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Liquid-hydrogel Hybrid Microfluidic Device
Application Measurement device for detecting of single-cell dynamics under environment perturbations or drug treatment. Key Benefits Fast determination of drug sensitivity. Long-term continuous cell-fate tracking. Time-lapse analysis of cell proliferation. Cell community analysis: intra-species interactions, inter-species interactions. Market...
Published: 12/20/2022       Contributor(s): Kyle Allison, Xin Fang, Devina Puri
Know@Home: Mobile App for Promoting the Prevention and Treatment of HIV
Application A healthcare oriented mobile app for promoting the prevention and treatment of HIV. Key Benefits User-friendly application. Contains educational information, assessments, locators, testing plans and reminders regarding sexual health and STI testing. Market Summary Human immunodeficiency virus (HIV) and acquired immunodeficiency...
Published: 12/20/2022       Contributor(s): Patrick Sullivan, Robert Stephenson
SARS-CoV-2 Neutralizing Human Monoclonal Antibodies
­ Application Monoclonal antibodies to SARS-CoV2 for use in COVID-19 diagnostics and therapeutics. Key Benefits Demonstrably neutralizing, important for therapeutic mAbs. Most bind both RBG and stalk portion of spike protein, useful in case SARS-CoV2 strains develop variation in RBD. Market Summary Coronavirus (COVID-19) is an infectious...
Published: 10/28/2022       Contributor(s): Jens Wrammert, Carl Davis, Mehul Suthar, Robert Kauffman
BG505 SOSIP Vaccine Elicited Neutralizing Monoclonal Antibodies for HIV
­ Application ELISA Western Blot Immunohistochemistry Specficity HIV-1 BG505 Env protein (clone name: YRK01, YRK02). Subtype Monoclonal antibody. Immunogen HIV-1 BG505 SOSIP Env trimer. Technical Summary HIV-1 envelope glycoprotein (Env) is a membrane protein complex involved in receptor recognition and viral fusion with CD4+ T cells...
Published: 9/29/2022       Contributor(s): Cynthia Derdeyn, Tysheena Charles
Treatment of Antimicrobial Resistance Infections
­ Application Novel compounds and peptides for the treatment of antibiotic-resistant infections. Key Benefits Novel mechanism of action that facilitates that killing of GAS in skin keratinocytes. Novel drugs may overcome bacterial resistance to commonly used FDA-approved modifications. Potentially synergy in combination with existing treatments. Possible...
Published: 9/29/2022       Contributor(s): Christopher LaRock, Doris LaRock
Combination of Tetrahydrobiopterin and Arginine/ ± Arginase Inhibitors for the Treatment of COVID-19
­ Application A novel drug combination to address acute arginine/BH4 dysregulation that develops with COVID-19 and MIS-C infection. Key Benefits Potential to improve outcomes of those infected with COVID-19 with few side effects. Repurposing opportunity with the combination of two approved drugs (tetrahydrobiopterin and arginine). Addresses...
Published: 10/28/2022       Contributor(s): Claudia Morris, Louann Brown
Small Molecule Inhibitors for the Treatment of COVID-19 Infection
­ Application Small molecule therapy to treat patients infected with COVID-19 virus. Key Benefits Current FDA-approved therapeutic can be repurposed to fight COVID-19 infection. Treatment option for infected COVID-19 patients. Market Summary Coronavirus (COVID-19) is an infectious disease that causes severe acute respiratory syndrome coronavirus...
Published: 12/20/2022       Contributor(s): Jack Arbiser, Martijn van Hemert, Melissa Thaler
Serological Test for SARS-CoV-2
­ Application Clinical assay for detecting SARS-CoV-2 neutralizing antibodies. Key Benefits Highly specific and sensitive. Fewer false positives than commercially available tests. Market Summary SARS-CoV-2 is currently causing a devastating pandemic and there is a pressing need to understand the dynamics, specificity, and neutralizing...
Published: 1/10/2023       Contributor(s): Rafi Ahmed, Mehul Suthar, John Roback, Jens Wrammert, Robert Kauffman
A New Method to Detect and Tackle Antibiotic Heteroresistance
­ Application A method to detect heteroresistance to antibiotics in bacteria. Key Benefits Significantly faster than commercially available options. Aside from the interferometer itself, no specialized reagents are required. Inexpensive to use. Market Summary Antibiotic resistance is a significant threat to public health. Rapid and sensitive...
Published: 1/10/2023       Contributor(s): David Weiss, Peter Yunker, David Hufnagel, Arben (Ben) Kalziqi
Frog Skin Peptides for Treatment of Human Influenza Viruses
Application A therapeutic peptide that treats Influenza A virus Key Benefits New method of action compared to antiviral drugs currently in use. Therapeutic peptide is virucidal against drug resistant strains. Market Summary Worldwide seasonal influenza epidemics can impact 5 – 15% of the population. The occurrence of vaccine mismatch...
Published: 9/29/2022       Contributor(s): Joshy Jacob, David Holthausen, Song Lee, Sanil George
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