Latest technologies from Emory Universityhttp://emoryott.technologypublisher.comBe the first to know about the latest inventions and technologies available from Emory Universityen-USMon, 27 Feb 2017 16:46:28 GMTTue, 21 Feb 2017 11:20:07 GMT 2017, Emory UniversityPostitive Allosteric Modulators that Treat Central Nervous System Disorders molecules that selectively potentiate N-methyl-D-aspartate (NMDA) receptor subunits GluN2C/GluN2D for the treatment of neurological conditions.Key BenefitsSelective potentiation of only NMDA receptor that contain GluN2C or GluN2D subunits will likely reduce adverse side effects.Selective potentiation of only NMDA receptor that contain GluN2C or GluN2D subunits may yield better pharmacological and pharmacokinetic properties versus global NMDA receptor antagonists.Market SummaryImpaired NMDA receptor function has been suggested in a wide range of neurological conditions includin...Tue, 21 Feb 2017 11:20:07 GMTott@emory.edu Drug Vehicle for Unregulated Blood Clotting micron-sized drug vehicles for targeted treatment of unregulated blood clotting.Key BenefitsFacilitates targeted release of drugs specifically for blood clotting disorders.Drug delivery vehicle can be used with newly discovered or known therapeutics on the market.Site specific biological mechanism may help increase drug efficacy and avoid side effects.Market SummaryLife threatening occurrences of unregulated blood clotting such as Hemophilia A/B or Deep Vein Thrombosis can result in severe blood loss or unwanted blood clotting, respectively. In cases of severe bloo...Mon, 20 Feb 2017 14:23:15 GMTott@emory.edu Syncytial Virus (RSV) A2 Expressing Firefly Luciferase, 19 Feb 2017 12:20:24 GMTott@emory.edu Plasmids for Rescue of Respiratory Syncytial Virus rescuing recombinant syncytial virus for RSV research and vaccine development.Key BenefitsAllow expression and recombination in vero cells.Optimized for human codon bios to increase expression in mammalian cells.Market SummaryRespiratory syncytial virus (RSV) is the major cause of acute lower respiratory tract infections in infants and young children. Infections often lead to hospitalizations and, in rare cases or underdeveloped countries, can result in death. RSV-related illnesses amongst the elderly are also on the rise. Currently, there are no effective therapeutics or v...Thu, 16 Feb 2017 10:21:06 GMTott@emory.edu – Software Toolbox for Electrophysiological Data, 16 Feb 2017 05:14:27 GMTott@emory.edu Device for Increased Viral Transduction Efficiency chip device for facilitating high throughput viral transduction for gene therapy applications.Key BenefitsImproves surface-to-volume ratio, allowing more efficient contact between lentiviruses and cellsIncreases efficiency while maintaining cell viability of traditional methods.Enables gene transfer for non-adherent cells.Compatible with syringe pump.Market SummaryLentiviral vector gene therapy is one of the predominant methods used for gene transfer during gene therapy applications. Although lentiviral vectors are very effective mechanism for gene transduction, one of ...Tue, 07 Feb 2017 08:39:36 GMTott@emory.edu for Measuring Cell Purity and Quality Control of Stem Cell-based Products assay for sensitive and specific detection of undifferentiated cells in stem cell-related research and development.Key BenefitsNanotechnology-based assay can detect residual undifferentiated cells and characterize cultures that may be tumorigenic. Technology is potentially more sensitive method compared to current methods. Market SummaryHuman pluripotent stem cells (hPSCs) have emerged as a potentially invaluable resource for cell therapy and regenerative medicine. A major concern is the potential risk for residual undifferentiated stem cells in preparations of hPSC deriv...Fri, 16 Dec 2016 13:39:49 GMTott@emory.edu Nanoparticles for Activation of Tumor-Specific Immune Responses iron-oxide nanoparticle (IONP) composition for the delivery of anti-PD-L1 peptides for treatment of cancers.Key BenefitsTargeted delivery can reduce level of dosing and side effects.Added IONP core allows concurrent imaging during treatment.Nanoparticle enables ability to tether multiple compounds to a single IONP core.Market SummaryCancer is the leading cause of death in the developed world and the second leading cause of death in the developing world. PD-L1 is expressed in tumor cells and tumor associated stromal cells to suppress function of cytotoxic T cells. Anti...Mon, 05 Dec 2016 12:27:19 GMTott@emory.edu<![CDATA[Plasmid for Respiratory Syncytial Virus (RSV) Vaccine Development & Research]]> ApplicationsBacterial artificial chromosome (BAC) plasmid containing the antigenomic sequence A2-BAG-BAF derived from multiple strains of RSV. Key BenefitsViral DNA is contained in a BAC, allowing for efficient mutagenesis and recombineering of viral DNA. BAC is stable and can be used for cloning in common bacteria types like E. coli.Provides powerful tool for use in engineering potential RSV vaccines. Market SummaryHuman Respiratory syncytial virus (RSV) RSV is a leading cause of respiratory infections in the US leading to over 57,000 infant hospitalizations annually. Beyond infants, RSV-rel...Tue, 29 Nov 2016 11:11:06 GMTott@emory.edu<![CDATA[Novel Tool for Respiratory Syncytial Virus (RSV) Vaccine Development & Research]]> ApplicationsBacterial artificial chromosome (BAC) plasmid containing the antigenomic sequence A2-BAG-BAF derived from multiple strains of RSV. Key BenefitsViral DNA is contained in a BAC, allowing for efficient mutagenesis and recombineering of viral DNA. BAC is stable and can be used for cloning in common bacteria types like E. coli.Provides powerful tool for use in engineering potential RSV vaccines. Market SummaryHuman Respiratory syncytial virus (RSV) RSV is a leading cause of respiratory infections in the US leading to over 57,000 infant hospitalizations annually. Beyond infants, RSV-rel...Mon, 14 Nov 2016 10:43:07 GMTott@emory.edu Respiratory Syncytial Virus (RSV) Firefly Luciferase Reporter Strain recombinant syncytial virus (RSV) strain expressing a bioluminescent reporter protein for high throughput screening and vaccine development.Key BenefitsProvides a new high throughput screening tool for RSV vaccine development and drug discovery.Firefly luciferase based assays show better signal-to-noise than fluorescence-based assays.Market SummaryRSV is a major cause of respiratory illness, especially in young children and the elderly. In the United States, nearly all children have been infected with RSV by age two, resulting in 75,000-125,000 hospitalization and 4,000 dea...Mon, 14 Nov 2016 10:43:06 GMTott@emory.edu Recombinant Fusion Protein for the Treatment of Autoimmune Diseases fusion protein comprising GM-CSF and interleukin-15 for treating autoimmune diseases.Key BenefitsrGIFT15 lacks any post-translation modification such as glycosylation.Market SummaryMore than 23 million Americans suffer from autoimmune diseases and that number is rising. Current therapies treat the symptoms, but do not provide a cure and currently available immunosuppressant treatments may lead to devastating, long-term side effects. There is a need for improved treatments for autoimmune diseases.Technical SummaryGIFT fusokines are fusion cytokine proteins that have power...Fri, 11 Nov 2016 08:57:15 GMTott@emory.edu Cancer Genetics Referral Screening Tool (B-RST 3.0), 29 Oct 2016 10:42:06 GMTott@emory.edu Asparagine Endopeptidase (Legumain) Inhibitors for Treating Cancers molecule inhibitors of asparagine endopeptidase for the treatment of cancers. Key BenefitsNontoxic and specific inhibitors selectively block asparagine endopeptidase (AEP), leaving other related cysteine proteases unaffected.Effectively represses the metastasis of breast cancer cells to lungs.Market SummaryAsparagine endopeptidase (AEP) is implicated in various human disorders including cancers and neurodegenerative diseases. AEP is upregulated in solid tumors and its endoprotease activity has been associated with increased invasive and aggressive behavior of several cancers, ...Tue, 25 Oct 2016 12:49:28 GMTott@emory.edu Endopeptidase (Legumain) Inhibitors for Treating Neurological Disorders, 25 Oct 2016 12:49:28 GMTott@emory.edu Inhibitors of the Measles and Nipah Viruses A cell-based assay to screen for inhibitors of the measles virus (MV). Highly active compounds have been identified and analogs have been synthesized and evaluated. Key BenefitsPotent (sub-nM range), non-peptidic, non-nucleosidic compounds. Robust, cell-based, high-throughput screening assay. Technical Summary Vaccination serves as the only technology presently available to prevent measles virus infection. However, immunity takes weeks to develop and vaccination is contra-indicated in immune compromised individuals. In addition, the current vaccine cannot be administered to infants...Tue, 18 Oct 2016 07:41:56 GMTott@emory.edu,8-Dihydroxyflavone Derivatives for Treating Neurological and Neurodegenerative Diseases, 18 Oct 2016 07:02:16 GMTott@emory.edu Frame for Resources Limited Settings surgical frame to stabilize and position a patient during spinal surgery.Key BenefitsPortable equipment can be broken down into components to fit in a suitcase.Provides the necessary setting for spinal surgery.Equipment has a fraction of the cost of traditional operating tables.Market SummarySurgical procedures continue to become more specialized and require more specialized operating room tables. Specialized operating tables allow surgeons to safely perform surgeries that require specific patient positioning. The operating room tables used for spinal surgery can cost tens ...Mon, 17 Oct 2016 11:40:47 GMTott@emory.edu Molecule Potentiators for Treatment of Central Nervous System Disorders, 17 Oct 2016 11:38:46 GMTott@emory.edu Probabilistic Algorithm for Spatial-Temporal, Personal Privacy Protection Software for location cloaking and privacy while using location-based services. Key Benefits Allows use of location-based services while maintaining the privacy of the user's location. Provides time-dependency for spatial-temporal cloaking. Operates faster than other location cloaking technologies. Market Summary Location-based services are computer program-level services which use location and time data to control features in computer programs. More than 150 million people access location-based services in the United States each year via mobile applications, GPS, and other pro...Wed, 17 Aug 2016 09:06:53 GMTott@emory.edu of Fibroblasts toward a Three-Dimensional Vascularized Cardiomimetic Tissue (CMT) Fibroblasts reprogrammed into tissue-like patch including functional cardiomyocyte, endothelial, smooth muscle and pericyte cells for treatment of cardiac diseases. Key Benefits Enables simultaneous reprogramming of multi-lineage cells including cardiomyocytes and endothelial cells Increases expression of cardioprotective paracrine factors. Provides cardiac functionality, with demonstrated muscle contractility. Market Summary Ischemic heart disease or coronary artery disease is the single leading cause of death and disability worldwide with over 600,000 deaths and 715,000 new h...Tue, 19 Jul 2016 06:54:09 GMTott@emory.edu for Smoothing Out Nasolabial Folds An in-office surgical nasolabial folds solution providing a permanent but reversible correction for lines associated with facial aging. Key Benefits Permanent correction preventing complications arising from multiple procedures. Gentle placement process allows for quick recovery and very small, hidden insertion site Can incorporate a variety of materials, such as approved hydrogels or other biologically compatable polymers. Market Summary Nasolabial folds, or parentheses, are the deep folds that form on the side of your nose and run to the corner of your mouth. Nasolabial folds...Fri, 24 Jun 2016 06:53:58 GMTott@emory.edu Target and Methods to Treat Sepsis identification of the coinhibitory receptor 2B4 and its ligand CD48 as targets for the treatment of sepsis.Key BenefitsA target for the prevention of mortality during sepsis. Blocking the 2B4 coinhibitory receptor or its ligand, CD48, may reduce mortality during sepsis in humans. Market SummaryThere are approximately 750,000 cases of sepsis annually in the U.S., with up to 370,000 deaths. Currently, there are no approved therapeutics available for the treatment of sepsis if antibiotics and supportive therapy fail. Immune dysregulation can result in immune incompetence, an import...Fri, 24 Jun 2016 06:53:51 GMTott@emory.edu Soluble Progesterone Analogues for Treatment of Traumatic Brain Injuries Shelf-stable, water-soluble prodrugs of progesterone oximes for the treatment of traumatic brain injuries (TBI). Key Benefits Compound has activity equal to native progesterone, but is readily soluble in aqueous based, injectable dose formulations and well suited for use in the clinic and by first responders. Compound has been shown to cross the blood brain barrier (BBB). Market Summary In the United States, an estimated 1.7 million people suffer a traumatic brain injury (TBI) and 52,000 result in deaths annually. Several compounds are being investigated for the treatment of acu...Fri, 24 Jun 2016 06:53:48 GMTott@emory.edu Biomarkers for Coronary Artery Disease (CAD), 16 Jun 2016 08:08:08 GMTott@emory.edu Application for Detection of Anemia without Blood Draw A smartphone application to detect anemia based on image analysis of the fingernail bed to detect paleness associated with low hemoglobin levels. Key Benefits Noninvasive testing method for anemia reduces risks associated with blood draw. Easy-to-use smartphone based screening tool for patients or health care providers. Market Summary Anemia is a common aliment characterized by low blood hemoglobin levels resulting in fatigue, weakness and, in severe untreated conditions, dangerous cardiovascular complications. The causes of anemia are various including chronic kidney disease, c...Tue, 14 Jun 2016 10:57:36 GMTott@emory.edu Polymer for Nanoparticle Coating, 01 Jun 2016 11:47:16 GMTott@emory.edu for Expression of the Catalytic Domain of PRDM9 Plasmids to produce the catalytic domain of human PRDM9 or mouse Prdm9 protein, a robust methyltransferase generating trimethylation of histone H3 lysine 4 (H3K4me3). Technical Summary PRDM9 specifically trimethylates lysine 4 of histone H3, but does not have the ability to mono- and dimethylate lysine 4 of histone H3. H3K4 methylation represents a specific tag for epigenetic transcriptional activation during early meiotic prophase and is essential for proper meiotic progression. Recombinant, purified catalytic domains of human PRDM9 (aa 194-414) and mouse Prdm9 (aa 195-368) can ge...Wed, 01 Jun 2016 11:47:15 GMTott@emory.edu Fusokine as Vaccine Adjuvant to Prevent Viral Infection anchored to virus-like particles (VLPs) as a prophylactic vaccine adjuvant to prevent chronic viral infections including HIV, HBV, HPV and influenza.Key BenefitsGIFT4-containing VLPs induce higher antibody response than non-adjuvanted VLPs. Effectively induce strong mucosal immune response. Market SummaryMore than 36 million people are living with HIV and more than 1 million people die from AIDS-related illnesses each year. Currently, there is no vaccine to prevent HIV infection. Although there has been an overall decrease in the number of new infections and AIDS-related death...Wed, 01 Jun 2016 11:47:10 GMTott@emory.edu (Cognitively-Based Compassion Training) Manual A tool for learning and/or teaching how to develop compassion using analytical meditation. Key Benefits Integrated, guided meditations for the systematic development of compassion. Adaptable format for implementing over days or weeks as needed. Suitable for a variety of ages. Market Summary Compassion is necessary to maintain positive mental health and social involvement. The benefits are not solely mental; studies have shown a correlation between practicing compassion and maintaining lower stress and improved immune system function. Further, practicing self-compassion can aid...Fri, 13 May 2016 11:45:05 GMTott@emory.edu Application for Disseminating Scientific Information software allowing new medical information and research gathered directly from scientific experts and sent to the general public.Key BenefitsInformation on the app is published by scientific and medical experts. Alert function and one-screen format allow users to easily stay up-to-date. Mobile platform provides versatility in access to scientific information. Market SummaryAs technology advances, the ability to access and share information is growing rapidly. In disciplines such as scientific research and drug development, engaging the general public is important from both edu...Fri, 13 May 2016 11:44:59 GMTott@emory.edu Biomarkers of Huntington’s Disease, 13 May 2016 11:44:55 GMTott@emory.edu for Continuous, Wireless Monitoring of Animal Behavior and Physiology, 26 Apr 2016 06:37:10 GMTott@emory.edu Small Molecules that Promote Osteogenesis Repurposed small molecules for use as a bone forming therapeutic during treatment of diseases requiring local bone formation such as fracture repair, spinal fusion, and large segmental bone defects. Key Benefits Current treatments require high concentrations of bone morphogenetic protein (BMP) which results in high costs, adverse side effects, and creates a barrier for routine clinical use. These novel small molecules modulate a part of the signaling pathway for BMP and can be administered locally to promote bone growth and healing. These repurposed therapeutics are already FDA...Thu, 14 Apr 2016 09:42:55 GMTott@emory.edu of Small Molecule Potentiators of NMDA Receptors with Subunit Selectivity Multiple series of small molecules that selectivity potentiate NMDA receptors composed of specific subunits including GluN2B, GluN2C, GluN2B/GluN2C/GluN2D, and GluN2C/GluN2D. Key Benefits Small molecule potentiators enhance endogenous signals without exogenous activation. Subunit selectivity allows targeting of specific subtypes of NMDA receptors. Class of molecules are highly brain penetrant. Market Summary The NMDA receptor is a complex ligand-gated ion channel that has been viewed as a therapeutic target for multiple diseases and disorders for over 30 years. Reduced NMDA fun...Thu, 14 Apr 2016 09:42:53 GMTott@emory.edu Application and Tool to Evaluate Quality and Sustainability of Safe Water in Healthcare Facilities collection tools to systematically assess safe water, sanitation, and hygiene (WASH) as well as sustainability of safe water in healthcare facilities in developing countries.Key BenefitsRapid data collection allows survey of facility within hours. Establishes a metric to compare progress at one facility over time or across facilities in geographic regions. Market SummarySafe water, sanitation, and hygiene (WASH) in healthcare facilities play critical roles in disease prevention and control. However, WASH conditions of healthcare facilities in the developing world remain relativ...Thu, 14 Apr 2016 09:12:58 GMTott@emory.edu Nanoparticle Conjugates for Regulating TNF-a, 01 Apr 2016 10:44:06 GMTott@emory.edu Interleukin 15, Sushi Domain, and TGF-ß Receptor Fusion Protein Therapeutic, 28 Mar 2016 09:12:14 GMTott@emory.edu Mouse Aortic Endothelial Cell Lines Immortalized (using polyoma middle T-antigen) mouse aortic endothelial primary cell lines for studying vascular biology and pathophysiology, including cardiovascular research. Key Benefits Immortalized from mouse artery endothelial cells using polyoma middle T-antigen. Validated retention of primary endothelial markers and structural phenotype in cell culture. Wild-type, p47phox-/-, eNOS-/-, and caveolin-1-/- knockout aortic endothelial cell llines. Technical Summary A lack of primary mouse aortic endothelial cells for cell culture remains a hindrance in endothelial cell biolog...Fri, 25 Mar 2016 10:31:30 GMTott@emory.edu Small Molecules as a Targeted, Combination Therapy for Multiple Myeloma of an inhibitor of glucose metabolism and BH3 mimetic for increased efficacy in the treatment of multiple myeloma.Key BenefitsActivates cell death pathways through independent molecular mechanisms, resulting in enhanced effect with combination therapy. Repurposed use of FDA-approved therapies to expand indications in oncology. Market SummaryMultiple myeloma (MM) is a plasma cell malignancy that is largely incurable and claims over 11,000 lives annually in the US alone. Despite use of new medicines, treatment options and stem cell replacement, MM remains an aggressive kil...Fri, 25 Mar 2016 06:30:03 GMTott@emory.edu that Bind to Amyloid Precursor Protein (APP) Peptides, 17 Mar 2016 13:24:38 GMTott@emory.edu Spectrum Vaccine to Human Rhinovirus Serotypes A vaccine that provides protection from a broad spectrum of human rhinovirus serotypes. Key Benefits Targets numerous, specific human rhinovirus (HRV) serotypes and provides broad neutralizing antibodies. Engineered bacterial artificial chromosome (BAC) expression of HRV to reproducibly express specific serotypes. BAC system allows for genetic manipulation of HRV to produce recombinant strains of virus potentially improving vaccine effectiveness. Market Summary Human rhinovirus (HRV) is the most common virus infecting humans, primarily impacting the nose, throat (pharynx) and si...Wed, 16 Mar 2016 05:04:18 GMTott@emory.edu Factor VIII for the Treatment of Hemophilia A variants of Factor VIII proteins with increased biosynthetic efficiency, specific activity, and stability as well as decrease immune reactivity for replacement therapy to treat patients with hemophilia A.Key BenefitsAncestral sequence-based factor VIII variants are functionally superior to human factor VIII in both protein replacement and gene therapy settings. Ancestral derived Factor VIII variants have increased pharmacological properties over current recombinant factor VIII products. Ancestral factor VIII variants display more efficient cellular biosynthesis that transl...Fri, 12 Feb 2016 08:34:57 GMTott@emory.edu Human Dopamine Beta-hydroxylase Mouse Model Mouse model that utilizes a BAC to express human dopamine beta-hydroxylase in the brain. Key Benefits In vivo approach to dissect role of single genes in the nervous system. May be used in the study of how human variants of dopamine beta-hydroxylase affect norepinephrine signaling in the brain. Technical Summary Dopamine beta-hydroxylase is encoded by the DBH gene and converts dopamine to norepinephrine. These signaling molecules are involved in a variety of processes important in Parkinson disease, drug dependence, and mental illness. Researchers at Emory have developed a mous...Tue, 09 Feb 2016 06:26:52 GMTott@emory.edu Cell Metabolism Inhibitors for Targeted Therapies Glutamate dehydrogenase (GDH1) inhibitors targeting cancer cell metabolic pathways. Key Benefits Targets tricarboxylic acid (TCA) cycle/mitochondrial metabolism utilized by several cancer cell types for cell growth and survival. Reduces cell proliferation and viability in several tumor derived cell lines as well as in xenograft tumor models. Limited effects on cell toxicity and proliferation rates observed in non-tumor derived cell lines or in tissues from mice treated with GDH1 inhibitors. Market Summary Statistics show cancer prevalence is on the rise and is projected to rise...Mon, 08 Feb 2016 07:18:34 GMTott@emory.edu That Binds to Asparagine Endopeptidase-Cleaved Type of Tau, 08 Feb 2016 07:18:22 GMTott@emory.edu Molecule Inhibitor of CHFR Small molecule inhibitor of CHFR to increase taxane efficacy in cancer treatment. Key Benefits Combination treatment, potentially effective against cancers resistant to taxane treatment. Market Summary Approximately 400,000 Americans are living with lung cancer and over 200,000 more are diagnosed each year. Microtubular-targeted chemotherapy agents such as taxanes are among the most widely prescribed first- and second- line chemotherapy choices for patients with the most common malignancies including lung-, breast-, and prostate cancer. Unfortunately, primary resistance to taxanes...Mon, 08 Feb 2016 07:17:48 GMTott@emory.edu<![CDATA[Recombinant RSV Strains Expressing Renilla Luciferase and G & F Proteins]]> Recombinant respiratory syncytial virus (RSV) strains expressing the G and F Proteins from RSV strains as well as renilla luciferase for use in drug and vaccine screening. Key Benefits Provides new and needed tool for screening potential RSV therapies, ensuring they are broadly effective against multiple, distinct strains of the virus. Expresses renilla luciferase for easy screening. Market Summary RSV is a common respiratory virus infecting most of the population at some point during their life and a major cause of lower respiratory tract infections in infants, children, and th...Tue, 19 Jan 2016 10:05:55 GMTott@emory.edu Start Treatment Planning, 19 Jan 2016 10:05:53 GMTott@emory.edu Molecules for Treating Cystic Fibrosis, 19 Jan 2016 10:05:44 GMTott@emory.edu Based Detection by DNA Machines DNA-based machines that roll rather than walk and can be used for single nucleotide polymorphism (SNP) analysis. Key Benefits Unique "rolling" cogwheel-like mechanism allows directional motion without a track or external guidance. Micron-sized cargo travels large distances; can be visualized using a smartphone camera equipped with an inexpensive lens. Moves up to 1,000 times faster than conventional DNA-based motors. Market Summary Single Nucleotide Polymorphism (SNP) genotyping is the screening and analysis of genetic variations of SNPs in the genome of various species. SNPs a...Tue, 19 Jan 2016 10:05:42 GMTott@emory.edu MRI Reporter to Monitor Stem Cells In Vivo MRI contrast that can be monitored in vivo during cell replacement therapy.Key Benefits Based on a magnetosome associated prokaryotic gene, MagA, leading to lower toxicity than nanoparticle systems. MagA can be used to monitor stem cell graft non-invasively. Technical SummaryCell replacement therapy and regenerative medicine has been investigated for treating incurable diseases including diabetes, autoimmune diseases, and neurodegenerative diseases. In these treatments, it is difficult to monitor the fate of grafted cells in a non-invasive manner over the lifetime of the c...Tue, 19 Jan 2016 10:03:52 GMTott@emory.edu CCR5/CXCR4 Chemokine Compounds for the Treatment of HIV, 08 Jan 2016 11:37:41 GMTott@emory.edu Antagonists for Treatment of Neurological Disorders new series of compounds for selectively inhibiting N-methyl-D-aspartate (NMDA) receptor subunits for the treatment of Parkinson's disease, schizophrenia, treatment-resistant depression, and ischemia. Key BenefitsImproved anatomical selectivity in NMDA receptor modulation may result in fewer adverse side effects. Targeted antagonism of the GluN2C/D subunits of the NMDA receptor may yield better pharmacological and pharmacokinetic properties than other NMDA receptor antagonists. Market SummaryN-methyl-D-aspartate (NMDA) receptors are widely dispersed in the central nervous system (C...Tue, 22 Dec 2015 11:31:23 GMTott@emory.edu A Rapid, Portable Technology to Screen for Concussions and Mild Traumatic Brain Injury DETECT is a computerized system for diagnosing mild traumatic brain injury (mTBI) in diverse and austere environments. Key Benefits Heads up display and immersive platform eliminate the need for controlled testing environments, allowing for neuropsychological testing in locations closer to point of injury (e.g. sports sidelines or battlefield). Allows for rapid administration (10-15 min) of sensitive neuropsychological tests to identify mTBI shortly after injury. Market Summary An estimated 3.8 million people suffer TBI each year in the U.S. Of them, approximately 75% are consid...Tue, 22 Dec 2015 11:31:15 GMTott@emory.edu Antiporter 3 (NHE3) Antibody, 26 Oct 2015 17:55:55 GMTott@emory.edu that Binds to Lysophosphatidic Acid Receptor 5 (LPAR5), 26 Oct 2015 17:55:51 GMTott@emory.edu That Reacts with Inositol Triphosphate (IP3) Receptor-binding Protein (IRBIT), 26 Oct 2015 17:55:45 GMTott@emory.edu VIII Antibody Epitope Mapping Array A microarray that can determine anti-fVIII Ab epitopes for hemophilia A patient personalized therapy planning. Key Benefits Has the potential to predict responses of patients with hemophilia A and inhibitors to fVIII infusions or combinations of fVIII and bypassing agents better than Ab titers alone. Has the potential to predict if patients will respond to ITI. The microarray uses minimal volume of patient plasma. Technical Summary Patients with high inhibiter titers are felt to be unlikely to respond to fVIII infusions and some patients treated with bypassing agents do not res...Thu, 08 Oct 2015 11:37:20 GMTott@emory.edu BAC - Transgenic Mouse Model of Obesity Mouse model represents GNB3 duplication related to childhood obesity syndrome. Key Benefits Models obesity syndrome caused by recurrent chromosomal translocation Investigates functional significance of GNB3-related pathways including BMI disorders Technical Summary Obesity can be a heritable condition that precedes other diseases including type-2 diabetes, cardiovascular disease, hypertension, or cancer. Recent research has shown that genomic copy number variation (CNV) leads to a syndrome associated with intellectual disability, seizures, macrocephaly, and obesity. In this rec...Wed, 30 Sep 2015 05:44:26 GMTott@emory.edu for Mucositis Associated with Cancer Therapy lozenges (and other oral therapies) for the maintenance of oral health and treatment of mucositis associated with chemotherapy/radiation treatment.Key BenefitsCurrent approaches to the treatment of mucositis associated with cancer therapy have not proven to be efficacious. An over the counter (OTC) supplement involving glutathione, an antioxidant, reduced mucositis symptoms by 70% in an animal model.Technical SummaryMucositis (inflammation of the oral mucosa) is a common, painful, and often dose-limiting side effect associated with chemotherapy and/or radiation therapy for canc...Tue, 01 Sep 2015 06:15:15 GMTott@emory.edu Cell Culturing Media for Enhanced Antibody Secretion and Plasma Cell Survival culture media that promotes the survival of human plasma cells and immunoglobin (Ig) secretion for laboratory research reagents, diagnostic reagents, and/or pharmaceutical reagents. Key BenefitsIncreases antibody-secreting cells (ASCs) found in blood after antigen exposure, which can be used to identify an active antigen or pathogen causing illness. Composed of mesenchymal stromal cells, increasing the survival potential in specific tissue culture. Market SummaryCell culture is the foundation of biopharmaceutical development and manufacturing, and makes up a nearly $1.4 billion...Mon, 22 Jun 2015 06:40:17 GMTott@emory.edu of Human Carbonic Anhydrase II carbonic anhydrase II (CAII) inhibitors for drug discovery and a method for designing them.Key BenefitsHighly potent molecules for inhibiting carbonic anhydrase. Compounds generated using a novel computational chemistry method based on a validated data retrieval platform. Market SummaryObesity is a chronic medical condition and is commonly associated with type 2 diabetes, hypertension, dyslipidemia, and coronary heart disease. Few medications are available for the management of obesity. Currently, the 3 major groups of drugs target the impairment of dietary intake, impairment...Mon, 22 Jun 2015 06:40:16 GMTott@emory.edu View: Radiation Therapy Optimization Software Software for planning radiation therapy and ensuring adequate clearance between the patient and the radiotherapy device during treatment Key Benefits 3-D optically scanned model takes into account the geometry of the entire body, allowing the planning of radiation therapy to be customized for each patient. Visualizes all possible gantry and couch positions to ensure optimized treatment planning. Market Summary Radiation therapy treatment is administered to patients using external beam radiation generated by a linear accelerator (LINAC). The LINAC is mounted on a rotating gantry,...Mon, 22 Jun 2015 06:40:13 GMTott@emory.edu Diabetes Education Program diabetes education program in Spanish for the Latino population.Key BenefitsCulturally appropriate program in Spanish and English. Program offers supplemental materials including DVD, website, and nutrition information. Program offers free monthly classes. Market SummaryDiabetes affects nearly 275 million people worldwide and type 2 diabetes is one of the fastest growing diseases in the US. Currently, there is no cure for diabetes, but it is often manageable through maintaining sufficient levels of circulating insulin. The growing population of Latinos in the country ...Tue, 16 Jun 2015 12:39:47 GMTott@emory.edu Molecule HIF-1 Pathway Inhibitors as Anticancer Drugs and Tracers for PET Imaging Small molecules that inhibit hypoxia-inducible factor (HIF)-1 pathway for use as cancer therapeutic and imaging agents. Key Benefits Inhibition of HIF-1 activity can prevent tumor vascularization and metastases. Small molecule HIF-1 pathway inhibitors have good lipid solubility. Water solubilizing subgroups added to our HIF-1 pathway inhibitors to address poor water solubility. Market Summary HIF-1's overexpression is detected in and positively associated with mortality in various human cancers, including bladder, brain, breast, cervix, colon, endometrium, esophagus, head and n...Wed, 10 Jun 2015 09:32:27 GMTott@emory.edu for Diagnosis and Treatment Management of Tuberculosis Biomarkers to diagnose active and latent tuberculosis infection and monitor treatment regimen. Key Benefits Three biomarkers accurately distinguish active tuberculosis (TB) from latent TB infections with 100% specificity and greater than 96% sensitivity. Faster and more accurate test to monitor treatment response among active tuberculosis patients. Uses blood samples instead of sputum samples that are more difficult to obtain in some patient population. Market Summary Tuberculosis (TB) remains a serious global health problem with more than 9 million new cases and 1.5 million de...Mon, 01 Jun 2015 12:37:51 GMTott@emory.edu to Treat Traumatic Brain Injury The use of progesterone to treat patients with traumatic brain injury (TBI) via a tapered administration protocol. Key Benefits Early administration of progesterone reduces cerebral edema and neural loss, and improves behavioral recovery from traumatic brain injury (TBI) in pre-clinical animal models. Tapered progesterone withdrawal enhances recovery after TBI compared to acute withdrawal. Progesterone reduces mortality by 50% and improves functional outcomes in patients with TBI in phase II clinical trials. Tested in phase II and phase III clinical trials and has an acceptabl...Mon, 01 Jun 2015 12:37:49 GMTott@emory.edu Molecule Therapeutic for Regeneration of Cartilage molecule therapeutic that can be delivered locally to enhance TGF-beta activity and promote cartilage growth.Key BenefitsIncreases production of protease inhibitors, simultaneously stimulating production and blocking degradation of extracellular matrix (ECM). Potentially reduces or eliminates need for joint replacements by regenerating articular cartilage Market SummaryEach year, there are approximately one million knee and hip replacements performed in the United States, often due to osteoarthritis (OA), a joint disease that results from the breakdown of joint cartilage and u...Mon, 01 Jun 2015 08:21:31 GMTott@emory.edu EP2 Receptor Antagonists for Reducing Inflammation small molecule therapeutic for treatment of peripheral inflammation, neurological disorders and carcinogenesis.Key BenefitsEP2 is a key receptor for cancer progression, peripheral and brain inflammation. Lead compound candidates display high EP2 potency and selectivity. Compound effectively inhibits inflammation Market SummaryThe inflammatory response is a significant component of the immune system. Both acute and chronic inflammation contribute to well over 10 million cases in the United States. These cases include post-operative cognitive dysfunction (POCD), post-operati...Mon, 18 May 2015 07:42:18 GMTott@emory.edu Media for Patients with Autoimmune Blistering Diseases Video explaining autoimmune blistering disease including possible causes, clinical manifestations, pathology, and treatments to patients. Key Benefits More clear and succinct than currently available written media. Can be viewed by