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Tyrosinase Viral Vectors for the Generation of Rodents Exhibiting Time -Dependent Production and Intracellular Accumulation of Human-Like Neuromelanin

Application Improved study of neurodegenerative diseases on mice. Key Benefits Ability to study neuromelanin’s association with neurodegenerative diseases with mice. Researchers can analyze overexpression of tyrosinase on specific cell types. Market Summary Neurodegenerative diseases such as Alzheimer’s and Parkinson’s...

Published: 5/13/2022 Contributor(s): David Weinshenker, Alexa Iannitelli

3D-Printed Mouse Headplates for Implantation of EEG, EMG and Depth Electrodes

Application Tool to precisely and reproducibly implant electrode and other instrumentation into the mouse brain for neurophysiology studies. Key Benefits Inexpensive, rapid and efficient reproduction of headplates. Allows consistent and quick surgical implantation. Capable of recording or stimulating multiple sites in the mouse brain. Market...

Published: 5/21/2020 Contributor(s): Nigel Pedersen, Lauren Aiani

ADGRB3/BAI3 Knockout Mouse

ApplicationKnockout mouse models for adhesion G protein-coupled receptors B3, brain-specific angiogenesis inhibitor-3 (ADGRB3/BAI3) gene study.Technical SummaryEmory University researchers have developed a knockout mouse model for the ADGRB3/BAI3 gene. Mice were generated by CRISP/cas9 technology on C57Bl6 background. These mice can be used to study...

Published: 7/9/2019 Contributor(s): Erwin Van Meir

ADGRB1/BAI1 Knockout Mouse

ApplicationKnockout mouse models for adhesion G protein-coupled receptors B1, brain-specific angiogenesis inhibitor-1 (ADGRB1/BAI1) gene study.Technical SummaryEmory University researchers have developed a knockout mouse model for the ADGRB1/BAI1 gene. These mice were developed through homologous recombination and have LacZ gene knock-in. Mice were...

Published: 7/9/2019 Contributor(s): Erwin Van Meir

Knock-In Mouse Model of Oculopharyngeal Muscular Dystrophy

ApplicationConditional knock-in mouse mimicking Oculopharyngeal muscular dystrophy.Technical SummaryOculopharyngeal muscular dystrophy (OPMD) is rare genetic disease caused by a mutation in the PABPN1 gene. In this mutation, the number of GCG trinucleotide repeats at the 5' end of PABPN1 are increased, which leads to an expansion of an alanine repeat...

Published: 9/27/2018 Contributor(s): Grace Pavlath, Anita Corbett, Katherine Vest

Human Osteopontin Knock-in Mouse Line

ApplicationMouse lines expressing isoforms a, b, and c of the Human Osteopontin (OPN) protein for cancer research.Technical SummaryThe murine OPN is not subject to splicing and therefore does not express different isoforms. Human cancers express splice variants. Emory researchers developed these mouse models to express each isoform independently from...

Published: 9/26/2018 Contributor(s): Alicia Lyle

3q29 Deletion Mice

ApplicationMouse models with the deletion of 3q29 for the study of neurological disorders such as schizophrenia, autism, and anxiety disorders.Technical SummaryCopy Number Variants (CNV’s) are large genomic deletion or duplications. One of the CNV’s, the 3q29 deletion, confers more than 40 fold increase in risk of schizophrenia. Most people...

Published: 8/23/2018 Contributor(s): Tamara Caspary, David Weinshenker, Stephen Warren

Cre-Lox PAR1 Conditional Knockout Mouse

Key BenefitsTissue-specific knockout mouse, allowing PAR1 to be inactivated in specific cell types in certain tissue.Inducible knockout mouse, allowing PAR1 to be temporally suppressed at a given time-point in embryonic, post-natal or adult animals.Eliminates drawbacks and side effects of traditional knockout processes that eliminate genes from the...

Published: 6/26/2018 Contributor(s): Stephen Traynelis

Dystonia Knock-in Mouse Model

ApplicationKnock-in mouse model for study of L-DOPA responsive dystonia.Useful for other movement disorders like dystonia and Parkinson’s disease.Technical SummaryDystonia is a neurological movement disorder characterized by persistent or intermittent muscle contractions causing abnormal, often repetitive, movements, postures, or both. There are...

Published: 1/21/2018 Contributor(s): Ellen Hess, Hyder Jinnah

Transgenic Mice for Studying Cell-Type Specific Immunity

ApplicationTransgenic mice expressing floxed mitochondrial antiviral-signaling protein (MAVS) for study of cell-type and tissue-specific immunity.Key BenefitsStudy cell-type and tissue-specific immunity.Can be crossed using CRE-recombinase system.Technical SummaryMitochondrial antiviral-signaling protein (MAVS) is a protein in humans that is encoded...

Published: 6/26/2017 Contributor(s): Mehul Suthar

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