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BG505 SOSIP Vaccine Elicited Neutralizing Monoclonal Antibodies for HIV
­ Application ELISA Western Blot Immunohistochemistry Specficity HIV-1 BG505 Env protein (clone name: YRK01, YRK02). Subtype Monoclonal antibody. Immunogen HIV-1 BG505 SOSIP Env trimer. Technical Summary HIV-1 envelope glycoprotein (Env) is a membrane protein complex involved in receptor recognition and viral fusion with CD4+ T cells...
Published: 5/17/2022       Contributor(s): Cynthia Derdeyn, Tysheena Charles
Treatment of Antimicrobial Resistance Infections
­ Application Novel compounds and peptides for the treatment of antibiotic-resistant infections. Key Benefits Novel mechanism of action that facilitates that killing of GAS in skin keratinocytes. Novel drugs may overcome bacterial resistance to commonly used FDA-approved modifications. Potentially synergy in combination with existing treatments. Possible...
Published: 5/13/2022       Contributor(s): Christopher LaRock, Doris LaRock
Combination of Tetrahydrobiopterin and Arginine/ ± Arginase Inhibitors for the Treatment of COVID-19
­ Application A novel drug combination to address acute arginine/BH4 dysregulation that develops with COVID-19 and MIS-C infection. Key Benefits Potential to improve outcomes of those infected with COVID-19 with few side effects. Repurposing opportunity with the combination of two approved drugs (tetrahydrobiopterin and arginine). Addresses...
Published: 3/16/2022       Contributor(s): Claudia Morris, Louann Brown
Small Molecule Inhibitors for the Treatment of COVID-19 Infection
­ Application Small molecule therapy to treat patients infected with COVID-19 virus. Key Benefits Current FDA-approved therapeutic can be repurposed to fight COVID-19 infection. Treatment option for infected COVID-19 patients. Market Summary Coronavirus (COVID-19) is an infectious disease that causes severe acute respiratory syndrome coronavirus...
Published: 2/23/2022       Contributor(s): Jack Arbiser, Martijn van Hemert, Melissa Thaler
Serological Test for SARS-CoV-2
­ Application Clinical assay for detecting SARS-CoV-2 neutralizing antibodies. Key Benefits Highly specific and sensitive. Fewer false positives than commercially available tests. Market Summary SARS-CoV-2 is currently causing a devastating pandemic and there is a pressing need to understand the dynamics, specificity, and neutralizing...
Published: 1/24/2022       Contributor(s): Rafi Ahmed, Mehul Suthar, John Roback, Jens Wrammert, Robert Kauffman
A New Method to Detect and Tackle Antibiotic Heteroresistance
­ Application A method to detect heteroresistance to antibiotics in bacteria. Key Benefits Significantly faster than commercially available options. Aside from the interferometer itself, no specialized reagents are required. Inexpensive to use. Market Summary Antibiotic resistance is a significant threat to public health. One estimate...
Published: 1/10/2022       Contributor(s): David Weiss, Peter Yunker, David Hufnagel, Arben (Ben) Kalziqi
Frog Skin Peptides for Treatment of Human Influenza Viruses
ApplicationA therapeutic peptide that treats Influenza A virusKey BenefitsNew method of action compared to antiviral drugs currently in use.Therapeutic peptide is virucidal against drug resistant strains.Market SummaryWorldwide seasonal influenza epidemics can impact 5 – 15% of the population, equating to roughly 3-5 million severe cases and 250,...
Published: 11/5/2021       Contributor(s): Joshy Jacob, David Holthausen, Song Lee, Sanil George
Frog Skin Peptides for Treatment of Zika Viruses
ApplicationA therapeutic peptide that treats Zika Virus.Key BenefitsPotential therapeutic to fight against the growing threat of the Zika virus.Peptide is fast acting and destroys Zika virions within 5 minutes of exposure.Market SummaryZika is an infectious disease spread primarily by Aedes mosquitoes and results in symptoms similar to those of the...
Published: 11/5/2021       Contributor(s): Joshy Jacob, Song Lee, David Holthausen, Sanil George
CRISPR Based System for Targeted Reduction of Gene Expression
ApplicationA CRISPR based gene silencing system using sequence specific RNA to repress expression of endogenous transcripts.Key BenefitsProvides a platform to target specific mRNA transcripts in both prokaryotic and eukaryotic cells. Potential therapeutic strategy against pathogenic bacteria and viruses. Market SummarySince the discovery of silencing...
Published: 12/10/2020       Contributor(s): David Weiss, Tim (Timothy) Sampson
Natural Antimicrobial Compound to Treat Multidrug Resistant Infections
Application Pentagalloylglucose and extracts of Anacardiaceae to treat multidrug resistant bacterial and fungal infections. Key Benefits Potential compounds to combat multidrug-resistant pathogens. Natural compound isolated from Schinus plants. Antibiotic activity against multidrug-resistant bacteria and fungi. Low likelihood to contribute to...
Published: 12/9/2020       Contributor(s): Cassandra Quave, Francois Chassagne, Lewis Marquez, Micah Dettweiler, Julia Kubanek, Anne Sweeney-Jones, Bhuwan Chhetri
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