patient before office visit, reducing the visitation time. Market Summary Autoimmune blistering diseases, most commonly divided into pemphigus and pemphigoid, are disorders whereby the body mistakenly attacks a protein that facilitates cell adhesion, leading to the formation of blisters on the skin and/or mucous membranes. Treatment options vary depen...Wed, 13 May 2015 05:58:21 GMTott@emory.edu Targeting Mitochondrial Complex I and HIF derived compounds that induce a therapeutic response in cancer cells through the synergistic targeting of mitochondrial complex I and hypoxia inducible factor (HIF). Key BenefitsUtilizes dual mechanisms of action for increased efficacy. Provides therapeutic window for selective targeting of cancer cells. Potent against glioblastoma, sarcoma and melanoma cell lines.Market SummaryTherapeutic regimens available to clinicians cause extreme side effects and remain non-effective against chemo-resistant cancers that are commonly present in relapsed patients. A promising route f...Fri, 08 May 2015 13:18:16 GMTott@emory.edu Insecticides Targeting Mitochondrial Complex I Benzohydrol derived inhibitors of mitochondrial complex I with significant insecticidal activity. Key Benefits Provides highly potent, complex I inhibitors requiring low amounts for efficacy. Synthesis of the compound is simpler than currently available compounds, reducing the cost of production Market Summary The 260 million acres of harvested area in the United States alone relies heavily on the performance and safety of insecticides in order to maximize crop yield while keeping consumers healthy. Currently used insecticides can cause negative side effects in both the environ...Fri, 08 May 2015 13:17:42 GMTott@emory.edu Survey for Adolescent Bullying and Isolation Survey for identifying patterns of social networking and cyber bullying among adolescents. Key Benefits Identifies specific behaviors and experiences to provide a more detailed analysis of cyber bullying. Survey is anonymous and requires no protected health information. Market Summary Internet usage among adolescents has increased tremendously in the last decade, resulting in an increase in unsupervised access to various forms of media and electronic content. A study by the Kaiser Foundation found that internet use among 8-18 year olds has increased from 47 to 85 percent in the ...Thu, 30 Apr 2015 13:40:34 GMTott@emory.edu Stabilizer for Minimally Invasive Cardiac Bypass Surgeries Heart stabilization device for use in minimally invasive cardiac bypass surgeries. Key Benefits Shorter and thinner articulating arm allows for smaller incisions and less crowding of the work field. Flexible articulating arm accommodates variations in patient anatomy. V-shaped stabilizing arms are much less bulky than those for currently available devices. Market Summary Coronary artery bypass surgery is one of the most commonly performed surgeries in the United States. Minimally invasive techniques in this surgery have become increasingly common. Additionally, bypass surgery c...Tue, 28 Apr 2015 10:20:34 GMTott@emory.edu ELISA for Determination of TrkB Activation A quantitative enzyme-linked immunosorbent assay (ELISA) for monitoring endogenous rat tyrosine receptor kinase B (TrkB) activation. Key Benefits Two quantitative ELISA approaches provide reliable methods to quantify the intensity of TrkB receptor activation in primary neurons with endogenous TrkB receptor. Enables high-throughput drug screening targeted at the TrkB receptor. Technical Summary Brain-derived neurotrophic factor (BDNF)/tyrosine receptor kinase B (TrkB) signaling plays essential roles in a variety of neurological processes. However, there is currently no quantitat...Mon, 27 Apr 2015 09:13:19 GMTott@emory.edu Assembled Nanoparticles for Oral Drug Delivery, 27 Apr 2015 09:13:17 GMTott@emory.edu Oligosaccharide-Coated Iron Oxide Nanoparticles Ultrafine magnetic iron oxide nanoparticles (IONPs) coated in oligosaccharides for enhanced contrast in magnetic resonance imaging (MRI). Key Benefits Oligosaccharide coating is biocompatible. Coating leads to increased water solubility and solution stability. Small size promotes a high efficiency contrast enhancement for MRI that can differentiate between tissue and vasculature. Improved clearance compared to IONPs coated in larger polymer-coated iron oxide nanoparticles. Market Summary Iron oxide nanoparticles (IONPs) are iron oxide particles with a diameter ranging from 1-1...Mon, 27 Apr 2015 09:13:16 GMTott@emory.edu Invasive Internal Suturing System Endoscopic suturing device for incision-less, minimally invasive tissue suturing. Key Benefits Able to be inserted into a hollow organ or body cavity, enabling incision-less tissue suturing. Air permeable fabric or membrane allows passage of suction or t-tag suture needle. Applicable to diverse surgeries. Market Summary Surgical suturing has been utilized to bind human tissues in close proximity since 3000 BC. Modern medicine is allowing many procedures to be completed with minimal invasiveness, but an internal suture, such as a gastric bypass procedure, requires the highly inv...Mon, 27 Apr 2015 09:13:15 GMTott@emory.edu App for Visualizing the Liver Educational mobile iOS application for the mastering and teaching of liver anatomy. Key Benefits Hands-on app with 3D zoom and rotation features allow more thorough mapping of the liver. Includes in-depth 12 minute tour of the liver, guided by an experienced surgeon. Market Summary Every year thousands of students register for medical school and must learn the detailed anatomy of the liver to pass though their education and residency. As a very complex and important organ, all medical practitioners from residents to experienced surgeons require a quick though detailed and reliab...Thu, 23 Apr 2015 12:32:10 GMTott@emory.edu Surgical Wrist Support support for physician's wrists during fine, microsurgical procedures.Key BenefitsUniversal design attaches to any surgical table. Full wrist and arm support during procedure reduces operative tremors and fatigue. Wrist supports adjustable in any direction, accommodating various positions and angles required during surgery. Market SummaryDemand for surgical procedures has increased enormously over recent years. According to the CDC, the number of surgical procedures increased by three million from 2008 till 2010. Many of these surgeries require fine motor skills and movemen...Thu, 16 Apr 2015 08:20:40 GMTott@emory.edu Resistant Antitumor T Cells Chimeric Antigen Receptor T-Cell based immunotherapy that can be used concomitantly with chemotherapy. Key Benefits T lymphocytes are engineered to be resistant to various chemotherapy agents, allowing for dual cell and chemotherapy-based approaches. Lymphocytes can be made to express a variable lymphocyte receptor (VLR) chimeric antigen receptor (CAR) to allow for more precise tumor targeting. Market Summary Chemotherapeutics are among the most used and successful cancer treatments, but they can cause harmful and undesirable side effects. Many of these effects stem from the dru...Tue, 14 Apr 2015 07:43:04 GMTott@emory.edu MR-TRUS Registration for Image-Guided Prostate Interventions Registration software for higher accuracy in magnetic resonance (MR) and transrectal ultrasound (TRUS) imaging. Key Benefits Increased accuracy of prostate radiotherapy by combining two imaging modalities that include identifying patient-specific prostate variations. Market Summary According to the American Cancer Society, there are 233,000 new cases of prostate cancer in the United States diagnosed yearly and about 29,480 men will die of prostate cancer per year. Current methods for the treatment of prostate cancer include magnetic resonance (MR) and transrectal ultrasound (TRUS)...Tue, 31 Mar 2015 12:44:46 GMTott@emory.edu Respiratory Syncytial Viruses (RSVs) Expressing the G and F Proteins from Various Strains RSV Strains Expressing the G and F Proteins from various geographically distributed RSV strains for use in drug and vaccine screeningKey BenefitsProvides new and needed tool for screening potential RSV therapies, ensuring they are broadly effective against multiple, geographically distinct strains of the virus Expresses the red fluorescent protein mKate2 for easy screening Market SummaryRSV is a common respiratory virus infecting most of the population at some point during their life and a major cause of lower respiratory tract infections in infants, children, and the el...Thu, 26 Mar 2015 12:52:26 GMTott@emory.edu a Suicide Prevention App is a mobile companion app for suicide prevention.Key BenefitsA companion app that includes mood tracking, reminders and safety plans. Location aware for finding the nearest hospitals and mental health treatment centers. Includes personalized coping mechanisms and assistance for finding therapists and support groups. Market SummarySuicide is the 10th leading cause of death in the United States accounting for 38,000 deaths per year. It is important to understand that deaths due to suicide are only a leading indicator of the individuals at risk. It is estimated that 11 attem...Thu, 26 Mar 2015 12:52:23 GMTott@emory.edu Cardiac Catheterization Procedure Notes Cardiac catheterization notes for electronic medical record systems that efficiently satisfy the requirements of today's healthcare environment. Key Benefits Provides ready-to-use templates for cardiac catheterization procedure notes and easy-to-read reports for electronic medical record (EMR) systems. Reduces documentation burden on providers and includes procedure codes to facilitate paperless billing. Optimizes capture of data for the NCDR CathPCI Registry® to improve performance in risk-adjusted outcomes metrics and the Appropriate Use Criteria for Revascularization. Adhere...Tue, 24 Mar 2015 09:07:04 GMTott@emory.edu Temperature Bacterial Expression Vector for Protein/Peptide Manufacturing, 24 Mar 2015 09:07:02 GMTott@emory.edu Implantable cardioverter defibrillator (ICD) Checklist Paper and electronic versions of an implantable cardioverter defibrillator checklist to ensure compliance with Medicare coverage rules. Key Benefits Simplifies compliance with Medicare National Coverage Determinations. Provides guidance and increases physician confidence on the appropriateness of implantation of implantable cardioverter defibrillators. Compatible with current electronic medical record systems. Market Summary Implantable cardioverter defibrillators (ICDs) can be life-saving in patients with advanced heart disease and who are at risk of life-threatening heart rhy...Tue, 24 Mar 2015 09:06:42 GMTott@emory.edu of Bone Formation with a Repurposed Drug as an Osteoporosis Therapeutic biologic, Abatacept, which promotes new bone formation via T-cell modulation for the treatment of osteoporosis.Key BenefitsIncreases osteoblast activity to promote new bone formation unlike a bisphosphonate which limits bone loss. Offers a once monthly injection option compared to daily injection. Abatacept already FDA approved for rheumatoid arthritis. Market SummaryThe National Osteoporosis Foundation estimates that 10 million Americans have osteoporosis and another 34 million have low bone mass. The standard of care for osteoporosis is anti-resorptive therapy to preven...Thu, 19 Mar 2015 08:40:54 GMTott@emory.edu Small Airway Cell Culture System for Drug Screening and Research of Airway Diseases and Conditions Cell culture system that acts as an in vitro model for infection and stress-induced airway inflammation; used for research and drug discovery/screening. Key Benefits Improved structure of system offers natural path for neutrophil transepithelial migration, unlike current systems. More accurately models pathological environment due to integration of airway fluid from patients. Could be used to model other tissues (e.g. gut) beyond small airways. Market Summary Human small airway epithelial cells (SAECs) are a subset of general respiratory epithelial cells isolated from normal hu...Thu, 12 Mar 2015 13:34:11 GMTott@emory.edu Nutritional Therapy for Autism/Apraxia and Malabsorption, 17 Feb 2015 10:29:25 GMTott@emory.edu Standalone smartphone app to increase vaccinations and improve vaccine knowledge for providers, pharmacists, and the general public. Key Benefits Provides detailed information about a variety of vaccines and diseases. Sends out alerts and updates. Market Summary Vaccines prevent millions of cases of infectious diseases each year; however, many parents are now refusing to have their children vaccinated. The decline in vaccination rate has contributed to outbreaks of preventable diseases in the developed world. Due to false information found on websites, message boards, and blogs,...Tue, 17 Feb 2015 10:26:13 GMTott@emory.edu Vaccine Antigen Presentation Platforms Combined antigen-adjuvant virus-like particle (VLP) vaccine platform for enhanced immune response. Key Benefits Chimeric VLPs (cVLPs) contain both antigen and adjuvant, thereby enhancing both cellular and humoral responses. cVLPs are safer than live replicating vectored vaccines because of their lack of infectivity. The cVLP manufacturing process is much shorter than current vaccine production. Market Summary Traditional vaccines are generally composed of dead or attenuated microbes that have lost their disease-causing properties, its toxins or one or more of its surface protei...Tue, 17 Feb 2015 10:00:22 GMTott@emory.edu<![CDATA[Modified Respiratory Syncytial Virus (RSV) Strain for Drug Screening & Vaccine Development]]> RSV and expression plasmid, strain A2-line19F, with improved characteristics for use in vaccine and drug development.Key BenefitsRecombinant virus was shown to have improved fusion activity compared to native line19F virus. Recombinant virus shown to induce greater viral load pathology in vivo with mice. Market SummaryRSV is a ubiquitous virus that is the most common cause for respiratory illness in infants and young children worldwide, causing almost 160,000 deaths each year. Nearly all children within the US have been infected with RSV before the age of two, leading to...Fri, 13 Feb 2015 07:59:33 GMTott@emory.edu Inhibitors of NOX2/ROS, 10 Feb 2015 09:03:14 GMTott@emory.edu Catheter for Delivery of Stem Cells or Cytokines to the Heart via the Pericardial Space A catheter for the delivery of biocompatible, polymer-embedded stem cells or cytokines to the heart via the pericardium. Key Benefits Minimally invasive procedure that does not require open heart surgery No risk of embolic stroke; greatly reduces risk of cardiac arrhythmia compared to other delivery techniques Creates a more advantageous environment for stem cells to survive after delivery to the heart. Market Summary In the United States, more than 700,000 people experienced heart attacks and over 5 million people experienced heart failure in one year alone. Current treatment ...Mon, 09 Feb 2015 08:26:25 GMTott@emory.edu of MicroRNA-miR712/miR205 for the Treatment of Atherosclerosis and Other Vascular Conditions Antisense oligonucleotide inhibitors of microRNA-miR712/miR205 to prevent or treat atherosclerosis and aortic aneurysm. Key Benefits 80% reduction on the expression of their microRNA targets. Reduces atheroma plaque formation in a mouse model of atherosclerosis. Provides potential non-surgical treatment for aortic aneurysm. Market Summary Heart disease is the leading cause of death worldwide, resulting in one in every four deaths in the United States. The health care services, medications, and lost productivity for coronary heart disease cost United States $108.9 billion annua...Mon, 09 Feb 2015 08:26:01 GMTott@emory.edu (TM) P3 (TM), 28 Jan 2015 09:19:51 GMTott@emory.edu An mHealth Application to Improve Patient Engagement for Rheumatological Diseases mobile app for iOS to capture and communicate joint pain and arthritic parameters to healthcare providers, particularly in children.Key BenefitsDesigned specifically for children to use. Employs a user friendly game and reward based system to collect data. Accurately captures disease data for diagnosis, management and surveillance. Market SummaryJuvenile arthritis is one of the most common childhood diseases in the US. Children and parents need to be able to report subjective levels of joint pain, swelling, and joint mobility in order to facilitate timely and accurate assessment a...Wed, 28 Jan 2015 09:19:47 GMTott@emory.edu Receptor Blocker for the Treatment of PTSD Use of neurokinin 3 receptor antagonist, osanetant, for the prevention and treatment of post-traumatic stress disorder (PTSD) and other anxiety disorders. Key Benefits Utilizes a repurposed drug that is safe for human use. Potential to treat specific PTSD symptoms better than antidepressants. Market Summary Post-traumatic stress disorder (PTSD) occurs in some individuals after witnessing or experiencing extreme traumatic events. Currently those suffering from PTSD are prescribed antidepressants, which have limited success in clinical trials. There are no treatments for specific ...Wed, 28 Jan 2015 09:19:44 GMTott@emory.edu Magnetic Resonance Imaging-Compatible Spinal Therapeutics Delivery System device that enables precise delivery of therapeutic or cells to specific locations in the spinal cord. Key BenefitsCompatible with real-time MRI imaging systems allowing for the targeting and delivery of therapies concurrent with imaging. Can precisely guide and deliver a multitude of therapies (small molecules, biologics or stem cells) to a specific location in the spinal cord. Market SummarySpinal cord injuries and diseases are complex, difficult to treat, and usually have a poor prognosis, resulting in a range of symptoms from pain and weakness to paralysis and inc...Wed, 28 Jan 2015 09:19:42 GMTott@emory.edu Manufacturing Process for GIFT Fusion Cytokines, 28 Jan 2015 09:19:35 GMTott@emory.edu Viruses: Viruses Targeted to Hypoxic Cells and Tissues Virus-based therapy that targets tumors for the treatment of cancer. Key Benefits Provides a virus platform for anti-tumor therapeutic genes. Selectively targets hypoxic tumor cells instead of systemic chemotherapy. Market Summary Virotherapy is an emerging niche in the field of cancer therapeutics. Oncolytic viruses are able to infect and damage cancer tissue without damaging normal tissue by targeting tumors with specific genetic alterations or gene expression. These anti-tumor agents are highly effective due to their intrinsic ability to kill the infected host while deliveri...Wed, 28 Jan 2015 07:57:04 GMTott@emory.edu Reagents for the Identification and Quantification of Most Pneumococcal Serotypes/Serogroups via Quantitative PCR, 07 Jan 2015 03:59:53 GMTott@emory.edu Therapy for the Treatment of Lung, Head, and Neck Cancers Combination of niclosamide and erlotinib to treat lung, head, and neck cancers as well as overcome resistance to alternative treatments. Key Benefits Anti-cancer treatment combines two existing and approved therapeutics. Effective cancer treatment for erlotinib resistant patients. Market Summary Although epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs) are effective anti-cancer agents, a recent emergence of resistance to these therapies is a major clinical problem. The majority of patients with EGFR-mutant advanced non-small cell lung cancer (NSCLC) show ...Wed, 10 Dec 2014 08:02:24 GMTott@emory.edu Hand Assist Device for Urinary Incontinence, 30 Oct 2014 09:42:50 GMTott@emory.edu’s Disease Mouse Model Expressing Mutant Huntingtin Gene, 08 Oct 2014 06:59:53 GMTott@emory.edu for the Treatment of a Traumatic Central Nervous System Injury of progesterone for the treatment of traumatic brain injury (TBI).Key BenefitsProgesterone has a demonstrated therapeutic benefit to TBI patients including reduced mortality, and a potential to reduce secondary injury and enhance functional recovery. These compounds are inexpensive, safe for administration to both man and women, and have only minor side-effects in contrast to current therapies. Technical SummaryAccording to recent estimates by the Centers for Disease Control and Prevention, approximately 1.4 million people suffer from traumatic brain injury (TBI) annually, and u...Wed, 08 Oct 2014 06:58:10 GMTott@emory.edu Medications for Treatment of PTSD and Other Anxiety-Related Disorders therapeutics for the treatment of post-traumatic stress disorder (PTSD) symptoms as well as other anxiety-related disorders.Key BenefitsThe renin-angiotensin pathway is a new target pathway for the treatment of PTSD. Drugs are FDA approved for hypertension and have an excellent safety profile with few side effects. Market SummaryPTSD is prevalent in highly traumatized civilian population as well as among soldiers returning from combat-military operations. It is estimated that as much as 15% of the US population may develop PTSD at some time due to traumatic events in thei...Fri, 26 Sep 2014 05:29:24 GMTott@emory.edu Sodium Channel (ENaC) Beta 60 Polyclonal Antibody Immunohistochemistry Immunoprecipitation Western blot Specificity mouse, rat, frog (Xenopus) Subtype Rabbit Polyclonal Technical Summary The antibody available for licensing was made using recombinant GST fusion protein against the C terminal domain of the epithelial sodium channel (ENaC) beta subunit. Specifically, the antibody detects ENaC beta subunit via immunoassays such as Western blot, immunoprecipitation, and immunohistochemistry from cellular or tissue lysates of mouse, rat, or Xenopus origin. Publications Alli et al., 2012. Am J Physiol Renal Physiol. 303: F800-F811....Fri, 01 Aug 2014 11:11:48 GMTott@emory.edu Sodium Channel (ENaC) Alpha 59 Polyclonal Antibody Immunohistochemistry Immunoprecipitation Western blot Specificity mouse, rat, frog (Xenopus) Subtype Rabbit Polyclonal Technical Summary The antibody available for licensing was made using recombinant GST fusion protein against the C terminal domain of the epithelial sodium channel (ENaC) alpha subunit. Specifically, the antibody detects ENaC alpha subunit via immunoassays such as Western blot, immunoprecipitation, and immunohistochemistry from cellular or tissue lysates of mouse, rat, or Xenopus origin. Publications Alli et al., 2012. Am J Physiol Renal Physiol. 303: F800-F8...Fri, 01 Aug 2014 11:11:47 GMTott@emory.edu Therapeutic for Treating Infection-Sensitized Neonatal Encephalopathy New use of fingolimod (GilenyaTM) to treat infection-sensitized neonatal hypoxic-ischemic encephalopathy (HIE) via inhibition of Sphingosine-1-Phosphate receptor (S1PR) activation. Key Benefits Has been shown to reduce inflammatory markers and brain loss in rat models of infection-sensitized hypoxia ischemia. Could be used to treat infection-sensitized neonatal encephalopathy, a condition with an unmet need. Is FDA approved to treat multiple sclerosis which potentially reduces regulatory hurdles. Market Summary In the developed world, the incidence of severe perinatal asphyxia ...Thu, 31 Jul 2014 12:37:21 GMTott@emory.edu Assay to Predict Small Cell Lung Cancer Responsiveness to Platinum Chemotherapy Agents, 31 Jul 2014 12:37:18 GMTott@emory.edu Ligands for the Synthesis of Reactive Transition Metal Complexes Tertiary trialkyl 1,4,7-triazacyclononane (R3tacn) ligands that can be used to create reactive metal oxo-, imido- and nitrido- complexes. Key Benefits The tri-tert-butyl tacn (tBu3tacn) ligand is capable of forming 4-coordinate compounds with MnII, FeII, CoII, and NiII. These complexes are unprecedented in the chemical literature. The synthesis of previously inaccessible tBu3tacn requires only three chemical transformations and employs simple purification techniques. tBu3tacn generated redox-inert tBu3tacn-cobalt and tBu3tacn-nickel complexes. Technical Summary The R3tacn serie...Mon, 07 Jul 2014 08:04:44 GMTott@emory.edu Treatment for Diabetic Retinopathy Repurposed L-DOPA for the treatment of diabetic retinopathy. Key Benefits Shows improved overall retinal and visual function. Delays progression of disease. L-DOPA is an FDA approved drug. Market Summary It is estimated that nearly one in ten people globally will have some form of diabetes by 2035 and diabetic retinopathy affects a third of diagnosed diabetics. Diabetic retinopathy occurs when diabetes weakens tiny blood vessels in the eyes which can burst and cause cloudy vision, scar tissue in the eye, and ultimately vision loss. There is no cure but if detected early, laser ...Fri, 30 May 2014 05:05:47 GMTott@emory.edu to Quantify and Predict Prostate Motion Due to Respiration Method to predict respiratory-induced motion of the prostate during radiotherapy for prostate cancer patients treated with image-guided radiation therapy (IGRT), and to convert an existing prostate tracking technology into a respiratory gauge. Key Benefits Provides individualized treatment method for radiation therapy via respiratory gating capabilities. Converts existing prostate or any organ tracking device into a potentially respiratory status monitory (i.e. dual purpose device). Predicts patient-specific prostate motion for treatment planning with multi-fractionated intensi...Fri, 30 May 2014 05:05:45 GMTott@emory.edu Classification of Tissue in Digital Breast Tomosynthesis Images Software program for the automatic classification of breast tissue in 3D mammography or Digital Breast Tomosynthesis (DBT) imaging. Key Benefits Better tissue classification in DBT images than methods currently available. Higher sensitivity and specificity compared to competing technology. Market Summary A recent study published in the New England Journal of Medicine estimated that more than one million women have been treated for cancers that likely would never have posed a threat to their lives. They estimated that up to one-third of breast cancer cases do not need treatment. T...Fri, 30 May 2014 05:05:37 GMTott@emory.edu and Treatment for Muscle Wasting A genetic biomarker for the detection and treatment of muscle atrophy. Key Benefits Remains stable in body fluids including urine and blood to enable non-invasive detection. Is simpler and less expensive than CT/MRI scans for detecting muscle wasting. Identifies skeletal muscle atrophy without the need for muscle biopsy. Market Summary There are many diseases and conditions that can lead to a reduction in muscle mass including congestive heart failure, rheumatoid arthritis, and cancer. Currently there are no non-invasive biomarkers for directly testing loss of muscle. Expensive...Fri, 30 May 2014 05:05:25 GMTott@emory.edu Vasoactive Intestinal Peptide (VIP) Signaling to Reduce Graft Versus Host Disease VIP antagonist for the prevention of graft-vs-host disease. Key Benefits Short (6hrs) ex-vivo exposure to VIP antagonist sufficient to prevent cell conversion. Prevents graft-vs-host disease without immune suppression. Market Summary Graft-vs-host disease is an inflammatory disease unique to bone marrow transplant recipients and is the only transplant procedure in which the transplanted cells must accept the body rather than the body accepting the new cells. There are nearly 20,000 bone marrow transplants performed each year in the US for a variety of malignant and non-malignant...Tue, 20 May 2014 11:17:11 GMTott@emory.edu Stem Cell Therapy for Cardiac Repair, self-assembling, nanomatrix gel for the enhancing cell retention and function in tissue for use in cell based therapy. Key BenefitsIncreases implanted cell retention and enhances cardiac repair after stem cell treatment. Mimics the extracellular matrix to encourage stem cell engraftment.Market SummaryNearly 1 million Americans have a heart attack each year. Patients who survive myocardial infarction are left with damaged heart tissue that decreases heart function below a critical threshold. Nearly half of these patients do not survive for one year. The only available tre...Tue, 20 May 2014 11:17:09 GMTott@emory.edu Nanosheets Two-dimensional sheets composed of collagen-mimetic peptides on the nanoscale that are highly-ordered and self-assembling. Key Benefits Thermal stability, sheet thickness, and sheet dimensions can be controlled through the peptide sequence and preparative conditions. Market Summary Collagens are used in a number of consumer and biomedical products including cosmetics, tissue repair, wound management, burn treatment, drug delivery, sutures, tissue engineering, and vasculature and valve replacements. Currently, collagen derivatives for medical applications originate primarily from ...Wed, 07 May 2014 14:52:46 GMTott@emory.edu Software for Individualized Treatment with Radiotherapy Predictive mathematical modeling to individualize radiation treatment margins for prostate cancer patients treated with image-guided radiation therapy (IGRT). Key Benefits Predicts patient specific prostate motion for treatment planning with multi-fractionated intensity modulated radiotherapy (IMRT). More accurate than conventional fixed treatment margin approaches which may over treat or undertreat some patients Potentially decreases toxicity by reducing radiation dose to the bladder and rectum. Market Summary Prostate cancer is the most common cancer in American men. Recent t...Wed, 07 May 2014 14:51:47 GMTott@emory.edu Surgery Pain Management, 29 Apr 2014 13:33:17 GMTott@emory.edu Image Processing Algorithm for Tumor Detection An image processing algorithm that differentiates between malignant and non-malignant cells in a hyperspectral image. Key Benefits Able to detect head and neck cancer in hyperspectral images with higher than 95% accuracy and sensitivity. Allows for the identification of head and neck caner without an invasive procedure or expensive contrast agents. Market Summary The healthcare industry is undergoing a shift towards non-invasive diagnostics and therapeutic procedures. Technologies such as optical imaging have the potential to revolutionize clinical diagnostic safety. This techno...Tue, 29 Apr 2014 13:33:14 GMTott@emory.edu Throughput Individual Platelet Nanomechanical Contraction Device, 29 Apr 2014 13:33:12 GMTott@emory.edu Image Algorithm for Cancerous Tissue Detection Classification algorithm for tumor detection in hyperspectral images. Key Benefits Better classification algorithms than currently available for hyperspectral images. Improved segmentation of diseased from healthy tissue and improved sensitivity, specificity, and accuracy compared to the gold standard. Market Summary Surgical resection of tumors is a common treatment option for cancer. There is a need for verification of complete removal of cancerous tissue. Unfortunately current diagnostic imaging techniques require cumbersome equipment that cannot be easily accessible during s...Wed, 16 Apr 2014 14:55:42 GMTott@emory.edu of Tumor Response to Treatment Using Level Set Clustering in PET Images Tumor response algorithm that corrects for anatomical changes and robustly identifies local changes in serial PET images through a clustering algorithm. Key Benefits Robust to noise and outliers and can tolerate imperfections in data acquisition. Could be applicable to many other imaging modalities in radiation therapy. More accurately assumes tumors and their response are heterogeneous and analyzes them at a more local level than current methods. Market Summary There is little information to determine treatment efficiency and accuracy during radiotherapy. Currently patients ar...Tue, 15 Apr 2014 06:52:35 GMTott@emory.edu and Software Application for the Diagnosis of Adverse Reactions to Blood Transfusion, 11 Apr 2014 11:26:49 GMTott@emory.edu Antifibrinolytic Agents as a Substitute for Platelet Transfusions to Prevent Bleeding in Severe Thrombocytopenia Patients Prophylactic administration of an antifibrinolytic agent, epsilon aminocaproic acid (EACA), to prevent bleeding in patients with thrombocytopenia from hematological malignancies. Key Benefits Orally bioavailable, repurposed drug. Commonly used and FDA approved to manage hemorrhage in patients with congenital bleeding. Cheaper and easier to administer to patients compared to platelet replacement therapy. Results from retrospective human study suggest it is safe and effective for patients with very severe and chronic thrombocytopenia. Market Summary Individuals with leukemia and...Wed, 09 Apr 2014 12:47:58 GMTott@emory.edu Peptides that Incorporates Cell Signaling Molecules Platform that creates conjugates of self-assembling peptides and cell signaling molecules as a potential therapeutic for the treatment and repair of tissue. Key Benefits Hydrogels form at physiological pH and osmolarity. Produces cells that display characteristics of adult cardiac muscle cells. Additional molecules (pro-growth or pro-repair) could be incorporated into the hydrogel and delivered to the body. Market Summary Ischemic heart disease, which includes myocardial infarction and angina, is the leading cause of death in the US. Drugs for ischemic heart disease address ac...Tue, 08 Apr 2014 13:13:37 GMTott@emory.edu Kinase Inhibitors as Vaccine Adjuvants Repurposed, small molecule kinase inhibitors, such as epidermal growth factor receptor (EGFR) inhibitors, as topical vaccine adjuvants. Key Benefits Improves immune response and efficacy of vaccines and vaccine candidates. Employs compounds that are already approved for human use. Market Summary In order to create long lasting protection from infection, many vaccines require the use of an adjuvant. Adjuvants for vaccines work to enhance the immune response particularly in cases where the vaccine alone is incapable of eliciting a sufficient response. Currently, there is growing i...Tue, 08 Apr 2014 13:13:35 GMTott@emory.edu Intervention and Training for At-Risk and HIV-Positive Females, 31 Mar 2014 06:32:47 GMTott@emory.eduµRay: A Modular, Point-of-Care Diagnostic Device A modular system for the detection of biomarkers consisting of a portable diagnostic device, customizable sensors for multiple diagnostic tests, and software to analyze results. Key Benefits Easy to use system reduces human error in diagnostic testing. Modular design lowers costs by using one diagnostic device for multiple tests. Small size allows for home or field use. Market Summary Early detection of disease is often critical for successful treatment outcomes, especially in progressive diseases such as cancer and infections. Although diagnostic tests exist for a large number...Mon, 31 Mar 2014 06:32:45 GMTott@emory.edu (TM): A Fly Genetically Programmed to Identify a Single Scent A fruit fly modified to express only a single odor receptor and therefore only capable of sensing one chemical odorant; used as an animal model for sensory and nervous system studiesor as a living biosensor for chemical identification. Key Benefits New model for sensory research that simplifies the olfactory system. Insect-based behavioral biosensors may be cheaper and easier to manage than digital/electrical systems or use of other animal species. Technical Summary Drosophila melanogaster is commonly used as a research tool for biological research. Because of their well-known a...Tue, 25 Feb 2014 11:54:57 GMTott@emory.edu App for Caregivers of Infants with Congenital Heart Disease Software application to connect clinicians and caregivers for the monitoring and collection of health data of infants with congenital heart defects. Key Benefits Mobile platform makes key health information easily accessible for caregivers. Allows remote monitoring of health data by clinical staff. Provides easier communication between caregiver and clinical staff. Market Summary The increased success rate in initial treatment of congenital heart defects (CHD) has led to an increase in the number of infants with CHD that are released from the hospital to non-medical caregivers. ...Tue, 25 Feb 2014 11:54:55 GMTott@emory.edu Ligand-Protease Fusion Peptide for Enhanced Tumor Targeting and Drug Delivery A ligand-protease fusion peptide that cuts through the tumor stromal barrier and provides enhanced tumor targeting and delivery efficiency for therapeutic agents. Key Benefits The protease activity of the fusion peptide enables breaking of the stromal matrix and allows migration into stroma-rich tumor tissues. Can be attached to nanoparticles or other imaging and drug delivery carriers for the enhanced tumor targeting and efficient therapeutic delivery By digesting the surrounding extracellular matrix this fusion peptide improves intratumoral distribution of the therapeutics to ...Tue, 25 Feb 2014 11:54:52 GMTott@emory.edu