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Automated Sleep Analysis Using Cardiovascular Signals
Application
Sleep stage classification algorithm and diagnostic platform.
Key Benefits
Real-time sleep classification using a single electrocardiogram sensor.
Eliminates the need for multiple head, eye, skin, and heart sensors with current diagnostics.
Preliminary results using human data demonstrate high accuracy in identifying different sleep...
Published: 9/26/2024
Contributor(s): Gari Clifford, Shamim Nemati, Qiao Li, Supreeth Shashikumar
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Use of miRNA-483 and its Target Genes in Treatment of Cardiovascular and Inflammatory Diseases
Application
Therapeutic use of miR-483 mimic for treating aortic valve clarification.
Key Benefits
MiR-483 or mimics of miR-483 could be used as a therapeutic.
Could also be a target for additional drug development toward a non-invasive therapy for aortic valve calcification.
Market Summary
Aortic stenosis (AS) is the most common type of heart...
Published: 11/20/2024
Contributor(s): Hanjoong Jo, Joan Fernandez Esmerats, Nicolas (Nico) Villa-Roel
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Biocompatible Nanoreporter for Measuring Fluidic Shear Stress
Application
A research tool for quantifying fluidic shear stress in vitro and in vivo.
Key Benefits
Directly measures sub-cellular shear stress from 0.5 dynes/cm2 to 100 dynes/cm2.
Can target specific ligands of interest.
Compatible with existing fluorescent approaches.
Flexible design allows for multiple modifications for a variety of...
Published: 7/30/2024
Contributor(s): David Myers, Yonggang Ke, Victor Pan, Shreyas Dahotre, Gabriel (Gabe) Kwong
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3D Model for Analysis and Treatment Planning of Vascular Disease
Application
A patient-specific, 3D model of pulmonary atresia for surgical planning.
Key Benefits
Patient-specific model.
Allows for accurate surgical planning.
Enables new anastomosis procedure.
Market Summary
Pulmonary atresia (PA), ventricular septal defect (VSD) with major aortopulmonary collateral arteries (MAPCAs) is a rare congenital...
Published: 12/4/2024
Contributor(s): Vahid Serpooshan, Holly Bauser-Heaton, Martin Tomov
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Torque Device for Procedures Using Guidewire
Application
Torque device for one-handed manipulation of guidewire during endovascular, interventional and catheterization lab procedures.
Key Benefits
Enables single-person, one-handed use.
Prevents ejection of guidewire during torque device removal.
Allows placement of torque device anywhere on the wire.
Market Summary
Interventional procedures,...
Published: 7/30/2024
Contributor(s): Yuriy Aranbayev, William Jordan, Jr.
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Small Molecule Inhibitors of NADPH Oxidase 4 (NOX4) Signaling
Application
Small molecule inhibitors of NOX4 signaling with a wide array of therapeutic potential.
Key Benefits
Small molecule inhibitors of NOX4 signaling.
Low cytotoxicity.
Market Summary
The NADPH oxidase 4 (NOX4) has gained considerable and growing attention during the past years because of its potential key involvement in a variety of...
Published: 10/28/2024
Contributor(s): Bernard Lassegue, Kathy Griendling, David Brown, Qian Xu, Osman Guner, J. Phillip Bowen, Amol Kulkarni, E. Blake Watkins
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Biological Pacemakers as Alternatives/Adjuncts to Electronic Pacing Devices
Application
Non-viral gene delivery and a small molecule that converts heart muscle cells to pacemaker cells for the device-free treatment of slow heart rhythm.
Key Benefits
Minimally invasive procedure provides cardiac pacing without device implant.
Restores natural heart rhythm.
Eliminates or reduces significant complications such as repeat...
Published: 11/20/2024
Contributor(s): Hee Cheol Cho, Jun Li
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Cre-Lox PAR1 Conditional Knockout Mouse
Key BenefitsTissue-specific knockout mouse, allowing PAR1 to be inactivated in specific cell types in certain tissue.Inducible knockout mouse, allowing PAR1 to be temporally suppressed at a given time-point in embryonic, post-natal or adult animals.Eliminates drawbacks and side effects of traditional knockout processes that eliminate genes from the...
Published: 12/4/2024
Contributor(s): Stephen Traynelis
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Targeting Peptide Improves Accurate Myocarditis Imaging and Diagnosis
ApplicationTargeting peptide molecule for image-based diagnosis of myocarditis.Key BenefitsEnables noninvasive diagnosis of myocarditis.Targets and binds to biomarker of myocarditis.Market SummaryMyocarditis is an inflammation of the heart muscle (myocardium). Myocarditis can affect your heart muscle and your heart's electrical system, reducing the...
Published: 7/30/2024
Contributor(s): Michael E. Davis, Mario Martinez
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Heart Stabilizer for Minimally Invasive Cardiac Bypass Surgeries
Application
Heart stabilization device for use in minimally invasive cardiac bypass surgeries.
Key Benefits
Shorter and thinner articulating arm allows for smaller incisions and less crowding of the work field.
Flexible articulating arm accommodates variations in patient anatomy.
V-shaped stabilizing arms are much less bulky than those for currently...
Published: 7/30/2024
Contributor(s): Michael Halkos
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