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Enhanced Delivery and Efficacy of Antisense Drugs via Covalently Linked Nanodisc Scaffolds
Application
A synthetic nanodisc (ND) scaffold for delivering antisense oligonucleotides (ASOs) for the treatment of disease.
Key Benefits
Improved cellular uptake and protein suppression using antisense oligos.
Longer ASO half-life compared to other ASO delivery methods.
Potential to overcome the delivery and efficacy challenges using ASOs for...
Published: 4/11/2024
Contributor(s): Khalid Salaita, Radhika Sharma
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Cost-Effective Catalysts for Industrial Chemical Applications
Application
A cost-effective catalyst for industrial chemical applications as an alternative to expensive rhodium-dependent dirhodium catalysts.
Key Benefits
Alternative catalysts to dirhodium using a straightforward synthesis process.
Preliminary data show the ability to self-assemble in a similar manner to dirhodium compounds.
Significantly...
Published: 3/1/2024
Contributor(s): Huw Davies, Joshua Sailer, Jack Sharland, Bo Wei
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Generation of Vaccines Preventing the Common Cold
Application
A new class of vaccines targeting the viruses causing the common cold, rhinoviruses (RV).
Key Benefits
Capsid-chimeric strains for developing new RV vaccines.
Preclinical data with a prototype show the ability to induce a robust capsid-specific immune response.
Straightforward and inexpensive vaccine manufacturing process utilizing...
Published: 1/17/2024
Contributor(s): Sujin Lee
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Reagents and Hardware for RNA Storage at Ambient Temperatures
Application
Simple and economical method for isolating and storing RNA from biological samples at room temperatures.
Key Benefits
Alternative, low-cost extraction method suitable for extracting RNA from biological samples for molecular analysis and disease diagnosis.
Eliminates the need for expensive proprietary materials, hazardous chemicals,...
Published: 4/9/2024
Contributor(s): Jesse Waggoner, David Myers, Sarah Hernandez, Dhruv Miglani
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Chameleon-Inspired Strain-Accommodating Smart Skin
Application
A flexible smart skin that changes its color in response to heat or sunlight.
Key Benefits
Strain-accommodating.
Thermal and photothermal responsive.
Light responsive.
Highly stretchable.
Market Summary
Hydrogels are water-insoluble, three-dimensional networks of polymer chains capable of holding large amounts of water. They are...
Published: 12/7/2023
Contributor(s): Khalid Salaita, Yixiao Dong
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Organocatalysts for Amide Bond Formation
ApplicationChemically catalyzed amide bond formation under mild reaction conditions.Key BenefitsEnables amide bond formation under mild reaction conditions.Organocatalyst are easily synthesized.Avoids the use and disposal of hazardous chemicals.Market SummaryAmide bonds are very frequently incorporated into active pharmaceutical ingredients (API). Amide...
Published: 11/27/2023
Contributor(s): Lanny Liebeskind, Pavan Kumar Reddy Gangireddy, Sri Rama Murthy Akondi, Vidyavathi Patro, Nikolay Orlov
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Desulfitative Redox Catalysis Method for Production of Amide and Peptide Linkages
ApplicationAn efficient and economic catalytic process for forming amide and peptide compounds.Key BenefitsUses more inexpensive reagents compared to other methods.Amide/peptide bond is generated in high yield at or near ambient temperature.Mild reaction conditions prevent generation of impurities.Market SummaryPeptide and amide linkages are important...
Published: 11/27/2023
Contributor(s): Lanny Liebeskind, Matthew Lindale
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Polymer that Neutralizes Toxic Chemical Threats
Application
A multifunctional polymer that captures and degrades chemical threats in the environment.
Key Benefits
Forms a gel that entraps toxic materials within seconds of contact.
Visible color change of gel confirms neutralization of toxic substance.
Modifiable structure allows for functional use against chemical entity of choice.
Market...
Published: 11/27/2023
Contributor(s): Craig Hill, Kevin Sullivan
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DNA Machines Enhance SNP Analysis Efficiency
Application
DNA-based machines that roll rather than walk and can be used for single nucleotide polymorphism (SNP) analysis.
Key Benefits
Unique "rolling" cogwheel-like mechanism allows directional motion without a track or external guidance.
Micron-sized cargo travels large distances; can be visualized using a smartphone camera equipped with...
Published: 4/8/2024
Contributor(s): Khalid Salaita, Kevin Yehl
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OSIRIS: An Information Management Application for Use in Drug Discovery and Development
Application
A web-based information management application for data tracking and sharing during the discovery and development of new small molecule therapeutics.
Key Benefits
Can be used to register compounds and display information about chemical structures and calculations.
Easily customizable and has a ticket system to allow administrators...
Published: 11/6/2023
Contributor(s): Serdar Kurtkaya, Iestyn Lewis, Michael Natchus, James Snyder
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