Radiation Treatment Planning Software Using Image Databases Software that finds similar Volumetric Modulated Arc Therapy (VMAT) cases of radiation therapy in a database, compares features of therapy and anatomy, and provides treatment recommendations based on these prior cases. Key Benefits Decreases treatment plan time and increases efficiency of delivery. Decreases organ-at-risk (OAR) and normal tissue exposure. Makes recommendations to the treatment planner automatically and quickly. Market Summary Nearly 50% of all cancer patients in the world will require radiation therapy at some point. Radiation therapy planning has its limitatio...Tue, 25 Feb 2014 11:54:50 GMTott@emory.edu Nanoparticles for Encapsulation and Delivery of Highly Potent Anticancer Agents Nanoparticle drug delivery vehicles that maintain potency yet diminish toxicity of maytansinoids as cancer therapeutics. Key Benefits Reduces cancer metastasis and could be used as a prophylactic treatment. Acts as a delivery vehicle for maytansinoids that simultaneously maintain potency, increase efficacy, and diminish toxicity. Shows reduced side effects of maytansinoids and increased drug circulation time in the blood. Market Summary The plant-derived maytansine and its derivatives, maytansinoids, have significant anti-tumorigenic effects. Maytansinoids inhibit tubulin polym...Tue, 25 Feb 2014 11:54:48 GMTott@emory.edu GM-CSF and IL-9 Fusion Protein for the Treatment of Chronic Infections, Melanoma, or Other Solid Tumors recombinant fusion cytokine that activates immune responses for use as a vaccine adjuvant or cancer therapy. Key BenefitsRetains the immune stimulatory properties of both its parental molecules. Enhances the production of mast cells as compared to GM-CSF, IL-9, or GM-CSF and IL-9 co-administration. Market SummaryImmunotherapy, or immune system stimulation, uses immunomodulators such as cytokines to trigger innate and adaptive immune responses. There are many immunomodulators currently on the market for a variety of indications. Recombinant cytokines are currently marketed as vacci...Mon, 27 Jan 2014 10:42:38 GMTott@emory.edu Cardiac Imaging Tool for Predicting Ventricular Arrhythmia Medical imaging software that predicts ventricular arrhythmia to aid in the selection of patients for implantable cardioverter defibrillator (ICD) for the primary prevention of sudden cardiac death in heart failure patients. Key Benefits Predicts ventricular arrhythmia with greater accuracy than current techniques. Improves patient selection for ICD primary prevention therapy. Increases survival rates in patients experiencing lethal cardiac arrhythmias. Market Summary Despite recent advances in treatment for heart failure (HF), the number of deaths from HF remains steady. Ventr...Tue, 14 Jan 2014 06:30:45 GMTott@emory.edu Combination Therapy Targeting HIV’s Latent Reservoir for Complete Virus Elimination Drug combination therapy for the elimination of HIV's latent reservoir, CD4+ memory stem cells. Key Benefits Targets HIV's latent reservoir in order to eliminate the pool of CD4+ memory stem cells which allow HIV to persist even with antiviral treatment. With HIV memory cells destroyed, antiviral treatment can eradicate HIV infection rather than just suppressing viral load. Market Summary There are approximately 2.3M individuals suffering from HIV/AIDS in the North America and Europe. Currently, HIV can be effectively managed with combination anti-retroviral therapies taken dail...Fri, 03 Jan 2014 10:55:55 GMTott@emory.edu (miRNAs) for the Treatment of Neurological Disorders, 03 Jan 2014 10:55:51 GMTott@emory.edu for Assessing the Effect of Visual Impairment on Quality of Life and Function in Children standardized series of questions for the assessment of vision related quality of life and visual function in children and adolescents.Key BenefitsProvides age-appropriate questions for children from ages 8-18 as an improvement to using currently available assessments geared toward adults. Allows the subjective assessment of the impact of visual impairment. Questions specific to children with uveitis are in development. Market SummaryVisual impairment in children is a significant problem in the US. Approximately 6.8% of children, or roughly 5 million children, have a diagnosed visi...Fri, 03 Jan 2014 10:55:48 GMTott@emory.edu of Endothelial Cells for the Repair of Ischemic Tissue Reprograming of adult fibroblasts into endothelial cells using a single transcription factor for the repair of ischemic tissue. Key Benefits Converts to endothelial cells with a single, non-tumorigenic, transcription factor. Bypasses a pluripotent stage and avoids the use of potentially tumorigenic stem cells. Market Summary Ischemic cardiovascular disease, including coronary artery disease and peripheral artery disease, is the most frequent cause of death in the US. These causes of death are the clinical manifestation of a loss of functional blood vessels. Because endothelial c...Wed, 04 Dec 2013 14:01:27 GMTott@emory.edu Inhibitor for the Treatment of Sickle Cell Disease A glycopeptide inhibitor of p-selectin for the treatment of sickle cell disease. Key Benefits Blocks the activity of P-selectin with nM affinity. Potential treatment forvaso-occlusive crisis associated with sickle cell disease. Inhibits the earliest stage of leukocyte activation helping to prevent immune response. Market Summary Sickle cell anemia, a serious disorder in which the body makes sickle-shaped red blood cells, affects an estimated 95,000 Americans and a majority of these are African Americans. About two million Americans or 1 in 12 of African Americans have the sick...Wed, 04 Dec 2013 14:01:24 GMTott@emory.edu Software for the Creation, Sharing, and Viewing of Medical Images for Educational Purposes PC and mobile applications designed for the creation and sharing of radiology case images for teaching and testing purposes. Key Benefits Allows for the creation of annotated medical image files for teaching. Facilitates effortless sharing of medical images to handheld devices for mobile teaching and testing. Market Summary In an academic setting, radiologists often spend time educating students and medical staff using a collection of medical images. These images are often stored on hospital workstations, carried on USB thumb drives, or emailed to facilitate the sharing of inter...Wed, 04 Dec 2013 14:01:22 GMTott@emory.edu Kidney Identification for Magnetic Resonance Images A software tool that can automatically identify kidney tissue in serial magnetic resonance (MR) images. Key Benefits Can replace time consuming and challenging manual identification of the kidney. Able to discern the border of the kidney in serial MR images even in areas of low contrast. Market Summary Reliable evaluation of the size of the kidney is important tool in the evaluation of kidney function. This measurement becomes increasingly important in the case of serial MRI as it allows for a non-invasive monitoring and assessment of the kidneys. Serial MRI of the kidney is mos...Wed, 04 Dec 2013 14:01:20 GMTott@emory.edu Protein Nanoparticles for the Treatment of Inflammatory Bowel Diseases, 07 Nov 2013 13:09:12 GMTott@emory.edu Test for Melanomas Responsive to Combination Treatments of Kinase Inhibitors and Immunotherapies Genetic biomarker test identifying melanoma cases that are responsive to vemurafenib when given in combination with immunotherapy versus those that are unresponsive. Key Benefits Identifies patients who would benefit from combination treatment of BRAF kinase inhibitor, vemurafenib, and immunotherapy. Screening reduces the application of ineffective treatments. Market Summary Over 132,000 cases of melanoma are diagnosed annually, and over 60% of melanomas express a mutation in the BRAF signaling pathway that leads to uncontrolled cell growth. In cases with the mutation, late stag...Sun, 03 Nov 2013 13:26:50 GMTott@emory.edu Respiratory Syncytial Virus (RSV) Vaccine with a mutated live-attenuated virus for respiratory syncytial virus (RSV) treatment.Key BenefitsIs stable and unlikely to revert back to wild-type virus. Contains mutations in the genes encoding nonstructural protein, rather than the genes encoding viral coat proteins. Expresses 75% less nonstructural protein compared to wild type, but retains 100% expression of wild type nucleoproteins. Market SummaryRSV is a major cause of lower respiratory track infections in infants, children, and the elderly. Currently, no RSV vaccine exists. RSV vaccine development has faced challenge...Sun, 03 Nov 2013 13:26:44 GMTott@emory.edu Biomarkers for Predicting Prostate Cancer Diagnostic test for predicting the recurrence of prostate cancer following prostatectomy using RNA biomarkers. Key Benefits A panel of twenty-four RNA biomarkers significantly predicts clinical recurrence of prostate cancer after radical prostatectomy. Test helps determine if surgery was sufficient or if additional therapies will be needed in treatment of prostate cancer. Out-performs other genetic test on the market. Biomarker screening can be performed six to eight weeks following prostatectomy. Market Summary Prostate cancer is the most common cancer effecting men in the U....Sun, 03 Nov 2013 13:26:39 GMTott@emory.edu Nanoparticles to Administer Pharmaceutical Products in Acidic Environments, 03 Nov 2013 13:26:31 GMTott@emory.edu Biomarkers for Alzheimer’s Disease, 03 Nov 2013 13:26:22 GMTott@emory.edu Computer Generated Medical Models Three-dimensional computer models of biological objects and medical devices. Key Benefits Generated with 3D Studio Max (.max files). Can be used to create animations and/or still graphics. May be of interest to device manufacturers, academia, healthcare professionals, and the general public. Technical Summary Emory researchers have created three-dimensional computer models of biological objects and medical devices using the software program 3D Studio Max (3ds). The models may be used to create animations or still graphics for the education of healthcare professionals and patien...Sun, 03 Nov 2013 13:26:20 GMTott@emory.edu Antibodies Against Influenza Virus, 03 Nov 2013 13:26:14 GMTott@emory.edu Kidney: An iPad App for Prospective Kidney Transplant Patients, 02 Oct 2013 11:42:43 GMTott@emory.edu Mouse Model for Studying Brain Tumor Formation model with a mutation in Arl13b to study medullablastoma formation.Key BenefitsArl13b conditional mice preserve Gli repressor activity (protective against medullablastomas) and modulate the Gli activator (formation of medullablastoma).Technical SummaryMedullablastomas are the most common form of brain cancer in pediatric patients and about 30% of medullablastomas result from aberrant signaling processes that control cell fate and growth. More specifically, Sonic hedgehog signaling (Shh) is transmitted through cilia by the Gli protein family, which can either stimulate or repre...Mon, 30 Sep 2013 12:53:32 GMTott@emory.edu Timing Pulse Generator and Programmer Electronic device that generates timing-control pulses for tests and experiments using the field programmable gate array (FPGA). Key Benefits Based on latest FPGA technology and supersedes commercially-available systems. Precise timing control with nanosecond time resolution with fast transitions and low jitter. Large number of channels and controllable channel outputs. Long pulse duration that satisfies relaxation-type experiments. Fast and flexible programming capabilities and customizable configurations. Market Summary Timing pulse generators are used in industry tests and...Fri, 20 Sep 2013 11:07:00 GMTott@emory.edu Vaccine for HIV Immunization Live bacteria-based vaccine that is delivered by oral route and stimulates the body's immune system to produce mucosal antibodies against HIV. Key Benefits Provides better vaccine scheme via mucosal immune response as a primary vaccine compared to other primary vaccines that are administered parenterally. Generates both antibody and T-cell responses. First-in-class treatment that could be combined with other approaches as well. Does not need refrigeration and is inexpensive to produce. Good safety profile already exists concerning human oral ingestion of L. lactis. Market Sum...Wed, 04 Sep 2013 07:56:59 GMTott@emory.edu Therapeutic that Targets the Elimination of Factor VIII Immune Cells Protein factor VIII fused or conjugated to a toxin for the prevention of the formation of inhibitory antibodies to factor VIII in hemophilic patients. Key Benefits Could be used as prophylactic and prevent the formation of factor VIII inhibitors in hemophilia A patients prior to initial dosing with factor VIII. Potentially eliminates inhibitors in patients who have received factor VIII therapy. Market Summary Factor VIII (FVIII) is a protein that functions in blood coagulation. Mutations in the FVIII result in decreased or defective FVIII protein and give rise to the bleeding di...Wed, 04 Sep 2013 07:56:58 GMTott@emory.edu Software to Quantitatively Measure Subcellular Distribution of Proteins that measures the subcellular distribution of proteins, termed Quantitative Subcellular Compartmentalization Analysis, or Q-SCAn.Key BenefitsProvides a quantitative measurement of target molecules in subcellular compartments. Method is rapid and automated and improves subcellular measurements. Other methods have not been extensively developed and existing methods are generally laborious and/or subjective. Technical SummaryIn eukaryotes, there are many significant examples of proteins that are localized in distinct subcellular compartments such as the pathway responsible for...Thu, 15 Aug 2013 13:35:56 GMTott@emory.edu Drug for the Treatment of Nephrogenic Diabetes Insipidous New use for metformin or other AMPK activators in treating nephrogenic diabetes insipidous (NDI). Key Benefits Lead candidate, metformin, is FDA-approved, safe, and currently in use for treating type II diabetes mellitus. There is no therapeutic available for NDI, current therapies only address symptoms. Repurposed metformin addresses the underlying cause of NDI. Market Summary Nephrogenic diabetes insipidus (NDI) is a form of diabetes insipidus due primarily to problems in the kidney, in which the kidney is unable to concentrate urine. It is defined as a rare or orphan indicat...Thu, 15 Aug 2013 13:35:40 GMTott@emory.edu PABPN1 Polyclonal Antibody Western blot Immunoprecipitation Specificity Recombinant His-tagged bovine polyadenylate-binding nuclear protein 1 (PABPN1) Subtype Rabbit polyclonal Technical Summary The bovine PABPN1 coding sequence was inserted into an Escherichia coli vector and was used for the production of His-tagged PABPN1. This PABPN1 sequence was then purified and used for the immunization of rabbits to obtain polyclonal anti-PABPN1 antibody. Publications Apponi et al. Hum. Mol. Genet. 2010. 19:1058-1065. Kuhn et al. J. Biol. Chem. 2003. 278:16916-16925. Mon, 05 Aug 2013 08:43:16 GMTott@emory.edu Antibodies as Additives that Increase Storage Life of Platelet Therapeutics, 01 Aug 2013 05:37:46 GMTott@emory.edu Therapeutic for Graft-versus-Host Disease (GvHD) Biotherapeutic activation of toll-like receptor 5 (TLR5) to treat graft-versus-host disease (GvHD). Key Benefits Administration of flagellin reduces both acute and chronic GvHD. Contrary to immunosuppressive drugs, flagellin enhances immunity and protects patients from opportunistic infections. Market Summary More than 25,000 stem cell transplantations are performed annually worldwide to treat bone marrow diseases. Transplant recipients are prone to rejecting the newly transplanted tissue, and 50% of recipients develop graft-versus-host disease in which the new donor cells destr...Fri, 26 Jul 2013 05:19:16 GMTott@emory.edu Expression as an Indicator of Taxane Sensitivity in Cancer Prognostic and potential diagnostic biomarker to indicate taxane sensitivity or resistance of non-small cell lung cancer (NSCLC). Key Benefits Examines the protein expression levels of an enzyme associated with cell cycle progression, CHFR (Checkpoint with forkhead and RING finger domains). Is the first known biomarker to predict response and resistance to taxane-based chemotherapy in NSCLC patients. Characterization of CHFR levels could be employed to personalize cancer therapy for patients with metastatic non-small cell lung cancer (NSCLC). Market Summary Non-small cell lung...Tue, 23 Jul 2013 11:15:37 GMTott@emory.edu Molecule Derivatives of Solenopsin for Cancer Treatment molecule analogs of the naturally-occurring compound solenopsin for the treatment of various cancers including melanoma and angiosarcoma.Key BenefitsAnalogs derived from a naturally-occurring alkaloid. Potential treatment of cancers for which there is a poor prognosis or low survival rate. Market SummaryPhosphoinositol-3 kinase (PI3K) and its downstream effector Akt, play a major regulatory role in control of apoptosis, proliferation, and angiogenesis. Many cancers show an overexpression of PI3K and Akt. For example, PI3K and Akt are amplified or overexpressed in sarcomas, ova...Fri, 19 Jul 2013 11:44:32 GMTott@emory.edu of the Cellular Immune Response to Treat Viral Infections use of a vasoactive intestinal peptide (VIP) antagonist to enhance the cellular immune response.Key BenefitsHas antiviral activity and increases the immune response following a vaccine or viral infection. Can be used in tandem with antivirals for more effective and efficient treatment. Upregulation of the cellular immune response has anti-cancer activity by targeting tumor cells for apoptotic cell death. Market SummaryMortality from viral infections including viral hepatitis, HIV, and influenza is a major concern in the United States and worldwide. Although current therapies exi...Mon, 15 Jul 2013 08:55:38 GMTott@emory.edu Emitting Silica Nanoparticles, 15 Jul 2013 08:55:24 GMTott@emory.edu Segmentation Software for Cardiac Images Software that can automatically segment the right ventricle in a live ultrasound image. Key Benefits Approximately 89% volume overlap between this method and the gold standard of manual segmentation for both epicardial and endocardial boundaries of the right ventricle. Automatic segmentation with a level of accuracy that enables quantified characterization of the right ventricle. Market Summary Reliable evaluation of the structure and function of heart ventricles from echocardiographic images is an important issue for clinical examination and diagnosis. Although a number of meth...Wed, 03 Jul 2013 07:18:43 GMTott@emory.edu Software for Reducing Violence Against Women A web-based application directed at college-aged men on behaviors that can reduce violence against women. Key Benefits An interactive online training program for sexual assault prevention. Aimed at educating college-aged males to change their behavior. Market Summary Sexual assault is the most common violent act at universities and it is estimated that a quarter of college woman are victims of sexual assault. Unfortunately, many attacks are committed by college acquaintances and are vastly underreported. Women hold the burden in practicing rape avoidance by employing precautiona...Mon, 01 Jul 2013 11:13:38 GMTott@emory.edu Room Table Clamp Universal clamp to mount objects to an operating table. Key Benefits Provides a low profile and pitch accommodation on the operating table and general ease of use in the OR. Designed to mate with standard OR table railings, allowing for widespread use in any type of hospital and with any type of surgery. Universal design decreases storage space and maintenance required for multiple OR clamps. Market Summary There is currently no universal clamp for operating tables available. There are instead many different clamps that are used to mount objects to the operating table. All of t...Mon, 01 Jul 2013 11:13:36 GMTott@emory.edu Room Video System Mounting and video system for video recording in the operating room. Key Benefits Can be used as a component of an overall intra-operative video system as well as a standalone product. Simple design is easy to manufacture and easy for the surgeon to operate. Allow devices to be mounted directly on the edge of the sterile field. Can streamline some of the equipment necessary in the room. Market Summary Operating room (OR) video recording has increased in recent years. Visual documentation of each surgery provides documentation for medical litigation, visual components to patien...Mon, 01 Jul 2013 11:13:34 GMTott@emory.edu Magnetic Iron Oxide Nanoparticles, 01 Jul 2013 11:13:32 GMTott@emory.edu and Ubiquitin-Like Proteins (UBLs)-Derived Probes to Study Enzymatic Functions of Ubiquitination Proteins Two series of probes that are derived from ubiquitin and UBLs to serve as research tools to identify and detect biological functions of ubiquitination/de-ubiquitination enzymes. Key Benefits Can monitor enzymatic activities of multiple deubiquitinating enzymes (DUBs) simultaneously. Able to identify novel ubiquitination/de-ubiquitination enzymes as potential targets for drug discovery from crude cell lysate. Can be easily equipped with radioactive 125I label or epitope tags for direct visualization, purification or identification purposes. Market Summary Ubiquitination is one ...Mon, 01 Jul 2013 11:13:24 GMTott@emory.edu Blocking JAML Antibodies for the Treatment of Inflammatory Diseases blocking anti-human junctional adhesion molecule-like (JAML) antibodies for the treatment of inflammatory diseases, such as inflammatory bowel disease, rheumatoid arthritis, and skin or eye inflammatory diseases.Key BenefitsBinds with higher affinity and specificity than currently available JAM antibodies based on comparative analyses. Market SummaryApproximately 1.4 million individuals in the US and 2.2 million individuals in Europe have inflammatory bowel disease, which includes both Crohn?s disease and ulcerative colitis. There is currently no cure for inflammatory b...Fri, 21 Jun 2013 09:29:49 GMTott@emory.edu Cancer Cell Lines that Mimic Epithelial–Mesenchymal Transition Prostate cancer cell lines that can undergo epithelial-mesenchymal transition to investigate metastatic biomarkers or screen therapeutics. Key Benefits Two genetically similar, but characteristically distinct prostate cancer cell lines that are either resistant or prone to metastasis. Mouse models injected with ARCaPE developed bone metastasis in 12.5% of mice, whereas those injected with ARCaPM all developed bone metastasis. Technical Summary The migration and invasiveness of metastasized cancer is thought to involve the epithelial-mesenchymal transition (EMT). Dr. Wu and colle...Fri, 21 Jun 2013 09:29:48 GMTott@emory.edu Time Imaging of HIV with a PET/CT Total Body Scan PET-based imaging of HIV anatomical reservoir locations for health monitoring and determination of therapy effectiveness. Key Benefits The only in vivo method for visualizing sites of HIV. Compatible with existing PET/CT imaging system. Market Summary AIDS is a worldwide pandemic, with over 35 million people carrying active HIV infections. The first line of therapy is administering anti-HIV drug cocktails to slow the progression of the disease; however, retroviruses quickly adapt to the regime and become resistant. With over 30% patients resistant to conventional drugs, an aggr...Fri, 21 Jun 2013 09:29:44 GMTott@emory.edu Protein (GLP) and Small Molecule Inhibitor Complex Complex of G9a-like protein and BIX-01294, a small molecule inhibitor of G9a and G9a-like protein. Key Benefits First example of inhibitor bound enzymatic SET domain structure of a protein lysine methyltransferase. May show improved potency and selectivity of the G9a/GLP inhibitor. Technical Summary Histone lysine methylation is an important regulator of gene expression and chromatin organization. The small molecule, BIX-01294 (a diazepin-quinazolin-amine derivative), inhibits G9a and G9a-like protein (GLP) histone lysine methyltransferases, which repress transcription by methyl...Fri, 21 Jun 2013 09:29:38 GMTott@emory.edu Tools for Myofiber Structure Extraction and Cardiac Function Assessment Software for 2D and 3D ultrasound-based imaging for the diagnosis of cardiovascular diseases. Key Benefits Ultrasound based imaging system that can quantify and display cardiac myofiber structures and functions. Can be used for the quantification of cardiac physiology in healthy subjects and quantification and diagnosis of pathology in affected patients. Market Summary Heart disease is the leading cause of death in the United States and approximately 600,000 people die of heart disease every year. Over $410.5 million was spent globally on cardiovascular monitoring devices in 201...Fri, 21 Jun 2013 09:29:37 GMTott@emory.edu An Information Management Application for Use in Drug Discovery and Development A web-based information management application for data tracking and sharing during the discovery and development of new small molecule therapeutics. Key Benefits Can be used to register compounds and display information about chemical structures and calculations. Easily customizable and has a ticket system to allow administrators to restrict and keep track of user access and updates that have been made to the database. Accessible from any personal computer, tablet, or smartphone device. Market Summary Although there are many applications that can store large amounts of informa...Fri, 21 Jun 2013 09:29:36 GMTott@emory.edu Software for Managing and Allocating Research Animal Colonies Animal inventory database software that combines animal tracking, usage requests, and animal allocation into one program through a web-based user interface. Highlights Streamlines colony management by using one program instead of separate programs for tracking, allocation, and usage requests. Built on open source software to allow easy customization to the specific needs of each institution. Market Summary The allocation of research animals is a time consuming process for research centers as animal status, upcoming research projects, and researcher requests are often maintained...Fri, 21 Jun 2013 09:29:32 GMTott@emory.edu<![CDATA[P81 & Q97 14-3-3 Polyclonal Antibodies]]> Western blot Immunoprecipitation Specificity Peptide sequences conserved within several human 14-3-3 protein subspeciesSubtype Rabbit polyclonalTechnical Summary Two rabbit sera identified as p81 and Q97 were made against synthetically synthesized peptides of 14-3-3 protein. The two antibodies are more specifically a beta-zeta 14-3-3 polyclonal antibody (p81) and a zeta-gamma ETA 14-3-3 polyclonal antibody (Q97).Polyclonal rabbit serum was raised against the pep-tide ELVQKAKLAEQA synthesized on a polylysine core (MAP resin). The identical sequence is found in several 14-3-3 family ...Fri, 21 Jun 2013 09:29:25 GMTott@emory.edu Compatible High Efficiency Stem Cell Differentiation Protocol for Endothelial Cell Generation A clinically-compatible protocol for differentiating human stem cells into endothelial cells for cardiovascular tissue regenerative medicine. Key Benefits Provides a high yield of differentiated endothelial cells, with an efficiency of up to 97%. These endothelial cells are generated using completely clinically compatible system which do not use any xenogeneic components such as animal serum or feeder cells, and utilize all the clinically-compatible defined ingredients. Because these endothelial cells are fully committed and functional, they are more effective than undifferentia...Fri, 21 Jun 2013 09:29:15 GMTott@emory.edu Antegrade Catheter for Delivery of Cardioplegia Solutions Catheter device for the delivery of cardioplegia solutions in conventional surgery using cardiopulmonary bypass and in minimally invasive cardiac surgery. Key Benefits One-piece design eliminates need to assemble separate components (tourniquet tubing), resulting in improved stability of the catheter, decreased clutter in the operative field, and increased economy of motion and visibility for healthcare provider. More compatible with minimally invasive cardiac surgery techniques compared to existing cardioplegia catheter designs. Stabilizes tension and locks the aortic tack site...Mon, 17 Jun 2013 13:26:52 GMTott@emory.edu Methyltransferases DNA methyltransferases that are S-adenosyl methionine (AdoMet)-dependent. Key Benefits Have distinctly different domains compared to other methyltransferases. Have active site residues and peptide binding channels. Technical Summary These AdoMet-dependent DNA methyltransferases have been isolated, purified, and characterized. Some of the domains of these methyltransferases bear no structural similarity to other AdoMet-dependent methyltransferases available. Their structures suggest a mechanism for the methylation reaction and provides structural basis for functional characteriza...Fri, 14 Jun 2013 12:43:10 GMTott@emory.edu Active Tet1 Catalytic Domain Active mouse Tet1 catalytic domain. Technical Summary Tet1 is a member of a conserved mammalian-specific family of TET (ten-eleven translocation) proteins. The activity of Tet1 converts 5-methylcytosine (5mC) to 5-hydroxymethylcytosine (5hmC) in DNA. TET1 is fused to the MLL (myeloid/lymphoid or mixed-lineage leukemia) protein, a histone methyltransferase, in a subset of acute myeloid leukemia patients. Developmental Stage Isolated, purified, and available for licensing. Publication: Hashimoto et al. Nucleic Acids Res 40:4841-4849. (2012)Fri, 14 Jun 2013 12:43:08 GMTott@emory.edu Multi-Parametric Ultrasound Imaging Technique for Evaluating Radiation-Induced Toxicity Algorithm for using ultrasound to image and quantitatively measure tissue damage. Key Benefits Uses ultrasound technology to evaluate the extent of fibrosis after radiation therapy. Reliable quantitative measurement that can aid in the development of new treatment options for radiation induced fibrosis. Market Summary There are approximately 14 million cancer survivors in the United States and approximately half of these patients will receive radiation treatment during the course of their disease. Radiation induced fibrosis (RIF) is a common side effect to radiation therapy and ...Fri, 14 Jun 2013 12:43:08 GMTott@emory.edu Prostate Cancer Imaging for High-Dose-Rate Brachytherapy Planning Software to register and fuse TRUS and CT images for use in high-dose-rate brachytherapy procedures. Key Benefits Integrates intra-operative ultrasound-based prostate volume into treatment planning. Improves prostate delineation and enables accurate dose planning and delivery which may improve outcomes from high dose rate brachytherapy treatments. Market Summary Prostate cancer is the second leading cause of cancer in men in the United States. One treatment option for prostate cancer patients is high-dose-rate (HDR) brachytherapy which uses small catheters inserted into the pros...Fri, 14 Jun 2013 12:43:07 GMTott@emory.edu Dnmt3a-Dnmt3L Protein Complex DNA methyltransferase 3a (Dnmt3a) bound to its regulatory factor DNA methyltransferase 3-like protein (Dnmt3L). Key Benefits Carboxyl-terminal domain of Dnmt3L interacts with the catalytic domain of Dnmt3a. Technical Summary Both DNA methyltransferase 3a (Dnmt3a) and its regulatory factor DNA methyltransferase 3-like protein (Dnmt3L) are required for the de novo DNA methylation of imprinted genes in mammalian germ cells. In the complex, the carboxyl-terminal domain of Dnmt3L interacts with the catalytic domain of Dnmt3a, suggesting that Dnmt3L acts by recruiting Dnmt3a to nucleoso...Fri, 07 Jun 2013 12:59:06 GMTott@emory.edu Fix: An Eye-Tracking Algorithm for the Measurement of Fixations and Saccades Software for more precise measurement of fixations and saccades during eye motion tracking. Key Benefits Increased precision by combining distance, velocity, acceleration and rotation measurements. Increased sensitivity by globally and locally evaluating scan paths. Market Summary Eye tracking technologies are instrumental for companies to evaluate consumer interactions with websites, advertisements, software, package designs, and any other media. With minimal user involvement, it provides instantaneous feedback on the reaction of consumers to target stimuli. Furthermore, eye tr...Fri, 07 Jun 2013 12:59:05 GMTott@emory.edu Arginine Methyltransferase 1 (PRMT1) His- S11-R361 An isolated, purified, and tested rat protein arginine methyltransferase, type 1 (PRMT1) His- S11-R361. Key Benefits Structures of PRMT1-AdoHyc and its complex with peptide substrates. Have active site residues and peptide binding channels. Technical Summary Protein arginine methylation is a common posttranslational modification in eukaryotes. The major type of PRMT1 transfers the methyl group from S-adenosyl-L-methionine (AdoMet) to the guanidine group of arginines in protein substrates. The rat PRMT1 described here is in complex with the reaction product S-adenosyl-L-homocyste...Fri, 07 Jun 2013 12:59:04 GMTott@emory.edu Quantum Dots Stabilized multifunctional luminescent nanoparticles for cancer targeting and imaging.Key BenefitsHave improved stable and tunable optical properties to allow for sensitive detection and multicolor imaging. Are nontoxic both in vitro and in vivo. Market SummaryProstate cancer is the leading cause of cancer incidence in men with 200,000 new cases each year and the second leading cause of cancer death in men in the United States. As the need for personalized cancer treatments increase, nanoparticle delivery of chemotherapy drugs and/or gene therapy agents has become a major focus due...Fri, 07 Jun 2013 12:59:02 GMTott@emory.edu and TrkB Stably Transfected Murine Cell Lines Cell lines (T17, T48, and T62) to screen for TrkA and/or TrkB agonists. Technical Summary Neurotrophins play an essential role in the development and maintenance of the nervous system. One such neutrophin, nerve growth factor (NGF) binds mainly tyrosine kinase A (TrkA). Docking of TrkA by NGF initiates receptor dimerization, phosphorylation of cytoplasmic tyrosine residues on the receptor, and a cascade of cell-signaling events. These signals lead to the prevention of apoptotic cell death, promotion of cellular differentiation and axon elongation, and up-regulation of choline acet...Thu, 06 Jun 2013 12:50:28 GMTott@emory.edu<![CDATA[The Antitussive Drug Noscapine & its Derivatives as Anti-Tumor Agents]]> Can be used for the treatment of neoplastic disease. Summary A variety of chemotherapeutic agents interact with tubulin, the major protein of mitotic spindles, resulting in mitotic arrest and ultimately cell death in rapidly dividing cells. Athough tubulin-targeting agents are capable of arresting cells in mitotis, these drugs indiscriminantly target both neoplastic and healthy cells resulting in toxic side effects. Thus, there is an urgent need to direct research efforts towards developing more specific chemotherapeutic agents. The Joshi laboratory has identified noscapiane, an op...Thu, 06 Jun 2013 12:50:08 GMTott@emory.edu Kit for Treating Age-Related Macular Degeneration (AMD) Instruments for surgical treatment of age-related macular degeneration (AMD). Key Benefits Surgical procedure provides a less costly, curative alternative to expensive drug therapeutics that usually only prevent or slow disease progression. One time surgical treatment applicable to both wet and dry AMD. Specialized instruments allow for precise manipulation of delicate optic tissue during the surgical procedure. Technical Summary AMD is the leading cause of blindness in people over the age of 50. There are two forms of AMD, wet and dry. Both result in deterioration of the retin...Thu, 06 Jun 2013 12:50:07 GMTott@emory.edu Cell Lines Expressing shRNAs of Human EPLIN Highly malignant and metastatic prostate cancer cell line. Key Benefits Prostate cancer cell line with reduced Epithelial Protein Lost In Neoplasm (EPLIN) expression. Cell line exhibits morphology characteristics of malignant cell lines and increased chemoresistance, migration, and invasion. Market Summary Prostate cancer is the most common cancer affecting males in the United States and is the second leading cause of cancer related deaths of males. In 2009, over 200,000 males were newly diagnosed with prostate cancer and prostate cancer resulted in nearly 30,000 deaths. Althoug...Tue, 28 May 2013 09:06:44 GMTott@emory.edu Acute Lymphoblastic Leukemia Cell Line EU-4 Cancer cell line derived from a pediatric patient with early B-cell precursor (Pre-B) acute lymphoblastic leukemia with myeloid phenotype. Key