Nanoparticle for in vivo tumor targeting and detection.
- Large optical enhancements were achieved under in vivo conditions in live animals.
- Conjugated nanoparticles were able to target tumor biomarkers on human cancer cells and in xenograft tumor models.
- Functionalized nanoparticles can be used as a diagnostic or therapeutic tool.
Dr. Shuming Nie and his team have developed biocompatible and nontoxic nanoparticles for in vivo tumor targeting and detection based on pegylated gold particles and surface-enhanced Raman scattering (SERS). These SERS nanoparticles are significantly brighter than semiconductor quantum dots with light emission in the near infrared spectrum. Nanoparticles in this size range (~70 nm) are advantageous compared to more traditional technology because the large surface area of the particle allows for conjugation of multiple diagnostic (e.g., optical, radioisotopic, or magnetic) and therapeutic agents.