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CRISPR Based System for Targeted Reduction of Gene Expression
ApplicationA CRISPR based gene silencing system using sequence specific RNA to repress expression of endogenous transcripts.Key BenefitsProvides a platform to target specific mRNA transcripts in both prokaryotic and eukaryotic cells. Potential therapeutic strategy against pathogenic bacteria and viruses. Market SummarySince the discovery of silencing...
Published: 12/10/2020       Contributor(s): David Weiss, Tim (Timothy) Sampson
Natural Antimicrobial Compound to Treat Multidrug Resistant Infections
Application Pentagalloylglucose and extracts of Anacardiaceae to treat multidrug resistant bacterial and fungal infections. Key Benefits Potential compounds to combat multidrug-resistant pathogens. Natural compound isolated from Schinus plants. Antibiotic activity against multidrug-resistant bacteria and fungi. Low likelihood to contribute to...
Published: 12/9/2020       Contributor(s): Cassandra Quave, Francois Chassagne, Lewis Marquez, Micah Dettweiler, Julia Kubanek, Anne Sweeney-Jones, Bhuwan Chhetri
HIV-1 Clade C Protein Immunogen as HIV-1 Vaccine
Application Novel stabilized HIV-1 Clade C gp140 trimeric immunogen useful as a vaccine. Key Benefits Vaccine for HIV-1 infections. Induces both neutralizing and V1V2 scaffold directed antibody responses. V1V2 scaffold directed antibodies bind to multiple strains of HIV-1 from different clades including Clades B and C. Market Summary HIV-1...
Published: 11/20/2020       Contributor(s): Rama Amara, Sailaja Gangadhara, Tiffany Styles, Anusmita Sahoo
Live Attenuated Zika Virus Vaccines
Application Yellow fever virus-based live attenuated Zika virus (ZIKV) vaccines. Key Benefits Reduces neurotropism from Zika virus. High safety and immunogenicity of chimeric vaccines. Market Summary Zika virus (ZIKV) belongs to the flavivirus family of viruses, which include West Nile (WN), Japanese encephalitis (JE), yellow fever (YF), dengue...
Published: 11/2/2020       Contributor(s): Baek Kim
Infection Control System for Resuscitation and Airway Management
Application Collapsible, single-use ‘pop-up tent’ system to prevent transmission of infectious disease during resuscitation and airway management. Key Benefits Provides protective barrier to prevent transmission of infectious disease. Allows adequate access to the patient for airway management procedures. Single-use to minimize infection...
Published: 9/15/2020       Contributor(s): Adam Klein, Russell Gore, David Wright
Boosting Immunogenicity of Vaccines Using Saponins and Agonists of the Intracellular STING Pathway
Application Vaccine formulation of an activator of the stimulator of interferon genes (STING) pathway and saponin adjuvant for enhanced protection of aged population. Key Benefits Significantly improved protective immunity of vaccine in the aged. More efficient than the current methods of influenza vaccination of population 65 years of age or...
Published: 4/24/2020       Contributor(s): Elena Vassilieva, Richard Compans
Plant-Based Small Molecules for Treatment of MRSA Infections
Application Small molecule inhibitor of the accessory gene regulator (agr) for the treatment of methicillin-resistant Staphylococcus aureus(MRSA) infections. Key Benefits Novel mechanism of action for the treatment of MRSA infections. Inhibits all four S. aureus agr types (I-IV) Targeted system is non-essential for S. aureus growth, creating...
Published: 4/23/2020       Contributor(s): Cassandra Quave, Akram Salam, Gina Porras Brenes, James Lyles
C19Check: COVID-19 Severity Stratification Tool
Application Algorithm for screening of individuals exhibiting coronavirus disease (COVID-19) symptoms. Key Benefits Allows mass screening of potential COVID-19 patients. Alleviates burden on hospitals and doctors’ offices. Reduces unnecessary interactions with individuals. May be used in regions with low internet access. Market Summary Coronavirus...
Published: 4/8/2020       Contributor(s): Justin Schrager, Alexander Isakov, David Wright, Anna Yaffee, Arthur Kellermann
Real-Time RT-PCR Assay for SARS-CoV-2
Application Triplex, internally-controlled real-time RT-PCR for Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2). Key Benefits Two viral targets to confirm detection in a single sample. Does not involve the performance of multiple reactions as are required for the majority of published assays. May be performed using several different...
Published: 4/8/2020       Contributor(s): Jesse Waggoner
Eradication of Pneumonococcal Carriage with Sodium Deoxycolate
Application Antibiotic use of sodium deoxycholate for preventing colonization with Streptococcus pneumoniae and treating pneumococcal infection. Key Benefits Effective against antibiotic-resistant pneumococcus. FDA-approved for use in humans. Safety already demonstrated in FDA trials for subcutaneous injection to dissolve fat deposits in humans. Market...
Published: 1/22/2020       Contributor(s): Jorge Vidal
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