Benefits Does not express p53 and expresses wild-type MDM2. Expresses wild-type Bax, over-expresses Bcl-xl, and does not express Bcl-2. Can be used as a tool for gene transfection assays in leukemia studies. Technical Summary p53 is a tumor suppressor protein that in humans is encoded by the TP53 gene. p53 regulates the cell cycle and thereby functions as a tumor suppressor that is involved in preventing cancer. Mutation or inactivation ...Fri, 24 May 2013 10:13:35 GMTott@emory.edu BEAST Surgical Support Device, 24 May 2013 10:09:08 GMTott@emory.edu Treatment to Increase Peripheral Nerve Regeneration Combination treatment of four enzymes to block nerve growth inhibitory molecules in peripheral nerve injury. Key Benefits Enzymes degrade all three families of growth inhibiting molecules in peripheral nerve injury. Combination treatment shows synergistic, not additive effect. Market Summary Peripheral nerve injury can occur in a variety of ways. They can be severed or crushed during traumatic injury, or degenerate as a symptom of progressive diseases such as diabetes. Loss of peripheral nerve function can lead to poor motor control of limbs and/or abnormal pain sensations. Curr...Fri, 24 May 2013 10:09:00 GMTott@emory.edu Molecule Treatment for Ischemic Stroke Repurposed TLR4 inhibitor (TAK-242) to block inflammatory signaling after ischemic stroke. Highlights Non-surgical treatment of ischemic stroke. TAK-242 has shown to be well-tolerated in clinical trials. Inhibits the release of multiple cytokines mediated by TLR4. Market Summary Stroke can affect people of all ages, including children. Many people with ischemic strokes are older (60 or more years old), and the risk of stroke increases with age. Stroke is the leading cause of disability and the third leading cause of death in the United States. More than 700,000 persons per year ...Fri, 24 May 2013 10:08:51 GMTott@emory.edu Acute Lymphoblastic Leukemia Cell Line EU-7 Cancer cell line derived from a relapsed pediatric patient with T-cell acute lymphoblastic leukemia. Key Benefits Well-characterized to have a point mutation of the p53 gene at codon 248. Expresses wild-type Bax and Bcl-xl, but does not express Bcl-2. Well used tool for p53 studies in leukemia. Technical Summary p53 is a tumor suppressor protein that in humans is encoded by the TP53 gene. p53 regulates the cell cycle and thereby functions as a tumor suppressor that is involved in preventing cancer. Mutation or inactivation of the p53 gene has been implicated in a wide range o...Fri, 24 May 2013 10:08:02 GMTott@emory.edu Pre-B Acute Lymphoblastic Leukemia Cell Line EU-1 Cancer cell line derived from a relapsed pediatric patient with early B-cell precursor (Pre-B) acute lymphoblastic leukemia. Key Benefits Well-characterized continuous leukemia-lymphoma cell line. Expresses wild-type p53 and over-expresses MDM2 oncoprotein. Expresses wild-type Bcl-2, Bcl-xl, and Bax. Technical Summary p53 is a tumor suppressor protein that in humans is encoded by the TP53 gene. p53 regulates the cell cycle and thereby functions as a tumor suppressor that is involved in preventing cancer. Mutation or inactivation of the p53 gene has been implicated in a wide r...Fri, 24 May 2013 10:02:43 GMTott@emory.edu Pre-B Acute Lymphoblastic Leukemia Cell Line EU-6 Cancer cell line derived from a relapsed pediatric patient with early B-cell precursor (Pre-B) acute lymphoblastic leukemia. Key Benefits Well-characterized to have a point mutation of the p53 gene at codon 273. Expresses wild-type Bax, Bcl-xl, and Bcl-2. Well used tool for p53 studies in leukemia. Technical Summary p53 is a tumor suppressor protein that in humans is encoded by the TP53 gene. p53 regulates the cell cycle and thereby functions as a tumor suppressor that is involved in preventing cancer. Mutation or inactivation of the p53 gene has been implicated in a wide range...Fri, 24 May 2013 10:02:27 GMTott@emory.edu that Mimics Microvasculature Systems for Blood Disease Diagnostics, Therapeutic Screens, and Hematology Studies, 06 May 2013 06:49:45 GMTott@emory.edu Based System for Targeted Reduction of Gene Expression A CRISPR based gene silencing system using sequence specific RNA to repress expression of endogenous transcripts. Key Benefits Provides a platform to target specific mRNA transcripts in both prokaryotic and eukaryotic cells. Potential therapeutic strategy against pathogenic bacteria and viruses. Market Summary Since the discovery of silencing genes through RNA interference (RNAi), researchers have spent over $10 billion in obtaining small RNAs. RNAi is an indispensable tool to study gene function and is extensively utilized in basic research as well as drug discovery. Due to the...Mon, 06 May 2013 06:49:43 GMTott@emory.edu Transporter (SERT) Monoclonal Antibody, 09 Apr 2013 12:23:36 GMTott@emory.edu Magnet Readiness Index (MRI) An evaluation tool for hospitals to track nursing care metrics and determine readiness to apply for Magnet status. Key Benefits Provides a quick assessment of the quality of nursing care over time prior to applying for Magnet status. Compares data to scores of current Magnet hospitals to see where they stand. Market Summary Magnet recognition was developed by the American Nurses Credentialing Center (ANCC), the largest nurse credentialing organization to gage the caliber of nursing care in hospitals and healthcare centers. There are currently 5,724 registered hospitals in the Un...Wed, 27 Mar 2013 09:28:26 GMTott@emory.edu Thymine DNA Glycosylase Mutant that Selectively Excises 5-Carboxylcytosine, 27 Mar 2013 09:28:18 GMTott@emory.edu Multifunctional Nanoparticle siRNA Delivery System Tumor receptor-targeted nanoparticle containing a siRNA DNA cassette for the knockdown of survival genes and treating cancer. Key Benefits Nanoparticles are targeted directly to tumors for treatment and/or diagnostic imaging. siRNA encoded by a DNA cassette has increased stability and more effective gene depletion. siRNA knockdown of survival genes increases susceptibility to chemotherapy. Can be used alone or combined/incorporated with chemotherapeutics. Market Summary Cancer is the second leading cause of death in the United States and while cancer survival rates have incre...Wed, 27 Mar 2013 09:28:00 GMTott@emory.edu of Specific Cell Types from Stem Cells via Fluorescent Probes Dual-labeled antisense oligonucleotide probes for fluorescent activated cell sorting (FACS) of pluripotent stem cells. Key Benefits Allows for the purification of a homogeneous cell population compared to currently available techniques which can only produce heterogeneous mixtures. Binds intracellular RNA using standard delivery techniques eliminating the need for known surface markers to be present within the cell population. Specific probes can be generated for different cell types. Market Summary The global market for flow cytometry products and reagents was estimated at $2....Wed, 27 Mar 2013 09:27:38 GMTott@emory.edu Biomarker for the Diagnosis of Amyotrophic Lateral Sclerosis and Frontotemporal Lobar Degeneration with TDP-43 Inclusions biomarker associated with abnormal accumulation of TAR DNA-binding protein 43, to identify amyotrophic lateral sclerosis (ALS) and the most common form of frontotemporal lobar degeneration (FTLD-TDP) in patients.Key BenefitsOffers a diagnosis that does not rely on physician observation of patient's symptoms. Provides high sensitivity and specificity for the detection of ALS and FTLD-TDP. Market SummaryALS is the most common cause of progressive weakness, and FTLD is the second most common cause of progressive dementia among those under the age of 65. Because ALS is phenotypicall...Fri, 15 Mar 2013 14:11:30 GMTott@emory.edu for the Bacterial Expression of Human Deubiquitinating Enzymes Vectors that express human deubiquitinating enzymes including UCH-L1, UCH-L3, Bap1, isopeptidase T (both short and long isoforms), and USP14. Technical Summary These vectors use a pRSET vector backbone and express human deubiquitiating enzymes including UCH-L1, UCH-L3, Bap1, isopeptidase T (both short and long isoforms), and USP14. These enzymes are expressed as full length proteins in bacteria under the control of the lac promoter. They can be used to produce recombinant enzymes. Publications Hu M., et al. (2002) EMBO.J. 24:3747-3756Johnston S.C., et al. (1997) EMBO.J. 16:3787-379...Fri, 15 Mar 2013 14:11:25 GMTott@emory.edu RSV A2-line 19F Strain Generated from BAC-RSV Clone, 04 Mar 2013 09:16:36 GMTott@emory.edu Virtual Class (I.V.C.), online language immersion program that has strong focus on the history and culture of Italy.Key BenefitsWeb based instructional materials, photos, videos and interviews with VIP from the region being studied. The culture and history of Italy is taught concurrently with teaching of the Italian language. The immersion based approach allows students to become fluent more quickly.Market SummaryThere are several types of ways that people learn a new language. Traditional textbooks lack the ability to be interactive with the material and have a strong focus on vocabulary and ...Mon, 04 Mar 2013 09:16:22 GMTott@emory.edu Restoration of Diabetic Bone Marrow-Derived Cells Methods for restoration of diabetic bone marrow cell function for cell based therapy, using pre-existing molecules and their derivatives. Key Benefits Ability to "reactivate" diabetic bone marrow-derived stem or progenitor cells which also include peripheral blood cells such as endothelial progenitor cells. Cells are more angiogenic and effective due to extensive gene silencing at key sites from endothelial progenitor cells. Some derivatives show enhanced activity and reduced toxicity over pre-existing molecules. Market Summary Approximately 26 million adults and children in t...Fri, 15 Feb 2013 10:51:56 GMTott@emory.edu for Off-Site Rapid Triage (SORT): An Assessment for Influenza Pandemics, 14 Feb 2013 11:44:22 GMTott@emory.edu Lung Microvascular Endothelial Cell Line, 14 Feb 2013 11:44:14 GMTott@emory.edu for Rapid Analysis of Staphylococcus aureus Genome Sequences Software that rapidly analyzes S. aureus-related sequences, additional tools to compare and identify other known sequences, and a database to store all results. Key Benefits Analyzes raw data to aid rapidly genotyping and diagnosis of S. aureus infections. Additional tools to produce phylogenetic trees. Can be used as a tool for research, diagnostics, and drug or vaccine development. Market Summary Staphylococcus aureus is a major bacterial pathogen that is a leading cause of hospital, community-acquired and animal infections. In fact, each year, approximately 500,000 patients ...Thu, 14 Feb 2013 11:44:05 GMTott@emory.edu B Activity as a Predictor and Diagnostic for the Two Sub-Groups of Diffuse Large B Cell Lymphoma, 08 Feb 2013 14:15:39 GMTott@emory.edu Scale: Emory Living with Atrial Fibrillation Quality of Life Scale Quality of life instrument administered to the patient that enables healthcare providers to assess the quality of life of patients with irregular heart rhythm atrial fibrillation. Key Benefits Allows healthcare provider to evaluate the effects of atrial fibrillation and treatments on a patient more reliably. Examines physical, emotional, psychological, and social functioning of patient and is sensitive to changes in patient quality of life. Can be used during treatment, clinical trials, and other professional organizations involved in the care of patients with atrial fibrillatio...Thu, 07 Feb 2013 11:17:06 GMTott@emory.edu Syncytial Virus (RSV) A/2001/2-20 Strain with Enhanced Pathogenesis, 07 Feb 2013 11:15:10 GMTott@emory.edu – Polyclonal Antibody against Protein Arginine N-Methyltransferase 1 (PRMT1) Blot SpecificityRat and mouse PRMT1Subtype Rabbit polyclonal Technical SummaryProtein arginine N-methyltransferase 1 (PRMT1) is an enzyme that functions as a histone methyltransferase. Methylation via PRMT1 plays an important role in the regulation of many biological processes. PRMT1 is responsible for the majority of cellular arginine methylation activity. The antibody available was produced using purified protein of 6xHis-tagged rat PRMT1 instead of a peptide sequence. The dilution of the serum is 1:1000 and the dilution of the purified antibodies is 1:10,000. Mon, 28 Jan 2013 11:06:20 GMTott@emory.edu – Polyclonal Antibody against Human DNA Methyltransferase 3-like (DNMT3L), 28 Jan 2013 11:06:17 GMTott@emory.edu Pathology Imaging Device and Software Automated tissue classification system for cancer detection and image-guided procedures. Key Benefits Allows fast and precise diagnoses of tissue abnormalities including tumors. Collects both spatial and spectral data of tissue. Provides multispectral imaging to extract and visualize additional information the human eye cannot detect. Captures numerical data for patient follow-up and tracking of small changes in patients. Market Summary Hyperspectral imaging extends human vision to near-infrared and infrared wavelength regions and can provide a powerful tool for non-invasive t...Mon, 28 Jan 2013 11:06:12 GMTott@emory.edu – Polyclonal Antibody against Mouse DNA Methyltransferase 3a (DNMT3A N-terminal), 28 Jan 2013 11:06:11 GMTott@emory.edu – Polyclonal Antibody against Human DNA Methyltransferase 1 (DNMT1 N-terminal) Blot SpecificityHuman Dnmt1 N-terminalSubtype Rabbit polyclonal ImmunogenNative ProteinTechnical SummaryDNA methyltransferase (DNMT) proteins are involved in DNA methylation in which a methyl group is added to a cytosine residue on DNA. Three families of DNMTs have been identified: DNMT1, DNMT2, and DNMT3. DNMT1 plays a role in the establishment and regulation of tissue-specific patterns of methylated cytosine residues. The antibody available was purified from rabbit using highly purified native protein as antigen. The dilution of the serum is 1:1000 and the dilution of the ...Mon, 28 Jan 2013 11:06:04 GMTott@emory.edu – Polyclonal Antibody against Mouse DNA Methyltransferase 3b (DNMT3B N-terminal), 28 Jan 2013 11:05:59 GMTott@emory.edu FileVault Management Tool for on-site and off-site IT protection.Key BenefitsEncryption status reporting allows administrators to look up encryption status of lost or stolen systems to prevent information breaches. Combines central management and encryption status reporting into a single program increases data security. Market SummaryIT security breaches are on the rise with as much as 85% of U.S. businesses falling victim to a data breach. The cost of IT security breaches most recently was reported to be $7.2 million. Because both the frequency and cost of an IT security breach are on the rise, com...Mon, 28 Jan 2013 11:05:52 GMTott@emory.edu Water Oxidation Catalyst for Hydrogen Fuel Production Oxidation catalysts for sunlight driven H2 fuel production. Key Benefits Faster reactivity compared to previously disclosed water oxidation catalysts (WOCs). Hydrolytic stability exceeds that observed for earlier catalysts. Easily prepared from readily available materials. Market Summary Hydrogen fuel is currently considered a potential replacement for today's fossil fuels due to its abundance and efficiency. Additionally, it produces no emissions and offers the potential to be renewable. If hydrogen were to replace oil, the demand would equal ~40% of the total energy demand in...Thu, 17 Jan 2013 13:14:38 GMTott@emory.edu PHF8 Protein, 14 Jan 2013 14:12:26 GMTott@emory.edu KIAA1718 Protein Jumonji Domain, 14 Jan 2013 14:12:25 GMTott@emory.edu PHF8 Protein Jumonji Domain, 14 Jan 2013 14:12:24 GMTott@emory.edu KIAA1718 Protein, 14 Jan 2013 14:12:22 GMTott@emory.edu Mouse Model for Neurochemical Studies A transgenic mouse model with a mutation that causes overexpression of VMAT2 thus enhancing monoamine signaling. Key Benefits Only VMAT2-overexpressing mouse model available. Could be used for studies of monoamine neurochemistry and neurological disorders such as attention deficit hyperactivity disorder (ADHD), schizophrenia, and mania. Technical Summary VMAT2 transports monoamines from cellular cytosol into synaptic vesicles. The first mouse model with overexpressed VMAT2 gene displaying enhanced monoamine signaling has been developed at Emory. This model may be useful for stud...Tue, 08 Jan 2013 11:10:22 GMTott@emory.edu Pulse Oximetry Data Interpretation Software and Mobile App Web software and mobile app for interpreting and qualifying newborn pulse oximetry data. Key Benefits Reduces interpretation of pulse oximetry data. Provides decision support type feedback. Based upon algorithm endorsed by the American Academy of Pediatrics and the American Heart Association. Market Summary In the past 10 years, the use of pulse oximetry as a tool for monitoring the health of patients has continued to grow. According to multiple market reports, the pulse oximetry market is expected to continue growing and reach $575 million by 2015. With regards to mobile appli...Tue, 08 Jan 2013 11:10:20 GMTott@emory.edu Stool Specimens with Quantitatively Titered Norwalk Viruses Human stool samples with pre-determined Norwalk virus titer that could be used as positive controls for Norwalk Virus-related studies or tests. Key Benefits Virus titer in each specimen has been pre-determined quantitatively. Accurate positive controls for disinfection studies as well as water/food quality control examinations. Technical Summary Norwalk viruses (NVs), also known as noroviruses, are the most common cause for viral gastroenteritis (stomach flu) in humans. According to CDC?s latest report, the viruses contribute to ~21 million cases of acute gastroenteritis each...Tue, 08 Jan 2013 11:10:15 GMTott@emory.edu GM-CSF and IL-4 Fusion Protein for Treating Cancer and Infectious Diseases A recombinant fusion cytokine that activates host immune responses for the treatment of cancer or infectious diseases and the development of adjuvant vaccines. Key Benefits Retains the immune stimulatory properties of both its parental molecules. Displays novel functions such as direct activation of B cells leading to anti-cancer and vaccine adjuvant activity. Technical Summary Cytokines are small cell-signaling proteins with immuno-modulatory properties. GM-CSF and IL-4 are two important cytokines with immuno-stimulatory activities, GM-CSF affects adaptive immunity by promoting...Tue, 08 Jan 2013 11:10:14 GMTott@emory.edu Reporting System to Locate Vulnerable Divisions to Phishing Attacks software to measure and map out an organization's vulnerable locations to phishing attacks. Key BenefitsCombines merits of reports with demographic data from the organization. Helps users of to pinpoint training weaknesses in an organization and customize education strategy based on the statistical reports generated. Market SummaryThe number of phishing attacks directed at individual accounts within a company shows a notable increase on both the global and domestic scale. Compared to the second half of 2011, the first half of 2012 marks a 19% increa...Tue, 27 Nov 2012 08:08:12 GMTott@emory.edu Tool for Vaccine Development for Respiratory Syncytial Virus (RSV) respiratory syncytial virus (RSV) A2-line19F strain with a point mutation and a protein encoding plasmid for expressing protein with same mutation for use in vaccine research for RSV.Key BenefitsMutated fusion protein shows a greater than 6-fold increase in fusion activity over line19 F protein. Mutated recombinant virus shows greater thermostabitily compared to parent line. Market SummaryRSV is a ubiquitous virus worldwide and is the most common cause of bronchiolitis in children under the age of 1. The CDC estimates that almost all children with have had an RSV infecti...Mon, 12 Nov 2012 11:02:57 GMTott@emory.edu Database for Matching Student Researchers with Ongoing Research Projects Research project database and web-based software that matches interested student researchers with faculty seeking assistance. Key Benefits Provides a single site for posting, searching, and joining research projects. Easily integrated into most existing IT infrastructures. Market Summary One of the biggest difficulties in undergraduate or medical fellow research is connecting research investigators with students interested in research. Typical methods for finding interested students or fellows involve posting flyers or word of mouth. For interested students, the process usually ...Mon, 12 Nov 2012 11:02:56 GMTott@emory.edu Universal News Center Database structure and software that automatically collects, displays on a webpage, and distributes via email news stories for an institution. Key Benefits Easily customizable and robust news aggregator, database, and media delivery software. Faster page loads and publishing capabilities. Able to provide alternative versions of a single story that is dependent on an internal or external audience. Provides an effective tool for centralizing (gathering, curating, organizing, and promoting) stories and content thereby allowing a decentralized organization to express its brand/iden...Mon, 12 Nov 2012 11:02:54 GMTott@emory.edu Polyclonal Antibody (Non-Phospho) Western Blot Immunohistochemistry Specificity Mouse PIKE-A Subtype Rabbit polyclonal Technical Summary PIKE-A is a ubiquitously expressed GTPase. Expression of PIKE-A enhances Akt activity and promotes invasiveness of cancer cell lines, while knockdown of PIKE-A decreases Akt activity and increases apoptosis. PIKE-A overexpression can mediate cell transformation, proliferation and migration remain and its overexpression is observed in various human cancer samples. The antibody available is against PIKE-A, specifically a part of the peptide sequence of His-PIKE-A. This antibod...Mon, 12 Nov 2012 11:02:35 GMTott@emory.edu Tristetraprolin/ZFP36 Mouse Model model that over expresses tristetraprolin (TTP), also known as zinc finger protein 36 homolog (ZFP36), in fat tissue.Key BenefitsUseful in the study of functions of high ZFP36 expression in fat tissue of mice, in inflammatory responses, in TNF-alpha production, and as a target for anti-TNF-alpha therapies. Model has good reproduction and no special husbandry requirements. Technical SummaryTristetraprolin (TTP) or zinc finger protein 36 homolog (ZFP36) is a protein that binds to untranslated regions of messenger RNA (mRNA) of some cytokines and promotes their degradation. For e...Fri, 02 Nov 2012 11:06:45 GMTott@emory.edu Assurance for Deformable Registration in Clinical Settings Fast and efficient method for quality assurance of deformable registration of images from PET or CT scans, particularly for adaptive radiotherapy. Key Benefits Quantitative metrics of registration quality designed for routine use that are algorithm-independent, labor-efficient, and accurate. Increased usability and accuracy in detecting unrealistic warping over classical registration assessment methods. Market Summary Image guided radiation therapy (IGRT) is a relatively new approach in imaging before and after treatment visualizes anatomical changes. This image-guided therapy i...Tue, 16 Oct 2012 07:44:13 GMTott@emory.edu Line for Fluorescent-based Whole Cell Assay of Vesicular Monoamine Transporter 2 Function Stably transfected cell line that allows for real time tracking of vesicular monoamine transporter 2 (VMAT2) function through the use of fluorescent markers in live cells. Key Benefits Can test target compound interaction with human dopamine transporter (hDAT) or VMAT2 in cultured cells instead of in harvested research animal tissue saving time and money. Uses fluorescent dyes in assays instead of radioactive markers, which eliminates the need for radiation certification. Can test potential VMAT2 agonists or antagonists in a whole cell model as opposed to isolated vesicle assays...Mon, 24 Sep 2012 13:42:28 GMTott@emory.edu Microarray for Immunochemistry Slides Calibration microarray that can be used for quantification and semi-quantification of immunochemistry slides for a multitude of biomarkers simultaneously. Key Benefits Higher level of comparability between immunohistochemistry slides. Higher level of fidelity of quantification of biomarkers in immunohistochemistry slides. Provides standardization for the subjective method of immunohistochemistry. Multiplexed ability to read multiple biomarkers quantitatively on a single slide. Market Summary Immunohistochemisty has a large role in the field of pathology and provides excellent ...Mon, 24 Sep 2012 13:42:25 GMTott@emory.edu Anti-SG2NA Monoclonal Antibody, 24 Sep 2012 08:38:53 GMTott@emory.edu Drug Treatment for Neoplasms Associated with Tuberous Sclerosis Combination of rapamycin and imatinib for the treatment of neoplasms associated with tuberous sclerosis (TS). Key Benefits Combined therapy shows 97% decrease in tumor volume in mouse model of TS compared to vehicle treatment. Dual therapy blocks two major signaling pathways implicated in TS. Market Summary Tuberous sclerosis (TS) is a rare genetic disease occurring in 1 in 6,000 births. The disease is characterized by benign neoplasm tumors in various organs including the brain, kidney, skin, heart, and lungs. Neoplasms can lead to the development of epilepsy, lesions of the ki...Tue, 18 Sep 2012 13:18:00 GMTott@emory.edu Time 3D Imaging and Dosimetry Treatment Planning for Targeted Radiotherapy/Drug Delivery and Response Assessment Software for an integrated image-guided dosimetry planning system to predict individual responses to delivery of targeted radiotherapy. Key Benefits Acquires, registers, and visualizes SPECT-CT data with anatomical MR imaging. Combines imaging data with computational dosimetry models for specific radionuclides in order to calculate absorbed doses on anatomical images. Provides quick assessment of chemotherapy effectiveness, even before the first cycle is complete. Allows clinician to adjust dose and chemotherapy agent earlier, sparing patients unnecessary treatments and side ef...Tue, 18 Sep 2012 13:17:36 GMTott@emory.edu Procedure for Chemical Profiles in Biological or Medical Samples Detected by Mass Spectrometry Normalization procedure that allows for the direct comparison of high-throughput liquid chromatography/mass spectrometry (LC/MS) metabolomic data gathered from different individuals at different times. Key Benefits Samples used can be collected at different times and/or analyzed by different mass spectrometers. Cumulative datasets can be compiled and datasets can be compared to each other. Useful for clinical diagnostics and research. Market Summary Metabolomic analyses are used in clinical diagnostics for a number of disorders including metabolic, hematologic, and endocrinolo...Tue, 18 Sep 2012 13:17:34 GMTott@emory.edu<![CDATA[Nanotherapeutics of ScEGFR, Heparin, & Cisplatin for Treating Lung Cancer]]> Nanoparticle drug delivery system in which cisplatin is conjugated to both heparin and a targeting ligand to be used for the treatment of non-small cell lung cancer (NSCLC). Key Benefits Smaller size and lower molecular weight than other targeted therapies. Less immunogenicity than full monoclonal antibody (mAb) therapeutics. Less off-target accumulation in normal organs. Prolonged blood circulation time and improved pharmacokinetics and biodistribution compared to cisplatin treatment alone. Enhanced antitumor activity of cisplatin in vivo without the weight loss observed in c...Tue, 18 Sep 2012 13:17:27 GMTott@emory.edu Analogs as a Potential Cancer Therapeutic Noscapine analogs that incorporate 9-aminonoscapine for use as a cancer treatment. Key Benefits Has higher tubulin activity than noscapine. Induces apoptosis selectively in ovarian and T-cell lymphoma tumor cells that are already drug-resistant. Market Summary Ovarian cancer affects approximately 13 of every 100,000 women and about 80 percent of patients with ovarian cancer will have a recurrence. The different types of T-cell lymphoma are considered rare diseases. A significant number of these patients do not respond to treatment, relapse after treatment, or become resistant to...Wed, 22 Aug 2012 12:12:28 GMTott@emory.edu syncytial virus (RSV) Reporter Plasmid for High Throughput Drug Screening reporter for high throughput respiratory syncytial virus (RSV) drug discovery.Key BenefitsSimple luciferase readout marker indicates RSV replication activity. Market SummaryRSV is a ubiquitous respiratory pathogen worldwide. It is the most common cause of severe lower respiratory tract disease among infants and young children worldwide, with about 160,000 deaths annually. Furthermore, RSV related illness in elderly is also on the rise. Currently there is a dearth of effective drugs against RSV, and there is an urgent need to devise strategies for RSV drug development...Wed, 22 Aug 2012 12:12:26 GMTott@emory.edu DNAzyme-Nanoparticle Conjugates for Gene Regulation Catalytic DNA molecules (DNAzymes) conjugated to gold nanoparticles for use as therapeutics to treat cancers, infections or other applications of gene therapy. Key Benefits DNAzyme-gold nanoparticles regulate gene expression through an RNAi independent mechanism. Each DNAzyme-gold nanoparticle is more catalytically active than a free DNAzyme molecule. Gold nanoparticle conjugation protects DNAzymes against nuclease degradation and extends their half-life and activity. DNAzyme gold nanoparticles are non-toxic and readily enter cells without transfection agent. DNAzyme-gold nano...Wed, 22 Aug 2012 12:12:25 GMTott@emory.edu for the Co-Registration of Intravascular Ultrasound Images for Coronary Artery Disease Assessment Algorithm for the co-registration of virtual histology intravascular ultrasound (VH-IVUS) images for tracking the progression or regression of plaque during coronary artery disease. Key Benefits Allows for regional assessment of plaque development and progression unlike traditional techniques that analyze plaque progression as one quantity for each paired VH-IVUS. Co-registration occurs in almost real time. Provides a method for quick, easy, and accurate comparisons of IVUS images. Market Summary IVUS is considered the gold standard for intravascular imaging. The global market ...Wed, 22 Aug 2012 12:12:16 GMTott@emory.edu for Combining and Viewing Planar Dynamic Radiolabeled Red Blood Cell Scintigraphy with Multiplanar CT for the Localization of Gastrointestinal Hemorrhages Software that merges radiologic images from red blood cell (RBC) scintigraphy with CT scan images in order for physicians to better localize the origin of a gastrointestinal (GI) bleed. Key Benefits Allows more accurate localization of GI bleeds than RBC scintigraphy alone. Fusion of two images can increase diagnostic confidence, especially in precise anatomic localization of potential sources of GI bleeding. Market Summary Approximately 400,000 upper and lower GI bleeds occur in the US annually. Esophagogastroduodenoscopy is the first choice for diagnosing upper GI bleeds and c...Wed, 22 Aug 2012 12:12:11 GMTott@emory.edu Flash Facts TM Educational and reference flashcards pertaining to radioactive tracers for physicians in training and radiologists. Key Benefits Provides a new learning methodology by creating flash cards detailing radiotracer physical and chemical characteristics and distribution. Helps the physician to recall essential facts for each radiotracer that may be used in everyday practice as well as for examinations. Tables could also be used for calculations needing decay factors. Market Summary There are approximately 30,000 radiologists in the US and 20,000 new medical school students every yea...Mon, 20 Aug 2012 08:02:47 GMTott@emory.edu Antagonists in Treatment of Cancer Nonpeptidic molecules that block the chemokine receptor, CXCR4, for treatment of proliferative disorders including inhibition of cancer metastasis. Key Benefits Modulate CXCR4 receptor activity by interfering with SDF-1 ligand binding. Inhibit migration of metastatic cancer cells by blocking chemokine receptor signaling. Show increased bioavailability and efficacy over known CXCR4 antagonists. Market Summary Most cancer deaths are attributed to metastasis, the migration of cancerous cells from primary tumor origin. Although several strategies have been developed to prevent meta...Fri, 17 Aug 2012 06:07:39 GMTott@emory.edu Technique for Early Detection and Diagnosis of Parkinson’s Disease, 15 Aug 2012 12:49:39 GMTott@emory.edu Biomarkers for Oxidative Stress in Diseases Characterized by Chronic Inflammation, 07 Aug 2012 13:56:58 GMTott@emory.edu and Integrated System of PET, CT, and Ultrasound for Image-Directed Prostate Biopsies and Cancer Diagnosis Software that automatically integrates both PET/CT and 3D ultrasound imaging for a molecular image-targeted prostate biopsy in real time. Key Benefits Incorporates both PET/CT imaging and 3D ultrasound imaging for improved accuracy of biopsy sampling and staging of prostate cancer. Useful for image-targeted biopsy, brachytherapy, radiofrequency thermal ablation, cryotherapy, and interstitial photodynamic therapy. The fusion software of PET/CT and ultrasound is also useful for prostate, ovarian, liver, and breast cancer detection. Market Summary An estimated 1.5 million prostate...Tue, 07 Aug 2012 13:56:56 GMTott@emory.edu Genes Expressed Following Disturbed Blood Flow in Mouse Carotid Artery Endothelium genes for use as a research tool to examine the causes and molecular mechanisms that lead to rapid endothelial dysfunction and atherosclerosis.Key BenefitsMechanosensitive genes involved in cell proliferation and morphology are expressed by 12 hours and in inflammatory and immune responses by 48 hours following disruption of blood flow. Genes show significantly higher expression in mouse aortic arch and in human coronary endothelium. Technical SummaryAtherosclerosis is a condition in which fatty deposits accumulate on artery walls and thicken the artery thus blockin...Tue, 07 Aug 2012 13:56:53 GMTott@emory.edu Inhibitory JAML Monoclonal Antibody DW100 Flow cytometry Immunoprecipitation Specificity Human JAML Subtype Mouse Monoclonal Isotype IgG1 Technical Summary Junctional adhesion molecule-like (JAML) protein plays a role in mediating monocyte transendothelial migration. These antibodies, with clone name DW100, can be used to detect human JAML by flow cytometry, immunoprecipitation, and other functional assays. The immunogen is recombinant human JAML and was produced in a mouse in P3U1 myeloma cells. The antibodies can be produced as ascites and as cell culture supernatant. JAML transfected CHO cells were used as positi...Tue, 31 Jul 2012 12:14:44 GMTott@emory.edu Monoclonal Antibody DW216 Flow cytometry Immunoprecipitation Specificity Human JAML Subtype Mouse Monoclonal Isotype IgG1 Technical Summary Junctional adhesion molecule-like (JAML) protein plays a role in mediating monocyte transendothelial migration. These antibodies, with clone name DW216, can be used to detect human JAML by flow cytometry, immunoprecipitation, and other functional assays. The immunogen is recombinant human JAML and was produced in a mouse in P3U1 myeloma cells. The antibodies can be produced as ascites and as cell culture supernatant. JAML transfected CHO cells were used as positi...Tue, 31 Jul 2012 12:14:41 GMTott@emory.edu Monoclonal Antibody DW55 Flow cytometry Immunoprecipitation Specificity Human JAML Subtype Mouse Monoclonal Isotype IgG2b Technical Summary Junctional adhesion molecule-like (JAML) protein plays a role in mediating monocyte transendothelial migration. These antibodies, with clone name DW55, can be used to detect human JAML by flow cytometry, immunoprecipitation, and other functional assays. The immunogen is recombinant human JAML and was produced in a mouse in P3U1 myeloma cells. The antibodies can be produced as ascites and as cell culture supernatant. JAML transfected CHO cells were used as positi...Tue, 31 Jul 2012 12:13:15 GMTott@emory.edu Model of Nemaline Myopathy An invertebrate animal model of nemaline myopathy using Caenorhabditis elegans. Key Benefits C. elegans with pathological mutations of tropomyosin that cause nemaline myopathy. Technical Summary Nemaline myopathy, or rod myopathy, is a congenital and hereditary neuromuscular disorder that causes muscle weakness of varying severity. It can even be life-threatening in severe cases, but no effective therapy for nemaline myopathy has been developed. Tropomyosin, an actin-binding protein that stabilizes actin filament dynamics, has been identified as a nemaline myopathy gene that is in...Tue, 31 Jul 2012 12:13:02 GMTott@emory.edu Cell Lines with LKB1 Depletion Cancer cell lines (specifically non-small cell lung cancer) with depleted levels of LKB1 protein. Key Benefits Multiple cancer cell lines are available. Produced with lentiviral LKB1 short hairpin RNA constructs. Technical Summary LKB1 is a serine/threonine kinase gene located on chromosome 19p13.3 and inactivation of LKB1 is present in approximately 30% of non-small cell lung cancer primary tumors and cell lines. LKB1 suppresses tumors, opposite to Akt, by negatively regulating the mammalian target of rapamycin through the activation of AMP-activated protein kinase and the TSC ...Tue, 31 Jul 2012 12:13:00 GMTott@emory.edu of Embryonic Stem Cells as a Diagnostic Model for Fetal Alcohol Syndrome Undifferentiated human embryonic stem cells exposed to ethanol as a diagnostic and research model for fetal alcohol syndrome. Key Benefits Ethanol introduced to human embryonic stem cells may provide information concerning ethanol-mediated apoptosis and its effects on early human development. Technical Summary Fetal alcohol syndrome is a pattern of mental and physical defects that can develop in a fetus in association with high levels of alcohol consumption during pregnancy. Exposure of human embryonic stem cells to common toxins and drugs has the potential to yield insight into h...Tue, 31 Jul 2012 12:12:52 GMTott@emory.edu Model for Rapid Endothelial Dysfunction and Atherosclerosis by Acutely Induced Disturbed Blood Flow via Partial Carotid Ligation Mouse model for the study of the causes and molecular mechanisms that lead to rapid endothelial dysfunction and atherosclerosis. Key Benefits There is currently no animal model in which disturbed blood flow can be acutely induced and cause atherosclerosis. Allows for studies to understand the links between disturbed flow and atherosclerosis. Can be used for genome-wide studies to determine molecular mechanisms underlying flow-dependent regulation of vascular disease. Technical Summary Atherosclerosis is a condition in which fatty deposits accumulate on artery walls and thicken ...Mon, 30 Jul 2012 08:43:25 GMTott@emory.edu Nanorod-Based System for Efficient Conversion of Sunlight into Hydrogen Water-soluble semiconductor nanorod crystals that allow for efficient light-driven hydrogen production. Key Benefits Provides almost 100% quantum efficiency for photoreduction of a redox mediator during solar-to-fuel conversion for use in batteries, fuel cells, and other energy sources. Provides unique absorption properties, larger extinction coefficients, weaker concentration dependence, and enhanced photostability compared to commonly-used molecular chromophores. Offers both efficient electron excitation and efficient photoreduction of the redox mediator into its active form. ...Mon, 30 Jul 2012 08:43:23 GMTott@emory.edu Syncytial Virus (RSV) Luminescent Reporter Strain, 30 Jul 2012 08:43:20 GMTott@emory.edu Device for Delivery of Therapeutics into Cells Microfluidic slide with individual cell holders for use in microinjection procedures. Key Benefits Open system - compatible with other microinjection technologies and existing research instrumentation. Compatible with both adherent and non-adherent cells. Enables high-throughput and high-precision delivery of substances into cells, specifically the nucleus if needed. Potentially low-cost and disposable. Market Summary The efficient capture and retention of individual cells for precise delivery of therapeutic agents remains a great challenge in microinjection procedures, especi...Thu, 12 Jul 2012 12:53:45 GMTott@emory.edu Y816 Antibody Immunohistochemistry Specificity Mouse Subtype Rabbit Polyclonal Technical Summary The anti-p-TrkB Y816 is specific for phosphorylated forms of tyrosine kinase B (TrkB). The antibody was raised against the [H]-CKLQNLAKASPV-pY-LDILG-[OH]. The antiserum was purified by affinity columns using the Affigel-10 cross-linked phosphopeptide antigen. This antibody has been used for previously for immunostaining brain sections.Fri, 06 Jul 2012 12:12:17 GMTott@emory.edu Syncytial Virus (RSV) Fluorescent Reporter Strain, 06 Jul 2012 12:12:14 GMTott@emory.edu Methyltransferase Dnmt3a Antibody Immunoblotting Immunoprecipitation Western Blot Specificity Mouse and human Dnmt3a - Specifically K44me2 of mDnmt3a and K47me2 of hDNMT3A Subtype Rabbit Polyclonal Technical Summary MPP8 mediates the interactions between DNA methyltransferase Dnmt3a and H3K9 methyltransferase GLP/G9a. DNA methylation and H3K9 methylation appear to co-occur in chromatin. The antibody was raised against the peptide CSATAR(Kme2)VGRPGR for mouse and YEPSTTAR(Kme2)VGRPGR for human. The peptide was conjugated to KLH via the N-terminal cysteine. Publication: Chang, Y et al. Nat Commun, 2011. 