Frog Skin Peptides for Treatment of Zika Viruses


A therapeutic peptide that treats Zika Virus.

Key Benefits

  • Potential therapeutic to fight against the growing threat of the Zika virus.
  • Peptide is fast acting and destroys Zika virions within 5 minutes of exposure.

Market Summary

Zika is an infectious disease spread primarily by Aedes mosquitoes and results in symptoms similar to those of the flu. Recently, Zika virus has gained notoriety as a cause of Guillain-Barré syndrome and microcephaly, and the virus is being investigated for links to other neurological complications. The emerging threat posed by the Zika virus mandates a quick response, but neither a vaccine nor antiviral drug is currently available.

Technical Summary

Emory University researchers have found that peptides secreted through the skin of frogs native to Southern India ( Hylarana aurantiaca) have potent virucidal effects against the Asian, African and South American Zika virus strains. These peptides effectively inhibit virion replication in vitro. Peptides have potential to be developed into potent antiviral therapeutics against Zika viruses, as well as Dengue viruses DENV 1, 2, 3, and 4.

Shown below are TEM micrograph of Zika Virus treated with a control (left) versus treated with peptide (right). Frog skin peptide treatment led to the loss of morphology and aggregation of virus particles.

Development Stage

Proof of principle experiments have been conducted in vitro.

Patent Information

App Type Country Serial No. Patent No. File Date Issued Date Patent Status
Nationalized PCT - United States United States 16/469,119 10,898,544 6/12/2019 1/26/2021 Issued
EP Registered Country France 17881084.2 3554533 7/1/2019 6/9/2021 Issued
EP Registered Country Germany 17881084.2 3554533 7/1/2019 6/9/2021 Issued
EP Registered Country United Kingdom 17881084.2 3554533 7/1/2019 6/9/2021 Issued
Nationalized PCT - Foreign EP 17881084.2 3554533 7/1/2019 6/9/2021 Issued
Divisional United States 17/127,161 11,666,630 12/18/2020 6/6/2023 Issued
Tech ID: 17057
Published: 11/5/2021