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MVA and DNA Based SARS-CoV-2 Vaccines
Application Modified Vaccinia virus Ankara (MVA)- and deoxyribonucleic acid (DNA)-based vaccine for Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2). Key Benefits Safety profile is known. Demonstrated antiviral activity against related Coronaviruses. Single dose of vaccination was shown to be effective against related Coronaviruses...
Published: 4/24/2020       Inventor(s): Rama Amara, Sailaja Gangadhara
Boosting Immunogenicity of Vaccines Using Saponins and Agonists of the Intracellular STING Pathway
Application Vaccine formulation of an activator of the stimulator of interferon genes (STING) pathway and saponin adjuvant for enhanced protection of aged population. Key Benefits Significantly improved protective immunity of vaccine in the aged. More efficient than the current methods of influenza vaccination of population 65 years of age or...
Published: 4/24/2020       Inventor(s): Elena Vassilieva, Richard Compans
Plant-Based Small Molecules for Treatment of MRSA Infections
Application Small molecule inhibitor of the accessory gene regulator (agr) for the treatment of methicillin-resistant Staphylococcus aureus (MRSA) infections. Key Benefits Targeted system is non-essential for S. aureus growth, creating less selective pressure for resistance. Does not harm beneficial host bacteria. May potentially be used concomitantly...
Published: 4/23/2020       Inventor(s): Cassandra Quave, Akram Salam, Gina Porras Brenes, James Lyles
Infection Control System for Resuscitation and Airway Management
Application Collapsible, single-use ‘pop-up tent’ system to prevent transmission of infectious disease during resuscitation and airway management. Key Benefits Provides protective barrier to prevent transmission of infectious disease. Allows adequate access to the patient for airway management procedures. Single-use to minimize infection...
Published: 4/13/2020       Inventor(s): Adam Klein, Russell Gore, David Wright
C19Check: COVID-19 Severity Stratification Tool
Application Algorithm for screening of individuals exhibiting coronavirus disease (COVID-19) symptoms. Key Benefits Allows mass screening of potential COVID-19 patients. Alleviates burden on hospitals and doctors’ offices. Reduces unnecessary interactions with individuals. Market Summary Coronavirus disease (COVID-19) is an infectious...
Published: 4/8/2020       Inventor(s): Schrager Justin, Alexander Isakov, David Wright, Anna Yaffee
Eradication of Pneumonococcal Carriage with Sodium Deoxycolate
Application Antibiotic use of sodium deoxycholate for preventing colonization with Streptococcus pneumoniae and treating pneumococcal infection. Key Benefits Effective against antibiotic-resistant pneumococcus. FDA-approved for use in humans. Safety already demonstrated in FDA trials for subcutaneous injection to dissolve fat deposits in humans. Market...
Published: 1/22/2020       Inventor(s): Jorge Vidal
Virus-Like Particles as RSV Vaccine Candidate
Application Virus-like particle (VLP) vaccine candidate(s) to prevent respiratory syncytial virus (RSV) infection. Key Benefits Candidates may have the most effective anti-viral and anti-inflammatory response. Potentially protects elderly and immunocompromised patients from re-infection with the RSV virus. Efficient, tunable and stable production...
Published: 1/15/2020       Inventor(s): Binh Ha, Larry Anderson, Elizabeth Wright
Mobile Applications for PrEP Participants
Application Mobile applications to monitor PrEP adherence and testing results for HIV patients and those at risk of acquiring HIV. Key Benefits Delivers push notifications for medication and testing reminders. Integrates a HIPPA compliant video calling service for remote clinician consultation. Tracks at-home test kits shipped to participants’...
Published: 12/2/2019       Inventor(s): Aaron Siegler
Antibacterial Treatment for Gum Disease
Application Small molecules that inhibit oral bacteria growth to treat gum disease and prevent tooth decay. Key Benefits Inhibits S. mutans biofilm formation. Reduces the number of bacteria by working in a bactericidal, as opposed to bacteriostatic, manner. Market Summary Periodontitis is a gum infection in which gums become inflamed due to...
Published: 12/2/2019       Inventor(s): William (Bill) Wuest, Amy Solinski, Marisa Kozlowski, Young Eun Lee, Thomas Paniak, Cristian Ochoa
Trimeric Immunogen for HIV-1 Vaccination
Application Trimeric gp120 immunogen that induces broadly cross-reactive V1V2-antibodies for HIV-1 vaccine. Key Benefits Possible oral administration. Broadly cross-reactive against HIV-1 panel. Promotes antibody responses as both a primary immunogen and boosting immunogen. Market Summary Antiretroviral therapy (ART) has dramatically prolonged...
Published: 8/26/2019       Inventor(s): Rama Amara, Andrew Jones, Raghavan Varadarajan, Sannula Kesavardhana
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