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Optimizing the Engineering of CAR-T Cells
Application
A method for selecting distinct T cell populations in order to generate more effective CAR-T cells.
Key Benefits
The proposed invention focuses on selecting the optimal “starting material” for the engineering CAR-T cells.
This selection method can be utilized for the development of any and all CAR-T therapies, not limited...
Published: 2/13/2025
Contributor(s): Byron Au-Yeung
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Advancing Lymphatic Endothelial Cell Generation from iPSCs
Application
The developed protocol offers a reproducible and scalable method for generating lymphatic endothelial cells (LECs) from induced pluripotent stem cells (iPSCs), addressing critical challenges in the field of lymphatic-related therapies.
Key Benefits
Reproducible and scalable protocol for generating LECs from iPSCs.
Utilizes specific...
Published: 2/13/2025
Contributor(s): Katherine Hekman, Katherine Owsiany
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Cost-Effective Catalysts for Industrial Chemical Applications
Application
A cost-effective catalyst for industrial chemical applications as an alternative to expensive rhodium-dependent dirhodium catalysts.
Key Benefits
Alternative catalysts to dirhodium using a straightforward synthesis process.
Preliminary data show the ability to self-assemble in a similar manner to dirhodium compounds.
Significantly...
Published: 2/13/2025
Contributor(s): Huw Davies, Joshua Sailer, Jack Sharland, Bo Wei
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Improving CAR T cell efficacy with Cytokine-Loaded Microparticles
Application
Novel reagents for manufacturing of CAR T cells with improved characteristics.
Key Benefits
A multi-cytokine backpack particle that can be used during manufacturing process of CAR T treatments to improve their phenotype and efficacy.
Preliminary data show the method can transduce primary healthy and patient T cells and promote CAR...
Published: 2/13/2025
Contributor(s): Sarwish Rafiq, Erik Dreaden, A K M Nawshad Hossian, Biaggio Uricoli
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High-Throughput Platform for Imaging and Maintaining Cells in Culture
Application
This closed-loop platform monitors and maintains traditional cell culture and bioengineered tissues to automate standard and custom cell maintenance protocols, including stem cell differentiations, bioengineered tissue generation, and functional maturation of complex cell cultures.
Key Benefits
Automation of cell culture maintenance
Integration...
Published: 2/13/2025
Contributor(s): Vahid Serpooshan, Ayda Melika, Amir Pourmorteza
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Ribosome Pegging: An Antibiotic-free System to Produce Recombinant Proteins
Application
Antibiotic-free method to prevent the growth of cells that fail to express high levels of a non-essential protein (target protein).
Key Benefits
Prevents the use of antibiotics and markers that promote resistance.
Facilitates the deployment of recombinant bacteria in uncontrolled environments.
Stabilizes heterologous expression of...
Published: 2/13/2025
Contributor(s): Ichiro Matsumura
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Platform for Transducing Target Cells with a Viral Vector
Application
System for quickly and efficiently obtaining therapeutic levels of transduction.
Key Benefits
Uses less viral vector to achieve high gene transfer.
Shortens transduction time.
Produces clinically relevant gene modified cell numbers.
Market Summary
Information relay at the molecular level, such as the transcription of RNA into proteins,...
Published: 2/13/2025
Contributor(s): Reginald Tran, Wilbur Lam, Christopher Doering, H. (Harold) Trent Spencer
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Specialized Cell Culturing Media for Enhanced Antibody Secretion and Plasma Cell Survival
Application
Cell culture media that promotes the survival of human plasma cells and enables immunoglobin (Ig) secretion from such plasma cells.
Key Benefits
Facilitates the isolation of antibody-secreting cells (ASCs) found in blood after antigen exposure, which can be used to identify an active antigen or pathogen causing illness.
Composed of...
Published: 2/13/2025
Contributor(s): Frances Eun-Hyung Lee, Ignacio (Inaki) Sanz, Doan Nguyen
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Novel Vaccine Antigen Presentation Platforms
Application
Combined antigen-adjuvant virus-like particle (VLP) vaccine platform for enhanced immune response.
Key Benefits
Chimeric VLPs (cVLPs) contain both antigen and adjuvant, thereby enhancing both cellular and humoral responses.
cVLPs are safer than live replicating vectored vaccines because of their lack of infectivity.
The cVLP manufacturing...
Published: 2/13/2025
Contributor(s): Baozhong Wang, Fu Shi Quan, Martin Moore, Richard Compans, Alan Aderem, Ioanna Skountzou, Jadranka Bozja
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Library of Lipase-Based Biocatalysts Derived from CALB
ApplicationA lipase-based platform technology that can be used in the production of fine chemicals, detergents, and pharmaceuticals.Key BenefitsEnhanced thermostability, activity, and enantioselectivity of enantiopure compounds including bulky substrates. Can be used at a concentration 100x less than that of other enzymes. Technical SummaryLipases are...
Published: 2/13/2025
Contributor(s): Stefan Lutz, Zhen Qian
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