11 Results

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RSV Vaccine for Infants and Children Application Vaccine for Respiratory Syncytial Virus (RSV) in infants and children. Key Benefits A novel vaccine targeting both the F and G proteins of the respiratory syncytial virus (RSV), including its variants. Preliminary data in in mice show the vaccine induced the production of antibodies associated with preventing disease. Potential to... Published: 2/13/2025       Contributor(s): Larry Anderson, Binh Ha, Heying Sun

Therapeutic to Treat Age-Dependent Idiopathic Pulmonary Fibrosis Application Therapeutic for treating age-associated lung fibrosis. Key Benefits Tecfidera (dimethyl fumarate - DMF) is an FDA approved therapy to treat multiple sclerosis via oral administration. A novel formulation for inhaled delivery demonstrated efficacy for a new indication: Idiopathic Pulmonary Fibrosis (IPF), where it promotes the reversal... Published: 2/13/2025       Contributor(s): Louise Hecker, Kosuke Kato, Priyadarshini Muralidharan, Heidi Mansour

Small Molecules for Treating Cystic Fibrosis ApplicationSmall molecule compounds to potentiate most common type of CFTR mutation in cystic fibrosis patients.Key BenefitsPotentiates ΔF508-hCFTR mutation, addressing more than 60 percent of CF patients. Market SummaryCystic fibrosis transmembrane conductance regulator (CFTR) is a membrane protein and ion channel that malfunctions in the genetic... Published: 2/13/2025       Contributor(s): Nael McCarty, Guiying Cui, Hanoch Senderowitz, Netaly Khazanov

Improving Pediatric Asthma Management for Urban Families Application Home-based family psychoeducational intervention for low-income children with persistent asthma. Key Benefits Medical and psychosocial needs of patients and family members can be addressed simultaneously. Significantly improved asthma management and caregiver stress in randomized controlled clinical trial. Market Summary Asthma... Published: 2/13/2025       Contributor(s): Marianne Celano, Lisa Kobrynski, Chanda Holsey

Quinazolin-4(3H)-one Derivatives as NOX-2 Inhibitors: Composition of Matter, Methods of Preparation and Their Use Application Quinazolin-4(3H)-one derivatives as selective NOX-2 inhibitors to prevent oxidative damage. Key Benefits Small molecule NOX-2 specific inhibitor. Prevents excessive reactive oxygen species (ROS) generation rather than removing them. Selective NOX-2 inhibition offers significant advantages to development of an effective therapy against... Published: 2/13/2025       Contributor(s): Thota Ganesh, Radhika Amaradhi, Jacek Zielonka

CFTR Modulators for Treating Rare Forms of Cystic Fibrosis Application Small molecules to treat cystic fibrosis and other pulmonary diseases. Key Benefits Rescue rare variants of CFTR gene. Serve as PDE4 inhibitors with strong anti-inflammatory effects. Market Summary Cystic fibrosis (CF) is a progressive, genetic disorder that arises from mutations in the cystic fibrosis transmembrane conductance... Published: 2/13/2025       Contributor(s): Eric J. Sorscher, Jeong Hong, Haian Fu, Yuhong Du, Huw Davies, Andras Rab, Candela Manfredi, Xun Yang, Zhi Ren

Mobile Application for COPD Patients Application Mobile application for teaching breathing techniques to patients with chronic obstructive pulmonary disease (COPD). Key Benefits Personalized coaching program. Tracks and saves lung performance. Adapts training program to patient’s lung performance. Can be done from the comfort of the patient’s home. Market Summary Chronic... Published: 2/13/2025       Contributor(s): Weihua Zhang

Virus-Like Particles as RSV Vaccine Candidate Application Virus-like particle (VLP) vaccine candidate(s) to prevent respiratory syncytial virus (RSV) infection. Key Benefits Candidates may have the most effective anti-viral and anti-inflammatory response. Potentially protects elderly and immunocompromised patients from re-infection with the RSV virus. Efficient, tunable and stable production... Published: 2/13/2025       Contributor(s): Binh Ha, Larry Anderson, Elizabeth Wright

Alexidine and Analogs to Treat Lung Cancer Application Small molecule therapeutic specifically targeting invasive cancer cells for treatment of lung cancer. Key Benefits Inhibits cancer cell invasion. Utilizes a novel mechanism of action. Market Summary One of the main barriers in developing new treatment strategies is the vast diversity between and within cancers. The cells within... Published: 2/13/2025       Contributor(s): Adam Marcus, Jessica Konen, Rachel Commander, Jamie Arnst, Thota Ganesh

GeneRegs: Nanoparticles for Treatment of Severe Asthma Application Gold nanoparticles coated with enzyme which specifically targets and degrades asthma-associated inflammation molecules. Key Benefits Specifically suppresses asthma associated inflammation. Easy self-administration by inhalation. Market Summary Asthma is defined as a chronic inflammatory lung disease with significant worldwide morbidity.... Published: 2/13/2025       Contributor(s): Khalid Salaita, Cherry Wongtrakool, Kornelia Galior

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