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Tyrosinase Viral Vectors for the Generation of Rodents Exhibiting Time -Dependent Production and Intracellular Accumulation of Human-Like Neuromelanin ­ Application Improved study of neurodegenerative diseases on mice. Key Benefits Ability to study neuromelanin’s association with neurodegenerative diseases with mice. Researchers can analyze overexpression of tyrosinase on specific cell types. Market Summary Neurodegenerative diseases such as Alzheimer’s and Parkinson’s... Published: 9/29/2022       Contributor(s): David Weinshenker, Alexa Iannitelli

3D-Printed Mouse Headplates for Implantation of EEG, EMG and Depth Electrodes Application Tool to precisely and reproducibly implant electrode and other instrumentation into the mouse brain for neurophysiology studies. Key Benefits Inexpensive, rapid and efficient reproduction of headplates. Allows consistent and quick surgical implantation. Capable of recording or stimulating multiple sites in the mouse brain. Market... Published: 8/1/2022       Contributor(s): Nigel Pedersen, Lauren Aiani

ADGRB3/BAI3 Knockout Mouse ApplicationKnockout mouse models for adhesion G protein-coupled receptors B3, brain-specific angiogenesis inhibitor-3 (ADGRB3/BAI3) gene study.Technical SummaryEmory University researchers have developed a knockout mouse model for the ADGRB3/BAI3 gene. Mice were generated by CRISP/cas9 technology on C57Bl6 background. These mice can be used to study... Published: 9/29/2022       Contributor(s): Erwin Van Meir

Knock-In Mouse Model of Oculopharyngeal Muscular Dystrophy ApplicationConditional knock-in mouse mimicking Oculopharyngeal muscular dystrophy.Technical SummaryOculopharyngeal muscular dystrophy (OPMD) is rare genetic disease caused by a mutation in the PABPN1 gene. In this mutation, the number of GCG trinucleotide repeats at the 5' end of PABPN1 are increased, which leads to an expansion of an alanine repeat... Published: 9/29/2022       Contributor(s): Grace Pavlath, Anita Corbett, Katherine Vest

Human Osteopontin Knock-in Mouse Line ApplicationMouse lines expressing isoforms a, b, and c of the Human Osteopontin (OPN) protein for cancer research.Technical SummaryThe murine OPN is not subject to splicing and therefore does not express different isoforms. Human cancers express splice variants. Emory researchers developed these mouse models to express each isoform independently from... Published: 7/29/2022       Contributor(s): Alicia Lyle

3q29 Deletion Mice Application Mouse models with the deletion of 3q29 for the study of neurological disorders such as schizophrenia, autism, and anxiety disorders. Technical Summary Copy Number Variants (CNV’s) are large genomic deletion or duplications. One of the CNV’s, the 3q29 deletion, confers more than 40 fold increase in risk of schizophrenia. Most... Published: 9/29/2022       Contributor(s): Tamara Caspary, David Weinshenker, Stephen Theodore Warren

Cre-Lox PAR1 Conditional Knockout Mouse Key BenefitsTissue-specific knockout mouse, allowing PAR1 to be inactivated in specific cell types in certain tissue.Inducible knockout mouse, allowing PAR1 to be temporally suppressed at a given time-point in embryonic, post-natal or adult animals.Eliminates drawbacks and side effects of traditional knockout processes that eliminate genes from the... Published: 7/29/2022       Contributor(s): Stephen Traynelis

Dystonia Knock-in Mouse Model ApplicationKnock-in mouse model for study of L-DOPA responsive dystonia.Useful for other movement disorders like dystonia and Parkinson’s disease.Technical SummaryDystonia is a neurological movement disorder characterized by persistent or intermittent muscle contractions causing abnormal, often repetitive, movements, postures, or both. There are... Published: 8/22/2022       Contributor(s): Ellen Hess, Hyder Jinnah

Transgenic Mice for Studying Cell-Type Specific Immunity ApplicationTransgenic mice expressing floxed mitochondrial antiviral-signaling protein (MAVS) for study of cell-type and tissue-specific immunity.Key BenefitsStudy cell-type and tissue-specific immunity.Can be crossed using CRE-recombinase system.Technical SummaryMitochondrial antiviral-signaling protein (MAVS) is a protein in humans that is encoded... Published: 7/29/2022       Contributor(s): Mehul Suthar

Transgenic Human Dopamine Beta-hydroxylase Mouse Model Applications Mouse model that utilizes a BAC to express human dopamine beta-hydroxylase in the brain. Key Benefits In vivo approach to dissect role of single genes in the nervous system. May be used in the study of how human variants of dopamine beta-hydroxylase affect norepinephrine signaling in the brain. Technical Summary Dopamine beta-hydroxylase... Published: 9/29/2022       Contributor(s): Joseph Cubells, David Weinshenker

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