10 Results

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Whole-Animal Genetic Model to Mimic Aspects of the Patient Phenotype of Classic Galactosemia ­ Application An animal model for studying the underlying causes of galactosemia and screening for novel drugs to treat the condition. Key Benefits The first animal model for elucidating the underlying causes of galactosemia in infants. Animals with galactosemia causing genetic knockout exhibit similar disease phenotypes and complications... Published: 7/30/2024       Contributor(s): Judith Fridovich-Keil

Strategy to Identify miRNAs for Disease Diagnosis Application Method to measure precursor and mature miRNA specifically. Key Benefits Unique primers can specifically identify miRNAs and precursor miRNAs by standard qRT-PCR without the requirement for an additional detection probe. Allows for amplification and quantification of both mature miRNA and precursor miRNAs. Potential technology to evaluate... Published: 9/26/2024       Contributor(s): Wenming Li

TaqMan Array Cards for Pneumococcal Detection and Serotyping ApplicationDiagnostic for identifying Streptococcus pneumonia serotypes.Key BenefitsAllows for rapid detection and serotype identification of Streptococcus pneumonia infections.Market SummaryStreptococcus pneumonia (Spn) is a gram-positive bacteria and significant human pathogen responsible for most pneumonia cases. Typically, Spn resides asymptomatically... Published: 7/30/2024       Contributor(s): Jorge Vidal Graniel, Fuminori Sakai, Lesley McGee, Velusamy Srinivasan

Therapeutic Target for Hepatic Fibrosis ApplicationPeriostin as a therapeutic target for liver disease.Key BenefitsNew therapeutic target for preventing fibrosis from entering cirrhosis stage.Therapeutic target may be used for identifying new therapy for fibrosis.Market SummaryCirrhosis is a condition in which the liver is unable to function normally due to chronic, or long lasting, injury.... Published: 11/20/2024       Contributor(s): Frank Anania, Pradeep Kumar

Targeting Peptide Improves Accurate Myocarditis Imaging and Diagnosis ApplicationTargeting peptide molecule for image-based diagnosis of myocarditis.Key BenefitsEnables noninvasive diagnosis of myocarditis.Targets and binds to biomarker of myocarditis.Market SummaryMyocarditis is an inflammation of the heart muscle (myocardium). Myocarditis can affect your heart muscle and your heart's electrical system, reducing the... Published: 7/30/2024       Contributor(s): Michael E. Davis, Mario Martinez

Bioluminescent Ion Indicator Proteins ApplicationFusion protein for non-invasive assessment of chloride fluctuations in neuronal processes.Key BenefitsEnables a non-invasive method of imaging chloride in animals.Offers high signal-to-noise ratio compared to fluorescent light.Market SummaryNeuronal chloride (Cl-) is involved in many normal neurophysiological activities, including synaptic... Published: 11/20/2024       Contributor(s): Robert E. Gross, Ken Berglund, Jack Tung

Compound and Method to Explore and Prepare O-Glycans from Living Cells ApplicationChemical compound and method that enables detection of O-glycans with higher sensitivity than conventional approaches.Key BenefitsHigher accuracy and sensitivity than current β-elimination method.Smaller sample quantities required compared to traditional mass spectrometry.Method promotes the discovery of novel glycans and study of cellular... Published: 9/26/2024       Contributor(s): Tongzhong Ju, Richard Cummings, Matthew Kudelka

High Temperature Bacterial Expression Vector for Protein/Peptide Manufacturing Application Plasmid for the expression and production of non-native proteins in Geobacillus stearothermophilus at high temperatures. Key Benefits Allows for improved manufacturing of peptides & proteins at higher temperatures than generally possible. High incubation temperature prevents contamination with other bacterial species. Market... Published: 11/20/2024       Contributor(s): Ichiro Matsumura, Kristen Blanchard

Innovative Method for Bulk Production of Sphingolipids ApplicationOptically pure D-erythro-Sphingosine that can be produced with high yield.Key Benefits Method efficiently produces D-erythro-Sphingosine and derivatives in bulk and with high optical purity. D-erythro-Sphingosine can be converted to many other sphingolipids for use in the production of therapeutics and cosmetics. Technical Summary Sphingolipids... Published: 12/4/2024       Contributor(s): Hao Yang, Lanny Liebeskind

Cytotoxicity-Based Genetic Selection for Targeted Drug Screening Applications Screening method for drug discovery and investigating protein-protein interactions. Technical Summary Drug discovery is typically dependant on screening methods that involve negative selection, or the death of cell cultures when exposed to a specific drug. This invention, a cytoxicity-based genetic selection method (TOXSEL), introduces... Published: 10/17/2024       Contributor(s): Raymond (Ray) Dingledine, John Collier, Haian Fu