5 Results

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ADGRB3/BAI3 Knockout Mouse ApplicationKnockout mouse models for adhesion G protein-coupled receptors B3, brain-specific angiogenesis inhibitor-3 (ADGRB3/BAI3) gene study.Technical SummaryEmory University researchers have developed a knockout mouse model for the ADGRB3/BAI3 gene. Mice were generated by CRISP/cas9 technology on C57Bl6 background. These mice can be used to study... Published: 10/28/2024       Contributor(s): Erwin Van Meir

Surgical Device for Eyelid Ptosis Correction ApplicationSurgical device to perform clamping, incision, and closure for correcting eyelid ptosis.Key BenefitsSimplifies the Müller muscle resection that decreases surgical procedure time.Eliminates the risk of cutting sutures that cause dehiscence and improves the final appearance.Market SummaryPtosis (drooping upper eyelids) is a common condition... Published: 12/4/2024       Contributor(s): Denise Kim, Jacquelyn Borinski, Andrew Kolpitcke, Mohamad Ali Naja, Drew Padilla

Knock-In Mouse Model of Oculopharyngeal Muscular Dystrophy ApplicationConditional knock-in mouse mimicking Oculopharyngeal muscular dystrophy.Technical SummaryOculopharyngeal muscular dystrophy (OPMD) is rare genetic disease caused by a mutation in the PABPN1 gene. In this mutation, the number of GCG trinucleotide repeats at the 5' end of PABPN1 are increased, which leads to an expansion of an alanine repeat... Published: 10/28/2024       Contributor(s): Grace Pavlath, Anita Corbett, Katherine Vest

Small Molecule Therapeutic for Regeneration of Cartilage ApplicationSmall molecule therapeutic that can be delivered locally to enhance TGF-beta activity and promote cartilage growth.Key BenefitsIncreases production of protease inhibitors, simultaneously stimulating production and blocking degradation of extracellular matrix (ECM). Potentially reduces or eliminates need for joint replacements by regenerating... Published: 12/4/2024       Contributor(s): Scott Boden, Sreedhara Sangadala

Nematode Model of Nemaline Myopathy Application An invertebrate animal model of nemaline myopathy using Caenorhabditis elegans. Key Benefits C. elegans with pathological mutations of tropomyosin that cause nemaline myopathy. Technical Summary Nemaline myopathy, or rod myopathy, is a congenital and hereditary neuromuscular disorder that causes muscle weakness of varying severity.... Published: 11/20/2024       Contributor(s): Shoichiro Ono