Technology Listings


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Therapeutic Compounds Inhibiting DUSP5 and DUSP6 for Cardiomyocyte Proliferation and Cardiac Regeneration
Application Therapeutics using siRNAs and small molecules to treat congenital heart defect and myocardial injuries. Key Benefits Reactivates cardiomyocyte (CM) cell replication, allowing regeneration of heart muscle after cardiac injuries. Therapeutic compounds may be administered for transient regeneration/repair of heart muscle after cardiac...
Published: 12/2/2019       Inventor(s): Ahsan Husain, Nawazish Naqvi
Combination Therapy Using Small Molecule Conjugation to Reovirus for TNBC Treatment
ApplicationSmall molecule inhibitor doxorubicin hydrochloride (Dox) conjugated to reovirus for targeted combination therapy of triple-negative breast cancer (TNBC).Key BenefitsTargeted treatment that directly infects and kills breast cancer cells.Increased cytopathicity, cytotoxicity and faster induction of cell death than virus alone.Enhanced selective...
Published: 10/11/2019       Inventor(s): Bernardo Mainou, Roxana Rodriguez, Angela Berger
Combination Therapy for Increasing Venetoclax Sensitivity in Multiple Myeloma
Application Marker and co-therapy that inhibits succinate dehydrogenase to increase patient response to venetoclax. Key Benefits Co-therapy increases MM sensitivity to venetoclax treatment. Identifies patients who will respond to venetoclax therapy. Market Summary Multiple Myeloma (MM) is a cancer of plasma cells responsible for making antibody...
Published: 6/18/2019       Inventor(s): Malathy (mala) Shanmugam, Richa Bajpai
Peptide Therapeutic for Acute Respiratory Distress Syndrome
ApplicationAnti-claudin 5 peptide to improve lung barrier function for the treatment of alcohol-induced acute respiratory distress syndrome (ARDS).Key BenefitsNew target for treating ARDS.Small inhibitory peptide to specifically target claudin-5.Market SummaryApproximately 200,000 cases of acute respiratory distress syndrome (ARDS) are diagnosed each...
Published: 5/13/2019       Inventor(s): Michael Koval, Barbara Schlingmann-Molina
Bacteria Strain in Probiotic Formulation for Weight Control
Application Bacterial strain from Lactococcus lactis as a potential dietary supplement or therapeutic to help weight control and control gut inflammation. Key Benefits Provides anti-inflammatory effects in the intestine. Improves weight control and protects against fatty liver disease in mice fed a high fat and high sugar Western-style diet. This...
Published: 3/26/2019       Inventor(s): Rheinallt Jones, Trevor Darby
IFN╬│ Prelicensing for Improved Mesenchymal Stromal Cell Function Post-Thaw
ApplicationMesenchymal stromal cells (MSC) prelicensed with pro-inflammatory cytokines for improved survival and immunosuppressive properties following cryopreservation.Key BenefitsPreserves the immunosuppressive function of MSCs following thawing.Improves effectiveness of transplanted MSCs following cryopreservation.Market SummaryMesenchymal stromal...
Published: 1/22/2019       Inventor(s): Jacques Galipeau, Raghavan Chinnadurai
Granulin for Treatment of Neurodegeneration
ApplicationGranulin proteins (GRNs) as potential therapeutics for multiple neurodegenerative disorders caused by lysosome dysfunction and inflammation.Key BenefitsNovel pathway and target provides new route for treatment.Granulins shown to rescue lysosomal defects in cell culture models.Market SummaryGranulins are small proteins that are derived by...
Published: 12/18/2018       Inventor(s): Thomas Kukar
Biological Pacemakers as Alternatives/Adjuncts to Electronic Pacing Devices
ApplicationNon-viral gene delivery and a small molecule that converts heart muscle cells to pacemaker cells for the device-free treatment of slow heart rhythm.Key BenefitsMinimally invasive procedure provides cardiac pacing without device implant.Restores natural heart rhythm.Eliminates or reduces significant complications such as repeat surgeries for...
Published: 11/16/2018       Inventor(s): Hee Cheol Cho, Jun Li
rGIFT15: Recombinant Fusion Protein for the Treatment of Autoimmune Diseases
ApplicationRecombinant fusion protein comprising GM-CSF and interleukin-15 for treating autoimmune diseases.Key BenefitsrGIFT15 lacks any post-translation modification such as glycosylation.Market SummaryMore than 23 million Americans suffer from autoimmune diseases and that number is rising. Current therapies treat the symptoms, but do not provide...
Published: 11/11/2016       Inventor(s): Jacques Galipeau, Andrea Pennati
SpineGuide: Magnetic Resonance Imaging-Compatible Spinal Therapeutics Delivery System
ApplicationMRI-compatible device that enables precise delivery of therapeutic or cells to specific locations in the spinal cord. Key BenefitsCompatible with real-time MRI imaging systems allowing for the targeting and delivery of therapies concurrent with imaging. Can precisely guide and deliver a multitude of therapies (small molecules, biologics or...
Published: 1/28/2015       Inventor(s): Nicholas (Nick) Boulis, John Oshinski, Jason Lamanna
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