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3D Model for Analysis and Treatment Planning of Vascular Disease
Application A patient-specific, 3D model of pulmonary atresia for surgical planning. Key Benefits Patient-specific model. Allows for accurate surgical planning. Enables new anastomosis procedure. Market Summary Pulmonary atresia (PA), ventricular septal defect (VSD) with major aortopulmonary collateral arteries (MAPCAs) is a rare congenital...
Published: 12/8/2020       Contributor(s): Vahid Serpooshan, Holly Bauser-Heaton, Martin Tomov
Small Molecule for Treatment or Prevention of Uremic Cardiomyopathy
Application Small molecule urea transporter (UT) inhibitors to treat or prevent conditions associated with chronic kidney disease. Key Benefits Provides a cardio-protective benefit in CKD patients. Suppresses cardiac hypertrophy and fibrosis. Market Summary Cardiovascular complications commonly occur in patients with chronic kidney disease...
Published: 11/2/2020       Contributor(s): Jeff Sands, Janet Klein, Xiaonan Wang
Therapeutic Compounds Inhibiting DUSP5 and DUSP6 for Cardiomyocyte Proliferation and Cardiac Regeneration
Application Therapeutics using siRNAs and small molecules to treat congenital heart defect and myocardial injuries. Key Benefits Reactivates cardiomyocyte (CM) cell replication, allowing regeneration of heart muscle after cardiac injuries. Therapeutic compounds may be administered for transient regeneration/repair of heart muscle after cardiac...
Published: 4/22/2020       Contributor(s): Ahsan Husain, Nawazish Naqvi
Torque Device for Procedures Using Guidewire
Application Torque device for one-handed manipulation of guidewire during endovascular, interventional and catheterization lab procedures. Key Benefits Enables single-person, one-handed use. Prevents ejection of guidewire during torque device removal. Allows placement of torque device anywhere on the wire. Market Summary Interventional procedures,...
Published: 1/28/2020       Contributor(s): Yuriy Aranbayev, William Jordan, Jr.
Beta Blocker Isomers as Angiogenesis Inhibitors
Application β-blocker inactive form of propranolol for treatment of angiogenic disease. Key Benefits Reduced side-effects, such as low blood pressure and low blood sugar. Increased anti-angiogenic activity compared to the active isoform. Market Summary Angiogenesis is the growth of blood vessels from the existing vasculature. While it...
Published: 7/29/2019       Contributor(s): Jack Arbiser
Small Molecule Inhibitors of NADPH Oxidase 4 (NOX4) Signaling
ApplicationSmall molecule inhibitors of NOX4 signaling with a wide array of therapeutic potential.Key BenefitsSmall molecule inhibitors of NOX4 signaling.Low cytotoxicity.Market SummaryThe NADPH oxidase 4 (NOX4) has gained considerable and growing attention during the past years because of its potential key involvement in a variety of diseases, some...
Published: 5/13/2019       Contributor(s): Bernard Lassegue, Kathy Griendling, David Brown, Qian Xu, Osman Guner, J. Phillip Bowen, Amol Kulkarni, E. Blake Watkins
Software for Extended and Accurate Analysis of Biomedical Signals
ApplicationComputational method designed for accurate rhythm sensing with reduced energy consumption of wireless body sensor network (WBSN) medical devices.Key BenefitsCompressed data collection reduces power consumption and addresses power needs of small devices.Addresses power needs of small devices.Increases device longevity.Market SummaryAtrial...
Published: 1/23/2019       Contributor(s): Giulia Da Poian, Roberto Rinaldo, Gari Clifford
Small Molecules for Development of Cardiac Chamber-Specific Myocytes
Application Small molecule activators and inhibitors of retinoic acid (RA) to create chamber-specific myocytes from pluripotent stem cells without cell sorting. Key Benefits Produces highly-enriched, subtype-specific populations of cardiac myocytes. Eliminates need for cell-sorting. Does not require transgenic changes to the human stem cells. Market...
Published: 11/16/2018       Contributor(s): Hee Cheol Cho, Pengcheng Han
Biological Pacemakers as Alternatives/Adjuncts to Electronic Pacing Devices
Application Non-viral gene delivery and a small molecule that converts heart muscle cells to pacemaker cells for the device-free treatment of slow heart rhythm. Key Benefits Minimally invasive procedure provides cardiac pacing without device implant. Restores natural heart rhythm. Eliminates or reduces significant complications such as repeat...
Published: 11/16/2018       Contributor(s): Hee Cheol Cho, Jun Li
Cre-Lox PAR1 Conditional Knockout Mouse
Key BenefitsTissue-specific knockout mouse, allowing PAR1 to be inactivated in specific cell types in certain tissue.Inducible knockout mouse, allowing PAR1 to be temporally suppressed at a given time-point in embryonic, post-natal or adult animals.Eliminates drawbacks and side effects of traditional knockout processes that eliminate genes from the...
Published: 6/26/2018       Contributor(s): Stephen Traynelis
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