2: 533....Fri, 06 Jul 2012 12:12:03 GMTott@emory.edu©TM: Software for Improved Design and Evaluation of Phase I Clinical Trials, 02 Jul 2012 13:32:34 GMTott@emory.edu Software to Determine Lead Placement of Cardiac Pacemakers MRI-based software to plan the position of the left ventricular pacing lead during cardiac resynchronization therapy (CRT). Key Benefits No software/methodology is available to plan the optimal position of the pacing lead. Software would be combined with MRI scan conducted prior to CRT. Software would include registered images of ventricle contraction timing, myocardial scar distribution, and coronary vein anatomy. Market Summary CRT is invasive, is costly, has significant associated risks, and requires lifelong dependency on a pacing device; however one out of three patients ...Tue, 12 Jun 2012 06:54:12 GMTott@emory.edu Tissue Strengthening and Port Access System for Transapical Cardiac Surgery that enhances the tissue mechanical strength of the heart apex allowing access to the cardiac chambers. Key BenefitsReduces procedural time and risks such as apical rupture and bleeding for transapical heart surgery. Improves tissue mechanical stability by enhancing tissue strength, particularly apex tissue which may be weakened in some patients. Facilitates easier and safer access to the interior structures of the heart during surgical procedures involving repair and replacement. Less risk of bleed complications compared to conventional suturing of the access site. Closure o...Fri, 08 Jun 2012 06:17:33 GMTott@emory.edu Transcatheter Mitral Valve Replacement System transcatheter valve replacement system is a system that enables the placement of a stent mounted bioprosthetic heart valve in the mitral position. This technology is based on a nesting coaxial stent system enables the placement of any existing aortic or pulmonary valves in the non-circular shaped mitral (D-shape) orifice. The dual stent MitraCath system has an outer stent to provide anchoring in the non-circular shaped annulus, and the inner stent to mount the circular valve.Key BenefitsSimple stent system to enable use of circular valves made for aortic and pulmonary repl...Fri, 08 Jun 2012 06:17:31 GMTott@emory.edu Transcatheter Mitral Valve Repair Technology, 08 Jun 2012 06:17:27 GMTott@emory.edu Deodorizer for Ostomy Pouches deodorizer that can be used to better control the odor of fecal and other collection bags used in a hospital setting.Key BenefitsSolid, dissolvable tablet that contains a deodorizer and activated charcoal. Provides extended and improved odor control resulting in a more pleasant environment within a hospital room for both patients and care-givers. Market SummaryIn the U.S., approximately 50,000 ostomy surgeries occur each year. While patients are recovering in the hospital from their surgery, fecal and urinary materials are collected in bags. The strong and unpleasant odors ...Fri, 08 Jun 2012 06:17:25 GMTott@emory.edu A Device for Minimally Invasive Robotic Mitral Valve Repair MitraSurg is a simple device for surgical correction of mitral valve lesions, which can be implanted using minimally invasive and robotic surgical techniques. Key Benefits Simple, collapsible design to enable delivery to the mitral valve via small incisions or ports. Does not require suturing to the valve, which reduces the time and risk associated with the procedure and improves patient quality of life. Enables free flow of blood through the valve, without the danger of valvular thrombosis or stenosis. Market Summary Mitral annuloplasty is the current standard of care to surgi...Fri, 08 Jun 2012 06:17:19 GMTott@emory.edu Wear Carrier for Liquid Deodorizers Used in an Ostomy Pouches A unique and highly effective carrier for liquid deodorizers that can be used to control the odor of collection bags used by patients who have an ostomy. Key Benefits This non-dissolvable device is mounted to the interior wall of a conventional ostomy pouch and is combined with a liquid deodorant to eliminate fecal and urinary odor. Enhances the effectiveness of liquid deodorants due to its absorptive, circulatory, and anti-microbial properties. Reduces the amount of liquid deodorant required and the number of applications of deodorant over the course of the day. Offers a signi...Fri, 08 Jun 2012 06:17:09 GMTott@emory.edu – A Device for Continuous Renal Replacement Therapy in Children that provides continuous renal replacement therapy (CRRT) for neonates and children with acute kidney injury, which is adjustable to treat adults as well. Key BenefitsCan be used in children - currently no CRRT device is approved for pediatric use. Improved accuracy over currently available devices due to novel pump and control system design. Easily integrated with other extracorporeal therapies. Reduced size of device and more user-friendly interface compared to other current therapy devices. Reduced risk of infection, bradykinin release syndrome, and transfusion reactions b...Mon, 04 Jun 2012 14:11:28 GMTott@emory.edu of Dry AMD and Other Ophthalmic Diseases Fulvene and fulvalene compounds that inhibit nicotinamide adenine dinucleotide phosphate (NADPH) oxidases for the treatment of ophthalmic diseases and disorders including the dry form of age-related macular degeneration. Key Benefits Lead compound candidate identified. Demonstrated positive effects in in vivo preclinical ocular models of retinal degeneration, oxygen-induced neovascularization, permeability and inflammation. Market Summary NADPH oxidase inhibitors are potential candidates for the treatment of the dry form of age-related macular degeneration (AMD). Approximately ...Mon, 04 Jun 2012 14:11:23 GMTott@emory.edu for Use as an Adjunct to Psychotherapy Use of alpha-melanocyte-stimulating hormone (MSH) receptor agonists as an adjunct to psychotherapy for the treatment of autism, post-traumatic stress disorder, anxiety disorders and other behavioral disorders. Key Benefits Manipulating the oxytocin system in the brain has been shown to increase trust, generosity, empathy, socially reinforced learning and attention to comprehension of emotional expression. Potential clinical candidates exist which have already been dosed to humans. Provides novel potential treatment for autism and other behavioral disorders. Market Summary Betwee...Mon, 04 Jun 2012 14:11:21 GMTott@emory.edu Fluid Management System for Continuous Hemofiltration that provides continuous veno-venous hemofiltration for adults and children with kidney failure. Key BenefitsUsed in combination with extracorporeal membrane oxygenation machines. Improves the accuracy and safety of fluid delivery and extraction compared to existing technology, thereby improving outcomes of critically ill patients. Can be used in children - currently no similar device is approved for pediatric use. Market Summary The dialysis device field consists of dialysis accessories, hemodialysis machines, and continuous renal replacement therapy. When continuous veno-ve...Mon, 04 Jun 2012 14:11:07 GMTott@emory.edu 3D Segmentation of Ultrasound Images for Prostate Cancer Assessment Automatic 3D segmentation method based on image registration and filters to determine edges and textures of prostate images for use in the diagnosis and assessment of prostate cancer. Key Benefits Provides an automatic segmentation method that does not require initialization, unlike currently available methods. Uses an image database and filters to train a statistical classification machine to segment novel images of prostate tissue. Market Summary An estimated 1.5 million prostate biopsies are performed on men each year. To date, 2D transrectal ultrasound (TRUS) image segmentat...Tue, 29 May 2012 11:52:07 GMTott@emory.edu Segmentation Method to Improve Prostate Cancer Imaging automatic method for image segmentation in prostate cancer detection and diagnosis. Key BenefitsOptimizes prostate biopsy by providing a method for 3D TRUS imaging that can be used in the diagnosis, staging, and monitoring of prostate cancer. Market SummaryAn estimated 1.5 million prostate biopsies are performed on men each year. To date, 2D transrectal ultrasound (TRUS) guided biopsy has been the clinical standard for prostate cancer diagnosis. 2D image partitioning is limited in its ability to extract texture features of the geometrical shape and boundaries of the prostate. Usi...Tue, 22 May 2012 06:32:07 GMTott@emory.edu Imaging System to Evaluate Prostate Cancer using Ultrasound and PET/CT Scans Imaging system that combines multiple scans for prostate cancer diagnosis, staging, and treatment assessment. Key Benefits Optimizes biopsy targeting by providing a 3D assessment of metabolic, functional and anatomical defects on the prostate surface, interior, and bladder neck regions. Increases the specificity and sensitivity of prostate examinations by providing a precise assessment of the location of cancer cells. Market Summary An estimated 1.5 million prostate biopsies are performed on men each year. To date, transrectal ultrasound (TRUS) guided biopsy has been the clinica...Tue, 22 May 2012 06:32:01 GMTott@emory.edu Tissue Classification of Breast CT Images for Breast Cancer Diagnostics A platform technology for breast cancer detection and diagnosis based on x-ray computed tomography (CT) imaging. Key Benefits Uses a multi-scale, bilateral filtering system to classify breast tissue based on composition, density and distribution. Automated system distinguishes between breast fat, skin, and glandular tissue and eliminates the need for manual segmentation. Market Summary The lifetime risk for women developing breast cancer in the US is one in eight. Currently, the most common test for detection of breast cancer is mammography, but one of its most significant limit...Thu, 17 May 2012 08:00:14 GMTott@emory.edu (clone 16E2) Polyclonal Antibody, 17 May 2012 08:00:10 GMTott@emory.edu Use of Dual Toll-Like Receptor (TLR) Ligands as Vaccine Adjuvants use of TLR4 and TLR7 ligands invirus-like-particles (VLPs) as potent adjuvants for prophylactic and therapeutic vaccines. Key BenefitsAble to elicit both cellular and humoral immunity. Synergistically improves the quality of B- and T-cell responses. Induces long-lived and persistent antigen-specific immune responses. Market SummaryTraditional vaccines normally consist of attenuated or dead microbes, or their fragments. Many of them lack sufficient immunogenicity and require adjuvants, sometimes multiple booster injections to increase their efficacy, such as those for H...Tue, 08 May 2012 13:36:05 GMTott@emory.edu Fluorescent Protein Antibodies, 30 Apr 2012 09:03:47 GMTott@emory.edu Analogs of Progesterone Analogs and pro-drugs of naturally occurring progesterone. Key Benefits Natural progesterone is the only therapeutic for TBI in clinical studies that has reproducible results. Progesterone analogs unlike natural progesterone are: Water soluble and hence can be administered via intramuscular injection or i.v. drip (possibly orally available) Easy method of transport and can be reconstituted immediately Rapidly reaches Cmax and provide much longer plasma half-lives. Market Summary Severe TBI occurs in over 1.1 million people across the US and other major countries. Approximat...Mon, 23 Apr 2012 12:02:31 GMTott@emory.edu Microcapsules for Treatment of Type 1 Diabetes Transplantation of microcapsules with insulin-producing porcine islet cells for use in Type 1 diabetes. Key Benefits Improved engineering of microcapsules prevents immune activation and microcapsule rejection. Encapsulated islet cells sense blood glucose levels and secrete insulin. Transplanted microcapsules demonstrate a long-term function for normalizing blood glucose levels. Market Summary Annually, over 15,000 individuals are diagnosed with Type 1 diabetes in the US. The prevalence of Type 1 diabetes is over 215,000 individuals in the US alone. Patients with Type 1 diabete...Mon, 23 Apr 2012 12:02:09 GMTott@emory.edu of Bcl-2 Inhibitors as Anti-Cancer Therapeutics Small molecule inhibitors of Bcl-2, an anti-apoptotic protein, for cancer treatment. Key Benefits Developed specifically to target the BH4 homology domain of Bcl-2 in order to improve binding affinity and anti-tumor efficacy over other Bcl-2 inhibitors. Compounds may simultaneously suppress a wider range of anti-apoptotic proteins than currently available Bcl-2 inhibitors. Market Summary Bcl-2, a protein overexpressed in many cancers, including lung cancer, makes cancer cells more resistant to chemotherapy. Small molecule inhibitors of Bcl-2 recorded $8.3B in global sales in 201...Mon, 23 Apr 2012 12:02:07 GMTott@emory.edu for Arteriovenous Fistula Dialysis Access Failure biomarker for the prediction of arteriovenous fistula (AVF) dialysis access failure during hemodialysis.Key BenefitsCirculating chymase levels predict AVF failure in chronic hemodialysis patients. Proprietary antibody while other proprietary antibodies do not work as biomarkers. The ability to predict AVF failure may help providers select an alternate dialysis modality or initial vascular access type. Market SummaryMore than 100,000 new patients with end-stage renal disease begin hemodialysis each year. Approximately half of the AVF's surgically created never mature sufficien...Mon, 23 Apr 2012 12:02:04 GMTott@emory.edu Valve for Bag-Valve-Mask Resuscitators Rate-controlling valve for Bag-Valve-Mask (BVM) resuscitators to prevent hyperventilation during manual resuscitation. Key Benefits The device utilizes a novel valve mechanism to regulate the reinflation rate of BVM resuscitators, and therefore prevents hyperventilation. The user-friendly device is compatible with current airway management add-ons. Market Summary A total of approximately 117 million patients visit the emergency room in the United States annually, and 1 in 10 needs manual ventilation via BVM resuscitators. Efficiency and safety of the procedure highly depends on ...Tue, 10 Apr 2012 14:17:51 GMTott@emory.edu Glycomics: A Microarray Strategy for Functional Glycomics Microarray based strategy for functional analyses of complex cellular glycomes. Key Benefits Identifies functionally relevant glycans. Allows focused structural analyses of biologically important glycans. New approach to label glycosphingolipids that retains their protein binding. Technical Summary Glycans mediate crucial cell-cell, cell-protein and cell-lipid interactions. Recognition and binding of glycans by glycan binding proteins (GBPs) is central to a variety of biological processes, such as movement and trafficking of white blood cells in inflammation and host pathogen r...Tue, 10 Apr 2012 14:17:35 GMTott@emory.edu System for Integrating Photographs with Medical Imaging Examinations in the PACS Environment Acquiring and integrating a digital photo of a patient with traditional medical imaging studies (X-ray, ultrasound, CT, MRI, etc.). Key Benefits Occurs at the point-of-care of medical imaging for accurate identification, diagnosis, and treatment of patients. Decreases human involvement in photo acquisition. Prevents patient mislabeling and misidentification during medical imaging that may result in misdiagnosis or the wrong treatment being administered to a patient. Reduces the time radiologists spend interpreting an imaging study. Increases radiologist confidence in interpret...Wed, 04 Apr 2012 07:32:56 GMTott@emory.edu Segmentation Software Suite for PET/MRI Brain Imaging Software suite for skull segmentation that can facilitate MR image-based attenuation correction of PET brain imaging. Key Benefits A post-processing software suite for skull segmentation that requires no manual intervention while maintaining high accuracy. Can be used to analyze images from independent PET and MRI scanners as well as the fully integrated imaging device. Insensitive to noise and able to process MR images with low quality. Market Summary Each year 6.6 million MRI head scans are performed in the United States. In 2010, 1.74 million clinical PET pati...Tue, 03 Apr 2012 10:41:16 GMTott@emory.edu Induced Pluripotent Stem (CiPS) Cells Generation of pluripotent stem cells from adult somatic cells for medical use. Key Benefits No exogenous genetic manipulations, which minimize oncogenic effects, were observed in current methods. Peripheral blood can be used as a source of parent cell instead of fibroblasts or keratinocytes. Market Summary The economic and psychological tolls of chronic, degenerative, and acute diseases in the United States are enormous. It has been estimated that up to 128 million people suffer from such diseases. Stem cell medicine has been identified as an emerging potential for the treatment...Thu, 29 Mar 2012 10:14:53 GMTott@emory.edu of Red Blood Cells (RBC) to Predict Post-Transfusion Survival to evaluate red blood cell units (RBC) and predict their post-transfusion survival.Key BenefitsNo existing techniques to predict post-transfusion survival of RBC units. Provides a quality control technique to predict post-transfusion survival of RBC units prior to transfusion. Market SummaryOver 15 million units of red blood cells (RBCs) are transfused into about 5 million patients in the US each year. The blood market includes products used for collecting, typing, processing, and transfusing of blood and this market was worth $30 billion worldwide in 2010 and is predicted...Tue, 27 Mar 2012 07:49:33 GMTott@emory.edu Inhibitor: Bone Forming Small Molecule for Use in Spinal Fusion Devices Bone forming therapeutic for use in spinal fusion devices and treatment of systemic bone diseases and disorders. Key Benefits Current devices for bone grafting procedures require high concentrations of bone morphogenetic protein (BMP) which results in a high cost and create a barrier for routine clinical use. Small molecule therapeutics that modulate Jab1 (part of the signaling pathway for BMP) have been identified and could be used locally or systemically to promote bone formation. Market Summary It is estimated that approximately 2.2 million bone grafting procedures are perfo...Tue, 27 Mar 2012 07:49:29 GMTott@emory.edu Inhibitor: Bone Forming Small Molecule for Use in Spinal Fusion Devices Bone forming therapeutic for use in spinal fusion devices and treatment of systemic bone diseases and disorders. Key Benefits Current devices for bone grafting procedures require high concentrations of bone morphogenetic protein (BMP) which results in a high cost and create a barrier for routine clinical use. Small molecule therapeutics that inhibit noggin (an extracellular inhibitor of BMP) have been identified and could be used locally to promote bone formation. Market Summary It is estimated that approximately 2.2 million bone grafting procedures are performed worldwide each ...Tue, 27 Mar 2012 07:49:28 GMTott@emory.edu LIVE network: A Motivational Audio Music Program for Compliance to Antiretroviral Therapies An audio program designed to improve patient adherence to anti-retroviral therapy (ART). Key Benefits Audio music program designed to educate and promote compliance and medication-related symptom management. Improves patient self-acceptance and self-image related to ART adherence. Market Summary An estimated 1.2 million people in the US are living with HIV infection with about 50,000 new cases occurring each year. For patients diagnosed with HIV, ART is the most commonly prescribed treatment. Despite the well-established efficacy of ART, typical adherence rates vary between 50% ...Wed, 22 Feb 2012 10:38:15 GMTott@emory.edu Bone Forming Compound for Use in Spinal Fusion Device Bone forming therapeutic for use in spinal fusion devices and treatment of systemic bone diseases and disorders. Key Benefits Current devices for bone grafting procedures require high concentrations of bone morphogenic protein (BMP) which results in a high cost and create a barrier for routine clinical use. Commercially available small molecule therapeutics that modulate Smurf1 (part of the signaling pathway for BMP) have been identified and these compounds induce bone formation. Lead compound is a major metabolite of a currently marketed, FDA-approved anti-microbial drug with ...Wed, 15 Feb 2012 11:57:31 GMTott@emory.edu Molecule Non-Nucleoside Inhibitors of the Measles Viruses Small molecule measles virus RNA Dependent RNA Polymerase (RDRP) inhibitors. Key Benefits Potent (nM) non-nucleoside small molecule inhibitors of the measles virus RDRP protein. No current drug therapy for measles. Market Summary The target market for this therapeutic agent is in the developing world where measles has been known to kill as many as one out of four people. In underdeveloped nations with high rates of malnutrition and poor healthcare, fatality rates have been as high as 28%. For immunocompromised patients (e.g. people with AIDS) with limited response to vaccinatio...Fri, 27 Jan 2012 10:30:37 GMTott@emory.edu C Virus (HCV) Mutants for Vaccine Development Mutated HCV as vaccine antigen. Key Benefits Non-infectious live HCV mutants which disrupt viral entry into healthy cells. No current vaccine for prevention of HCV infection. Market Summary Hepatitis C virus chronically infects more than 170 million people worldwide, with just over 3 million of these infections occurring in the United States. While 15-20% of HCV patients are able to clear the infection without treatment, the majority of HCV patients become chronically infected leading to serious symptoms such as cirrhosis and liver cancer. As such, HCV is the leading indicatio...Fri, 27 Jan 2012 10:30:31 GMTott@emory.edu A Novel Biologic to Treat Chronic Infections and Cancer, 19 Jan 2012 13:23:43 GMTott@emory.edu Computer-Based Calculator to Assess Tumor Response to Treatment Software to automatically calculate Response Evaluation Criteria in Solid Tumors (RECSIT) and assess a patient's response to cancer treatment. Key Benefits Provides the automated evaluation of response to cancer treatment. Enables a more consistent assessment than current methods. User-friendly data input format. Market Summary RECSIT criteria are utilized in evaluating a cancer patient's condition in clinical trials. There are nearly 3,000 clinical trials for new cancer therapies currently on-going in the US alone, and even more across the rest of the world. All of these tri...Tue, 17 Jan 2012 15:12:50 GMTott@emory.edu Inhibitory JAML Monoclonal Antibodies Flow Cytometry Immunoprecipitation Functional Assays Specificity Human Subtype Mouse Monoclonal Immunogen Recombinant human JAML Technical Summary Junctional adhesion molecules (JAMs) are a family of glycoproteins important in the control of vascular permeability and leukocyte transmigration across endothelial-cell surfaces. JAMs play a vital role in epithelial inflammation by regulating leukocyte transmigration and barrier function. Emory researchers have created several mAbs that bind differently to JAML with partial to complete inhibition of JAML ligands. Tue, 17 Jan 2012 14:55:14 GMTott@emory.edu to CD44v6, A Cell Marker for Various Cancers and Inflammation Flow Cytometry ELISA Immunofluorescence Functional Assays Immunoblotting Western Blot Immunoprecipitation Specificity Human Subtype Mouse Monoclonal Antigen CD44v6 (v6 variant-exon containing form of CD44) Technical Summary Antibody binding is increased in the epithelium of inflamed intestinal tissue in mice and in humans with inflammatory bowel disease. CD44v6 is a variation of CD44 that is reported as a cell surface marker for various cancers and inflammation. Emory Researchers have created an antibody, GM35 (an interferon gamma-stimulated intestinal epithelial cell), to...Tue, 17 Jan 2012 14:55:12 GMTott@emory.edu System for Studying Gammaherpesvirus Recombinant viral system created to study Gammaherpesvirus pathogenesis. Technical Summary Neoplastic disease is a frequent complication in patients with immunodeficiency diseases (i.e. AIDS). Many of these neoplasms are caused by either Epstein-Barr virus (EBV) or Kaposi's sarcoma-associated herpes virus (KSHV). The treatment of these immunosuppressed patients can be challenging. The viral origin of these tumors offer targets for the development pathogenesis-based therapies. Gammaherpesvirus 68 (MHV68) infection in mice is a model system for studying these tumors, enabling evalua...Fri, 06 Jan 2012 09:14:54 GMTott@emory.edu Inhibitors as Potential Cancer Therapeutics A new potential anti-cancer agent that inhibits the glycolytic enzyme PGAM1 and thereby tumor growth. Key Benefits Targets tumor metabolism by inhibiting glycolytic enzyme and turning off tumor metabolism. Inhibition of glycolytic enzyme (PGAM1) by these inhibitors leads to significant reduction in tumor growth. Market Summary Treating cancer remains a scourge of the medical world. In 2011, there have been 1.6 million new cancer diagnoses which lead to nearly 600,000 deaths in the U.S. alone. Over a lifetime, 1 in every 2 or 3 Americans will develop cancer, and survival rates ...Fri, 02 Dec 2011 12:19:30 GMTott@emory.edu Molecule TAK-1 Inhibitors, 03 Nov 2011 10:51:22 GMTott@emory.edu based System for Detecting Cellular Forces, 03 Nov 2011 10:51:11 GMTott@emory.edu Monoclonal Antibody Against Human CD47, 06 Oct 2011 11:00:17 GMTott@emory.edu Derivatives for Pain Management molecules that can be used in the treatment of neuropathic pain. Key BenefitsCyclopropylamines have shown reduced side effects compared to other SNRIs for the treatment of neuropathic pain. Cyclopropylamine derivatives are more potent than other SNRI medication. Technical SummaryNeuropathic pain is a chronic/persistent state resulting from nerve damage due to trauma, disease, or chemical injury. Recent studies and surveys have suggested that up to 30% of adults in the US report suffering from chronic pain, with one third of those identifying their pain as moderate to severe in...Thu, 06 Oct 2011 11:00:15 GMTott@emory.edu Porcine Model of Proliferative Vitreoretinopathy A large animal model of Proliferative Vitreoretinopathy (PVR) in pigs, allows for surgical manipulation and intervention that is not possible in other animal models. Technical Summary Proliferative vitreoretinopathy (PVR) is the principle cause for failed retinal detachment (RD) surgery. Currently there is a rabbit model used for research of PVR. However, this model has several limitations which could be addressed with a larger animal model. A large animal model of PVR such as a pig, presents these following advantages: 1) Larger eye that allows for surgical intervention, 2) a hol...Thu, 06 Oct 2011 11:00:14 GMTott@emory.edu Test for Non-Verbal Children, 06 Oct 2011 11:00:12 GMTott@emory.edu Software for Tracking Animal Genetics Software tracks and sorts genetic information among animals for transplantation and vaccine studies. Pedigree analysis for animal breeders. Key Benefits Allows for easy visualization, searching and matching of genetic information such as MHC type. Simplifies the process of setting up animal matings. Built on open source software, allowing the user to custom tailor it to their needs. Technical Summary Researchers at Emory University have developed a software program that simplifies monitoring and tracking of an animal's genetic background. Knowledge of g...Thu, 06 Oct 2011 11:00:10 GMTott@emory.edu Polyclonal Cav1.3 Antibodies Western Blot Immunohistochemistry (Paraffin) Specificity Human Rat Subtype Polyclonal Immunogen GST-tagged recombinant protein corresponding to the N-terminus sequence of rat Ca(v) 1.3 alpha1 subunit. Technical Summary Ca(v) 1.3 alpha1 subunit is a part of the Ca(v) 1.3 voltage-gated Ca2+ channel, which has become of key importance in regulating Ca2+ at excitatory synapses. The Ca(v) 1.3 channel controls neurotransmitter release from inner hair cells, release of insulin in the pancreas and pace-making activity in the heart. The Ca(v) 1.3 alpha1 subunit interacts with PDZ and...Fri, 30 Sep 2011 12:40:49 GMTott@emory.edu Antibody Against Human DNA Methyltransferase 1 (DNMT1) Blot SpecificityHumanSubtypePolyclonalImmunogenNative ProteinTechnical SummaryDNMT1-DNA methyltransferase 1 (or DNMT 1) proteins are involved in DNA methylation in which a methyl group is added to a cytosine residue on DNA, commonly at the C5 position of a CpG dinucleotide. Three families of DNMTs have been identified: DNMT1, DNMT2, and DNMT3 (comprised of DNMT3A and DNMT3B).DNMT1 is the most abundant DNMT in somatic cells and shows a preference for methylating hemi-methylated DNA. It is considered to be a maintenance DNA methyltransferase that is important in the maintenanc...Fri, 30 Sep 2011 12:40:48 GMTott@emory.edu Antibodies Directed Against Human Flightless I Homolog Western Blot Immunofluorescence Immunoprecipitation Specificity Human Subtype Polyclonal Immunogen (DP63/DP64) corresponding to residues 450-477 and 1152-1173 of Human Flightless I homolog Technical Summary Protein flightless-1 homolog (Flightless 1) is a member of the gelsolin family of actin-remodeling proteins. It interacts with various other proteins such as ACTL6A, NCOA2, CARM1, LRRFIP1 and LRRFIP2.The cytoskeletal actin remodeling process in Flightless 1 involves severing filaments, capping filament ends, and nucleating actin assembly . It is a nuclear receptor co-activa...Fri, 30 Sep 2011 12:40:43 GMTott@emory.edu Antibody against Mouse DNA Methyltransferase 3b (PWWP), 30 Sep 2011 12:40:41 GMTott@emory.edu Discharge Alert Software Software tool for alerting medical care providers of abnormal trends or laboratory values when discharging a patient. Key Benefits Alerts provider of potential premature patient discharge based upon selected common biological indicators or markers. Software also includes a filter which sifts through data, alerting provider of trends within and among indicators. Technical Summary Patients can be discharged from hospitals despite having abnormal laboratory values or trends among multiple measures. This is in part due the due to heavy workloads, increasingly hectic schedules, and o...Mon, 26 Sep 2011 08:34:58 GMTott@emory.edu Fluorescent Nanoparticle-dye Conjugates for Tumor Imaging or Drug Delivery dye combination that allows for locating and precision mapping of a tumors under near infrared (NIR) light and delivering chemotherapeutic agents.Key BenefitsNanoparticle-dye combination fluoresces under NIR light when in contact with a tumor; enables better mapping and allows more rapid analysis of treatments. Can carry either hydrophilic or hydrophobic therapeutics to tumor locations. Nanoparticle is based on iron oxide core, which is in clinical use and nontoxic in humans. NIR dye. Technical SummaryCurrent nanoparticle dye conjugates do not target cancer ...Tue, 20 Sep 2011 12:47:49 GMTott@emory.edu Particle (VLP) Vaccine for Respiratory Syncytial Virus (RSV) Infection Safe and effective Respiratory Syncytial Virus (RSV) vaccine. Key Benefits VLPs are safer than live replicating vectored vaccines because of their lack of infectivity. VLPs are highly immunogenic and can elicit both cellular and humoral responses. Technical Summary Respiratory syncytial virus (RSV) is the leading cause of lower respiratory tract illness in infants and children worldwide. In the U.S., roughly 70,000 to 120,000 infants are hospitalized annually with RSV related pneumonia or bronchiolitis. Effective therapies are not widely available, and there is no licensed vacci...Thu, 15 Sep 2011 11:18:59 GMTott@emory.edu<![CDATA[Novel Tool for Respiratory Syncytial Virus (RSV) Vaccine Development & Research]]> Bacterial artificial choromosome (BAC) plasmid containing the antigenomic sequence of RSV that can be used for directed mutations of the virus and thus vaccine generation. Key BenefitsViral DNA is contained in a BAC, Allowing for efficient