Technology Listings


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Small Molecules to Promote Bone Growth
Application Small molecule sclerostin-inhibitors to enhance the canonical Wnt pathways and promote BMP-induced osteoblast differentiation. Key Benefits Repurposing opportunities of FDA approved drugs. Lower cost compared to currently available monoclonal antibody or recombinant protein therapies. Stable compounds with established safety profiles...
Published: 12/3/2019       Inventor(s): Scott Boden, Steven Presciutti, Sreedhara Sangadala
Autoencoding Neural Networks with Applications to Brain-machine Interfaces
Application Machine learning software for brain-machine interface and neuro-stimulation device-controlling. Key Benefits Significantly improves machine learning performance by minimizing overfitting. Market Summary In machine learning (ML), autoencoder, a type of unsupervised artificial neural network, attempts to learn efficient data coding....
Published: 11/22/2019       Inventor(s): Chethan Pandarinath, Mohammadreza Keshtkaran
TGFβR3-based Biomaterial to Treat Bone Damage
Application PEG-MAL (Poly(ethylene glycol) methyl ether maleimide) polymer gel composition containing soluble TGFβ3R or embedded with modified TGFβ3R over-expressing cells for bone growth and repair therapy. Key Benefits Targets a non-BMP2 signaling pathway to improve BMP signaling. •Avoids complications associated with BMP2. Market Summary Whether...
Published: 9/20/2019       Inventor(s): Steven Goudy
ADGRB3/BAI3 Knockout Mouse
ApplicationKnockout mouse models for adhesion G protein-coupled receptors B3, brain-specific angiogenesis inhibitor-3 (ADGRB3/BAI3) gene study.Technical SummaryEmory University researchers have developed a knockout mouse model for the ADGRB3/BAI3 gene. Mice were generated by CRISP/cas9 technology on C57Bl6 background. These mice can be used to study...
Published: 7/9/2019       Inventor(s): Erwin Van Meir
ADGRB1/BAI1 Knockout Mouse
ApplicationKnockout mouse models for adhesion G protein-coupled receptors B1, brain-specific angiogenesis inhibitor-1 (ADGRB1/BAI1) gene study.Technical SummaryEmory University researchers have developed a knockout mouse model for the ADGRB1/BAI1 gene. These mice were developed through homologous recombination and have LacZ gene knock-in. Mice were...
Published: 7/9/2019       Inventor(s): Erwin Van Meir
Surgical Device for Eyelid Ptosis Correction
ApplicationSurgical device to perform clamping, incision, and closure for correcting eyelid ptosis.Key BenefitsSimplifies the Müller muscle resection that decreases surgical procedure time.Eliminates the risk of cutting sutures that cause dehiscence and improves the final appearance.Market SummaryPtosis (drooping upper eyelids) is a common condition...
Published: 6/18/2019       Inventor(s): Denise Kim, Jacquelyn Borinski, Andrew Kolpitcke, Mohamad Ali Naja, Drew Padilla
Femoroplasty Device that Repairs the Hip Bone
Application Less invasive surgical alternative to a total hip replacement (THR) that restores the shape and function of the hip joint. Key Benefits Requires less invasive surgery of the hip, reducing recovery time. Prevents the patient from needing a THR or delays it for at least 10 years. Less expensive than a THR. Market Summary The femoral...
Published: 3/4/2019       Inventor(s): Zachary Bercu, Janice Newsome, Jonathan Martin, Elizabeth Marr, Nicholas Arce, Kathryn Martin
Knock-In Mouse Model of Oculopharyngeal Muscular Dystrophy
ApplicationConditional knock-in mouse mimicking Oculopharyngeal muscular dystrophy.Technical SummaryOculopharyngeal muscular dystrophy (OPMD) is rare genetic disease caused by a mutation in the PABPN1 gene. In this mutation, the number of GCG trinucleotide repeats at the 5' end of PABPN1 are increased, which leads to an expansion of an alanine repeat...
Published: 9/27/2018       Inventor(s): Grace Pavlath, Anita Corbett, Katherine Vest
Repurposed Small Molecules that Promote Osteogenesis
ApplicationRepurposed small molecules for use as a bone forming therapeutic during treatment of diseases requiring local bone formation such as fracture repair, spinal fusion, and large segmental bone defects. Key BenefitsCurrent treatments require high concentrations of bone morphogenetic protein (BMP) which results in high costs, adverse side effects,...
Published: 4/14/2016       Inventor(s): Scott Boden, Sreedhara Sangadala
Small Molecule Therapeutic for Regeneration of Cartilage
ApplicationSmall molecule therapeutic that can be delivered locally to enhance TGF-beta activity and promote cartilage growth.Key BenefitsIncreases production of protease inhibitors, simultaneously stimulating production and blocking degradation of extracellular matrix (ECM). Potentially reduces or eliminates need for joint replacements by regenerating...
Published: 6/1/2015       Inventor(s): Scott Boden, Sreedhara Sangadala
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