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Smartphone Diagnostic for Rapid Respiratory Virus Detection
Application Diagnostic and automatic surveillance platform to identify RSV, Influenza A, and COVID-19 in real-time. Key Benefits Rapid smartphone-based detection of multiple respiratory viruses in nasal swab, breath condensate, and saliva. Requires few reagents and no expensive equipment. Limit of detection on par with PCR and rapid readout. Enables...
Published: 7/19/2024       Contributor(s): Selma Piranej, Khalid Salaita
MVA and DNA Based SARS-CoV-2 Vaccines
Application Modified Vaccinia virus Ankara (MVA)- and deoxyribonucleic acid (DNA)-based vaccine for Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2). Key Benefits Safety profile is known. Demonstrated antiviral activity against related Coronaviruses. Single dose of vaccination was shown to be effective against related Coronaviruses...
Published: 6/21/2024       Contributor(s): Rama Rao Amara, Sailaja Gangadhara
Combination Antibiotic Therapy to Exploit Multiple Heteroresistance
Application Treatment with combinations of FDA-approved antibodies targeting small drug-resistant cell populations for infectious disease. Key Benefits Specific combinations of existing drugs that target small subpopulations of bacterial cells resistant to many standard of care treatment regimens. Potential to overcome the drug resistance crisis...
Published: 6/21/2024       Contributor(s): David Weiss, David Hufnagel, Victor Band
Vaccines and Antibody Therapeutics for HPV-related Cancers
Application Treatment and prevention of HPV-induced malignancies. Key Benefits Identification of a protein expressed in a large number of HPV-induced cancers. Antibodies have been generated that bind to the protein and potentially elicit an immune response to the cancer cells. The antibodies can be used to develop new treatments and vaccines...
Published: 5/21/2024       Contributor(s): Rafi Ahmed, Andreas Wieland
EF-Tu Targeting Antibody for Infection Treatment
Application Therapeutic monoclonal antibodies directed to Elongation Factor-Tu (EF-Tu) for the treatment of infections. Key Benefits An antibody that targets the protein EF-Tu, which is present on many types of bacteria involved in life-threatening infections. A research-grade antibody has been developed with animal data showing the ability to...
Published: 10/13/2023       Contributor(s): Joanna Goldberg, Dina Moustafa
Generation of Vaccines Preventing the Common Cold
Application A new class of vaccines targeting the viruses causing the common cold, rhinoviruses (RV). Key Benefits Capsid-chimeric strains for developing new RV vaccines. Preclinical data with a prototype show the ability to induce a robust capsid-specific immune response. Straightforward and inexpensive vaccine manufacturing process utilizing...
Published: 6/7/2024       Contributor(s): Sujin Lee
Reagents and Hardware for RNA Storage at Ambient Temperatures
Application Simple and economical method for isolating and storing RNA from biological samples at room temperatures. Key Benefits Alternative, low-cost extraction method suitable for extracting RNA from biological samples for molecular analysis and disease diagnosis. Eliminates the need for expensive proprietary materials, hazardous chemicals,...
Published: 7/2/2024       Contributor(s): Jesse Waggoner, David Myers, Sarah Hernandez, Dhruv Miglani
RSV Vaccine for Infants and Children
Application Vaccine for Respiratory Syncytial Virus (RSV) in infants and children. Key Benefits A novel vaccine targeting both the F and G proteins of the respiratory syncytial virus (RSV), including its variants. Preliminary data in in mice show the vaccine induced the production of antibodies associated with preventing disease. Potential to...
Published: 7/19/2024       Contributor(s): Larry Anderson, Binh Ha, Heying Sun
Therapeutic for Potential Elimination of Chronic Hepatitis B
Application A therapeutic technique to eliminate infection of patients suffering from chronic Hepatitis B Virus infection. Key Benefits May provide a cure for chronic HBV infection rather than just simple management. High efficiency of infection targeting may produce minimal side effects. May be used in combination with other HBV inhibitors. Market...
Published: 4/23/2024       Contributor(s): Raymond Schinazi, Leda Bassit, Ting Nie
Method for Identifying and Optimizing the Development of Heterodimeric Monoclonal Antibodies
Application Method to generate IgG heterodimers that can be used to generate bi-specific monoclonal antibodies for disease treatment. Key Benefits A novel method of screening and developing novel IgG heterodimers used for generating monoclonal antibodies for many diseases. Preliminary data demonstrate efficient production of IgG heterodimers that...
Published: 6/21/2024       Contributor(s): Eric Sundberg, Jonathan Du, Tala Azzam
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