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Repurposed Treatment for Cocaine Use Disorder
Application Repurposed drug for transcriptomic-driven treatment of cocaine use disorder. Key Benefits FDA-approved drug. Outperformed current targets undergoing clinical trials for CUD at the mRNA level. Market Summary In 2018, there were approximately 2.2 million regular users of cocaine in the United States, and 1 million individuals with...
Published: 1/23/2021       Contributor(s): Rohan Palmer, Spencer Huggett
Multimodal Prospective Learning Test
Application Multimodal learning test to assess naming and facial recognition in post-operative epilepsy patients. Key Benefits Provides non-invasive, age-appropriate neuropsychological testing. Allows clinicians to simultaneously assess multiple modalities. Market Summary Epilepsy is a chronic neurological disorder characterized by unpredictable,...
Published: 12/10/2020       Contributor(s): Daniel Drane, Keith Adams
System for Automated Analysis of Sleep and Wake States
Application Algorithm for automatic diagnostic or prognostic monitoring of sleep/wake stages from movement and physiological signals. Key Benefits Device captures and differentiates unbiased sleep or wake information from different physiological signals. 99.8% less data storage space needed over current technology. Capable of use in privacy of...
Published: 11/18/2020       Contributor(s): Gari Clifford, Ayse Cakmak, Adam Willats, Christopher Rozell
SPIRIT Intervention Training Manual And SPIRIT Intervention Guide
Application Training manual and intervention guide designed for care providers of dementia patients to promote patients’ and their family caregivers’ decision-making regarding end-of-life care. Key Benefits Helps patients and their family caregivers prepare for end-of-life decision making. Provides training and intervention guide for...
Published: 11/2/2020       Contributor(s): Mi-Kyung Song
3D-Printed Mouse Headplates for Implantation of EEG, EMG and Depth Electrodes
Application Tool to precisely and reproducibly implant electrode and other instrumentation into the mouse brain for neurophysiology studies. Key Benefits Inexpensive, rapid and efficient reproduction of headplates. Allows consistent and quick surgical implantation. Capable of recording or stimulating multiple sites in the mouse brain. Market...
Published: 5/21/2020       Contributor(s): Nigel Pedersen, Lauren Aiani
Chimeric Molecule for the Treatment of Depression
Application Small molecules for treating depression and/or depression associated with cancer/chemotherapy. Key Benefits Potentially a dual mechanism compound – working via monoamine reuptake inhibition and HDAC inhibition (epigenetic modification). Quicker acting compound compared to current therapies in the market. Works better than the...
Published: 4/17/2020       Contributor(s): Hyunsuk Shim, Huw Davies, Hyun Min Park, Yoon Hyeun Oum
Strategy to Identify miRNAs for Disease Diagnosis
Application Method to measure precursor and mature miRNA specifically. Key Benefits Unique primers can specifically identify miRNAs and precursor miRNAs by standard qRT-PCR without the requirement for an additional detection probe. Allows for amplification and quantification of both mature miRNA and precursor miRNAs. Potential technology to evaluate...
Published: 1/22/2020       Contributor(s): Wenming Li
Psychosis Prediction Using Speech Patterns
Application Linguistic software to predict and diagnose psychosis. Key Benefits New method of diagnosing psychosis. Very high accuracy rate (86.7%). Market Summary Psychotic disorders are mental illnesses characterized by delusions, hallucinations, and disorganized thinking and speaking. Schizophrenia is an example of a psychotic disorder....
Published: 1/14/2020       Contributor(s): Phillip Wolff, Jinho Choi
Subunit-Selective NMDAR Antagonists for Treatment of Neurological Disorders
Application GluN2C/2D selective inhibitors that modulate N-methyl-D-aspartic acid receptors (NMDAR) in a subunit-selective manner for treatment of neurological disorders. Key Benefits Specifically targets NMDARs that contain the GluN2C/2D subunit. Higher potency and efficacy compared to previously reported GluN2C/2D-selective modulators. Market...
Published: 1/10/2020       Contributor(s): Yao Jing, Stephen Traynelis, Dennis Liotta
Autoencoding Neural Networks with Applications to Brain-machine Interfaces
Application Machine learning software for brain-machine interface and neuro-stimulation device-controlling. Key Benefits Significantly improves machine learning performance by minimizing overfitting. Market Summary In machine learning (ML), autoencoder, a type of unsupervised artificial neural network, attempts to learn efficient data coding....
Published: 11/22/2019       Contributor(s): Chethan Pandarinath, Mohammadreza Keshtkaran
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