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ADGRB3/BAI3 Knockout Mouse
ApplicationKnockout mouse models for adhesion G protein-coupled receptors B3, brain-specific angiogenesis inhibitor-3 (ADGRB3/BAI3) gene study.Technical SummaryEmory University researchers have developed a knockout mouse model for the ADGRB3/BAI3 gene. Mice were generated by CRISP/cas9 technology on C57Bl6 background. These mice can be used to study...
Published: 7/9/2019       Inventor(s): Erwin Van Meir
ADGRB1/BAI1 Knockout Mouse
ApplicationKnockout mouse models for adhesion G protein-coupled receptors B1, brain-specific angiogenesis inhibitor-1 (ADGRB1/BAI1) gene study.Technical SummaryEmory University researchers have developed a knockout mouse model for the ADGRB1/BAI1 gene. These mice were developed through homologous recombination and have LacZ gene knock-in. Mice were...
Published: 7/9/2019       Inventor(s): Erwin Van Meir
Knock-In Mouse Model of Oculopharyngeal Muscular Dystrophy
ApplicationConditional knock-in mouse mimicking Oculopharyngeal muscular dystrophy.Technical SummaryOculopharyngeal muscular dystrophy (OPMD) is rare genetic disease caused by a mutation in the PABPN1 gene. In this mutation, the number of GCG trinucleotide repeats at the 5' end of PABPN1 are increased, which leads to an expansion of an alanine repeat...
Published: 9/27/2018       Inventor(s): Grace Pavlath, Anita Corbett, Katherine Vest
Human Osteopontin Knock-in Mouse Line
ApplicationMouse lines expressing isoforms a, b, and c of the Human Osteopontin (OPN) protein for cancer research.Technical SummaryThe murine OPN is not subject to splicing and therefore does not express different isoforms. Human cancers express splice variants. Emory researchers developed these mouse models to express each isoform independently from...
Published: 9/26/2018       Inventor(s): Alicia Lyle
3q29 Deletion Mice
ApplicationMouse models with the deletion of 3q29 for the study of neurological disorders such as schizophrenia, autism, and anxiety disorders.Technical SummaryCopy Number Variants (CNV’s) are large genomic deletion or duplications. One of the CNV’s, the 3q29 deletion, confers more than 40 fold increase in risk of schizophrenia. Most people with a 3q29...
Published: 8/23/2018       Inventor(s): Tamara Caspary, David Weinshenker, Stephen Warren
Cre-Lox PAR1 Conditional Knockout Mouse
Key BenefitsTissue-specific knockout mouse, allowing PAR1 to be inactivated in specific cell types in certain tissue.Inducible knockout mouse, allowing PAR1 to be temporally suppressed at a given time-point in embryonic, post-natal or adult animals.Eliminates drawbacks and side effects of traditional knockout processes that eliminate genes from the...
Published: 6/26/2018       Inventor(s): Stephen Traynelis
Dystonia Knock-in Mouse Model
ApplicationKnock-in mouse model for study of L-DOPA responsive dystonia.Useful for other movement disorders like dystonia and Parkinson’s disease.Technical SummaryDystonia is a neurological movement disorder characterized by persistent or intermittent muscle contractions causing abnormal, often repetitive, movements, postures, or both. There are multiple...
Published: 1/21/2018       Inventor(s): Ellen Hess, Hyder Jinnah
Transgenic Mice for Studying Cell-Type Specific Immunity
ApplicationTransgenic mice expressing floxed mitochondrial antiviral-signaling protein (MAVS) for study of cell-type and tissue-specific immunity.Key BenefitsStudy cell-type and tissue-specific immunity.Can be crossed using CRE-recombinase system.Technical SummaryMitochondrial antiviral-signaling protein (MAVS) is a protein in humans that is encoded...
Published: 6/26/2017       Inventor(s): Mehul Suthar
Transgenic Human Dopamine Beta-hydroxylase Mouse Model
Applications Mouse model that utilizes a BAC to express human dopamine beta-hydroxylase in the brain. Key Benefits In vivo approach to dissect role of single genes in the nervous system. May be used in the study of how human variants of dopamine beta-hydroxylase affect norepinephrine signaling in the brain. Technical Summary Dopamine beta-hydroxylase...
Published: 2/9/2016       Inventor(s): Joseph Cubells, David Weinshenker
GNB3 BAC - Transgenic Mouse Model of Obesity
Application Mouse model represents GNB3 duplication related to childhood obesity syndrome. Key Benefits Models obesity syndrome caused by recurrent chromosomal translocation Investigates functional significance of GNB3-related pathways including BMI disorders Technical Summary Obesity can be a heritable condition that precedes other diseases including...
Published: 9/30/2015       Inventor(s): M. Katharine (katie) Rudd, Ian Goldlust
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