Rabbit Polyclonal Antipike Antibody


  • Immunoblotting
  • Immunoprecipitation
  • Immunofluorescence


Rabbit Polyclonal Anti-PIKE Antibody



Technical Summary

PIKE-activating Akt (PIKE-A), an isoform of PIKE GTPase that enhances phosphatidyl- inositol 3-kinase (PI3-kinase) activity. PIKE will specifically binds to active Akt but not PI3-kinase. PIKE-A stimulates Akt activity in a GTP-dependent manner and promotes invasive- ness of cancer cell lines. PIKE-A is amplified in a variety of human cancers and that amplified PIKE-A directly stimulates Akt and inhibits apoptosis compared to cells with normal PIKE-A copy number. Overexpression of PIKE-A wild-type but not dominant-negative mutant stimulates Akt activity and prevents apoptosis. Moreover, knockdown of PIKE-A diminishes Akt activity and increases apoptosis. It is suggested that PIKE-A amplification may contribute to cancer cell survival and progression by inhibiting apoptosis through up regulating Akt.


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J. Cell Sci. 117: Pt. 2: 155-161 (2004).

Patent Information

Tech ID: 05004
Published: 3/26/2009