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Smartphone Diagnostic for Rapid Respiratory Virus Detection
Application
Diagnostic and automatic surveillance platform to identify RSV, Influenza A, and COVID-19 in real-time.
Key Benefits
Rapid smartphone-based detection of multiple respiratory viruses in nasal swab, breath condensate, and saliva.
Requires few reagents and no expensive equipment.
Limit of detection on par with PCR and rapid readout.
Enables...
Published: 11/20/2024
Contributor(s): Selma Piranej, Khalid Salaita
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Drug Platform for L-Asparaginases for the Treatment of Leukemias
Application
A novel humanized therapeutic L-asparaginase compound to treat acute lymphoblastic leukemia (ALL) and other cancers.
Key Benefits
A novel drug discovery platform for developing asparaginase-based compounds to treat leukemias and other cancers.
The derivatives could exhibit less immunogenicity and systemic toxicity than FDA-approved...
Published: 11/20/2024
Contributor(s): Sunil Raikar, Christopher Doering, H. (Harold) Trent Spencer, Kristopher Knight, Harrison Brown
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Automated Sleep Analysis Using Cardiovascular Signals
Application
Sleep stage classification algorithm and diagnostic platform.
Key Benefits
Real-time sleep classification using a single electrocardiogram sensor.
Eliminates the need for multiple head, eye, skin, and heart sensors with current diagnostics.
Preliminary results using human data demonstrate high accuracy in identifying different sleep...
Published: 9/26/2024
Contributor(s): Gari Clifford, Shamim Nemati, Qiao Li, Supreeth Shashikumar
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Machine Learning Diagnostic for Automated Identification and Classification of Bone Marrow Cells
Application
Machine learning tool to aid in the diagnosis of hematologic disorders of bone marrow.
Key Benefits
Automated machine learning-based approach for performing bone marrow differential counts that accounts for all viable cells on the smear.
Data generated by a prototype shows the system is fast and demonstrates precision compared to manual...
Published: 10/17/2024
Contributor(s): Lee Cooper, David Gutman, David Jaye, Ahmed Aljudi, Ramraj Chandradevan
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Improving CAR T cell efficacy with Cytokine-Loaded Microparticles
Application
Novel reagents for manufacturing of CAR T cells with improved characteristics.
Key Benefits
A multi-cytokine backpack particle that can be used during manufacturing process of CAR T treatments to improve their phenotype and efficacy.
Preliminary data show the method can transduce primary healthy and patient T cells and promote CAR...
Published: 11/20/2024
Contributor(s): Sarwish Rafiq, Erik Dreaden, A K M Nawshad Hossian, Biaggio Uricoli
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Liquid-hydrogel Hybrid Microfluidic Device
Application
Measurement device for detecting of single-cell dynamics under environment perturbations or drug treatment.
Key Benefits
Fast determination of drug sensitivity.
Long-term continuous cell-fate tracking.
Time-lapse analysis of cell proliferation.
Cell community analysis: intra-species interactions, inter-species interactions.
Market...
Published: 10/17/2024
Contributor(s): Kyle Allison, Xin Fang, Devina Puri
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Microfluidic and Organotypic Tumor Slice Culture Drug Testing Platform for Individualized Cancer Therapy
Application
A drug combination screening/testing platform for individualized cancer therapy.
Key Benefits
Rapid screening of effective drug combination.
Integrated tumor microenvironment.
Identifying personalized therapy for individual cancer patient.
Market Summary
Traditional two-dimensional (2D) in vitro culture models for drug development...
Published: 10/28/2024
Contributor(s): Tobey John MacDonald, Anna Kenney, Abhinav Dey, YongTae (Tony) Kim
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Using Mobile Location Data to Construct Large Social Networks
Application
A software model for generating colocalization information from mobile data and constructing a social network.
Key Benefits
Software that can be licensed.
Constructs social networks from any mobile location data.
Largely reducing the total computational time by over 20 times.
Scalable to extremely high data volumes.
Market...
Published: 10/17/2024
Contributor(s): David Schweidel, Hanyu Zhang, Kunpeng Zhang
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A New Method to Detect and Tackle Antibiotic Heteroresistance
Application
A method to detect heteroresistance to antibiotics in bacteria.
Key Benefits
Significantly faster than commercially available options.
Aside from the interferometer itself, no specialized reagents are required.
Inexpensive to use.
Market Summary
Antibiotic resistance is a significant threat to public health. Rapid and sensitive...
Published: 10/17/2024
Contributor(s): David Weiss, Peter Yunker, David Hufnagel, Arben (Ben) Kalziqi
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Ribosome Pegging: An Antibiotic-free System to Produce Recombinant Proteins
Application
Antibiotic-free method to prevent the growth of cells that fail to express high levels of a non-essential protein (target protein).
Key Benefits
Prevents the use of antibiotics and markers that promote resistance.
Facilitates the deployment of recombinant bacteria in uncontrolled environments.
Stabilizes heterologous expression of...
Published: 9/26/2024
Contributor(s): Ichiro Matsumura
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