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Enhanced Delivery and Efficacy of Antisense Drugs via Covalently Linked Nanodisc Scaffolds
Application
A synthetic nanodisc (ND) scaffold for delivering antisense oligonucleotides (ASOs) for the treatment of disease.
Key Benefits
Improved cellular uptake and protein suppression using antisense oligos.
Longer ASO half-life compared to other ASO delivery methods.
Potential to overcome the delivery and efficacy challenges using ASOs for...
Published: 4/23/2024
Contributor(s): Khalid Salaita, Radhika Sharma
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Repurposing a Potent MDM2 Inhibitor for Leukemia Treatment
Application
VERU-111, also known as sabizabulin, is a potent microtubule inhibitor and, notably, an MDM2 inhibitor. This repurposed compound demonstrates remarkable efficacy in the treatment of Acute Myeloid Leukemia (AML).
Key Benefits
Unique dual-action functionality as a microtubule and MDM2 inhibitor.
Successful inhibition of MDM2, an oncogene...
Published: 4/23/2024
Contributor(s): Deborah DeRyckere, Muxiang Zhou, Lu Bing Gu, Douglas Graham, Tao Liu
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Optimizing the Engineering of CAR-T Cells
Application
A method for selecting distinct T cell populations in order to generate more effective CAR-T cells.
Key Benefits
The proposed invention focuses on selecting the optimal “starting material” for the engineering CAR-T cells.
This selection method can be utilized for the development of any and all CAR-T therapies, not limited...
Published: 4/11/2024
Contributor(s): Byron Au-Yeung
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Liposome Encapsulated Tyrosine Kinase Inhibitors to Treat Leukemia
Application
Lipid encapsulation of MRX-2843 for the treatment of leukemia.
Key Benefits
Encapsulation of a tyrosine kinase inhibitor called MRX-2843 within a liposome improves its performance in an animal model of acute lymphoblastic leukemia.
Systemic delivery of this therapeutic requires a lower dose and less frequent administration than oral...
Published: 4/23/2024
Contributor(s): Erik Dreaden, James Kelvin, Deborah DeRyckere, Douglas Graham, Juhi Jain
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Indolium 1 for Advanced Melanoma Treatment
Application
A small molecule compound for the treatment of melanoma.
Key Benefits
Novel small molecule compound for the treatment of resistant melanoma.
Well tolerated in vivo.
Market Summary
Malignant melanoma is a type of skin cancer that begins in melanocyte cells. Melanoma is the 19th most commonly occurring cancer. Exposure to UV radiation...
Published: 1/17/2024
Contributor(s): Jack Arbiser
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Drug Platform for L-Asparaginases for the Treatment of Leukemias
Application
A novel humanized therapeutic L-asparaginase compound to treat acute lymphoblastic leukemia (ALL) and other cancers.
Key Benefits
A novel drug discovery platform for developing asparaginase-based compounds to treat leukemias and other cancers.
The derivatives could exhibit less immunogenicity and systemic toxicity than FDA-approved...
Published: 3/1/2024
Contributor(s): Sunil Raikar, Christopher Doering, H. (Harold) Trent Spencer, Kristopher Knight, Harrison Brown
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Markers Predictive of Therapeutic Response in B-cell Malignancies
Application
Test to detect NF-kB2 breaks to guide treatment with proteasome inhibitors and its use with other therapeutic agents.
Key Benefits
Improved the prediction model to determine which patients are more likely to respond to bortezomib treatment.
Improved the efficacy of treatment for patients with multiple myeloma and lymphomas.
Market...
Published: 4/23/2024
Contributor(s): Leon Bernal-Mizrachi
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Artificial Neural Network for Prediction of Clinical Outcomes
Application
A machine learning model to predict the need for ventriculoperitoneal shunt after posterior fossa tumor resection.
Key Benefits
Highly accurate prediction of post-surgical complications.
Reducing healthcare costs by predicting prognoses and increasing efficiency of post-surgical treatment.
Market Summary
Neurosurgical procedures...
Published: 11/27/2023
Contributor(s): Kimberly Hoang, Ali Alawieh, David Bray
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Pig Lentiviral-Induced Spinal Cord Glioblastoma
Application
Porcine model of spinal cord glioblastoma for the development and testing of pre-clinical therapeutic for spinal cord tumors.
Key Benefits
Novel lentiviral gene transfer offers a viable pathway to modeling glioblastoma in higher order species.
The existing model is the first reproducible immunocompetent large animal model of spinal...
Published: 4/23/2024
Contributor(s): Muhibullah (Mohib) Tora, Pavlos Texakalidis, Thais Buchman, Nicholas Boulis
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Vaccines and Antibody Therapeutics for HPV-related Cancers
Application
Treatment and prevention of HPV-induced malignancies.
Key Benefits
Identification of a protein expressed in a large number of HPV-induced cancers.
Antibodies have been generated that bind to the protein and potentially elicit an immune response to the cancer cells.
The antibodies can be used to develop new treatments and vaccines...
Published: 4/23/2024
Contributor(s): Rafi Ahmed, Andreas Wieland
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