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CXCR4-Targeting Molecules for Tumor Metastasis and PET Imaging
Application
Positron emission tomography (PET) imaging agents with high specificity for metastatic cancer.
Key Benefits
18F-labeled CXCR4 (partial) antagonist without stem cell mobilizing property is safe to be given to patient multiple times.
Identifies tumor location non-invasively and provides an indication of tumor’s metastatic potential.
Market...
Published: 4/23/2024
Contributor(s): Hyunsuk Shim, Mark Goodman, Dinesh Shetty, Yoon Hyeun Oum
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Precursor PET Compound for Imaging Infections
Application
Diagnostic molecules for detecting bacterial infections using nuclear imaging.
Key Benefits
May improve the detection of infections within the body.
Potentially facilitates earlier treatment and superior clinical outcomes compared to other diagnostic radiotracers.
Market Summary
The rising incidences of bacterial infections resistant...
Published: 4/23/2024
Contributor(s): Mark Goodman, William Robert Taylor, Wone Woo Seo, Malgorzata Lipowska
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Amino Acid-Derived Radiotracer Compounds for PET Cancer Imaging
Application
New class of fluorine-18 labeled amino acid-derived radiotracer compounds for positron emission tomography (PET) cancer imaging.
Key Benefits
Next generation of cancer imaging agents.
Enhanced sensitivity to detect glioblastoma, prostate cancer and other cancers.
Market Summary
PET imaging is a type of nuclear medicine procedure...
Published: 4/23/2024
Contributor(s): Mark Goodman, Lanny Liebeskind, Thomas Pickel
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Dual Purpose Radiotracer for Renal Imaging
Application
Radioactive tracer with improved plasma clearance for use as either a planar or positron emission tomography (PET) renal imaging agent.
Key Benefits
Rapid renal excretion.
Minimal localization at other body sites.
More rapid blood clearance than current standard.
Can be adapted for either standard planar or positron emission tomography...
Published: 4/23/2024
Contributor(s): Jeffrey Klenc, Malgorzata Lipowska, Andrew Taylor, Jr.
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LED Emitting Silica Nanoparticles
Application
LED dye-linked silica nanoparticles with tunable size for imaging applications.
Key Benefits
Incorporation of a naphthalimide derivative greatly enhances photostability and increases pH tolerance.
Large size range and easily tunable.
Excited by visual light, 450-495 nm (blue) & emits visual wavelength, 545 nm (green).
Particle...
Published: 4/23/2024
Contributor(s): George Beck, Jr., Mervyn Neale Weitzmann, Shin Woo Ha, Jin-Kyu Lee, Hak-Sung Jung
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Real Time Imaging of HIV with a PET/CT Total Body Scan
Application
PET-based imaging of HIV anatomical reservoir locations for health monitoring and determination of therapy effectiveness.
Key Benefits
The only in vivo method for visualizing sites of HIV.
Compatible with existing PET/CT imaging system.
Market Summary
The first line of therapy for AIDS is administering anti-HIV drug cocktails to...
Published: 4/23/2024
Contributor(s): Philip Santangelo, Francois Villinger
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CRF-1 Receptor Antagonists for PET Imaging or as Potential Therapeutics
ApplicationSmall molecule corticotrophin releasing factor 1 (CRF-1) antagonists, for use as PET imaging agents or potential therapeutics for treating generalized anxiety disorder. Key BenefitsCan image CRF-1 receptor density and distribution via PET Potential antagonist and therapeutics for psychological disorders including anxiety and depression Technical...
Published: 4/23/2024
Contributor(s): Jeffrey Stehouwer, Mark Goodman, Clint Kilts, Charles Nemeroff
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Renal Imaging Utilizing Tc-99m-NTA Improves Tubular Measurements
Application
Diagnostic imaging of the kidneys for the determination of renal function.
Key Benefits
Renal tracer for measuring the effective renal plasma flow.
99mTc-labeled small molecule has renal clearance characteristics that are superior to currently available tracers.
First-in-man studies have been performed with resulting image quality...
Published: 4/23/2024
Contributor(s): Malgorzata Lipowska, Andrew Taylor, Jr., Luigi Marzilli
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Polymer Coated SERS Nanoparticle Tags
Application
Nanoparticle for in vivo tumor targeting and detection.
Key Benefits
Large optical enhancements were achieved under in vivo conditions in live animals.
Conjugated nanoparticles were able to target tumor biomarkers on human cancer cells and in xenograft tumor models.
Functionalized nanoparticles can be used as a diagnostic or therapeutic...
Published: 7/28/2023
Contributor(s): Ximei Qian, Dominic Ansari, Shuming Nie
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Synthesizing Noscapine Analogues for Drug Resistance
Application Synthesis of noscapine analogs and their use as cancer treatments, including drug resistant cancers. Key BenefitsEfficient, high yielding synthesis of noscapine derivatives. Selective for cancer cells over normal human cells.Technical Summary The effectiveness of microtubule-targeting drugs as treatments for cancer has been validated through...
Published: 4/23/2024
Contributor(s): Harish Joshi, Ritu Aneja
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