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Cre-Lox PAR1 Conditional Knockout Mouse
Key BenefitsTissue-specific knockout mouse, allowing PAR1 to be inactivated in specific cell types in certain tissue.Inducible knockout mouse, allowing PAR1 to be temporally suppressed at a given time-point in embryonic, post-natal or adult animals.Eliminates drawbacks and side effects of traditional knockout processes that eliminate genes from the...
Published: 6/26/2018       Inventor(s): Stephen Traynelis
Specialized Cell Culturing Media for Enhanced Antibody Secretion and Plasma Cell Survival
ApplicationCell culture media that promotes the survival of human plasma cells and enables immunoglobin (Ig) secretion from such plasma cells.Key BenefitsFacilitates the isolation of antibody-secreting cells (ASCs) found in blood after antigen exposure, which can be used to identify an active antigen or pathogen causing illness.Composed of factors ...
Published: 5/24/2018       Inventor(s): Frances Lee, Ignacio Sanz, Doan Nguyen
Wound Care Booklet for Patient Use
ApplicationBooklet/card to help patients with low literacy care for wounds and track wound healing.Key BenefitsAvailable in English and Spanish.Includes pictures for patients with low literacy and low health literacy.Built in ruler and record space helps patients track wound size for easy reporting to clinician.Market SummaryWound care management i...
Published: 4/9/2018       Inventor(s): Georgette Cox
Organocatalysts for Amide Bond Formation
ApplicationChemically catalyzed amide bond formation under mild reaction conditions.Key BenefitsEnables amide bond formation under mild reaction conditions.Organocatalyst are easily synthesized.Avoids the use and disposal of hazardous chemicals.Market SummaryAmide bonds are very frequently incorporated into active pharmaceutical ingredients (API). ...
Published: 4/6/2018       Inventor(s): Lanny Liebeskind, Pavan Kumar Reddy Gangireddy, Sri Rama Murthy Akondi, Vidyavathi Patro, Nikolay Orlov
Human Induced Pluripotent Stem Cells
ApplicationHuman induced pluripotent stem cells useful for human stem cell biology, Lesch-Nyhan disease or DYT1 dystonia.Technical SummaryLesch-Nyhan syndrome (juvenile gout) is a rare, inherited disorder caused by deficiency in hypoxanthine-guanine phosphoribosyltransferase (HGPRT). The disease causes overproduction of uric acid often leading to g...
Published: 3/26/2018       Inventor(s): Hyder Jinnah
SkinDexMini: Quality of Life Instrument for Skin Disease
ApplicationQuestionnaire to measure quality of life and functional impact in patients with skin disease.Key BenefitsA quantitative measure of disease burden in patients with skin disease.SkinDexMini can be used to measure a patient's response to a therapy.SkinDexMini may be useful as an end point for epidemiologic and burden of disease studies or c...
Published: 1/22/2018       Inventor(s): Robert Swerlick, Suephy Chen, MarY-Margaret Chren
Antibodies for a-Synuclein Cleavage by Asparagine Endopeptidase (AEP) and Activated AEP
ApplicationELISAWestern BlotImmunohistochemistrySubtypeRabbit polyclonalTechnical SummaryParkinson's disease (PD) is a progressive neurodegenerative disorder that affects movement. It is characterized by the loss of predominately dopamine-producing neurons in a specific area of the brain called substantia nigra. α-Synuclein is a component of ...
Published: 1/21/2018       Inventor(s): Keqiang Ye
Dystonia Knock-in Mouse Model
ApplicationKnock-in mouse model for study of L-DOPA responsive dystonia.Useful for other movement disorders like dystonia and Parkinson’s disease.Technical SummaryDystonia is a neurological movement disorder characterized by persistent or intermittent muscle contractions causing abnormal, often repetitive, movements, postures, or both. There ...
Published: 1/21/2018       Inventor(s): Ellen Hess, Hyder Jinnah
Study Management and Retention Toolkit (SMART)
ApplicationSoftware for management of research studies involving human patients.Key BenefitsSupports a variety of study formats.Combines management of all parts of study in one place.Automatically reminds patients and research staff of upcoming appointments and tasks.Exports completed data for faster analysis.Market SummaryResearch studies involvin...
Published: 12/4/2017       Inventor(s): Eli Rosenberg
Bioluminescent Ion Indicator Proteins
ApplicationFusion protein for non-invasive assessment of chloride fluctuations in neuronal processes.Key BenefitsEnables a non-invasive method of imaging chloride in animals.Offers high signal-to-noise ratio compared to fluorescent light.Market SummaryNeuronal chloride (Cl-) is involved in many normal neurophysiological activities, including synapt...
Published: 9/26/2017       Inventor(s): Robert Gross, Ken Berglund, Jack Tung
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