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Engineering Asymmetrically Glycosylated IgG Antibodies
Application
A method to produce asymmetrically glycosylated antibodies for the treatment and prevention of diseases including cancer, auto-immune disorders, and infectious diseases.
Key Benefits
This strategy has potential to produce a new class of therapeutic antibodies for treating and preventing a wide range of human diseases.
Market Summary
Monoclonal...
Published: 6/22/2026
Contributor(s): Tala Azzam, Eric J. Sundberg, Jonathan Du, Diego Sastre
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Tinker Tales: Interactive AI Storytelling for Early Learners
Application
A hybrid tangible-digital storytelling platform designed to teach artificial intelligence (AI) literacy to children aged 5 through 8.
Key Benefits
Provides a hands-on, developmentally appropriate learning experience for young children, enhancing engagement and retention.
Enables dynamic, real-time co-creation of stories, fostering...
Published: 6/15/2026
Contributor(s): Jinho Choi, Ikseon (Ike) Choi, Nayoung Choi
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DNA EndosomaL Escape Vehicle Response (DELVR) as a Platform to Boost Antisense Oligonucleotide (ASO) Efficacy
Application
A versatile delivery platform for antisense oligonucleotides (ASOs) enabling transient downregulation of protein expression.
Key Benefits
Broadly boost the efficacy of nucleic acid-based drugs.
Drastic reduction in toxicity.
DELVR strategy can rescue clinically tested ASOs that didn’t progress to FDA approval due to off-target...
Published: 5/22/2026
Contributor(s): Steven Narum, Khalid Salaita
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Next Gen Immune-Optimized Gene Delivery
Application
An advanced gene therapy approach that improves therapeutic efficiency by protecting transgene expressing cells from host immune responses, through modulation of a key immune checkpoint pathway.
Key Benefits
Enhanced efficiency across viral and non-viral gene delivery systems, including AAV, lentivirus, LNPs, and electroporation.
Enables...
Published: 6/15/2026
Contributor(s): Matthew (Matt) Gardner, Michael Kuipa, Abubakarr Koroma, Isai Leguizamo
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Non-invasive Diagnostic for Meningiomas
Application
A non-invasive molecular diagnostic tool that reliably predicts the tumor characteristics and risk of recurrence of meningiomas.
Key Benefits
Combines meningioma gene expression data, construction of a gene interaction network, and tumor histology data to diagnose and predict clinical outcomes.
Complete analytical handling from specimen...
Published: 1/28/2026
Contributor(s): Ali Alawieh, Youssef Ismail, Tomas Garzon-Muvdi
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Smartphone Diagnostic for Rapid Respiratory Virus Detection
Application
Diagnostic and automatic surveillance platform to identify RSV, Influenza A, and COVID-19 in real-time.
Key Benefits
Rapid smartphone-based detection of multiple respiratory viruses in nasal swab, breath condensate, and saliva.
Requires few reagents and no expensive equipment.
Limit of detection on par with PCR and rapid readout.
Enables...
Published: 6/15/2026
Contributor(s): Selma Piranej, Khalid Salaita
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Next Generation L-Asparaginase Cancer Therapeutics
Application
A humanized therapeutic L-asparaginase compound to treat acute lymphoblastic leukemia (ALL) and other cancers.
Key Benefits
Human‑aligned variants may reduce immunogenicity and systemic toxicity compared to current FDA‑approved asparaginase drugs.
Opportunity to improve treatment outcomes by minimizing the severe hypersensitivity reactions...
Published: 5/22/2026
Contributor(s): Sunil Raikar, Christopher Doering, H. (Harold) Trent Spencer, Kristopher Knight, Harrison Brown
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Improving CAR T cell efficacy with Cytokine-Loaded Microparticles
Application
Novel reagents for manufacturing of CAR T cells with improved characteristics.
Key Benefits
A multi-cytokine backpack particle that can be used during manufacturing process of CAR T treatments to improve their phenotype and efficacy.
Preliminary data show the method can transduce primary healthy and patient T cells and promote CAR...
Published: 9/3/2025
Contributor(s): Sarwish Rafiq, Erik Dreaden, A K M Nawshad Hossian, Biaggio Uricoli
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Liquid-hydrogel Hybrid Microfluidic Device
Application
Measurement device for detecting of single-cell dynamics under environment perturbations or drug treatment.
Key Benefits
Fast determination of drug sensitivity.
Long-term continuous cell-fate tracking.
Time-lapse analysis of cell proliferation.
Cell community analysis: intra-species interactions, inter-species interactions.
Market...
Published: 1/20/2026
Contributor(s): Kyle Allison, Xin Fang, Devina Puri
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Antisense Oligonucleotides Therapeutics Targeting Specific Tissues or Cells
Application
Antisense oligonucleotide (ASO) therapies for the treatment of rare diseases and cancer.
Key Benefits
Novel approach to ASO therapeutics that potentially improve tissue/cell targeting capabilities.
Increases the efficacy of ASOs while decrease off-target toxicity.
Potential to treat a variety of genetic diseases such as cancer, blood...
Published: 3/10/2026
Contributor(s): Jiahui Zhang, Khalid Salaita, Hanjoong Jo
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