mutagenesis and recombineering of viral DNA. BAC is stable, can be used for cloning in common bacteria types like E. Coli. Provides powerful tool for vaccine developers to use in engineering potential RSV vaccines. Technical SummaryHuman RSV is a leading cause of respiratory infections in the US leading to over 100,000 infant hospitalizations an...Wed, 14 Sep 2011 13:22:35 GMTott@emory.edu Raised Against ERK302me1 (Human Estrogen Receptor Alpha Monomethylated at Lysine Residue 302) Blot Elisa Specificity HumanSubtypePolyclonalImmunogenA peptide corresponding to amino acids 297-308 of ER mono-methylated at K302 (NH2-MIKRS(meK)KNSLALCCOOH)Technical SummaryEstrogen receptor alpha (ER) is a ligand-dependent transcription factor. Upon binding estrogen, ER recruits coactivator complexes with histone acetyltransferase or methyltransferase activities to activate downstream target genes. In addition to histones, coactivators can modify ER itself and other proteins in the transactivation complex. Here, we show that ER is directly methylated at lysine 302 (K302)...Wed, 14 Sep 2011 13:22:34 GMTott@emory.edu Adjuvant for DNA-Based Vaccine, capable of boosting the immunogenicity and effectiveness of a DNA or MVA-based vaccines.Key BenefitsStimulates CD8+ (cytotoxic) T cells directly, which boosts the immune system response against infected cells. Bypasses the need for CD4+ (helper) T cells to help raise functional CD8+ T cells. Offers new therapeutic option for creating vaccines against otherwise untreatable diseases. Technical SummaryThe lack of success of DNA or MVA-based vaccines in human clinical trials has refocused researchers on vaccine approaches, capable of increasing both cellular and humoral immuni...Wed, 14 Sep 2011 11:45:40 GMTott@emory.edu Receptor Antagonists for PET Imaging or as Potential Therapeutics, 06 Sep 2011 11:55:04 GMTott@emory.edu Patient Data Display Software Software program providing a real-time display of actionable, patient-specific data to be used by care givers in a particular care unit. Key Benefits Easy-to- use, color coded display of patient specific data. Improves quality of care by identifying those patients within a unit not receiving a particular key care measure. Tracks key quality of care metrics for a unit. Compatible with other common healthcare software programs. Technical Summary Improving healthcare through the use of information technology (IT) solutions is an expanding segment of the heathcare industry, expecte...Tue, 06 Sep 2011 11:55:03 GMTott@emory.edu<![CDATA[SurvivorLink: A Website for Pediatric Cancer Survivors, Their Families, & Physicians]]> Website for storing/sharing personal medical information between patient and physician and accessing resources regarding pediatric cancers and survivorship. Key Benefits Secure, HIPPA compliant, sharing of medical records; allows patient to control and track access to stored records. Provides primary care physicians with easy-to-use references and CME modules. Built off common web platform, compatible with most other web software. Administration functions easy to use and manage. Technical Summary Nearly 80 percent of children treated for cancer are now cured of their original d...Tue, 06 Sep 2011 11:54:54 GMTott@emory.edu Mouse for Studying Lesch-Nyhan Disease Transgenic mouse model that expresses the phosphoribosyltransferase domain containing 1 gene for the study of Lesch-Nyhan disease as well as the function of the phosphoribosyltransferase domain containing 1 (PRTFDC1) gene. Technical Summary Lesch-Nyhan disease (LND) is a severe X-linked neurological disorder caused by a deficiency of hypoxanthine phosphoribosyltransferase (HPRT). This results in poor muscle control, mental retardation, and leads to a build-up of uric acid in body fluids, gout, and kidney disease. HPRT deficiency is modified by the presence/absence of phosphoribosyl...Tue, 30 Aug 2011 11:18:46 GMTott@emory.edu and Automated Identification Colorectal Cancer Biomarkers Software to quickly and reliably detect and quantify a panel of colorectal cancer biomarkers. Key Benefits Compatible with current automated tissue staining and analysis technology. Identifies and quantifies a panel of molecular biomarkers as well as analyzing biomarker distribution to determine risk. Shortened development time; already being used in trials. Technical Summary Colorectal cancer is the third most commonly diagnosed cancer in the world, but it is distinctly more common in developed countries. In 2008, 1.23 million new cases of colorectal cancer were clinically diag...Tue, 30 Aug 2011 11:18:42 GMTott@emory.edu of Enigmol and its Analogues, 30 Aug 2011 11:18:34 GMTott@emory.edu Real-Time Software System to Monitor Central Line CVC Use in Hospitals A real-time system for tracking, reporting and correcting errors in documentation of central venous catheter (CVC) use to improve the validity of electronic CVC data. Key Benefits Provides a constant update of central line CVC use. Summarizes central line CVC use for each patient at the end of their hospitalization. It is compatible with existing electronic patient record systems. Enables patients and practitioners to make informed decisions regarding medical care based on device-associated data. Technical Summary CVCs are intravenous catheters used to administer fluids or med...Mon, 22 Aug 2011 14:15:46 GMTott@emory.edu Antibody Against Human SIRP alpha (Clone SAF10.1) Western blot Immunoprecipitation Immunofluorescence Flow cytometry Specificity Binds domain 1 of SIRP alpha and SIRP beta. Produced in mouse Isotype IgG1 Subtype Anti-Human Monoclonal Technical Summary Signal regulatory proteins (SIRP) are a family of glycoproteins that regulate innate immune functions including leukocyte migration and chemotaxis. In humans, SIRPS are expressed in dendritic cells, monocytes, ganulocytes, neutrophils, and bone marrow progenitor cells. The SIRP family can be further distinguished into two subtypes: SIRP alpha, which possesses a cytoplasmic...Thu, 04 Aug 2011 12:32:42 GMTott@emory.edu Monoclonal Antibody Against Human CD47, 04 Aug 2011 12:32:40 GMTott@emory.edu of Glycolysis and the IGF1-Receptor for Cancer Treatment combinational cancer therapy that inhibits cancer cell signaling and metabolism.Key BenefitsInhibits two key cancer regulatory systems for a synergistic effect. Optimizes proposed methods of cancer treatment. Technical SummaryThe basis for 2-deoxyglucose (2-DG) as a cancer therapeutic is centered on in vitro studies demonstrating the ability of 2-DG to inhibit glycolysis by the deletion of intracellular ATP. However, since 2-DG also activates the Akt pathway through insulin growth factor 1 (IGF1) receptor (IGF1R) signaling, a feedback loop is established that counteracts the 2-DG ...Thu, 04 Aug 2011 12:32:33 GMTott@emory.edu Cell Holder Device for the Delivery of Therapeutic Agents to Cells A platform technology to be used to effectively deliver select agents to cells. Key Benefits Optimizes the in vitro and ex vivo delivery of factors to the nuclei of individual cells. Minimizes the risk of cell damage associated with traditional electroporation techniques. Technical Summary Emory investigators have created a cell holder device that traps individual cells on a grid so that they can be manipulated using a number of methods, including microneedle injection or electroporation. The device is a three-layer microfluidic system that contains a loading chamber, a cell ho...Thu, 04 Aug 2011 12:32:29 GMTott@emory.edu Cellular Adjuvant for Human Monoclonal Antibody Production platform technology to robustly produce monoclonal antibodies specific for complex human protein variants.HighlightsAllows for enhanced specificity of monoclonal antibodies to human proteins. Enhances antibody signal and binding affinity. Technical SummaryEffective methods for generating antibodies that recognize human specific protein sequence polymorphisms do not currently exist. This is largely due to incomplete homology between human proteins and proteins of other species. Consequently, antibodies, in most cases, only recognize select portions of the human protein and cannot f...Thu, 04 Aug 2011 12:32:24 GMTott@emory.edu Rings for Tricuspid Valve Repair, 04 Aug 2011 12:32:21 GMTott@emory.eduß-secretase (BACE) Monoclonal Antibody, 26 Jul 2011 13:29:34 GMTott@emory.edu Factor as a Treatment for Obesity Therapeutic use of Glial Cell Line-Derived Neurotrophic Factor (GDNF) to treat obesity. Potential drug target for further therapeutic development. Key Benefits Growth Factor expression in the brain causes a reduction in high fat diet-induced obesity. Fat level reduction has been shown in both mouse and human cells. Reducing obesity can lower risk of coronary heart disease and type-II diabetes. Technical Summary Obesity is a growing problem, both in the United States and internationally. The US has the highest rate of obesity in the world, with over 30% of adults considered o...Thu, 30 Jun 2011 11:05:22 GMTott@emory.edu Catalyst for Enantioselective Reactions of Aryl- and Styryldiazoacetates Catalysis of highly enantioselective cyclopropanations, tandem cyclopropanation/Cope rearrangements and combined C-H functionalization/Cope rearrangement reactions. Key Benefits Exhibits good tolerance to large ester groups for electron-withdrawing in high asymmetric induction. Efficient reactions in dichlormethane allowing broader range of substrates than other enantioselective catalyst. Technical Summary Researchers have sought a chiral dirhodium catalyst for use in reactions involving diazo compounds; these reactions rely heavily on the ability of a catalyst to drive the prod...Thu, 30 Jun 2011 11:05:19 GMTott@emory.edu Analogues of Progesterone Therapeutic treatment of traumatic brain injury and other uses of progesterone where composition of matter intellectual property are required. Key Benefits 20 fold increase in solubility relative to the hormone progesterone. Synthetic analogues are as effective as progesterone in reducing cerebral edema following traumatic brain injury. Technical Summary Traumatic brain injury (TBI) occurs in 1.4 million members of the U.S. population per year, resulting in more than 50,000 deaths annually and significant long-term neuronal damage in many of those affected. To date, progesteron...Wed, 08 Jun 2011 07:22:26 GMTott@emory.edu Vaccine Using Virus-Like Particles (VLPs) VLPs containing modified HIV Env have been developed for an AIDS vaccine, capable of inducing cellular and humoral immune responses; including neutralizing activities. Key Benefits VLPs are safer than live replicating vectored vaccines because of their lack of infectivity, allowing for use in immunocompromised patients. HIV VLPs extract both arms of immunity and create immune responses at local and distal, mucosal surfaces. Technical Description One of the major obstacles in developing an effective AIDS vaccine is the difficulty in inducing antibodies that are broadly reactive a...Mon, 23 May 2011 14:00:31 GMTott@emory.edu Sheath Technology For Local Drug Delivery Following Angioplasty, 19 May 2011 15:49:39 GMTott@emory.edu Cardiopulmonary Resuscitation (CPR) Manikin, 19 May 2011 15:49:38 GMTott@emory.edu Drug Targeting for Glioblastoma Multiforme-derived Cancer Stem Cells delivery system for Glioblastoma Multiforme-derived Cancer Stem Cells. Key BenefitsReliable cell surface glycan markers identified for Glioblastoma Multiforme-derived Cancer Stem Cells (GBM-CSCs). Lectin-conjugated nanoparticles target these glycan epitopes for delivering drugs to GBM-CSCs. Technical SummaryResearchers at Emory have invented novel nanoparticles to deliver drugs to GBM-CSCs via cell surface glycan biomarkers. Dr. Nash's group has previously determined that lectins such as GS2 and DBA can bind to the glycan epitopes N-acetyl galactosamine (GalNAc) and N-acetyl gl...Thu, 19 May 2011 15:45:44 GMTott@emory.edu of Bax Activators as a New Class of Anti-Cancer Drugs for treatment of cancer. Key BenefitsThe first in class, potent and selective agonists of Bax with nanomolar activity. Bax activators have significantly less apoptotic effect on normal cells as compared to cancer cells. Compounds have shown high selectivity for tumor cells. Technical SummaryPatients with cancer have poor prognosis due to chemoresistance. Development of more effective, new drugs that act through basic molecular mechanism (i.e. apoptosis) to overcome chemoresistance is essential to improve the prognosis of patients with various types of cancer. Bax is a ma...Thu, 19 May 2011 15:44:14 GMTott@emory.edu Virus-Like Particle (VLP) Vaccine Safe and effective vaccine for HIV. Key Benefits VLPs are safer than live replicating vectored vaccines because of their lack of infectivity, allowing for use in immunocompromised patients. HIV VLPs extract both arms of immunity and create immune responses at local and distal, mucosal surfaces. Technical Summary Most scientists agree that a successful HIV vaccine should induce both antibody and cell-mediated immune responses. Emory scientists have successfully constructed HIV virus-like particles (VLPs) that have been shown to induce both antibody and cellular immune responses i...Thu, 19 May 2011 15:44:10 GMTott@emory.edu for the Visualization of Patient Satisfaction Data analysis and presentation program for use by healthcare organizations that enables the user to quickly and simply visualize and understand data from patient satisfaction surveys.Key BenefitsPresents patient satisfaction data graphically as well as in tables. Accelerates data compilation and analysis. Displays relationships between data in new and useful ways. Technical SummaryThis technology transforms raw survey data into relational tables, run charts, and easy-to-understand graphs. Users are able to visualize data by department, a specific time period, or the category of a ce...Tue, 03 May 2011 12:53:19 GMTott@emory.edu against Phosphorylated Ser794 of Ataxia-Telangiectasia Mutated (ATM) Western Blot Immunohistochemistry Immunoprecipitation Specificity Human Immunogen KLH tagged synthetic 16mer phosphopeptide corresponding to residues surrounding Ser794 of human ATM (Acetyl-CLSNATKpSPNKIASG-amide). Subtype Rabbit polyclonal Technical Summary Ataxia-Telangiectasia Mutated (ATM) is an important kinase that plays key roles in mediated cellular responses to DNA damage. Mutations of ATM can lead to abnormalities in immune function as well as sensitivity to radiation, predisposition to cancer, accelerated aging and neurodegeneration. How ATM is activated following D...Wed, 27 Apr 2011 14:50:32 GMTott@emory.edu (miRNAs) Capable of Inhibiting Human Tumor Growth Small RNA molecules for the treatment of stomach and lung cancer. Key Benefits Reduces growth survival or proliferation of neoplastic cells. Enhances the efficacy of anti-cancer drugs. Technical Summary Uncontrolled cell growth and proliferation is a distinctive feature of cancer. As critical molecules in cell-cycle regulation, small, endogenous inhibitory molecules known as microRNAs (miRNAs) play an important role in regulating cell development and programmed cell death. MiRNAs are short, functional RNA molecules that regulate expression by binding to target nucleotide sequenc...Thu, 21 Apr 2011 11:43:43 GMTott@emory.edu Conjugates to Prevent Oxidative Injury in Tissues Targeted anti-oxidative therapy for ischemia-reperfusion injury, hemorrhage, major surgery, kidney transplant, or acute renal failure. Key Benefits Conjugation of Tempol with Folate does not alter the antioxidant property of Tempol. Tempol-Folate conjugates are more effective than Tempol alone at preserving kidney structure and function after ischemia-reperfusion injury. Conjugate enables the selective targeting of tissues, allowing a lower antioxidant dose, reducing possible side effects. Technical Summary Emory investigators have synthesized a novel tissue directed antioxid...Tue, 19 Apr 2011 05:45:56 GMTott@emory.edu Receptor Expression in Parathyroids: Diagnostic Imaging and Therapeutic Opportunities Parathyroid imaging and treatment using directed delivery of a noninvasive radiodiagnostic agent. Key Benefits Improved identification and localization of parathyroid tumors. Increased sensitivity and selectivity in the targeting of parathyroid tissue. May be used to deliver therapeutic agents selectively to malignant parathyroid carcinoma cells. Technical Summary Our technology describes the use of technetium 99-m (99mTc) folate to image parathyroid tissue. 99mTc folate binds to folate receptor positive cells and tissues with high affinity. The current standard of parathyroid ...Mon, 18 Apr 2011 10:35:37 GMTott@emory.edu Model of Galactosemia Whole animal genetic model for Galactosemia. Fly model can be used to test efficacy of novel therapeutic interventions. Genetic system enables screening for suppressors and/or genetic modifiers of Galactosemia. Key Benefits First whole-animal genetic model to study GALT and GALE function. Only model that mimics acute and long-term outcomes seen in human patients. Technical Summary Emory researchers have created a novel fly model for galactosemia which has distinct advantages over previously used in vitro cell culture systems and in vivo mouse models as it...Thu, 14 Apr 2011 09:10:19 GMTott@emory.edu Diagnostic Test to Assess Antidepressant Drug Therapy This technology provides a method of measuring a patient's response to antidepressant drug therapy on the transport inhibition of monoamine neurotransmitters. Technical Summary Treatment of neuropsychiatric disorders often involves manipulation of neurotransmitter transport systems with pharmaceutical agents that inhibit or antagonize a particular transporter. Application of an appropriate antagonist to block uptake prolongs and enhances the action of the neurotransmitter. Determination of the amount of transporter antagonism as a function of drug dose or blood concentration is mos...Thu, 14 Apr 2011 09:10:12 GMTott@emory.edu Iron Oxide Nanoparticles for Delivery Anti-Cancer Therapeutics, 31 Mar 2011 14:58:43 GMTott@emory.edu as a Therapeutic Agent to Treat Chronic Viral Infections, 22 Mar 2011 08:47:04 GMTott@emory.edu Device to Predict Epileptic Seizures A system to predict the onset of seizures associated with epilepsy and abort such seizure activity. Technical Summary Epilepsy affects approximately 1% of the population in the United States and approximately 2% of the population worldwide. Of those affected by the disease, approximately one-third have seizures that cannot be controlled by medication or cured by surgery. Epilepsy surgery requires locating the region of the brain where seizure onset occurs and the pathways through which the seizures spread, a process that is not completely accurate and reliable. Moreover, epilepsy s...Mon, 21 Mar 2011 11:35:24 GMTott@emory.edu of Myxoviruses and Related Negative Strand RNA Viruses small molecule inhibitors of RNA viruses that cause many highly contagious and dangerous diseases such as canine distemper, RSV, influenza, and measles. Key BenefitsInhibits measles, canine distemper, human parainfluenza, and influenza A viruses. May be used for the management of a disease and for rapid control of possible outbreaks. Molecules are directed against host factors that are involved in viral reproduction thus reducing the possibility of viral resistance. Provides a therapeutic and an improved alternative to current vaccinations. Technical SummaryThis technology id...Mon, 21 Mar 2011 11:35:20 GMTott@emory.edu of the Anti-Cancer Agent, Noscapine, as an Immunological Adjuvant for Tumor Therapy These compounds can be used in the treatment of neoplastic disease. They are useful as adjuvant compositions to increase cell-mediated immunity for the treatment of tumors and as an adjuvant for vaccines. Technical Summary The immune system mounts a strong response when foreign objects are detected within the body. This is not only the premise for fighting foreign invaders, but is the underlying basis for vaccines, as they must induce an immune response in order for the body to produce antibodies to the desired antigen. Some antigens are highly immunogenic and are capable of elic...Mon, 21 Mar 2011 11:35:15 GMTott@emory.edu Imaging Software with Attenuation Correction Facilitates the use of MRI/PET hybrid systems for several biomedical applications including detecting and studying mechanisms of various human diseases. Key Benefits Comprehensive, automatic image-processing software suite for dual MRI/PET technology. Stand-alone package that can be installed as post-processing software compatible with any MRI/PET hardware system. Integrates automatic image registration, segmentation and classification algorithms into an MRI-guided attenuation correction approach resulting in a multimodal diagnostic imaging software. The software enables quanti...Thu, 17 Mar 2011 09:41:51 GMTott@emory.edu Instrument for Implanting Medical Devices, 07 Mar 2011 08:48:55 GMTott@emory.edu for Suppressing Fragile X Premutation rCGG Repreat-Mediated Toxicity Compounds for the treatment of Fragile X-associated tremor/ataxia syndrome. Key Benefits 11 known, FDA approved drugs identified that reduced rCGG-mediated lethality to a certain degree. 3 of these drugs also rescued locomotion deficits. Technical Summary Fragile X syndrome (FXS) is the most common inheritable form of cognitive disability affecting nearly 1 in 4000 males and 1 in 6000 females. FXS usually results from the expansion of the CGG trinucleotide repeat in the 5' untranslated region (5' UTR) of the fragile X mental retardation 1 (FMR1) gene. Within the last decade, Frag...Thu, 24 Feb 2011 14:27:32 GMTott@emory.edu of Redox-Active Complexes as Catalysts for Air-Based Decontamination of Toxic and Odorous Compounds A new catalytic material for decontamination of toxics and odorants using only ambient air as the oxidant. Key Benefits Decontaminates nerve agents, toxic industrial chemicals, and odorous household compounds. Oxygen is the only other reagent needed for the reaction to occur. Technical Summary Our new decontaminant comprises of tetra-n-butylammonium (TBA) and an iron salt of bromide ions. It can be used to convert nerve agents and other toxic or odorous compounds to benign products. Oxygen is the only reagent needed to complete the reaction, and our research has proven that the ...Fri, 07 Jan 2011 06:02:03 GMTott@emory.edu<![CDATA[New, Efficient, Synthesis Method for Producing Peptide & Protein-based Therapeutics]]> Efficient scalable method for creating peptide or amide linkages and generating peptides, proteins, or glycoproteins. Key Benefits Reactions involved are simple, mild, generalizable, and efficient, potentially reducing production costs. Starting materials needed for this synthesis can also be produced easily and can be generated in situ. Technical Summary Manufacturing peptide or protein-based therapeutics can often be challenging and expensive, particularly when compared to small molecule-based therapies. These challenges are even greater for larger peptides and proteins whose ...Fri, 07 Jan 2011 06:02:01 GMTott@emory.edu Assay to Measure Phosphatase Activity An enhanced assay to measure phosphorylation activity for therapeutic monitoring of calcineurin activity in transplant patients as well as a number of other enzyme activity monitoring in medicine and research. Key Benefits Entire assay can be completed in a single plate. Fast, easy to use, non-radioactive method suitable for high-throughput assays. Enzyme specific substrates can be used to tailor assay for a number of applications. Technical Summary This technology is an enhancement to our previous method to measure phosphatase activity. Our modification describes an ?in-soluti...Fri, 07 Jan 2011 06:01:54 GMTott@emory.edu Use of Progesterone in the Treatment of Central Nervous System Tumors for neuroblastoma and other tumors in the central nervous system.Key BenefitsInduces cell death in tumor cells while having no negative effects on surrounding neurons. Slows the rate of neuroblastoma tumor growth. Technical SummaryEmory researchers have shown that progesterone caused significant cell death in tumor cells while remaining absolutely safe in primary cortical neurons. After a single treatment of progesterone a significant decrease in cell survival on human neuroblastoma was observed in vitro. Cell death of human neuroblastoma and glioblastoma cells increased a...Wed, 24 Nov 2010 10:06:52 GMTott@emory.edu Inhibitors as Anti-Cancer Agents vinyl diazo compounds for use in the treatment of cancer.Key BenefitsInhibits aromatase in a potent and specific manner. Provides alternatives to the current medications that act as non-specific aromatase inhibitors. Technical SummaryWe have developed exemestane-based vinyl diazo compounds that act as aromatase inhibitors to be used in the treatment of cancer, particularly breast and ovarian cancer. Exemestane is structurally related to androstenedione and acts as an irreversible, steroidal aromatase inactivator. Our aromatase inhibitors are based upon the steroid scaf...Wed, 24 Nov 2010 10:06:50 GMTott@emory.edu Small Molecule that Acts as an Insulin Synergistic for the Treatment of Diabetes Non-peptidyl, small molecule that is synergistic with insulin and selectively activates the insulin receptor. Key Benefits Dramatic hypoglycemic effect in normoglycemic and hyperglycemic mice Effectiveness occurs in comparable time as insulin and lasts longer than insulin. Highly selective and sensitive for insulin receptors. Sensitizes insulin activity and does not compete with insulin. Market Summary Diabetes affects nearly 275 million people worldwide and is often managed by maintaining sufficient levels of circulating insulin using insulin injections. Subcutaneous insulin ...Mon, 11 Oct 2010 05:51:17 GMTott@emory.edu Agonists for the Treatment of Obesity and Neurological Diseases Catecholamine derivatives, methods and compositions effective for the treatment of obesity and neurological diseases and disorders. Key Benefits Catecholamine derivatives for the treatment of metabolic disorders, such as obesity, have been developed. Catecholamine derivatives promote neuroprotection and may be useful in the prevention and/or treatment of ALS, Parkinson's disease, Alzheimer's disease and other neurological diseases and disorders. Technical Summary Neurotrophins are a family of proteins that induce the survival, development and function of neurons. ...Mon, 11 Oct 2010 05:50:38 GMTott@emory.edu Noscapine as a Potent Anti-Inflammatory, 11 Oct 2010 05:48:35 GMTott@emory.edu Combinations to Reduce the Therapeutic Concentration of Direct Thrombin Inhibitors, 22 Sep 2010 12:06:23 GMTott@emory.edu Surface Coatings for Minimizing Nonspecific Binding of Nanoparticles coatings for minimizing nonspecific binding of quantum dots and other nanoparticles.Key BenefitsCoating method generated a 140-fold reduction in nonspecific binding relative to that of carboxylated quantum dots and 10-20-fold reduction relative to that of PEG- and protein-coated quantum dots. Technical SummaryQuantum-dot (QD) nanocrystals are promising fluorescent probes for multiplexed staining assays in biological applications. However, nonspecific QD binding to cellular membranes and proteins remains a limiting factor in detection sensitivity and specificity. Drs. Shuming...Wed, 22 Sep 2010 12:06:16 GMTott@emory.edu Nanoparticles as Therapeutics for Osteoporosis, 09 Sep 2010 13:55:58 GMTott@emory.edu Protein Polymers (B10) B10 protein polymers can be used to build small diameter arterial vascular grafts as well as a host of other potential cardiovascular constructs. The proteins may provide an important vehicle for the design of a variety of medically implanted devices. Technical Summary The emergence of genetically engineered synthetic polypeptides has enabled the design of protein polymers composed of complex peptide sequences in which individual peptide repeat sequences can be selected with distinct mechanical, chemical, or biological properties. The inventors recently synthesized a new class of p...Thu, 09 Sep 2010 13:55:57 GMTott@emory.edu Inorganic Polyoxometalate-Based Water Oxidation Catalysts for Hydrogen Production, 02 Aug 2010 05:46:04 GMTott@emory.edu and Methods for Local Drug Delivery A device for the local delivery of a drug. Technical Summary One of the most complex and difficult problems that has plagued the medical profession and pharmaceutical industry for decades is the problem of achieving a therapeutic concentration of a drug locally at a target site within the body without producing unwanted systemic side effects. Parenteral or oral therapy of substances directed at treating disease in a particular internal organ must often be given in amounts dependent upon achieving critical systemic blood levels that can produce devastating side effects at other area...Thu, 22 Jul 2010 08:13:19 GMTott@emory.edu Assay to Measure Activity of Phosphate Modifying Enzymes Clinical assay to predict therapeutic outcomes based on kinase or phostphatase activity. Key Benefits Eliminates inconsistencies stemming from variable baseline activity. Selective measurement of specific enzymatic activity within a heterogeneous sample. Technical Summary Researchers at Emory University have developed assays to selectively measure the activity of a specific phosphate modifying enzyme within a heterogeneous samples. Unlike existing detection methods, which rely upon the incorporation or removal of radiolabelled phosphate, this novel assay measures the binding of ...Thu, 22 Apr 2010 08:19:02 GMTott@emory.edu 1 N-Terminal Monoclonal Antibody Immunoblotting Immunocytochemistry Specificity Human Presenilin-1 N-terminal Subtypes Rat monoclonal Technical Summary By immunoblotting applications the antibody recognizes a predominant 32 kDa polypeptide in a varitety of samples including PC12 cells transfected with human PS1, complimentary DNA brain biopsy specimens from dementia patients and postmortem Alzheimer's disease patients. PS1 is expressed primarily in neurons, with the protein localizing in the soma and dendritic processes. In contrast, in sporadic Alzheimer's disease cases PS1 immunoreactivity is present in the ...Thu, 15 Apr 2010 13:37:51 GMTott@emory.edu 1 C-Terminal Monoclonal Antibody Immunoblotting Immunohistochemistry Specificity Human Presenilin-1 C-terminal Subtypes Mouse Monoclonal Technical Summary By immunoblotting applications the antibody recognizes a predominant 32 kDa polypeptide in a varitety of samples including PC12 cells transfected with human PS1, complimentary DNA brain biopsy specimens from dementia patients and postmortem Alzheimer's disease patients. PS1 is expressed primarily in neurons, with the protein localizing in the soma and dendritic processes. In contrast, in sporadic Alzheimer's disease cases PS1 immunoreactivity is present in t...Thu, 15 Apr 2010 13:37:50 GMTott@emory.edu Associated Protein 1B (Hap1B) Rabbit Polyclonal Antibodies Western blot Immunoprecipitation Immunocytochemistry Specificity Huntingtin Associated Protein 1B isoforms. No detectable cross reactivity to other proteins by Western blot. Subtype Rabbit Polyclonal Technical Summary Huntington's disease (HD) is an autosomal dominant neurodegenerative disorder caused by an expanded trinucleotide repeat in the IT15 gene. Huntington Associated Protein 1 (Hap1) was initially identified as a protein that interacts with huntingtin, the protein encoded by the gene responsible for the development of HD. These antibodies can be used to specifically...Thu, 15 Apr 2010 13:37:50 GMTott@emory.edu and Cell Lines Expressing Uncleavable Forms of Brain Angiogenesis Inhibitor 1 (BAI1) or its Extracellular Fragments Neovascular assays for the examination of antiangiogenic and antitumor effects of BAI1. Technical Summary The transmembrane protein BAI1 is subject to extracellular proteolytic cleavage, rendering a 120kDa fragment that is capable of inhibiting angiogenesis. Emory University researchers have generated several plasmids and cell lines capable of expressing multiple forms of this gene, making them useful for studying the therapeutic potential of these proteins. An uncleavable form of BAI1 is available that was generated through site directed alanine mutagenesis of the G-protein coupl...Thu, 15 Apr 2010 13:24:27 GMTott@emory.edu Cell Lines Specifically Deficient in O-linked Glycosylation technology allows for the study of N-linked glycosylation in the absence of O-linked glycosylation, and may lead to the production of glycoproteins.Technical SummaryUDP-galactose 4-epimerase (GALE) is an enzyme that enables the body to break down the sugar galactose. While the E. Coli form of this enzyme catalyzes only the reversible interconversion of UDPgalactose (UDP-gal) and UDP-glucose (UDP-glc), the human form can also catalyze the interconversion of UDP-N-acetylgalactosamine (UDP-galNAc) and UDP-N-acetylglucosamine (UDP-glcNAc). GALE is therefore an important regulator o...Thu, 15 Apr 2010 13:24:19 GMTott@emory.edu Transporter cDNA and Cell Line Cloning and studying of the norepinephrine transporter. Technical Summary This invention is the first cDNA clone encoding a norepinephrine transporter. The cDNA allows high-level expression of the transporter in non-neuronal eukaryotic and prokaryotic systems suitable for isolation of the protein. This invention has applications in the research and drug development regarding behavioral disorders and makes it possible to perform high-level structure analysis of norepinephrine uptake. This will allow for a precise study of the manner by which anti-depressants, cocaine, and am...Thu, 15 Apr 2010 13:24:17 GMTott@emory.edu Murine Cell Lines, 15 Apr 2010 13:24:16 GMTott@emory.edu Ester) Co-Methyl Methacrylate Networks Biodegradable polymer for use in medical implants. Key Benefits Ability to tailor mechanical properties to desired medical application. Easily adjustable biodegradation profile. Technical Summary Studies into the properties of methyl methacrylate (MMA) networks have led Emory University scientists to develop biodegradable polymers that can be tailored to a wide array of precise medical uses. Unlike the formulation of existing biomedical polymers, the ability to alter the ratio of acrylate compounds within the polymer permits wide variation in elastic modulus, tensile strengths, ...Wed, 24 Mar 2010 08:56:14 GMTott@emory.edu Vivo RBC Manipulation to Augment Immunogenicity Novel method of treatment to increase RBC immunogenicity. Key Benefits Short, inexpensive treatment that complements existing alloimmunization techniques. RBC processing involves compounds approved by the FDA for human use. Potentially elevates antibody titer against any rare RBC antigen. Technical Summary Several immune globulin therapeutics are generated by immunizing volunteers with RBCs and harvesting the volunteer's antibodies. For reasons that are largely unknown, it is difficult to elicit an immune response against rare RBC antigens in a manner that yields a sufficient a...Tue, 23 Mar 2010 12:38:31 GMTott@emory.edu Lines Expressing the p14 RF Tumor Suppressor Gene LNZ308 and LN229 glioma cell lines stably expressing p14ARF under a tet-on inducible system Technical Summary To study the biological effects of ARF, we have restored ARF gene expression in ARF-deficient human glioblastoma tumor cells. We engineered two ARF-null cell lines to stably express a cDNA for conditional expression of p14ARF using the tet-on system. We generated Tet-on p14ARF clones in wt-p53 cell line LN229-L16 (clones A5, A18) and p53-null cell line LNZ308-C16 (clone C19). We found that ARF expression is tightly induced by doxycycline (dox) and is associated with an incr...Tue, 23 Mar 2010 12:38:26 GMTott@emory.edu Antibodies and VPO1 Protein, 23 Mar 2010 12:38:25 GMTott@emory.edu Against Brain Angiogenesis Inhibitor 1 (BAI1) Immunoblotting Immunocytochemistry Immunohistochemistry Specificity Specific for human BAI1; does not detect BAI2 or BAI3. Subtype Rabbit polyclonal Immunogen KLH tagged synthetic protein corresponding to the N terminus (103-118a.a.) of human BAI1 (CQFDSFLESTRTYLGVE). Technical Summary Although BAI1 is specifically expressed in the brain, it is not expressed in glioblastoma cell lines; therefore, BAI1 likely plays a significant role as an inhibitor of angiogenesis and a growth suppressor of glioblastomas. The finding that BAI1 proteins are lost during tumor formation is of