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Small Molecule Compound to Treat Neurological Diseases
Application
NMDAR agents for the treatment of various neurological diseases.
Key Benefits
Exemplary compound EU1180-490 is a potent and selective potentiator of GluN1/GluN3 NMDARs.
The compound has excellent Lipinski drug-like properties including low molecular weight and cLogP, as well as water solubility.
The initial studies have determined...
Published: 7/30/2024
Contributor(s): Dennis Liotta, Stephen Traynelis, Hongjie Yuan, Matthew Epplin, Samantha Summer, David Menaldino, Leon Jacobs, Adam McCallum
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SPIRIT Intervention Training Manual And SPIRIT Intervention Guide
Application
Training manual and intervention guide designed for care providers of dementia patients to promote patients’ and their family caregivers’ decision-making regarding end-of-life care.
Key Benefits
Helps patients and their family caregivers prepare for end-of-life decision making.
Provides training and intervention guide for...
Published: 7/30/2024
Contributor(s): Mi-Kyung Song
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Strategy to Identify miRNAs for Disease Diagnosis
Application
Method to measure precursor and mature miRNA specifically.
Key Benefits
Unique primers can specifically identify miRNAs and precursor miRNAs by standard qRT-PCR without the requirement for an additional detection probe.
Allows for amplification and quantification of both mature miRNA and precursor miRNAs.
Potential technology to evaluate...
Published: 9/26/2024
Contributor(s): Wenming Li
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Psychosis Prediction Using Speech Patterns
Application
Linguistic software to predict and diagnose psychosis.
Key Benefits
New method of diagnosing psychosis.
Very high accuracy rate (86.7%).
Market Summary
Psychotic disorders are mental illnesses characterized by delusions, hallucinations, and disorganized thinking and speaking. Schizophrenia is an example of a psychotic disorder....
Published: 7/30/2024
Contributor(s): Phillip Wolff, Jinho Choi
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3q29 Deletion Mice
Application
Mouse models with the deletion of 3q29 for the study of neurological disorders such as schizophrenia, autism, and anxiety disorders.
Technical Summary
Copy Number Variants (CNV’s) are large genomic deletion or duplications. One of the CNV’s, the 3q29 deletion, confers more than 40 fold increase in risk of schizophrenia. Most...
Published: 9/26/2024
Contributor(s): Tamara Caspary, David Weinshenker, Stephen Theodore Warren
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Human Induced Pluripotent Stem Cells
ApplicationHuman induced pluripotent stem cells useful for human stem cell biology, Lesch-Nyhan disease or DYT1 dystonia.Technical SummaryLesch-Nyhan syndrome (juvenile gout) is a rare, inherited disorder caused by deficiency in hypoxanthine-guanine phosphoribosyltransferase (HGPRT). The disease causes overproduction of uric acid often leading to gout...
Published: 9/26/2024
Contributor(s): Hyder Jinnah
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Small Molecule Potentiators of NMDA Receptors for Treating Neurological Conditions
Application
Multiple series of small molecules that selectivity potentiate NMDA receptors composed of specific subunits including GluN2B, GluN2C, GluN2B/GluN2C/GluN2D, and GluN2C/GluN2D.
Key Benefits
Small molecule potentiators enhance endogenous signals without exogenous activation.
Subunit selectivity allows targeting of specific subtypes of...
Published: 7/30/2024
Contributor(s): Dennis Liotta, Ethel Garnier-Amblard, Gabriela Fernandez-Cuervo, Lanny Liebeskind, Pavan Kumar Reddy Gangireddy, Stephen Traynelis, Katie Strong, Rose Santangelo-Freel
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Progesterone to Treat Traumatic Brain Injury
Application
The use of progesterone to treat patients with traumatic brain injury (TBI) via a tapered administration protocol.
Key Benefits
Early administration of progesterone reduces cerebral edema and neural loss, and improves behavioral recovery from traumatic brain injury (TBI) in pre-clinical animal models.
Tapered progesterone withdrawal...
Published: 7/30/2024
Contributor(s): Donald Stein, Stuart Wayne Hoffman, Arthur Kellermann, David Wright, Douglas Lowery-North, Sarah Cutler
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ReliefLink: a Suicide Prevention App
Application
ReliefLink is a mobile companion app for suicide prevention.
Key Benefits
A companion app that includes mood tracking, reminders and safety plans.
Location aware for finding the nearest hospitals and mental health treatment centers.
Includes personalized coping mechanisms and assistance for finding therapists and support groups.
Market...
Published: 7/30/2024
Contributor(s): Nadine Kaslow, Stephanie Johnson, Zhe (eric) Li, Lu Dong, R. Shawn Williams, Claire Lisco
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Nematode Model of Nemaline Myopathy
Application
An invertebrate animal model of nemaline myopathy using Caenorhabditis elegans.
Key Benefits
C. elegans with pathological mutations of tropomyosin that cause nemaline myopathy.
Technical Summary
Nemaline myopathy, or rod myopathy, is a congenital and hereditary neuromuscular disorder that causes muscle weakness of varying severity....
Published: 11/20/2024
Contributor(s): Shoichiro Ono
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