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Biodegradable Nanoparticle Encapsulating Anti-Cancer Drug for the Treatment of Therapy-Resistant Cancers
Application
A targeted polymeric nanoparticle drug that inhibits NADPH Oxidase (NOX1/4)-Reactive oxygen species (ROS) signal for the treatment of chemotherapy drug and radiotherapy resistant cancers.
Key Benefits
Inhibits tumor growth.
Dual chemo-and radiotherapy enhancer.
Excellent biocompatibility and stability.
CD44 targeted drug delivery...
Published: 2/13/2025
Contributor(s): Lily Yang, Lei Zhu
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Engineering Tighter Binding Spherical Nucleic Acids
Application
Method to enhance the affinity of spherical nucleic acids for their targets.
Key Benefits
Facile method for molecular printing on surface of NP.
Massive improvement of SNA’s binding affinity to the target can provide strategies in applications for therapeutics and diagnostics.
May maximize DNA density on the NP surface.
Market...
Published: 2/13/2025
Contributor(s): Brendan Deal, Khalid Salaita
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Targeted Theranostic NanoToxin for Treating Metastatic and Drug-resistant Tumors
Application
Magnetic theranostic nano-toxin for imaging and drug delivery applications in cancer therapy.
Key Benefits
Induces tumor cell death via a different biological mechanism, compared to current chemotherapeutics, to overcome drug resistance mechanisms in tumor cells.
Delivers high levels of therapeutic agents into metastatic tumors, while...
Published: 2/13/2025
Contributor(s): Lily Yang, Xiangxue Guo, Hui Mao, Wei Chen
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GeneRegs: Nanoparticles for Treatment of Severe Asthma
Application
Gold nanoparticles coated with enzyme which specifically targets and degrades asthma-associated inflammation molecules.
Key Benefits
Specifically suppresses asthma associated inflammation.
Easy self-administration by inhalation.
Market Summary
Asthma is defined as a chronic inflammatory lung disease with significant worldwide morbidity....
Published: 2/13/2025
Contributor(s): Khalid Salaita, Cherry Wongtrakool, Kornelia Galior
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Anti-biofouling Polymer for Nanoparticle Coating
Application
A functionally amenable copolymer of polyethylene glycol (PEG) and allyl glycidyl ether (AGE) that improves the specificity and targeting of nanoparticles compared to PEG coating.
Key Benefits
Amphiphilic properties significantly reduce non-specific adsorbtion of proteins compared to PEG.
Improves targeting and cell-specific uptake...
Published: 2/13/2025
Contributor(s): Hui Mao, Yuancheng Li, Lily Yang
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Layer-by-layer Assembled Nanoparticles for Oral Drug Delivery
Application
Layered, casein coated magnetic nanoparticles for oral delivery of drugs protected from acid degradation.
Key Benefits
Enables oral delivery of hydrophobic drugs that are sensitive to acid degradation in stomach condition.
Replaces injections and infusions, reducing side effects and improving patient’s quality of life.
Allows...
Published: 2/13/2025
Contributor(s): Hui Mao, Jing Huang
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A Ligand-Protease Fusion Peptide for Enhanced Tumor Targeting and Drug Delivery
Application
A ligand-protease fusion peptide that cuts through the tumor stromal barrier and provides enhanced tumor targeting and delivery efficiency for therapeutic agents.
Key Benefits
The protease activity of the fusion peptide enables breaking of the stromal matrix and allows migration into stroma-rich tumor tissues.
Can be attached to nanoparticles...
Published: 2/13/2025
Contributor(s): Lily Yang, Xiangxue Guo
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