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Frog Skin Peptides for Treatment of Human Influenza Viruses
Application
A therapeutic peptide that treats Influenza A virus
Key Benefits
New method of action compared to antiviral drugs currently in use.
Therapeutic peptide is virucidal against drug resistant strains.
Market Summary
Worldwide seasonal influenza epidemics can impact 5 – 15% of the population. The occurrence of vaccine mismatch...
Published: 7/30/2024
Contributor(s): Joshy Jacob, David Holthausen, Song Lee, Sanil George
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Antibodies for Zika and Dengue Viruses
Applications
ELISA
Western Blot
Immunohistochemistry
Specificity
Human monoclonal
Technical Summary
Zika Virus (ZIKV) is a mosquito borne filovirus responsible for a 2016-2017 epidemic in North and South America. ZIKV nonstructural protein 1 (NS1) is a pathogenicity factor implicated in virus replication, host interaction and immune invasion....
Published: 7/30/2024
Contributor(s): Jens Wrammert, Mark Mulligan
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Respiratory Syncytial Virus Strain A2-2-20F
Application
Strain of respiratory syncytial virus (RSV) for vaccine and therapeutic research and development.
Key Benefits
Higher early viral load.
Induces greater necrotic airway damage and neurophil infiltration.
Market Summary
RSV is a highly contagious and ubiquitous virus that causes respiratory tract infections in individuals of all ages,...
Published: 9/26/2024
Contributor(s): Martin Moore
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Respiratory Syncytial Virus (RSV) A2 Expressing Firefly Luciferase
Application
Recombinant RSV strain expressing firefly luciferase and the F & G genes from clinical strain A2001/2-20 for research and development of vaccines.
Key Benefits
F & G proteins included in this strain show different behavior than those of the typical A2 strain proteins.
May be adapted in a variety of assays, enabling the identification...
Published: 9/26/2024
Contributor(s): Martin Moore, Christopher Stobart
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Plasmid for Respiratory Syncytial Virus (RSV) Vaccine Development & Research
Applications
Bacterial artificial chromosome (BAC) plasmid containing the antigenomic sequence A2-BAG-BAF derived from multiple strains of RSV.
Key Benefits
Viral DNA is contained in a BAC, allowing for efficient mutagenesis and recombineering of viral DNA.
BAC is stable and can be used for cloning in common bacteria types like E. coli.
Provides...
Published: 9/26/2024
Contributor(s): Martin Moore, Anne Hotard (Lopez-Ona)
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Recombinant Respiratory Syncytial Virus (RSV) Firefly Luciferase Reporter Strain
Application
Modified recombinant syncytial virus (RSV) strain expressing a bioluminescent reporter protein for high throughput screening and vaccine development.
Key Benefits
Provides a new high throughput screening tool for RSV vaccine development and drug discovery.
Firefly luciferase based assays show better signal-to-noise than fluorescence-based...
Published: 9/26/2024
Contributor(s): Richard Plemper, Martin Moore
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Recombinant RSV Strains Expressing Renilla Luciferase and G & F Proteins
Application
Recombinant respiratory syncytial virus (RSV) strains expressing the G and F Proteins from RSV strains as well as renilla luciferase for use in drug and vaccine screening.
Key Benefits
Provides new and needed tool for screening potential RSV therapies, ensuring they are broadly effective against multiple, distinct strains of the virus....
Published: 9/26/2024
Contributor(s): Martin Moore, Jia Meng
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Recombinant Respiratory Syncytial Viruses (RSVs) Expressing the G and F Proteins from Various Strains
ApplicationRecombinant RSV Strains Expressing the G and F Proteins from various geographically distributed RSV strains for use in drug and vaccine screeningKey BenefitsProvides new and needed tool for screening potential RSV therapies, ensuring they are broadly effective against multiple, geographically distinct strains of the virus Expresses the red...
Published: 9/26/2024
Contributor(s): Martin Moore, Anne Hotard (Lopez-Ona), Christina Rostad, Barney Graham, Syed Moin
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Real Time Imaging of HIV with a PET/CT Total Body Scan
Application
PET-based imaging of HIV anatomical reservoir locations for health monitoring and determination of therapy effectiveness.
Key Benefits
The only in vivo method for visualizing sites of HIV.
Compatible with existing PET/CT imaging system.
Market Summary
The first line of therapy for AIDS is administering anti-HIV drug cocktails to...
Published: 9/26/2024
Contributor(s): Philip Santangelo, Francois Villinger
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Respiratory Syncytial Virus (RSV) A/2001/2-20 Strain with Enhanced Pathogenesis
Applications
Strain of respiratory syncytial virus (RSV) for use in drug and vaccine development.
Key Benefits
Exhibits increased mucin expression and early epithelial damage in mouse models.
Provides a platform for animal models focused on early airway histopathology.
Market Summary
RSV is the most common cause of severe respiratory illness...
Published: 9/26/2024
Contributor(s): Martin Moore
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