|
A GALT-null Rat Model for Studies of Classic Galactosemia
Application
Pre-clinical rodent model to study classic galactosemia disease.
Key Benefits
Identify striking differences in GALT-independent galactose metabolism among tissues and across post-natal time points.
Study the relationship between galactose metabolite levels in blood and other tissues.
Study the impact of rigorous galactose restriction...
Published: 11/20/2024
Contributor(s): Judith Fridovich-Keil
|
|
Mouse Model for Specific Proteomic Labeling
Application
Proteomic labeling (labeling of proteins).
Key Benefits
Method can be used to express TurboID in any cell type.
The mouse line can be crossed with any existing Cre line and can be extended to any organ/tissue system.
Detection of labeled biomarkers can be identified in biofluids as biomarkers of cell specific disease mechanisms.
Can...
Published: 9/26/2024
Contributor(s): Srikant Rangaraju, Nicholas (Nick) Seyfried, Sruti Rayaprolu
|
|
Pig Lentiviral-Induced Spinal Cord Glioblastoma
Application
Porcine model of spinal cord glioblastoma for the development and testing of pre-clinical therapeutic for spinal cord tumors.
Key Benefits
Novel lentiviral gene transfer offers a viable pathway to modeling glioblastoma in higher order species.
The existing model is the first reproducible immunocompetent large animal model of spinal...
Published: 9/26/2024
Contributor(s): Muhibullah (Mohib) Tora, Pavlos Texakalidis, Thais Buchman, Nicholas Boulis
|
|
Whole-Animal Genetic Model to Mimic Aspects of the Patient Phenotype of Classic Galactosemia
Application
An animal model for studying the underlying causes of galactosemia and screening for novel drugs to treat the condition.
Key Benefits
The first animal model for elucidating the underlying causes of galactosemia in infants.
Animals with galactosemia causing genetic knockout exhibit similar disease phenotypes and complications...
Published: 7/30/2024
Contributor(s): Judith Fridovich-Keil
|
|
Tyrosinase Viral Vectors for the Generation of Rodents Exhibiting Time -Dependent Production and Intracellular Accumulation of Human-Like Neuromelanin
Application
Improved study of neurodegenerative diseases on mice.
Key Benefits
Ability to study neuromelanin’s association with neurodegenerative diseases with mice.
Researchers can analyze overexpression of tyrosinase on specific cell types.
Market Summary
Neurodegenerative diseases such as Alzheimer’s and Parkinson’s...
Published: 11/20/2024
Contributor(s): David Weinshenker, Alexa Iannitelli
|
|
3D-Printed Mouse Headplates for Implantation of EEG, EMG and Depth Electrodes
Application
Tool to precisely and reproducibly implant electrode and other instrumentation into the mouse brain for neurophysiology studies.
Key Benefits
Inexpensive, rapid and efficient reproduction of headplates.
Allows consistent and quick surgical implantation.
Capable of recording or stimulating multiple sites in the mouse brain.
Market...
Published: 10/28/2024
Contributor(s): Nigel Pedersen, Lauren Aiani
|
|
ADGRB3/BAI3 Knockout Mouse
ApplicationKnockout mouse models for adhesion G protein-coupled receptors B3, brain-specific angiogenesis inhibitor-3 (ADGRB3/BAI3) gene study.Technical SummaryEmory University researchers have developed a knockout mouse model for the ADGRB3/BAI3 gene. Mice were generated by CRISP/cas9 technology on C57Bl6 background. These mice can be used to study...
Published: 10/28/2024
Contributor(s): Erwin Van Meir
|
|
Knock-In Mouse Model of Oculopharyngeal Muscular Dystrophy
ApplicationConditional knock-in mouse mimicking Oculopharyngeal muscular dystrophy.Technical SummaryOculopharyngeal muscular dystrophy (OPMD) is rare genetic disease caused by a mutation in the PABPN1 gene. In this mutation, the number of GCG trinucleotide repeats at the 5' end of PABPN1 are increased, which leads to an expansion of an alanine repeat...
Published: 10/28/2024
Contributor(s): Grace Pavlath, Anita Corbett, Katherine Vest
|
|
Human Osteopontin Knock-in Mouse Line
ApplicationMouse lines expressing isoforms a, b, and c of the Human Osteopontin (OPN) protein for cancer research.Technical SummaryThe murine OPN is not subject to splicing and therefore does not express different isoforms. Human cancers express splice variants. Emory researchers developed these mouse models to express each isoform independently from...
Published: 9/26/2024
Contributor(s): Alicia Lyle
|
|
3q29 Deletion Mice
Application
Mouse models with the deletion of 3q29 for the study of neurological disorders such as schizophrenia, autism, and anxiety disorders.
Technical Summary
Copy Number Variants (CNV’s) are large genomic deletion or duplications. One of the CNV’s, the 3q29 deletion, confers more than 40 fold increase in risk of schizophrenia. Most...
Published: 9/26/2024
Contributor(s): Tamara Caspary, David Weinshenker, Stephen Theodore Warren
|
