Technology Listings


Serotonin Transporter (SERT) Monoclonal Antibody

Applications

Immunohistochemistry

Specificity

Rat serotonin transporter - N-terminus

Subtype

Monoclonal Mouse IgG1

Technical Summary

The serotonin transporter (SERT) is a monoamine transporter protein, which works to recycle serotonin (5-HT) from the synaptic cleft thus regulating the 5-HT concentration in the synapse. SERT is the site of action of the selective serotonin reuptake inhibitors (SSRIs) class of antidepressants, which work by increasing 5-HT levels in the synapse through inhabitation of 5-HT reuptake. Additionally, SERT metabolism has been implicated in a host of phenomena ranging from alcoholism and clinical depression to obsessive compulsive disorder. These monoclonal antibodies have been generated against a rat SERT NH2-terminus/gluthionone S-transferase fusion protein and used extensively for immunohistochemical staining. They do not appear to be appropriate for western blotting or immunoprecipitation purposes.

Publications

Inazu et al. Neurochem Int, 2001. 39:39-49
Pickel et al. J Neurosci, 1999. 19:7356-7366
Schroeter et al. Mol Cell Neurosci, 1997. 9:170-184

Patent Information
Tech ID: RT002
Published: 4/9/2013
Category
Research Tools

Contact
Tom Tachovsky
Senior Licensing Consultant
Emory University
404-727-2211
ttachov@emory.edu

Inventor(s)
Kenneth Gould
Jeremy Dahl

Keywords
Antibody