Transgenic Mice for Studying Cell-Type Specific Immunity
ApplicationTransgenic mice expressing floxed mitochondrial antiviral-signaling protein (MAVS) for study of cell-type and tissue-specific immunity. Key Benefits- Study cell-type and tissue-specific immunity.
- Can be crossed using CRE-recombinase system.
Technical SummaryMitochondrial antiviral-signaling protein (MAVS) is a protein in humans that is encoded by the MAVS gene. It is the central adaptor protein for the RIG-I signaling pathway and promotes induction of type I interferon and other antiviral responses. Emory inventors have created homozygous floxed MAVS mice in a C57BL/6N background. These mice have normal life span and fertility. The line is useful to study cell and tissue-specific innate immune signaling when crossed to various Cre-recombinase expressing mouse lines.
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