18 Results

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Dual Mobility Femur Prosthetic to Reduce Post-Operative Hip Dislocation Application A new design of a modular hip implant with a rotational proximal junction in the femoral stem to minimize post-operative hip dislocation. Benefits Rotating femoral component alleviates torsional strain on implant, a primary cause of implant impingement and failure. Market Summary Peri-prosthetic hip dislocation is the number one... Published: 11/20/2024       Contributor(s): George Guild, III

Predicting Treatment Response in Patients with Spinal Muscular Atrophy (SMA) Application Prognostic model predicts treatment response to nusinersen (Spinraza®) in patients with spinal muscular atrophy. Key Benefits A prediction model using baseline CHOP-INTEND, IL-8, fractalkine, and MCP-1 accurately predicts CHOP-INTEND outcomes in children treated with nusinersen The model can also be incorporated into future therapeutic... Published: 11/20/2024       Contributor(s): William Hu, Sumit Verma

Three-piece Partially Biodegradable Screw for Use in Ankle Surgery Application Three-piece, partially biodegradable cannulated screw for use in syndesmosis ankle surgery. Key Benefits Implant removal is not necessary. Allows for both rigid initial fixation to allow syndesmotic healing and physiologic micro motion at the syndesmosis for long term support and function. Higher biomechanical strength than absorbable... Published: 7/30/2024       Contributor(s): Jason Bariteau, Marissa McLaren, John Watson, Tyler Jenkins, Matthew (Matt) Metzger, Yuen Bak Ching

Myosoft: Automated Muscle Histology Analysis Application Software to automatically measure muscle fiber types and sizes. Key Benefits Accurately identify and characterize different muscle fiber types within a sample. Market Summary Despite generations of technological advancements in disease interpretation and testing technologies, accurate diagnosis of myopathy remains a challenge. Myopathy,... Published: 10/28/2024       Contributor(s): Hyojung Choo, H. Criss Hartzell, Jr., Lucas Encarnacion-Rivera, Steven Foltz

Autoencoding Neural Networks with Applications to Brain-machine Interfaces Application Machine learning software for brain-machine interface and neuro-stimulation device-controlling. Key Benefits Significantly improves machine learning performance by minimizing overfitting. Market Summary In machine learning (ML), autoencoder, a type of unsupervised artificial neural network, attempts to learn efficient data coding.... Published: 11/20/2024       Contributor(s): Chethan Pandarinath, Mohammad Reza Keshtkaran

TGFβR3-based Biomaterial to Treat Bone Damage Application PEG-MAL (Poly(ethylene glycol) methyl ether maleimide) polymer gel composition containing soluble TGFβ3R or embedded with modified TGFβ3R over-expressing cells for bone growth and repair therapy. Key Benefits Targets a non-BMP2 signaling pathway to improve BMP signaling. Avoids complications associated with BMP2. Market... Published: 7/30/2024       Contributor(s): Steven Goudy

ADGRB3/BAI3 Knockout Mouse ApplicationKnockout mouse models for adhesion G protein-coupled receptors B3, brain-specific angiogenesis inhibitor-3 (ADGRB3/BAI3) gene study.Technical SummaryEmory University researchers have developed a knockout mouse model for the ADGRB3/BAI3 gene. Mice were generated by CRISP/cas9 technology on C57Bl6 background. These mice can be used to study... Published: 10/28/2024       Contributor(s): Erwin Van Meir

Surgical Device for Eyelid Ptosis Correction ApplicationSurgical device to perform clamping, incision, and closure for correcting eyelid ptosis.Key BenefitsSimplifies the Müller muscle resection that decreases surgical procedure time.Eliminates the risk of cutting sutures that cause dehiscence and improves the final appearance.Market SummaryPtosis (drooping upper eyelids) is a common condition... Published: 9/26/2024       Contributor(s): Denise Kim, Jacquelyn Borinski, Andrew Kolpitcke, Mohamad Ali Naja, Drew Padilla

Knock-In Mouse Model of Oculopharyngeal Muscular Dystrophy ApplicationConditional knock-in mouse mimicking Oculopharyngeal muscular dystrophy.Technical SummaryOculopharyngeal muscular dystrophy (OPMD) is rare genetic disease caused by a mutation in the PABPN1 gene. In this mutation, the number of GCG trinucleotide repeats at the 5' end of PABPN1 are increased, which leads to an expansion of an alanine repeat... Published: 10/28/2024       Contributor(s): Grace Pavlath, Anita Corbett, Katherine Vest

Repurposed Small Molecules that Promote Osteogenesis Application Repurposed small molecules for use as a bone forming therapeutic during treatment of diseases requiring local bone formation such as fracture repair, spinal fusion, and large segmental bone defects. Key Benefits Current treatments require high concentrations of bone morphogenetic protein (BMP) which results in high costs, adverse side... Published: 7/30/2024       Contributor(s): Scott Boden, Sreedhara Sangadala

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