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Whole-Animal Genetic Model to Mimic Aspects of the Patient Phenotype of Classic Galactosemia
Application
An animal model for studying the underlying causes of galactosemia and screening for novel drugs to treat the condition.
Key Benefits
The first animal model for elucidating the underlying causes of galactosemia in infants.
Animals with galactosemia causing genetic knockout exhibit similar disease phenotypes and complications...
Published: 7/30/2024
Contributor(s): Judith Fridovich-Keil
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Strategy to Identify miRNAs for Disease Diagnosis
Application
Method to measure precursor and mature miRNA specifically.
Key Benefits
Unique primers can specifically identify miRNAs and precursor miRNAs by standard qRT-PCR without the requirement for an additional detection probe.
Allows for amplification and quantification of both mature miRNA and precursor miRNAs.
Potential technology to evaluate...
Published: 9/26/2024
Contributor(s): Wenming Li
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Glycoprotein Tetramer for Identifying Antigen-specific B Cells
Application
Ectodomain of viral glycoprotein tetramers detects antigen-specific memory B Cells.
Key Benefits
Viral glycoprotein tetramers detect antigen-specific memory B cells in the peripheral blood and tissues.
Hepatitis C virus E2 protein triggers immune response, which may yield an effective vaccine against hepatitis C virus.
Market Summary
Hepatitis...
Published: 10/28/2024
Contributor(s): Arash Grakoui, Joseph Marcotrigiano
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Granulin for Treatment of Neurodegeneration
Application
Granulin proteins (GRNs) as potential therapeutics for multiple neurodegenerative disorders caused by lysosome dysfunction and inflammation.
Key Benefits
Novel pathway and target provides new route for treatment.
Granulins shown to rescue lysosomal defects in cell culture models.
Market Summary
Granulins are small proteins that...
Published: 11/20/2024
Contributor(s): Thomas Kukar, Christopher Holler, Georgia Taylor
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TaqMan Array Cards for Pneumococcal Detection and Serotyping
ApplicationDiagnostic for identifying Streptococcus pneumonia serotypes.Key BenefitsAllows for rapid detection and serotype identification of Streptococcus pneumonia infections.Market SummaryStreptococcus pneumonia (Spn) is a gram-positive bacteria and significant human pathogen responsible for most pneumonia cases. Typically, Spn resides asymptomatically...
Published: 7/30/2024
Contributor(s): Jorge Vidal Graniel, Fuminori Sakai, Lesley McGee, Velusamy Srinivasan
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Therapeutic Target for Hepatic Fibrosis
ApplicationPeriostin as a therapeutic target for liver disease.Key BenefitsNew therapeutic target for preventing fibrosis from entering cirrhosis stage.Therapeutic target may be used for identifying new therapy for fibrosis.Market SummaryCirrhosis is a condition in which the liver is unable to function normally due to chronic, or long lasting, injury....
Published: 11/20/2024
Contributor(s): Frank Anania, Pradeep Kumar
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Targeting Peptide Improves Accurate Myocarditis Imaging and Diagnosis
ApplicationTargeting peptide molecule for image-based diagnosis of myocarditis.Key BenefitsEnables noninvasive diagnosis of myocarditis.Targets and binds to biomarker of myocarditis.Market SummaryMyocarditis is an inflammation of the heart muscle (myocardium). Myocarditis can affect your heart muscle and your heart's electrical system, reducing the...
Published: 7/30/2024
Contributor(s): Michael E. Davis, Mario Martinez
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DHAA and Derivatives for Treatment of BRAF-V600E-Positive Cancer
Application
Hypolipidemic dehydroacetic acid (DHAA) treatment to prevent growth of BRAF V600E positive tumors.
Key Benefits
Treatment with slows BRAF V600E-positive tumor growth.
Repurposed compound may speed FDA approval.
May be used in combination with other therapies.
Market Summary
Up to 50% of melanoma cases harbor the BRAF V600E mutation,...
Published: 11/20/2024
Contributor(s): Jing Chen, Jack Arbiser, Brian Pollack, Siyuan Xia
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Bioluminescent Ion Indicator Proteins
ApplicationFusion protein for non-invasive assessment of chloride fluctuations in neuronal processes.Key BenefitsEnables a non-invasive method of imaging chloride in animals.Offers high signal-to-noise ratio compared to fluorescent light.Market SummaryNeuronal chloride (Cl-) is involved in many normal neurophysiological activities, including synaptic...
Published: 11/20/2024
Contributor(s): Robert E. Gross, Ken Berglund, Jack Tung
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Compound and Method to Explore and Prepare O-Glycans from Living Cells
ApplicationChemical compound and method that enables detection of O-glycans with higher sensitivity than conventional approaches.Key BenefitsHigher accuracy and sensitivity than current β-elimination method.Smaller sample quantities required compared to traditional mass spectrometry.Method promotes the discovery of novel glycans and study of cellular...
Published: 9/26/2024
Contributor(s): Tongzhong Ju, Richard Cummings, Matthew Kudelka
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