spe...Tue, 23 Mar 2010 12:38:10 GMTott@emory.edu for the Treatment of Influenza compositions containing glutathione and glutathione disulfide for the prevention and treatment of influenza.Key BenefitsGlutathione and glutathione disulfide compositions can be applied directly to the epithelia. Can be delivered through inexpensive and practical delivery methods, such as lozenges, oral rinses, and nasal sprays. Acts without interfering with the body's natural elimination of infected cells. May be effective on multiple influenza strains due to its method of action. Technical SummaryThe glutathione and glutathione disulfide compositions used in this te...Tue, 23 Mar 2010 12:38:05 GMTott@emory.edu Properties of Galectins Against Bacteria Expressing Host Cell Surface Antigens Antibiotic protein with the ability to target pathogens expressing the blood group B antigen. Key Benefits Naturally occurring factors produced by humans. Induces rapid cell death in bacteria expressing the blood group B antigen. Does not harm commensal bacteria. Technical Summary Emory University scientists have successfully demonstrated in vivo that two Galectin family members, Galectin-4 and -8, possess antibiotic properties that effectively treat pathogenic E. coli infections. Galectin interaction with cell surface antigens resembling blood group B provides a means to selec...Tue, 23 Mar 2010 12:38:04 GMTott@emory.edu Glioma Cell Lines for Doxyxycline-Inducible Gene Expression, 23 Mar 2010 12:38:04 GMTott@emory.edu Helper Integration Site 1 (Ahi1) Rabbit Polyclonal Antibody Immunoblotting Immunoprecipitation Immunocytochemistry Immunohistochemistry Specificity Mouse Ahi1 isoforms Subtype Rabbit Polyclonal Technical Summary A number of neurological disorders are associated with genes that regulate neurogenesis and neural differentiation. One such gene encodes the Ableson helper integration site 1 (Ahi1) protein, and is required for proper formation of the cerebellum and brainstem. A role for Ahi1 has been suggested in common disorders that affect cognition and behavior, including Joubert syndrome and Huntington's disease, as well as autism and sc...Tue, 23 Mar 2010 12:38:02 GMTott@emory.edu Cell-Based Therapy for Vascular Disease, 23 Mar 2010 12:37:53 GMTott@emory.edu Rapamycin to Modulate T Cell Immunity During Immunization, Chronic Infection and Tumors Repurposed therapeutic used in conjunction with vaccination boosts the number of antigen-specific, high quality memory T cells. Key BenefitsNovel use for FDA-approved repurposed therapeutic. Administration during a traditional vaccination protocol boosts acquired immunity by increasing the stock of memory T cells. Technical Summary Vaccines are designed to strengthen the acquired immune response by increasing the stock of rare antigen-specific memory T cells, however this process is often inefficient, requiring multiple boosters to achieve immunity. The time between the prime and b...Tue, 26 May 2009 08:25:46 GMTott@emory.edu Human Clonal Antibody - B/Shanghai/361/2004 Research tools - immunoblotting. Therapeutics - transient immunization with monoclonal antibodies could provide rapid and effective protection and clearance to infectious agents such as Influenza, HIV, bioterrism threats such as anthrax, or cytolomegalovirus that is a major cause of mortality for transplant recipient. Specificity Materials Available CDR cDNA Light and heavy chain expression vectors Technical Summary We have developed a method which can be used to rapidly identify, isolate and clone human antigen specific monoclonal antibodies. Using this method, therapeuti...Mon, 11 May 2009 12:50:17 GMTott@emory.edu Human Clonal Antibody - H3N2: A/Wisconsin/67/2005(2006/7) Research tools - immunoblotting. Therapeutics - transient immunization with monoclonal antibodies could provide rapid and effective protection and clearance to infectious agents such as Influenza, HIV, bioterrism threats such as anthrax, or cytolomegalovirus that is a major cause of mortality for transplant recipient. Specificity Materials Available CDR cDNA Light and heavy chain expression vectors Technical Summary We have developed a method which can be used to rapidly identify, isolate and clone human antigen specific monoclonal antibodies. Using this method, therapeuti...Mon, 11 May 2009 12:50:17 GMTott@emory.edu Human Clonal Antibody - H1N1: A/New Caledonia/20/99 Research tools - immunoblotting. Therapeutics - transient immunization with monoclonal antibodies could provide rapid and effective protection and clearance to infectious agents such as Influenza, HIV, bioterrism threats such as anthrax, or cytolomegalovirus that is a major cause of mortality for transplant recipient. Specificity Materials Available CDR cDNA Light and heavy chain expression vectors Technical Summary We have developed a method which can be used to rapidly identify, isolate and clone human antigen specific monoclonal antibodies. Using this method, therapeuti...Mon, 11 May 2009 12:50:17 GMTott@emory.edu Human Clonal Antibody - H3N2: A/California/7/2004 Research tools - immunoblotting. Therapeutics - transient immunization with monoclonal antibodies could provide rapid and effective protection and clearance to infectious agents such as Influenza, HIV, bioterrism threats such as anthrax, or cytolomegalovirus that is a major cause of mortality for transplant recipient. Specificity Materials Available CDR cDNA Light and heavy chain expression vectors Technical Summary We have developed a method which can be used to rapidly identify, isolate and clone human antigen specific monoclonal antibodies. Using this method, therapeuti...Mon, 11 May 2009 12:50:16 GMTott@emory.edu Human Clonal Antibody B/Malaysia/2506/2004 Research tools - immunoblotting. Therapeutics - transient immunization with monoclonal antibodies could provide rapid and effective protection and clearance to infectious agents such as Influenza, HIV, bioterrism threats such as anthrax, or cytolomegalovirus that is a major cause of mortality for transplant recipient. Specificity Materials Available CDR cDNA Light and heavy chain expression vectors Technical Summary We have developed a method which can be used to rapidly identify, isolate and clone human antigen specific monoclonal antibodies. Using this method, therapeuti...Mon, 11 May 2009 12:50:16 GMTott@emory.edu Mouse Movement Analysis Web Search User Intent Browser mouse monitoring algorithms for improved targeting of web advertisement to client needs. Key Benefits Novel integration of client side instrumentation and server side information. Detects misleading information that otherwise misclassifies client intent. Technical Summary Software has been developed that combines a novel algorithm with the integration of user side instrumentation and server side information that is capable of picking up on the subtleties of internet user activities translating into more accurate measurement and categorization of the client ...Mon, 11 May 2009 12:50:14 GMTott@emory.edu Enteric Neuronal Cell Line Fetal and postnatal enteric neuronal cell lines for use in studying the enteric nervous system. Technical Summary We have developed fetal (IM-FEN) and postnatal (IM-PEN) enteric neuronal cell lines with features similar to primary enteric neurons. The IM-FEN and IM-PEN have been passaged 40 times since their isolation and have shown no major changes in their cell growth characteristics, morphology, neuronal properties, or GDNF sensitivity. This homogeneity suggests that the lines will tend to remain phenotypically and biologically stable in vitro for many generations. We have shown...Mon, 11 May 2009 12:50:06 GMTott@emory.edu Rats Antidepressant drug screening for depression studies. Technical Summary We have developed different lines of rats by behavioral testing and then selective breeding of those showing desired characteristics in attempting to rat models for study of affective disorders. The lines were directed at possibly improving both drug screens (i.e., improved sensitivity and selectivity of detection of antidepressant drugs) and "homologous" models of depression (i.e., rats that show characteristics seen in human depression). While simply measuring baseline home-cage ambulatory activity of a larg...Mon, 11 May 2009 12:50:03 GMTott@emory.edu Rat Glioma Cell Line Compound screening Technical Summary The pBI-GL-HRE V6R plasmid containing six copies of hypoxic responsive element (HRE) derived from the human VEGF gene was used to generate a plasmid (pACN188) containing an alkaline phosphatase gene under the V6R HRE promoter. LN229 cells were cotransfected with the resulting plasmid and pcDNA3 vector carrying a neomycin-resistant gene. Stable clones were selected by through antibiotic resistance and further tested for hypoxia inducible alkaline phosphatase expression. The clone (LN229-HRE-AP #16) with the highest expression ratio of alkaline p...Mon, 11 May 2009 12:50:02 GMTott@emory.edu Adhesin, DNA Sequences Development of vaccines to CS2 protein on enterotoxigenic Escherichia coli. Technical Summary This invention identifies the nucleotide sequence encoding a CS2 pilin protein of enterotoxigenic Escherichia coli. Also identified are the nucleotide sequences of coding sequences linked to the CS2 coding sequence, which other coding sequences must be expressed to allow the synthesis and assembly of the CS2 pili on the cell surface. Enterotoxigenic Escherichia coli strains (ETEC) are a major cause of diarrheal disease. Accordingly, there is a need for a vaccine for preventing the disease...Mon, 11 May 2009 12:49:49 GMTott@emory.edu of Recombinant Peptide Growth Factors to Improve Antioxidant Capacity and Prevent Oxidative Damage Recombinant peptide growth factors for the prevention of oxidative stress or damage in the gastrointestinal tract during reduced feeding. Technical Summary The present disclosure describes methods for minimizing oxidative damage in an animal or human during or after malnutrition, underfeeding or fasting, especially during refeeding after undernutrition or malnutrition, and for minimizing oxidant damage during or after toxicity resulting from chemotherapy, alcoholism, irradiation therapy or chemical or environmental exposure to a toxic compound. Administration of an effective amoun...Mon, 11 May 2009 12:49:45 GMTott@emory.edu of Keratinocyte Growth Factor to Improve Systemic and Tissue Antioxidant Capacity In Vivo, 11 May 2009 12:49:45 GMTott@emory.edu T219 Antibody Western Blot Immunoprecipitation Immunohistochemistry Specificity Human, mouse and rat Subtype Rabbit Polyclonal Antibody Synthesis The T219 antibody was generated using TRRG-T(PO3H2)-RGGARGRGRGC-NH2 as the antigen. Amount Available 150-200 mL at 1.5-3 mg/mL Technical Summary Nuclear PI3K and its downstream effectors play essential roles in a variety of cellular activities including cell proliferation, survival, differentiation, and pre-mRNA splicing. Aly is a nuclear speckle protein implicated in mRNA export. Dr. Ye's group has shown that Aly is a physiological target of nucl...Wed, 29 Apr 2009 12:19:01 GMTott@emory.edu T387 Antibody Western Blot Immunoprecipitation Immunohistochemistry Specificity Human, mouse and rat Subtype Rabbit Polyclonal Antibody Synthesis The T387 antibody was generated using EEGTMKRRDEp-TMQPA as the antigen. Amount Available 150-200 mL at 1.5-3 mg/mL Technical Summary Oxidative stress can induce apoptosis through activation of MstI, subsequent phosphorylation of FOXO and nuclear translocation. MstI is a common component of apoptosis initiated by various stresses. MstI kinase activation requires autophosphorylation and proteolytic degradation by caspases. Dr. Ye's group has demonst...Wed, 29 Apr 2009 12:19:01 GMTott@emory.edu Phospho-Pike-A S472 Western blotting Immunohistochemistry Immunoprecipitation Specificity Human, mouse and rat Subtype Rabbit Polyclonal Antibody Synthesis The S472 antibody was generated using Ac-CRNLARAL(pS)TD-amide as the antigen. Amount Available 150-200 mL at 1.5-3 mg/mL Techcnial Summary PIKE-A is a ubiquitously expressed GTPase, which binds and enhances Akt kinase activity in a guanine nucleotide-dependent manner. PIKE-A is one of the components of CDK4 amplicon, which is amplified in numerous human cancers. PIKE-A itself overexpression alone can mediate cell transformation, proliferation...Wed, 29 Apr 2009 12:19:01 GMTott@emory.edu Antibody Western Blot Immunoprecipitation Immunohistochemistry Specificity Human, mouse and rat SRPK2 Subtype Rabbit Polyclonal Antibody Synthesis The T492 antibody was generated using acetyl-DRSR[pT]VSASSTG-Ahx-C-amide as the antigen. Amount Available 150-200 mL at 1.5-3 mg/mL Technical Summary SRPK, a family of cell cycle regulated protein kinases, phosphorylate Serine/Arginine (SR) domain-containing proteins in nuclear speckles and mediate the pre-mRNA splicing. SRPK2 is highly expressed in brain, and Dr. Ye's group has shown that SRPK2 binds and phosphorylates acinus, an SR protein...Wed, 29 Apr 2009 12:19:00 GMTott@emory.edu Phospho-S315 Antibody Western Blot Immunoprecipitation Immunohistochemistry Specificity Human, mouse and rat Subtype Rabbit Polyclonal Antibody Synthesis Synthesized S315 phosphorylated peptide (CRRRKAD-(PO3)S-LEVQQMKAQAREEKARK-COOH) was conjugated to keyhole limpet hemocyanin (KLH) and injected into rabbits. Antibodies were affinity purified from serum using unphosphorylated peptide crosslinked to Affi-Gel 10 or Affi-Gel 15. Amount Available 150-200 mL at 1.5-3 mg/mL Technical Summary The neurofibromatosis-2 (NF2) tumour-suppressor gene encodes an intracellular membrane-associated protein, called...Wed, 29 Apr 2009 12:19:00 GMTott@emory.edu Phospho-S422 Antibody, 29 Apr 2009 12:19:00 GMTott@emory.edu Lists for Nutritional Management of Metabolic Disorders, 29 Apr 2009 12:18:58 GMTott@emory.edu Models of Generalized Epilepsy Study of the mechanism of epilepsy. Evaluation of the efficacy of pharmacological agents. Technical Summary Mutations in the voltage-gated sodium channel SCN1A cause several subtypes of dominant idiopathic generalized epilepsy (IGE) including Generalized Epilepsy with Febrile Seizures Plus (GEFS+). GEFS+ is a dominant familial disorder characterized by febrile (fever-induced) seizures that persist beyond the age of six and that are often followed by the development of adult epilepsy. Affected individuals within GEFS+ families often display a wide variety of IGE subtype...Wed, 29 Apr 2009 12:18:58 GMTott@emory.edu Associated Protein (HAP1) Knockout Mouse Huntingtin Associated Protein (HAP1) knockout mice for the study of neurodegeneration in Huntington's Disease. Technical Summary Mice homozygous for the Huntingtin Associated Protein (HAP1)-deficient Hap1tm1Xjl allele have neurodegeneration in areas of the hypothalamus that control feeding behavior, resulting in decreased feeding behavior, dehydration, hypoactivity, and death between two and 15 days after birth. No protein expression from the targeted gene is observed in brain tissue from homozygous mice. Hypothalamus tissue from HAP1-deficient homozygotes exhibit reduced levels o...Wed, 29 Apr 2009 12:18:57 GMTott@emory.edu Model of Neurodegeneration Transgeneic mouse model for the study of spinocerebellar ataxia 17 (SCA17) and polyglutamine (polyQ) related neurodegeneration. Technical Summary These transgenic mice express human TATA box binding protein,TBP, containing a 71 polyQ repeat expansion, under the control of the mouse prion protein promoter. The 71 polyQ-expansion is detected by Western blot analysis. At 6.5 months of age, hemizygous transgenic mice are smaller than wildtype littermates and appear ungroomed. These transgenic mice have a shortened lifespan of approximately 9 months and begin to die as early as 21 week...Wed, 29 Apr 2009 12:18:57 GMTott@emory.edu N23 Antibody, 29 Apr 2009 12:18:57 GMTott@emory.edu of Septanose Oligosaccharides that efficiently produces septanose oligosaccharides. Key BenefitsSeptanose oligosaccharides may have interesting activity as biocompatible materials and could serve as drug delivery agents. Technical SummarySeven-membered ring (septanose) oligosaccharides are unknown in nature, since natural sugars have a thermodynamic preference of five- and six-membered rings. They are homologs of pyranoses and their similarity to natural carbohydrates suggests that they should have interesting and potentially useful physical, chemical, and biological properties. Emory investigators have d...Wed, 29 Apr 2009 12:18:57 GMTott@emory.edu Knockout Mice, 29 Apr 2009 12:18:56 GMTott@emory.edu Isoform Expression Vectors and Recombinant Proteins for use in Bioassays vectors and recombinant proteins for use in 14-3-3 based bioassays and a variety of research applications. Technical Summary14-3-3 proteins are a family of phosphoserine/threonine recognition proteins that play important roles in diverse cellular processes, including cell proliferation, cell cycle progression, and apoptosis control. There are seven isoforms of the 14-3-3 genes from different chromosomes. 14-3-3 proteins function in cells primarily through their binding to diverse family of client proteins. These interactions are mediated by the recognition of phosphorylat...Wed, 29 Apr 2009 12:18:56 GMTott@emory.edu Vector for Gram+ Bacteria Counterselectable system for use in Gram+ bacteria. Key Benefits Useful for developing genetic systems in Gram+ bacteria. Versatile design allows shuttling between Gram+ and Gram- bacteria. Technical Summary This technology is a counterselectable system for use in Gram+ (G+) bacteria. A plasmid vector has been constructed that can be selected against G+ bacteria by adding streptomycin to the medium. The rpsL streptococcal gene was cloned into a vector and allows selection against the plasmid and thus selection for integration of any homologous region that has been clone...Wed, 29 Apr 2009 12:18:55 GMTott@emory.edu Mice with Exaggerated Contact Hypersensitivity Responses Testing of therapeutics that seek to inhibit consequences of T cell-mediated immune responses. Identification of chemicals with weak contact sensitizing activity. Technical Summary The keratinocytes of the mouse model constitutively express both the costimulatory molecule B7-1 and the human class II transactivator (CIITA) proten. B7-1 provides an important second signal for T cell activation and CIITA induces the expression of class II MHC molecules involved in antigen presentation to T cells at high levels. As a result of keratinocyte B7-1 and class II MHC expressi...Wed, 29 Apr 2009 12:18:54 GMTott@emory.edu Support System for Intravenous Insulin Infusion the insulin infusion rate for patient treatment in acute care and outpatient settings.Key Benefits Reduces the risk of hypoglycemia. Allows the user to assign glycemic targets according to patient condition. Novel algorithm provides a more flexible target glucose range compared to existing methods. Technical SummaryPatients under medical stress are often unable to produce amounts of insulin sufficient to meet their basic metabolic needs. Having abnormally low or high levels of glucose complicates therapy and recovery. Under some conditions, the subcutaneous route of adminis...Wed, 29 Apr 2009 07:29:03 GMTott@emory.edu Nitrilotriacetic Acid (Tc-99m-NTA) for Renal Imaging and Measurement of Tubular Function Diagnostic imaging of the kidneys for the determination of renal function. Key Benefits Renal tracer for measuring the effective renal plasma flow. 99mTc-labeled small molecule has renal clearance characteristics that are superior to currently available tracers. First-in-man studies have been performed with resulting image quality and renogram parameters comparable to 131I-OIH, the gold standard radiolabeled renal tracer. Technical Summary In the U.S., approximately eight million adults have kidney disease. In order to diagnose and treat renal diseases and disorders, it is esse...Wed, 29 Apr 2009 07:29:02 GMTott@emory.edu Adenine Dinucleotide (NAD) for the Treatment of Cardiac Arrhythmia of cardiac arrhythmias, pain, and seizures from the administration of nicotinamide adenine dinucleotide (NAD).Key BenefitsTherapeutic approach involving the oxidized and reduced forms of NAD, a biological coenzyme. Potential treatment for heart failure, cardiac arrhythmias, pain, and seizures. Technical SummaryCardiac arrhythmia is a condition in which the electrical activity of the heart is irregular or abnormal. Some arrhythmias are life-threatening and can cause cardiac arrest and sudden death. Others cause aggravating symptoms, such as palpitations. Voltage-gated sodiu...Wed, 29 Apr 2009 07:29:01 GMTott@emory.edu Stress Markers Predict Atrial Fibrillation Diagnostic test for predicting the onset of atrial fibrillation (AF). Key Benefits Potential diagnostic test to predict susceptibility to arrhythmia. Extensive (100kb) of SCN5A promoter sequence has been identified. Technical Summary The invention provides oxidative stress blood markers for use in predicting the onset of atrial fibrillation (AF). The markers may also have utility in predicting complications of AF. Identification of the markers in this invention resulted from a study of human patients with persistent or permanent AF that revealed increases in certain oxidative st...Wed, 29 Apr 2009 07:29:01 GMTott@emory.edu Development for Neisseria meningitidis of vaccines against Neisseria meningitidis.Key BenefitsGenes involved in the adhesion and invasion of N. meningitidis serogroup B for vaccine applications. Provides a potential antigen for the development of a vaccine against serogroup B, which is currently not available in the U.S. Technical SummaryN. meningitidis is the causative agent of epidemic meningitis and fatal septic shock. There are 5 main strains of N. meningitidis (A, B, C, Y, W-135). Current vaccine formulations, which cover 4 of the 5 most prevalent serogroups consist of the capsular polysaccharide of the ...Wed, 29 Apr 2009 07:28:59 GMTott@emory.edu Approach To Surgical Repair of Type A Aortic Dissection with Modified Stent Transapical approach to endovascular surgical repair of aortic dissections using a modified stent. Key Benefits Minimally invasive, controllable method of device delivery allows for endovascular repair. The stent can be modified to account for the aortic condition being treated. A unique feature of this device is the method and location of introduction as most existing devices of this nature are introduced through the femoral artery. Technical Summary Aortic aneurisms and aortic dissections can occur in the descending, ascending or transverse arch of the aorta. One feature of a...Thu, 09 Apr 2009 14:32:09 GMTott@emory.edu for Treating Neurodegenerative Diseases Gedunin and its derivatives for the treatment of Parkinson's disease, Alzheimer's disease, HIV-related dementia, multiple sclerosis, amyotrophic lateral sclerosis, stroke, and Huntington's disease. Technical Summary The invention comprises gedunin derivatives for the treatment of neurological disorders. These compounds are TrkB agonists, and mimic the action of the natural ligand, brainderived neurotrophic factor (BDNF). TrkB is a receptor tyrosine kinase (RTK) with high affinity for neurotrophins, polypeptide growth factors responsible for neuronal differentiation and survival via...Thu, 26 Mar 2009 15:49:49 GMTott@emory.edu Junctional Adhesion Molecule (JAM-A) Mouse Monoclonal Antibodies Western blot Immunoprecipitation Immunocytochemistry Specificity Human junctional adhesion molecule (JAM-A). No detectable cross reactivity to other proteins by Western blot. Subtype Mouse IgG1 Technical Summary Junctional adhesion molecule A (JAM-A) is a transmembrane structural component of intercellular junctions implicated in the regulation of platelet aggregation, cellular adhesion, leukocyte transmigration/inflammation, and in the regulation of paracellular permeability at the level of epithelial and endothelial tight junctions. These monoclonal antibodies (J3F.1, J4F.1, J10....Thu, 26 Mar 2009 15:49:48 GMTott@emory.edu A Quality of Life Instrument for Scalp Dermatitis, 26 Mar 2009 15:49:48 GMTott@emory.edu A Pruritus-Specific Quality of Life Instrument, 26 Mar 2009 15:49:47 GMTott@emory.edu, a Rosacea-Specific Quality of Life Instrument, 26 Mar 2009 15:49:47 GMTott@emory.edu Polyclonal Antipike Antibody Immunoblotting Immunoprecipitation Immunofluorescence Specificity Rabbit Polyclonal Anti-PIKE Antibody Subtype Anti-Rabbit Technical Summary PIKE-activating Akt (PIKE-A), an isoform of PIKE GTPase that enhances phosphatidyl- inositol 3-kinase (PI3-kinase) activity. PIKE will specifically binds to active Akt but not PI3-kinase. PIKE-A stimulates Akt activity in a GTP-dependent manner and promotes invasive- ness of cancer cell lines. PIKE-A is amplified in a variety of human cancers and that amplified PIKE-A directly stimulates Akt and inhibits apoptosis compared to cells with normal...Thu, 26 Mar 2009 15:49:46 GMTott@emory.edu Antibody for High-Affinity Choline Transporter, 26 Mar 2009 15:49:46 GMTott@emory.edu Associated Protein 1AB (Hap1AB) Mouse Monoclonal Antibodies blot Immunoprecipitation Immunocytochemistry SpecificityHuntingtin Associated Protein 1A and B isoforms. No detectable cross reactivity to other proteins by Western blot.Subtype Mouse Monoclonal Technical SummaryHuntington's disease (HD) is an autosomal dominant neurodegenerative disorder caused by an expanded trinucleotide repeat in the IT15 gene. Huntington Associated Protein 1 (Hap1) was initially identified as a protein that interacts with huntingtin, the protein encoded by the gene responsible for the development of HD.These antibodies can be used to specifically detect...Thu, 26 Mar 2009 15:49:45 GMTott@emory.edu Structure of Neurospora SET Domain Protein DIM-5, a Histone H3 Lysine Methyltransferase Drug design and development; research. Technical Summary Crystallography data are commercially used for rational drug design and for experimentally testing interactions of candidate drugs with their targets. The current invention provides the first X-ray crystal structure of a histone methyltransferase, DIM 5. DIM-5 belongs to the family of histone lysine methyltransferases and can profoundly influence gene expression. DIM-5 is also required for DNA methylation, a process often associated with cancer formation in mammals. The structure can serve as a guideline for genetic and bioc...Thu, 26 Mar 2009 15:49:44 GMTott@emory.edu cDNA and Enzymes for Drug Discovery, for Diagnostics, and as Research Tools Target for drug discovery, gene therapy and to create a diagnostic tool relevant to conditions involving inappropriate cell proliferation. Technical Summary Reactive oxygen species (ROS) include superoxide and hydrogen peroxide. ROS are increasingly being recognized as playing a central role in diverse physiologic and pathologic processes. When produced in high amounts, for example by specific immune cells, ROS are chemically reactive, causing mutations and chemical damage to DNA, protein, biomembranes, etc. This property of ROS is utilized by immune cells to kill invading micro...Thu, 26 Mar 2009 15:49:43 GMTott@emory.edu Catheter for the Reduction of Reperfusion Injury Controlled delivery of fluids or drugs; perfusion/reperfusion. Key BenefitsReperfusion methods to prevent tissue damage. Controlled delivery of blood, fluids, or drugs into the vasculature. Technical Summary The construction and use of catheters and related medical devices is well known. Such devices allow for the catheterization of arteries and veins and allow for the expansion of atherosclerotic plaques in an angioplasty procedure. However, current technologies do not allow for controlled delivery of blood and fluids or targeted delivery of drugs, which would be of great use in t...Thu, 26 Mar 2009 15:49:43 GMTott@emory.edu Regulators and Targets for Drug Development, 26 Mar 2009 15:49:38 GMTott@emory.edu Acetylcholine Receptor m2 Antibody Immunohistochemistry Western blotting Specificity m2 muscarinic acetylcholine receptor Subtype Rat Monoclonal Technical Summary The m2 muscarinic acetylcholine receptor is a membrane bound G-protein coupled receptor highly expressed throughout the basal forebrain, as well as in cardiac tissue. These monoclonal antibodies were generated in rats and are specific to the m2 muscarinic acetylcholine receptor, showing no cross reactivity with other receptor subtypes. These antibodies are appropriate for immunofluorescence and immunoblotting applications; however do not work wel...Thu, 26 Mar 2009 15:49:38 GMTott@emory.edu Analogs with Antitumor and Antiangiogenic Properties Compounds that block tumor angiogenesis and growth. Technical Summary This invention describes a group of compounds that block tumor angiogenesis and growth without exhibiting a high level of toxicity with regard to normal vascular endothelial cells. The anti-angiogenic and anti-tumor compounds of this invention can be useful in the treatment of any condition benefiting from angiogenesis inhibition, such as cancer and chronic inflammation. In addition, the analogs may be useful for therapy of restenosis that occurs following angioplasty and stent deployment, diabetic retinopathy ...Thu, 26 Mar 2009 15:49:37 GMTott@emory.edu of Gram-Positive Pili to Deliver Antigens as Vaccines Protein expression on the tip of pili in gram-positive bacteria including Lactococcus lactis. Applications include the development of live bacteria-based vaccines that do not require refrigeration and are inexpensive to produce; and other live bacteria-based therapeutics, utility for food processing, probiotic applications and as biocatalysts. Key Benefits Technology platform for a new bacterial expression system that covalently links a protein external to the bacterial surface. Expression system has been demonstrated in Lactococcus lactis. Multiple potential applic...Wed, 25 Mar 2009 09:03:15 GMTott@emory.edu New Targeted Non-Toxic Anti-Cancer Drug Compositions and methods for treating cancer and inflammatory disease using noscapine and noscapine analogues conjugated to targeting molecules. Key Benefits Noscapine is a plant-derived alkaloid with a long-history of human use as an anti-cough agent. Noscapine is currently in phase I clinical trials for the treatment of cancer. Noscapine conjugate (Targetin) retains the parent compound microtubule binding and resulting microtubule dynamics attenuating activities. Since activated macrophages also over express receptors for Targetin, it can be used for th...Tue, 24 Feb 2009 14:05:36 GMTott@emory.edu Pellet Dispenser with Microchip Reader Records the ID and time of food consumption of individual members in a group. Key Benefits Records food (pellet) intake by individual members of a group 24 hours a day, 7 days a week. Uses a basic PC computer, AVID microchip ID reader, any AVID and fecava coded microchips, and a simple Visual Basic program. Computer is controlled remotely by VNC software. Technical Summary This technology consists of a computer-controlled pellet dispenser with a microchip reader. An AVID 6" ring antenna is located directly in front of the dispenser opening and scans the ID of...Tue, 24 Feb 2009 14:05:22 GMTott@emory.edu Expression Vector Replication and protein expression in a range of bacterial hosts. Key Benefits Expression vector is engineered for high-copy replication and transcription in a variety of bacteria hosts. Vector backbone offers a multicloning site and the versatile Streptococcus feacalis kanamycin resistance gene for selection in gram-negative and grampositive bacteria. Technical Summary Many contemporary molecular biological approaches are predicated on the ability to express a foreign protein of interest in a bacterial host. Protein expression, however, must often be screened through severa...Tue, 24 Feb 2009 14:05:16 GMTott@emory.edu and Accurate Measurement of Liver Lipid and Iron Levels Simultaneous assessment of lipid and iron content of the liver.Highlights A non-invasive, MRS-based method for rapidly (within 15 seconds) and accurately measuring both liver lipid and iron levels simultaneously. A technique that eliminates the need for invasive, risky and painful liver biopsies to assess hepatic lipid and iron levels. Technical Summary Abnormal elevation of liver lipid (fat) levels is becoming the most important liver disorder in the U.S. and in other industrialized and developing countries. Currently, the standard diagnostic tool for measuring liver lipid levels ...Tue, 24 Feb 2009 14:05:07 GMTott@emory.edu Coated SERS Nanoparticle Tags Nanoparticle for in vivo tumor targeting and detection. Key Benefits Large optical enhancements were achieved under in vivo conditions in live animals. Conjugated nanoparticles were able to target tumor biomarkers on human cancer cells and in xenograft tumor models. Functionalized nanoparticles can be used as a diagnostic or therapeutic tool. Technical Summary Dr. Shuming Nie and his team have developed biocompatible and nontoxic nanoparticles for in vivo tumor targeting and detection based on pegylated gold particles and surface-enhanced Raman scattering (SERS). These SERS ...Tue, 24 Feb 2009 14:04:59 GMTott@emory.edu for Detection of Mouse ENaC Polyclonal antibody for the detection of mouse Epithelial Sodium Channel (ENaC) a subunit in western blots. Key Benefits Affinity purified rabbit polyclonal antibody recognizes the 85kDa a subunit of mouse Epithelial Sodium Channel (ENaC). Immunizing peptide consisting of mouse specific sequence was used to limit cross-reactivity. Technical Summary Polarized epithelium bears many responsibilities including maintenance of apical and basal fluid homeostasis. These cells affect important fluid characteristics by moving a range of ions both into and out of the extracellular space ...Tue, 24 Feb 2009 14:04:57 GMTott@emory.edu as MRI contrast agents and drug delivery tools Highly magnetic nanoparticles as MRI contrast agents and drug delivery tools. Key BenefitsEnhanced magnetization through use of elemental iron rather than iron oxide. Ability to functionalize nanoparticles with antibodies, proteins, and therapeutics. Suitable for research tool use, imaging purposes, and localized hyperthermia therapy for cancer treatment. Technical Summary Magnetic nanoparticles have been explored for potential use in biomedical applications such as drug delivery, cancer detection, and chemotherapy. The currently used magnetic nanoparticle technology relies on the ...Tue, 24 Feb 2009 14:04:51 GMTott@emory.edu Analog Scale for Dyspnea in Heart Failure A visual analog scale (VAS) used in clinical trials to determine self-perceived change in dyspnea (breathlessness). Highlights Defines a scale for measuring self-perceived change in dyspnea that has been used with heart failure patients. Improved accuracy over standards set for VAS used in measurement of dyspnea in asthma patients. Technical Summary Dyspnea is a common symptom that is presented by heart failure patients admitted into the emergency departments. During an evaluation of heart failure patients, physicians often gauge the severity of the illness and response to therapy ...Tue, 24 Feb 2009 14:04:48 GMTott@emory.edu High Throughput Assay to Screen for BMP Modulators A high throughput screening assay to identify bone morphogenic protein (BMP) modulators. Key Benefits Homogeneous proximity-induced interaction method. Robust, highly sensitive, easy to use method of monitoring BMP interaction. Characterization of potential BMP modulators for therapeutic development. Technical Summary The BMP/BMP receptor interaction represents an important target for the discovery of novel therapeutic agents for the treatment of various BMP-signaling mediated diseases. Emory researchers have shown that BMP is a potent pro-inflammatory cytokine that causes ...Tue, 24 Feb 2009 14:04:43 GMTott@emory.edu to Measure Kinase Phosphatase Activity Research kit capable of selectively measuring kinase/phosphatase activity within a heterogeneous sample. Key Benefits Reaction conditions can be tailored to a particular enzyme, eliminating background noise. Accurate readings can be obtained using a multitude of sample types. High throughput capabilities. Technical Summary Emory University researchers have devised methods to detect the activity of a specific kinase/phosphatase within a heterogenous sample, eliminating inefficiency and radioactivity issues that exist with current methods. This novel assay measures the binding of...Tue, 