Technology Listings


31 Results Sort By:
A Predictive Marker and Treatment to Sensitize Multiple Myeloma Patients to Venetoclax (ABT-199)
Application A marker that predicts Venetoclax (ABT-199) sensitivity that can also be targeted with a drug to help multiple myeloma patients. Key Benefits Marker that predicts if venetoclax will be an effective treatment in multiple myeloma patients. A drug that targets venetoclax resistant multiple myeloma cells to improve treatment in patients. Market...
Published: 2/23/2022       Contributor(s): Malathy (mala) Shanmugam, Richa Bajpai
Frog Skin Peptides for Treatment of Human Influenza Viruses
ApplicationA therapeutic peptide that treats Influenza A virusKey BenefitsNew method of action compared to antiviral drugs currently in use.Therapeutic peptide is virucidal against drug resistant strains.Market SummaryWorldwide seasonal influenza epidemics can impact 5 – 15% of the population, equating to roughly 3-5 million severe cases and 250,...
Published: 11/5/2021       Contributor(s): Joshy Jacob, David Holthausen, Song Lee, Sanil George
Frog Skin Peptides for Treatment of Zika Viruses
ApplicationA therapeutic peptide that treats Zika Virus.Key BenefitsPotential therapeutic to fight against the growing threat of the Zika virus.Peptide is fast acting and destroys Zika virions within 5 minutes of exposure.Market SummaryZika is an infectious disease spread primarily by Aedes mosquitoes and results in symptoms similar to those of the...
Published: 11/5/2021       Contributor(s): Joshy Jacob, Song Lee, David Holthausen, Sanil George
Natural Antimicrobial Compound to Treat Multidrug Resistant Infections
Application Pentagalloylglucose and extracts of Anacardiaceae to treat multidrug resistant bacterial and fungal infections. Key Benefits Potential compounds to combat multidrug-resistant pathogens. Natural compound isolated from Schinus plants. Antibiotic activity against multidrug-resistant bacteria and fungi. Low likelihood to contribute to...
Published: 12/9/2020       Contributor(s): Cassandra Quave, Francois Chassagne, Lewis Marquez, Micah Dettweiler, Julia Kubanek, Anne Sweeney-Jones, Bhuwan Chhetri
Photocaged Cytokines for Cancer Immunotherapy
Application Light-responsive cytokine prodrugs with controlled activation for improved cancer immunotherapy. Key Benefits Spatiotemporal control of therapeutic cytokine activation leads to controlled local activation and reduces off-target toxicity. Prolonged circulation means less frequent dosing is required. Biased activity towards CD8+ T-cells...
Published: 11/2/2020       Contributor(s): Erik Dreaden, Lacey Perdue, Priscilla Do
Live Attenuated Zika Virus Vaccines
Application Yellow fever virus-based live attenuated Zika virus (ZIKV) vaccines. Key Benefits Reduces neurotropism from Zika virus. High safety and immunogenicity of chimeric vaccines. Market Summary Zika virus (ZIKV) belongs to the flavivirus family of viruses, which include West Nile (WN), Japanese encephalitis (JE), yellow fever (YF), dengue...
Published: 11/2/2020       Contributor(s): Baek Kim
Therapeutic Compounds Inhibiting DUSP5 and DUSP6 for Cardiomyocyte Proliferation and Cardiac Regeneration
Application Therapeutics using siRNAs and small molecules to treat congenital heart defect and myocardial injuries. Key Benefits Reactivates cardiomyocyte (CM) cell replication, allowing regeneration of heart muscle after cardiac injuries. Therapeutic compounds may be administered for transient regeneration/repair of heart muscle after cardiac...
Published: 4/22/2020       Contributor(s): Ahsan Husain, Nawazish Naqvi
Combination Therapy to Treat Pediatric Brain Tumor
Application Combination therapy (inhibition of STAT3 and YB-1) to treat medulloblastoma. Key Benefits Drug combination targets cancer stem cells. Increased apoptosis of cancer cells compared to current chemotherapeutic agents. Market Summary Medulloblastoma (MB) is the most common cancerous brain tumor that affects children and survival rates...
Published: 1/28/2020       Contributor(s): Tobey MacDonald, Anna Kenney, James Felker, Abhinav Dey
Combination Therapy for Increasing Venetoclax Sensitivity in Multiple Myeloma
Application Marker and co-therapy that inhibits succinate dehydrogenase to increase patient response to venetoclax. Key Benefits Co-therapy increases MM sensitivity to venetoclax treatment. Identifies patients who will respond to venetoclax therapy. Market Summary Multiple Myeloma (MM) is a cancer of plasma cells responsible for making antibody...
Published: 6/18/2019       Contributor(s): Malathy (mala) Shanmugam, Richa Bajpai
Peptide Therapeutic for Acute Respiratory Distress Syndrome
ApplicationAnti-claudin 5 peptide to improve lung barrier function for the treatment of alcohol-induced acute respiratory distress syndrome (ARDS).Key BenefitsNew target for treating ARDS.Small inhibitory peptide to specifically target claudin-5.Market SummaryApproximately 200,000 cases of acute respiratory distress syndrome (ARDS) are diagnosed each...
Published: 5/13/2019       Contributor(s): Michael Koval, Barbara Schlingmann-Molina
1 2 3 4