye Injuries
Application Small molecule HIOC derivatives as a therapeutic for preventing vision loss in traumatic eye injuries. Key Benefits Reduces blindness in a model of traumatic optical injury. May be administered systemically and penetrates tissues in and adjacent to the brain. This treatment method has potential for indications outside of retinal injury. Market...
Published: 5/5/2021       Contributor(s): Paul Iuvone, Frank Mcdonald, Christopher Walker
Engineering Tighter Binding Spherical Nucleic Acids
Application Method to enhance the affinity of spherical nucleic acids for their targets. Key Benefits Facile method for molecular printing on surface of NP. Massive improvement of SNA’s binding affinity to the target can provide strategies in applications for therapeutics and diagnostics. May maximize DNA density on the NP surface. Market...
Published: 11/2/2020       Contributor(s): Brendan Deal, Khalid Salaita
Small Molecule for Treatment or Prevention of Uremic Cardiomyopathy
Application Small molecule urea transporter (UT) inhibitors to treat or prevent conditions associated with chronic kidney disease. Key Benefits Provides a cardio-protective benefit in CKD patients. Suppresses cardiac hypertrophy and fibrosis. Market Summary Cardiovascular complications commonly occur in patients with chronic kidney disease...
Published: 11/2/2020       Contributor(s): Jeff Sands, Janet Klein, Xiaonan Wang
Galectin-9 Directed CAR T-cells for Overcoming Resistance to Chemotherapy in Hematological Malignancies
Application Anti-human Galectin-9-directed chimeric antigen receptor (CAR) T-cells for treatment of hematological malignancies (B-ALL, T-ALL, and DLBCL) in normal, overweight, and obese patients. Key Benefits Can be used as a stand-alone or in-combination product to treat patients with hematological malignancies, particularly overweight and obese...
Published: 10/13/2020       Contributor(s): Curtis Henry, Miyoung (Mi-Young) Lee, Sunil Raikar, Jamie Hamilton, Anthony Ross
Plant-Based Small Molecules for Treatment of MRSA Infections
Application Small molecule inhibitor of the accessory gene regulator (agr) for the treatment of methicillin-resistant Staphylococcus aureus(MRSA) infections. Key Benefits Novel mechanism of action for the treatment of MRSA infections. Inhibits all four S. aureus agr types (I-IV) Targeted system is non-essential for S. aureus growth, creating...
Published: 4/23/2020       Contributor(s): Cassandra Quave, Akram Salam, Gina Porras Brenes, James Lyles
Small Molecule Inhibitor of Akt Activity for Lung Cancer Treatment
Application Mcl-1/Akt targeting small molecule with strong antitumor activity against lung cancer. Key Benefits Novel molecule. Novel target presents new path to lung cancer treatment. Potentially extend survival rate of lung cancer patients. Market Summary Lung cancer is the number one leading cause of death among cancer patients. Patients...
Published: 4/17/2020       Contributor(s): Xingming Deng
Small Molecule for Treatment-Resistant Lung Cancer
Application Small molecule agonist for treating cancers involving KRAS mutations. Key Benefits Specifically targets mutant KRAS in non-small-cell lung carcinoma (NSCLC). Selective for mutant KRAS lung cancer cells over normal cells. Non-toxic to normal cells. Market Summary Lung cancer is the leading cause of cancer death in the US. Lung cancer...
Published: 1/14/2020       Contributor(s): Xingming Deng
Subunit-Selective NMDAR Antagonists for Treatment of Neurological Disorders
Application GluN2C/2D selective inhibitors that modulate N-methyl-D-aspartic acid receptors (NMDAR) in a subunit-selective manner for treatment of neurological disorders. Key Benefits Specifically targets NMDARs that contain the GluN2C/2D subunit. Higher potency and efficacy compared to previously reported GluN2C/2D-selective modulators. Market...
Published: 1/10/2020       Contributor(s): Yao Jing, Stephen Traynelis, Dennis Liotta
Antibacterial Treatment for Gum Disease
Application Small molecules that inhibit oral bacteria growth to treat gum disease and prevent tooth decay. Key Benefits Inhibits S. mutans biofilm formation. Reduces the number of bacteria by working in a bactericidal, as opposed to bacteriostatic, manner. Market Summary Periodontitis is a gum infection in which gums become inflamed due to...
Published: 12/2/2019       Contributor(s): William (Bill) Wuest, Amy Solinski, Marisa Kozlowski, Young Eun Lee, Thomas Paniak, Cristian Ochoa
TGFβR3-based Biomaterial to Treat Bone Damage
Application PEG-MAL (Poly(ethylene glycol) methyl ether maleimide) polymer gel composition containing soluble TGFβ3R or embedded with modified TGFβ3R over-expressing cells for bone growth and repair therapy. Key Benefits Targets a non-BMP2 signaling pathway to improve BMP signaling. •Avoids complications associated with BMP2. Market...
Published: 9/20/2019       Contributor(s): Steven Goudy
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