24 Feb 2009 14:04:36 GMTott@emory.edu of BAI1 Through Chromatin Modifiers For Tumor Suppression Vasculostatin fragments can be used as anti-angiogenic and anti-tumorigenic therapies. Key Benefits Transcription enhancement and/or post-translational cleavage of endogenous or expressed BAI1 increases the amount of vasculostatin fragments bioavailable for suppression of angiogenesis and tumorigenesis. Purified vasculostatin fragments can be administered as anti-angiogenics and anti-tumorigenics. Technical Summary Tumorigenesis is a complex process during which transformed cells hyperproliferate to form a tumor mass. The induction of new blood vessel formation, known as angio...Tue, 24 Feb 2009 14:04:32 GMTott@emory.edu AH12.2 Desmoglein-2 Antibodies Immunocytochemistry Western Blot Immunoprecipitation Specificity Human Desmoglein-2 (Dsg2) protein. No detectable cross reactivity with other proteins by western blot. Subtype Mouse Monoclonal Technical Summary Desmogleins are a family of cadherin proteins that play an important role in the formation of desmosomes, cell-to-cell adhesions, often found in both simple and squamous epithelium. These adhesions are important to ensuring tissue integrity and regulation of paracellular movement of solutes, as well as restricting access of luminal pathogens to underlying tissue c...Tue, 24 Feb 2009 14:04:29 GMTott@emory.edu Cardiac Imaging Tool This technology can be used to create an imaging program or system that images both the heart and thoracic cavity with increased accuracy. Distortions such as "heart drift," which occur when fusing CT and PET images, are corrected via this technology. Key Benefits Delivers improved images of the heart and lungs using PET/CT imaging when compared to currently used methods. Images both the heart and lungs accurately by correcting for the heart drift artifact without rotating the CT image. Does not relocate or shift highly attenuating tissues, like bone, when constructing images....Tue, 24 Feb 2009 14:04:20 GMTott@emory.edu A Tumor Suppressing Protein, 24 Feb 2009 14:04:17 GMTott@emory.edu Vocal Fold and Dry Micrrolaryngeal Surgical Simulator Training device that simulates the human vocal fold (SVF) is designed to assist in the development of fine manual dexterity and instrument precision necessary for physicians to perform microlaryngeal surgical dissection. Key Benefits The SVF housed within a plastic larynx model approximates the both the delicate tissue and limited operating access typical in microlaryngeal surgery. SVF can be created to mimic various surgical scenarios such as vocal polyps, cysts, and benign or malignant neoplasms. Technical Summary Microlaryngeal surgery requires fine manual dexterity and pr...Tue, 24 Feb 2009 14:04:14 GMTott@emory.edu Factor as Therapeutic for Diabetes, 24 Feb 2009 14:04:13 GMTott@emory.edu Epoxides for Treating Neurological Diseases Aza-peptide epoxides are a class of protease inhibitors and may be useful in the treatment of a number of neurological diseases.Technical Summary Drs. Powers and Glass have developed aza-peptide epoxide caspase inhibitors that can be used for the treatment and/or prevention of nerve degeneration in mammals. Such aza-peptide epoxide compositions can treat or prevent diseases, including but not limited to, Alzheimer's disease, Parkinson's disease, multiple sclerosis, neuropathies, Huntington's disease, dentatorubropallidomysian atrophy, spinocerebellar atrophies, spinal bulbar muscul...Tue, 24 Feb 2009 14:04:08 GMTott@emory.edu Potentially Imageable Fluorinated Anticancer Alkaloid Synthesis of noscapine analogs and their use as cancer treatments, including drug resistant cancers. Key BenefitsEfficient, high yielding synthesis of noscapine derivatives. Selective for cancer cells over normal human cells.Technical Summary The effectiveness of microtubule-targeting drugs as treatments for cancer has been validated through the extensive clinical use of vinca alkaloids and taxanes. Though useful, the success of the currently used microtubule drugs is limited due to their insolubility in water, emergence of drug resistance, and associated toxicities. Noscapine, whi...Tue, 24 Feb 2009 14:04:05 GMTott@emory.edu Production of Optically Pure Sphingolipids and Derivatives, 24 Feb 2009 14:04:01 GMTott@emory.edu for the Treatment of Fragile X Syndrome and Methods of Screening Small molecule compounds that may have therapeutic efficacy in Fragile X Syndrome and chemical genetic screens for potential drug targets. Technical Summary Fragile X Syndrome (FXS), the most common heritable form of mental retardation, is caused by transcriptional misregulation of the FMR1 gene and a subsequent loss of function of the RNA binding protein, fragile X mental retardation protein (FMRP). FXS is also the leading known cause of autism. Currently there is no effective drug therapy for FXS, and there have been no FMR1-based assays amenable to candidate drug screens. Dr...Tue, 24 Feb 2009 14:03:52 GMTott@emory.edu of Thrombin Mutant to Reverse the Effect of Direct Thrombin Inhibitors The thrombin mutant provides a quick and powerful antidote to synthetic direct thrombin inhibitors. Technical Summary Direct thrombin inhibitors (DTIs) are a relatively new class of agents which specifically bind to and inactivate one or more of the active sites on the thrombin molecule. These drugs exhibit a number of advantages that make them uniquely attractive as potential therapeutic agents. Such advantages include the fact that Antithrombin III is not required as a cofactor, they can inhibit clot-bound thrombin, circulating inhibitors do not inhibit their function, and they d...Tue, 24 Feb 2009 14:03:52 GMTott@emory.edu Imaging Agents for the Diagnosis of Prostate and Other Cancers Radiolabeled amino acids can be used in conjunction with PET to image tumors or other areas of rapidly proliferating cells. Key BenefitsLabeled amino acids can reliably and readily be produced. Uses non-natural amino acids which are readily transported into cells but not incorporated into new proteins. Increased half-life of the radiolabel allows for off-site production. Technical Summary Rapidly proliferating cells, such as cancerous tumor cells, require high levels of amino acids to divide and grow. This requirement can be exploited to identify tumors through the use of radiolabe...Tue, 24 Feb 2009 14:03:49 GMTott@emory.edu Systems for Evaluating Antiviral Agent Toxicity Transgenic mice with myocardial targeted overexpression of genes encoding proteins for mitochondrial import, phosphorylation, dephosphorylation, and mitochondrial DNA replication. Key Benefits Unique in vivo method to elucidate mechanism of AIDS related mitochondrial cardiomyopathy. Selective overexpression of both native and mutant genes. Ability to assess antiviral compound toxicity. Technical Summary Survival with AIDS has improved dramatically with the introduction of highly active antiretroviral therapy (HAART). However, one of the major components of this treatment, nu...Tue, 24 Feb 2009 14:03:47 GMTott@emory.edu Screening of Kinase and Phosphatase Activators and Inhibitors High-throughput screening for kinases and phosphatases regulators. Key Benefits Identifies regulators of kinases and phosphatases by their interaction with 14-3-3 proteins. Eliminates the need for radiolabeled tracers or antibodies when screening. Ideal method for high-throughput screening. Technical Summary Phosphorylation is a common post-translational modification used to regulate many cellular processes. Phosphate groups are added to targets (usually a protein or peptide) by kinase enzymes and removed via phosphatase enzymes. The addition or removal of phosphate groups c...Tue, 24 Feb 2009 14:03:34 GMTott@emory.edu of Lipase-Based Biocatalysts Derived from CALB lipase-based platform technology that can be used in the production of fine chemicals, detergents, and pharmaceuticals.Key BenefitsEnhanced thermostability, activity, and enantioselectivity of enantiopure compounds including bulky substrates. Can be used at a concentration 100x less than that of other enzymes. Technical SummaryLipases are a group of specialized enzymes that are also important biocatalysts for the chiral synthesis of the active ingredients of pharmaceuticals and specialty chemicals. Among the most commonly used biocatalysts is lipase B from Candida Antarctica (CALB...Tue, 24 Feb 2009 14:03:32 GMTott@emory.edu Computational Platform for IMRT Treatment Planning Global optimization of treatment planning for external beam radiation therapy. Technical Summary External beam radiation therapy is a well-known option for treating and controlling certain central nervous systems lesions, such as arteriovenous malformations, metastatic lesions, malignant gliomas, and tumors in various parts of the body. The process of treating a patient using external beam radiation therapy consists of constructing a precise three-dimensional map of the anatomical structures in the location of interest (target volume), developing a treatment plan for delivering a p...Tue, 24 Feb 2009 14:03:26 GMTott@emory.edu Conformal Barriers for Cell Transplantation Coatings that protect islet cells during transplantation for the treatment of Type I diabetes. Key Benefits Ability to control permeability characteristics of shape conforming barrier coating. Application to genetically engineered cells, neurons, cardiac myoblasts, myocardial cells, chondrocytes, dopamine secreting cells, or other cell types intended for cell therapy. Technical Summary A major obstacle in islet cell transplantation to treat insulin insufficiency in Type 1 diabetics is a high rate of primary nonfunction and early islet destruction after intraportal islet infus...Tue, 24 Feb 2009 14:03:18 GMTott@emory.edu Conjugates Biologic conjugates that have anti-inflammatory properties and can be used as systemic agents for treatment of blood clots, stroke, heart attack, or other inflammatory/prothrombotic conditions. Key Benefits Can also be used to coat cells and tissues to enhance their anti-inflammatory properties or can be used to coat devices such as vascular grafts, stents, heart valves, dialysis membranes, membrane oxygenators, catheters, or guide wires to alter surface properties. Has dramatically enhanced water solubility, improved plasma half-life, increased stability, and possibly decrease...Tue, 24 Feb 2009 14:03:14 GMTott@emory.edu for Tagging and Isolating Cells Tagging and isolating cells; cell selection (sorting); research tool; diagnostic tool. Technical Summary This invention is comprised of a cell isolation system. In short, the target cell type to be isolated is engineered to express a protein "tag." This "tag" is subsequently used to isolate the cell by means of a highly selective affinity capture technique coupled to one of several substrates. This simple invention is a significant improvement over existing technology in that it requires shorter incubation times and yields higher percentages of isolated targeted cells (with fewe...Tue, 24 Feb 2009 14:03:11 GMTott@emory.edu Tags Using Dye-Embedded Nanoparticles and Surface-Enhanced Raman Scattering Surface-enhanced Raman nanoparticles for multiplexed analysis of molecular biomarkers and multiparameter flow cytometry. Technical Summary Surface-enhanced Raman scattering (SERS) is capable of providing rich vibrational information at the level of single molecules and single nanoparticles. The inventors have developed a class of dye-embedded core-shell nanoparticles that are highly efficient for surface Raman enhancement and could be used as spectroscopic tags for multiplexed detection and spectroscopy. The core-shell particles contain a metallic core for optical enhancement, a ...Tue, 24 Feb 2009 14:03:07 GMTott@emory.edu Magnetic Nanoparticle Probes for Molecular Imaging Sensitive, specific, and rapid nucleic acid detection. High signal-to-noise ratio and ultra-low false-positives in molecular imaging. Detection of gene expression, including genetic expression associated with an infection or disease state.Technical Summary This invention provides for multifunctional magnetic nanoparticle probe for molecular imaging and monitoring, comprising a nucleic acid or polypeptide probe, a delivery ligand, and a magnetic nanoparticle with a biocompatible coating. The probe can include a fluorescent or luminescent resonance energy transfer moiety. The researc...Tue, 24 Feb 2009 14:03:02 GMTott@emory.edu Mouse, 24 Feb 2009 14:03:01 GMTott@emory.edu Expressing Mice as an Animal Model for Colon Cancer Animal model system used to test the efficacy of new anti-cancer drugs. Technical Summary A mouse that expresses human Nox1 in colonic epithelium has been developed, and shows markedly increased reactive oxygen generation selectively in these cells. Nox1 has been implicated in mitogenic and angiogenic growth related to colon cancer, and Nox1 overexpressing mice show hyperplasia of colonic epithelium. In addition, by crossing these overexpressing animals with mice that are prone to develop polyps (such as min mice or other mice mutated in the APC tumor suppressor) it may be possi...Tue, 24 Feb 2009 14:02:54 GMTott@emory.edu A Regulatory Protein for Nox Enzymes Cell-free assay system useful for discovering inhibitors of Nox enzymes. These inhibitors may be useful as drugs for cancer, atherosclerosis, hypertension, and inflammatory diseases such as arthritis, inflammatory bowel disease, etc. Technical Summary Nox enzymes play an important role in mitogenic cell growth and angiogenesis, and their aberrant regulation is implicated in cancer and atherosclerosis. The Nox family consists of 7 unique gene products in humans, but regulatory proteins for Nox enzymes have not been previously described. This invention provides the following: nucl...Tue, 24 Feb 2009 14:02:54 GMTott@emory.edu Syntheses of Chain-Length and Sequence Specific Synthetic Polymers This invention provides methods that can be used to directly translate DNA strands, or genes, into different synthetic polymers. Technical Summary In typical biological systems, polymerization reactions are driven along a template using a catalyst to specifically read sequence-specific and chain-length-specific information. Typically, the set of structural components involved in these in vivo reactions is limited to the four base pairs that comprise DNA. Additionally, the resulting polymers are limited to structures having phosphate-based backbones. Despite these limitations, bi...Tue, 24 Feb 2009 14:02:49 GMTott@emory.edu Antibodies Directed Against PHAPI/I1PP2A/PP32/LANP/etc. (E32+E36) and PHAPII/I2PP2A/SET/Nup214/TAF2beta/etc. (E38) Immunoprecipitation Immunofluorescence Immunoblotting Specificity Polyclonal antibodies that recognize PHAPs/IPP2As/etc. isoforms Technical Summary It has been reported that PHAPs/IPP2As/SET/etc. are increased or to have alterations in the expression of their different isoforms/alternative splice variants in a number of human tumors such as leukemias, Wilms tumor, and prostate cancer. The expression of these peptides may therefore provide useful clinical markers for cancer diagnosis and staging of tumors. Dr. Pallas has made several pan type antibodies that should recognize...Tue, 24 Feb 2009 14:02:43 GMTott@emory.edu Anti-yeast PME-1 (Protein Phosphatase Methylesterase-1) Polyclonal Antibody This antibody detects PME-1 in cell lysates and immunoprecipitates native protein. Technical Summary Dr. Pallas has made a polyclonal antibody to yeast PME-1, a protein methylesterase for which PP2A (protein phosphatase 2A) is a substrate. This antibody is raised against a PME-1 peptide. At this point there are no similar antibodies available commercially. This antibody can be used for immunoblotting and immunoprecipitation. It has not been tested on immunofluorescence or histochemistry. Tue, 24 Feb 2009 14:02:43 GMTott@emory.edu Phosphatase 2A Regulatory b' Subunit Polyclonal Antibody (AR1) Immunohistochemistry Immunofluorescence Immunoblotting Specificity Polyclonal antibody to the PP2A pan-B' subunit Subtype Anti-rabbit Technical Summary This antibody is useful in studying the B' family of PP2A subunits. The antibody was generated against a sequence highly conserved in all known PP2A B' subunits and is termed AR-1. AR-1 recognized known B' subunits that migrated at 56 and 74 kDa, as well as three unknown proteins that migrated at polyclonal antibody to a PP2A B' subunit peptide. This antibody works in Western blotting, but not for immunoprecipitation. The...Tue, 24 Feb 2009 14:02:43 GMTott@emory.edu Phosphatase 2A Regulatory Balpha Subunit Polyclonal Antibody Polyclonal antibody to PP2A Balpha subunit peptide that can be used for Western blotting and perhaps immunofluorescence or histochemistry. Technical Summary Dr. Pallas has made a polyclonal antibody to a PP2A Balpha subunit peptide. This antibody works in Western blotting (especially after immunoaffinity purification), but not for immunoprecipitation. This antibody could perhaps be used for immunofluorescence or histochemistry but it has not been tested. Tue, 24 Feb 2009 14:02:43 GMTott@emory.edu Polyclonal Antibody, RK130, 24 Feb 2009 14:02:42 GMTott@emory.edu Polyclonal Antibody RK16 Immunoprecipitation Immunofluorescence Immunoblotting Specificity A polyclonal antibody to striatin Subtype Anti-rabbit Technical Summary The inventor has made polyclonal antibodies to a striatin peptide. Striatin is a calmodulin (CaM)-binding proteins that forms a stable complex with PP2A A and PP2A C heterodimers. While this antibody is polyclonal, it was made to a specific peptide and is highly specific and can be used for multiple applications. This antibody can be used for Western blotting and immunofluorescence. The antibody also immunoprecipitates native striatin ...Tue, 24 Feb 2009 14:02:42 GMTott@emory.edu Phosphatase 2A Regulatory A Subunit (4G7) Monoclonal and (R39) Polyclonal Antibodies Immunoblotting Immunofluorescence Histochemistry Specificity Monoclonal and polyclonal antibodies that recognize the PP2A A subunit Subtype Anti-mouse Technical Summary The inventor has made monoclonal (4G7) and polyclonal (R39) antibodies to the PP2A A subunit peptide (DP32). Most A subunit antibodies available are polyclonal antibodies. This hybridoma provides a continuous source of monoclonal antibody that will help provide consistency of results better than with polyclonal antibodies. May be useful for detecting A alpha or A beta mutants or expression changes that ma...Tue, 24 Feb 2009 14:02:42 GMTott@emory.edu anti-PME-1 (Protein Phosphatase Methylesterase-1) Polyclonal Antibody, 24 Feb 2009 14:02:42 GMTott@emory.edu phase Nuclear Autoantigen (SG2NA) Monoclonal (S68) and Polyclonal (RK115) Antibodies Immunoprecipitation Immunofluorescence Immunoblotting Specificity Monoclonal and polyclonal antibodies to SG2NA Subtype Anti-rabbit Technical Summary SG2NA is a calmodulin-binding proteins that form stable complexes with PP2A A and PP2C heterodimers. The inventor has made monoclonal and polyclonal antibodies to an SG2NA peptide. The hybridoma provides a continuous source of monoclonal antibody that will provide consistency of results and can be used in multiple applications. The polyclonal antibody is also of very high quality. They both work in Western blotting, immunop...Tue, 24 Feb 2009 14:02:41 GMTott@emory.edu for Vaccine Development Vaccines to prevent infection from pathogenic Neisseria bacteria. Key Benefits Engineered Neisseria mutants for the development of a vaccine based on the outer membrane protein. Absence of the lipooligosaccharide from the outer membrane eliminates toxicity. Technical Summary Neisseriae bacteria represent a major human pathogen. These strains produce endotoxins harmful to humans that can result in bacterial meningitis, sepsis, bacteremia, and gonorrhea. Mortality of bacterial meningitis is ~85% if left untreated. The existing capsular polysaccharide vaccines against Neisseria i...Tue, 24 Feb 2009 14:02:36 GMTott@emory.edu and Use of C-terminal Aldehyde Inhibitors of Ubiquitin-like Protein Processing Enzymes Synthesis of glycine-aldehydes for the C-terminus of peptides and proteins; research tool for studying ubiquitin and regulation of cell processes. Technical Summary The regulation of a protein's function is a complex combination of processes that control synthesis, localization, and degradation. All of these processes must be properly regulated and are often interrelated. A key mediator of cytoplasmic and nuclear protein degradation is the protein, ubiquitin, which binds covalently to proteins in a specific domain. The ubiquitin-dependent proteolysis pathway is of vital importance ...Tue, 24 Feb 2009 14:02:31 GMTott@emory.edu of High Affinity Mutants of 4E mRNA Isolation/Purification Isolation and purification of mRNA; identification of drug targets. Technical Summary Isolation mRNA is the first step to sequencing expression sequence tags, which are the foundation of any genome sequencing project. Current methods of mRNA isolation depend on the presence of a 3' poly(A) tail. Therefore mRNAs that lack this 3' poly(A) tail or that have short poly(A) tails are not included in human genome microarrays. MRNAs with high degrees of structure also prevent poly(A) dependent methods for isolating mRNA. As a result, there are likely to be other biologically critical mRNAs...Tue, 24 Feb 2009 14:02:30 GMTott@emory.edu Assemblies for Cell and Drug Encapsulation and Other Implantable Devices An artificial cell membrane that has enhanced surface and mass transport properties, which can be used in implantable devices. Technical Summary Several approaches have been proposed for improving the biocompatibility of biomaterials useful in medical applications. Many of these methods, however, have the disadvantage of being nonpermanent systems in that the surface coating is eventually stripped off or leached away. Membranes, as self-organizing noncovalent aggregates, offer a model for molecular engineering in which the constituent members can be controlled, modified, precise...Tue, 24 Feb 2009 14:02:29 GMTott@emory.edu Oxidases as Mitogenic and Endocrine Regulators Useful as a target for drug development/discovery for parasitic diseases. May also be useful in agriculture to prevent crop damage from nematodes. Technical Summary Parasitic diseases are a major cause of morbidity and mortality worldwide in humans, and also have a significant impact on agricultural productivity due to parasitic infections of livestock. Parasitic diseases have proven difficult to treat, in part due to the presence of the cuticle, a tough exosketal protective structure surrounding the nematode. The availability of an agent that disrupts the formation of the cutic...Tue, 24 Feb 2009 14:02:28 GMTott@emory.edu for Adjuvant Brachytherapy Treatment Planning Can be used for determining tumor volume definition from medical images for general cancer treatment in LDR and HDR brachytherapy. Technical Summary Soft-tissue sarcomas are tumors that arise in the soft tissues that connect, support and surround other parts of the body, such as muscles, tendons, fat, joint linings, and blood vessels. Approximately 6,000 new cases are diagnosed each year in the U.S. Although soft-tissue are sarcomas are relatively rare, representing only about one percent of all cancer cases, they provide unique challenges in detection and treatment. In the past, t...Tue, 24 Feb 2009 14:02:27 GMTott@emory.edu Antibodies to RFP The inventors have successfully raised a high titer polyclonal antibody against RFP. RFP was produced in E.Coli , Ni ++ column purified. The RFP band was excised from SDS-PAGE gel and injected into chicken. The antibody produced was harvested from egg yolk. Tue, 24 Feb 2009 14:02:25 GMTott@emory.edu Oxygenase Regulators for Drug Discovery Can be used as a target for drug discovery, gene therapy and to create a diagnostic tool. These applications are relevant to conditions involving inappropriate cell proliferation (e.g., cancer, atherosclerosis), angiogenesis, and tissue damage associated with inflammatory diseases. Technical Summary Reactive oxygen species (ROS) include superoxide and hydrogen peroxide. ROS are increasingly being recognized as playing a central role in diverse physiologic and pathologic processes. When produced in high amounts, for example by specific immune cells, ROS are chemically reactive, ...Tue, 24 Feb 2009 14:02:25 GMTott@emory.edu Human Liver Monoamine Oxidase A and B Large scale expression of recombinant human Monoamine Oxidase A and B. Key Benefits Pastoris strains expressing recombinant human Monoamine Oxidase. Technical Summary Monoamine oxidase B (MAO B) is a flavoenzyme bound to the outer mitochondrial membrane and is responsible for oxidative deamination and subsequent degradation of dopamine as well as dietary amines in our body. Due to the lack of structural information on MAO B and the lack of enzymological studies on the purified enzyme, the reason for the observed differences between human and rat MAO Bs is not well understood. Com...Tue, 24 Feb 2009 14:02:24 GMTott@emory.edu, A Novel Genetic Element that Confers Macrolide Resistance in Streptococcus Pneumoniae Genetic element that confers macrolide drug resistance in Streptococcus pneumoniae for use in patient screening and diagnosis as well as drug development. Key Benefits Genetic element allows identification of Streptococcus pneumoniae strains that are resistant to macrolide antibiotics. Expressed efflux proteins identified by this element provide potential targets for drug development. Market Summary Infections caused by Streptococcus pneumoniae are a significant health problem worldwide, being the leading causes of bacterial pneumonia, meningitis, acute otitis media, and acute s...Tue, 24 Feb 2009 14:02:23 GMTott@emory.edu Membrane-Mimetic Assemblies Coatings for small diameter blood vessel prosthetic materials, blood contacting materials, and other implantable medical devices and prosthetics. Market Summary Atherosclerosis continues to be a cause of morbidity and mortality despite advances in preventive measures and pharmacological therapeutics. Nearly 700,000 vascular surgical procedures are performed each year in the U.S. along with several hundred thousand peripheral and coronary angioplasties. Prosthetic bypass grafts and, more recently, arterial stents and other endovascular prosthesis have been utilized in association...Tue, 24 Feb 2009 14:02:23 GMTott@emory.edu Analogs as Anti-Inflammatory Agents Small molecule therapeutics for the treatment of inflammation and autoimmune disorders. Key Benefits Decreased toxicity compared to the natural product triptolide. Improved aqueous solubility compared to triptolide. Market Summary Inflammation is known to be a component in a wide range of disease states including arthritis, asthma, and many types of cancer. For arthritis and joint disease, almost 20 percent of the US population, approximately 43 million people, is affected. This number is predicted to rise above 60 million people in the US alone by 2020. Current treatment for ...Tue, 24 Feb 2009 14:02:23 GMTott@emory.edu, 1d6, and 4e1 anti-PP2A Catalytic Subunit (Protein Phosphatase 2A) Methylation-Sensitive Monoclonal Antibodies Immunoblo Immunoblotting Immunoprecipitation Immunofluorescence Histochemistry Specificity Monoclonal antibodies specific for thr PP2A xatalytic subunit. Subtype Anti-Mouse Technical Summary The inventor has developed an anti-PP2A C-terminal peptide monoclonal antibodies, specific for the PP2A C subunit, 1d6, 4b7, and 4e1. These antibodies almost exclusively recognize the PP2A catalytic subunit in its unmethylated state. The antibodies are inhibited by methylation of PP2A and are therefore useful for assaying the PP2A methylation state in a quantitative manner. While 4...Tue, 24 Feb 2009 14:02:18 GMTott@emory.edu anti-PME-1 (Protein Phosphatase Methylesterase-1) Polyclonal Antibody antibody to detect mammalian PME-1 that can be used for immunoblotting and immunoflorescence and possibly histochemistryTechnical SummaryDr. Pallas has developed a polyclonal antibody to PME-1, a protein methylesterase for which PP2A (protein phosphatase 2A) is a substrate. PP2A is a highly conserved serine/threonine phosphatase involved in the regulation of a wide variety of enzymes, signal transduction pathways, and other cellular events. In accordance with these diverse roles, PP2A has been found localized to the nucleus, cytoplasm, cytoskeleton, and membranes. This antibody ...Tue, 24 Feb 2009 14:02:17 GMTott@emory.edu Proteins Involved in Alzheimer's Disease Western Blot Immunoprecipitation Immunocytochemistry Specificity C-elegans SPE-4 protein as well as other presenilin family proteins. No detectable cross reactivity with other proteins by western blot. Subtype Rabbit IgG1 Technical Summary Alzheimer's disease is a neurodegenerative disease characterized by progressive cognitive deterioration together with a decline in activity and neuropsychiatric symptoms. In many patients suffering from Alzheimer's disease, mutations in the presenilin proteins are observed. The SPE-4 protein is a presenilin family transmembrane protein...Tue, 24 Feb 2009 14:02:16 GMTott@emory.edu Method and Device for the Transdermal Delivery of Lithium Lithiderm patch for transdermal lithium delivery. Key Benefits Minimizes need for routine blood concentration monitoring. Inexpensive, effective method for lithium delivery. Technical Summary Lithium is a successful treatment for mania, bipolar disorder, and other psychiatric disorders and, over the past 50 years, has remained the first-line therapy for mood stabilization. Tolerability and compliance issues, however, are a concern for one-third or more of patients. Contraindications are related to pharmacodynamic dosing complications following conventional oral administration...Tue, 24 Feb 2009 14:02:13 GMTott@emory.edu Phosphatase 2A Demethylase Protein and DNA Sequences Can be used in assays to search for drugs that modulate protein phosphatase 2A (PP2A) methylesterase activity or to make recombinant protein to be used in assays. Such derivatives have potential application as anti-cancer and Alzheimer's treatment drugs. Technical Summary Protein phosphatase 2A (PP2A) is involved in the regulation of a wide variety of enzymes, signal transduction pathways, and cellular events. Therefore, it is not surprising that PP2A is highly regulated. This invention describes the cloning of a modulating enzyme for human PP2A, named Protein Phosphatase Methyles...Tue, 24 Feb 2009 14:02:13 GMTott@emory.edu RF Pulse to Provide T1rho Weighting to Medical Images Made Using Nuclear Magnetic Resonance, 24 Feb 2009 14:02:12 GMTott@emory.edu Cytotoxicity-Based Genetic Selection Technology (TOXSEL) Screening method for drug discovery and investigating protein-protein interactions. Technical Summary Drug discovery is typically dependant on screening methods that involve negative selection, or the death of cell cultures when exposed to a specific drug. This invention, a cytoxicity-based genetic selection method (TOXSEL), introduces a new screening method for drug discovery and protein-protein interactions in which the selection method is dependant on cell survival. The technology utilizes a construct containing a segment of the diphtheria toxic (DT) gene causing cell death...Tue, 24 Feb 2009 14:02:09 GMTott@emory.edu RNA Binding Proteins to Deliver mRNA for Gene Therapy and Cell Transplantation Possible applications for this invention include transient expression of specific gene products in stem cells prior to transplantation to protect the cells or stimulate them to differentiate into a desired cell-type (e.g., pancreatic islet cells for diabetic patients). This technology could also have great utility in the development of RNA-based vaccines and gene-based therapies for different forms of cancer. Technical Summary In eukaryotes, protein synthesis is the process by which messenger RNA (mRNA) interacts with ribosomes, cofactors, and enzymes to translate the mRNA's nu...Tue, 24 Feb 2009 14:02:07 GMTott@emory.edu Personalized, Sequencing-Based Bacterial Meningitis Diagnostic, 24 Feb 2009 14:01:58 GMTott@emory.edu Vision Accommodating Intraocular Lens with Adjustable Power Restoration of accommodation following cataract surgery. Technical Summary Accommodation is the ability of the eye to focus upon near objects. All individuals eventually lose this ability due a condition known as presbyopia, an age related loss of elasticity in the crystalline lens. Persons reaching this stage of life become dependent on reading glasses for close work. In a separate disorder, individuals experience a clouding of the lens due to cataract formation which can result in a total loss of vision. Replacement of dysfunctional crystalline lenses or cataracts and impleme...Tue, 24 Feb 2009 14:01:48 GMTott@emory.edu cDNA for the Human a 1d Subtype Adrenergic Receptor Study of adrenergic receptor disease; drug development. Technical Summary The diagnosis and treatment of Adrenergic Receptor (AR) diseases has been confounded by the variety of AR subtypes. Drs. Esbenshade and Minneman have successfully cloned the human Alpha 1d AR subtype, which is specific for cardiovascular tissue. This new clone will facilitate a better understanding of cardiovascular AR disease and provide a means for developing improved pharmaceuticals to manage the disease. Clinicians do not always appreciate the disparate efficacy of AR receptor pharmaceuticals. ...Tue, 24 Feb 2009 14:01:40 GMTott@emory.edu for the Human Propeptide/Prohormone Convertases PC1 and PC2, 24 Feb 2009 14:01:36 GMTott@emory.edu Phosphatase 2A Polyclonal Antibodies (R2, R42), 24 Feb 2009 14:01:36 GMTott@emory.edu Transporter cDNA and Cell Line Cloning and studying the serotonin transporter. Technical Summary This invention is the first cDNA clone encoding a serotonin transporter. The cDNA allows high-level expression of the transporter in non-neuronal eukaryotic and prokaryotic systems suitable for isolation of the protein. This invention has applications in the research and drug development regarding behavioral disorders and makes it possible to perform high-level structure analysis of serotonin uptake. This will allow for a precise study of the manner by which anti-depressants, cocaine, and amphetamine interac...Tue, 24 Feb 2009 14:01:35 GMTott@emory.edu and Cell Line for L-Proline Transporter Cloning and studying the L-proline transporter. Technical Summary This invention is the first cDNA clone encoding a L-proline transporter. The clone makes it possible to perform high-level structural analysis of L-proline uptake. The clone permits the generation of antibodies capable of specifically recognizing L-proline in the pathways in which it is expressed. The precise role of L-proline as a neurotransmitter is the subject of current investigation. Certain results suggest that L-proline plays a role in interacting with glutamatenergic neurons, possibly as an inhibitor....Tue, 24 Feb 2009 14:01:32 GMTott@emory.edu Fabric Catalysts for Air Purification, 24 Feb 2009 14:01:27 GMTott@emory.edu Cellular Model for Huntington's Disease Diagnosis and treatment of Huntington's disease. Technical Summary Huntington's disease (HD) is a genetically inherited disease that leads to progressive neurodegeneration, resulting in motor disturbances, loss of memory and cognition, and psychiatric manifestations. The underlying molecular and biochemical basis of HD are not fully understood, and consequently there is no treatment effective in delaying or preventing the onset and progression of this devastating disorder. HD cell models are useful tools in elucidating the mechanistic basis of HD. However, most of the rep...Tue, 24 Feb 2009 14:01:27 GMTott@emory.edu Novel Category of Bioactive Diiminopiperazines These methods and compositions will be useful in controlling the biological processes affected by sphingolipids and for the treatment of disease that have disorders involving cell regulatory pathways. Technical Summary Sphingolipids are a group of lipids found in all eukaryotic cells, as well as some prokaryotes and viruses. The structural backbone of the sphingolipids are sphingosine and other long-chain (sphingoid) bases and have been found to affect diverse cellular systems including, protein kinase C, Na+, K+-ATPase, phosphatidic acid phosphatase, phospholipases (including p...Tue, 24 Feb 2009 14:01:25 GMTott@emory.edu