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Technology for Assessment in Enhancing Memory Measurement in ECT Therapy
Application The Electroconvulsive Cognitive Assessment (ECA) is a 10-minute cognitive exam designed for use during and after Electroconvulsive Therapy (ECT). It focuses on assessing memory deficits associated with ECT, offering a quick and targeted evaluation tool for healthcare professionals. Key Benefits Rapid cognitive assessment in under 10...
Published: 4/11/2024       Contributor(s): Adriana Hermida
A 3D In Vitro Model of the Human Locus Coeruleus
Application A brain organoid model for the human locus coeruleus to study its function and dysfunction in neurological diseases. Key Benefits Locus coeruleus region-specific neural organoid model for studying this deep region of the human brain. The organoid synthesizes norepinephrine, allowing for study of diseases related to these neurotransmitters. The...
Published: 4/8/2024       Contributor(s): Fikri Birey, David Weinshenker
The CaRE Course: CaREgiving While Black
Application The CaRE Course is a curriculum to develop caregiving mastery of people living with dementias (PLWD) while understanding, acknowledging, and addressing the influence of race, culture, and disparities on caregivers’ mental health, medical, spiritual, and safety needs during the COVID-19 pandemic. Key Benefits Augments caregiver's...
Published: 12/1/2023       Contributor(s): Fayron Epps, Kenneth Hepburn, Carolyn Clevenger, Stephanie Bennett
Human Brain Proteins with Evidence Consistent with Causality of Alzheimer’s and Depression
Application Research and therapeutic targets for Alzheimer’s disease, depression, and other neurological conditions mediated by protein expression in the brain. Key Benefits These findings can be utilized as a research tool to better understand the genetic basis of Alzheimer’s disease. Can also be utilized to develop therapeutics for...
Published: 12/20/2023       Contributor(s): Aliza Wingo, Thomas Wingo, Yue Liu, Allan Levey, Nicholas Seyfried, Duc Duong
Implanted Passive Pressure Sensor Interrogated with (Ultra)-Sound (iPPSIS)
Application Easy-to-use, short and long-term, minimally invasive, MR-safe approach for directly measuring the variation of intracranial pressure. Key Benefits A minimally invasive device that is compatible with MRI imaging for quantitatively measuring intracranial pressure. A prototype has been developed showing the ability to measure shunt pressure...
Published: 3/1/2024       Contributor(s): David Myers, Nicholas Au Yong, Brooks Lindsey, Cecilia Alessandra Luna, Saeyoung (Sunny) Kim, Bowen Jing
Antisense Restoration of ELAVL3 for Neurological Diseases
Application Antisense therapeutics targeting ELAVL3 expression for neurodegenerative disorders. Key Benefits Antisense approach for restoring protein levels and function of ELAVL3 and TDP-43. Preclinical data show the ability of several ELAVL3-targeting ASOs to restore protein expression via in vitro experiments. Potential to be a new medicine...
Published: 3/1/2024       Contributor(s): Zachary McEachin
Latent Variable Modeling for Developing Neuroprosthetic Devices
Application A high-performing neural decoder that reconstructs spiking data from local field potentials to analyze neural recordings for developing neuro-prosthetic devices. Key Benefits Capable of augmenting local field potential to overcome perturbations in data. Improved decoding stability with high accuracy. Potential to lead to the development...
Published: 1/25/2024       Contributor(s): Brianna Karpowicz, Chethan Pandarinath, Yahia Ali, Marc Slutzky, Robert Flint, Bareesh Bhaduri
Faith-based Home Activity Toolbox (HAT)
Application Set of interventional activity tools designed to incorporated faith-based principles to improve the quality of life of individuals living with or family members caring for persons with moderate to severe Alzheimer Disease or related dementias. Key Benefits Provides relief from anxiety. Reduced behavior disturbances. Improved quality...
Published: 11/27/2023       Contributor(s): Fayron Epps
Dementia-Friendly Online Worship Services
Application Religious (Christian) service videos available through a public online platform that are tailored to support the well-being of caregivers and family members of persons living with dementia (PLWD). Key Benefits Provides relief from anxiety. Reduced behavior disturbances. Improved quality of life for individuals living with dementia...
Published: 10/10/2023       Contributor(s): Fayron Epps
Flumazenil for Treatment of CNS Symptoms in Myotonic Dystrophy
Application A class of drugs that inhibit molecules responsible for the severe nervous system complications associated with myotonic dystrophy. Key Benefits Potentially the first medication for treating the severe nervous system symptoms associated with myotonic dystrophy by targeting GABRG2. Transdermal and oral administration. May drive the...
Published: 12/1/2023       Contributor(s): Gary Bassell, Andrew Jenkins, David Rye, Eric Wang, Maurice Swanson, Lyndon Lien
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