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Mouse Model for Specific Proteomic Labeling
Application Proteomic labeling (labeling of proteins). Key Benefits Method can be used to express TurboID in any cell type. The mouse line can be crossed with any existing Cre line and can be extended to any organ/tissue system. Detection of labeled biomarkers can be identified in biofluids as biomarkers of cell specific disease mechanisms. Can...
Published: 12/7/2023       Contributor(s): Srikant Rangaraju, Nicholas Seyfried, Sruti Rayaprolu
Pig Lentiviral-Induced Spinal Cord Glioblastoma
Application Porcine model of spinal cord glioblastoma for the development and testing of pre-clinical therapeutic for spinal cord tumors. Key Benefits Novel lentiviral gene transfer offers a viable pathway to modeling glioblastoma in higher order species. The existing model is the first reproducible immunocompetent large animal model of spinal...
Published: 11/27/2023       Contributor(s): Muhibullah (Mohib) Tora, Pavlos Texakalidis, Thais Buchman, Nicholas Boulis
Whole-Animal Genetic Model to Mimic Aspects of the Patient Phenotype of Classic Galactosemia
­ Application An animal model for studying the underlying causes of galactosemia and screening for novel drugs to treat the condition. Key Benefits The first animal model for elucidating the underlying causes of galactosemia in infants. Animals with galactosemia causing genetic knockout exhibit similar disease phenotypes and complications...
Published: 7/28/2023       Contributor(s): Judith Fridovich-Keil
Tyrosinase Viral Vectors for the Generation of Rodents Exhibiting Time -Dependent Production and Intracellular Accumulation of Human-Like Neuromelanin
­ Application Improved study of neurodegenerative diseases on mice. Key Benefits Ability to study neuromelanin’s association with neurodegenerative diseases with mice. Researchers can analyze overexpression of tyrosinase on specific cell types. Market Summary Neurodegenerative diseases such as Alzheimer’s and Parkinson’s...
Published: 7/28/2023       Contributor(s): David Weinshenker, Alexa Iannitelli
3D-Printed Mouse Headplates for Implantation of EEG, EMG and Depth Electrodes
Application Tool to precisely and reproducibly implant electrode and other instrumentation into the mouse brain for neurophysiology studies. Key Benefits Inexpensive, rapid and efficient reproduction of headplates. Allows consistent and quick surgical implantation. Capable of recording or stimulating multiple sites in the mouse brain. Market...
Published: 12/1/2023       Contributor(s): Nigel Pedersen, Lauren Aiani
ADGRB3/BAI3 Knockout Mouse
ApplicationKnockout mouse models for adhesion G protein-coupled receptors B3, brain-specific angiogenesis inhibitor-3 (ADGRB3/BAI3) gene study.Technical SummaryEmory University researchers have developed a knockout mouse model for the ADGRB3/BAI3 gene. Mice were generated by CRISP/cas9 technology on C57Bl6 background. These mice can be used to study...
Published: 12/1/2023       Contributor(s): Erwin Van Meir
Knock-In Mouse Model of Oculopharyngeal Muscular Dystrophy
ApplicationConditional knock-in mouse mimicking Oculopharyngeal muscular dystrophy.Technical SummaryOculopharyngeal muscular dystrophy (OPMD) is rare genetic disease caused by a mutation in the PABPN1 gene. In this mutation, the number of GCG trinucleotide repeats at the 5' end of PABPN1 are increased, which leads to an expansion of an alanine repeat...
Published: 12/1/2023       Contributor(s): Grace Pavlath, Anita Corbett, Katherine Vest
Human Osteopontin Knock-in Mouse Line
ApplicationMouse lines expressing isoforms a, b, and c of the Human Osteopontin (OPN) protein for cancer research.Technical SummaryThe murine OPN is not subject to splicing and therefore does not express different isoforms. Human cancers express splice variants. Emory researchers developed these mouse models to express each isoform independently from...
Published: 7/28/2023       Contributor(s): Alicia Lyle
3q29 Deletion Mice
Application Mouse models with the deletion of 3q29 for the study of neurological disorders such as schizophrenia, autism, and anxiety disorders. Technical Summary Copy Number Variants (CNV’s) are large genomic deletion or duplications. One of the CNV’s, the 3q29 deletion, confers more than 40 fold increase in risk of schizophrenia. Most...
Published: 7/28/2023       Contributor(s): Tamara Caspary, David Weinshenker, Stephen Theodore Warren
Cre-Lox PAR1 Conditional Knockout Mouse
Key BenefitsTissue-specific knockout mouse, allowing PAR1 to be inactivated in specific cell types in certain tissue.Inducible knockout mouse, allowing PAR1 to be temporally suppressed at a given time-point in embryonic, post-natal or adult animals.Eliminates drawbacks and side effects of traditional knockout processes that eliminate genes from the...
Published: 7/28/2023       Contributor(s): Stephen Traynelis
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