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Discovery of A Dual Inhibitor of NQO1 and GSTP1 for Treating Malignant Glioblastoma
Application
A small molecule compound to treat Malignant Glioblastoma multiforme.
Key Benefits
Dual inhibition of NQO1 and GSTP1 induces cell death in glioblastoma cells.
Inhibition of NQO1 and GSTP1 by MNPC suppresses tumor growth and elongates the life span of the animals with GBM.
Market Summary
Approximately 30% of patients diagnosed...
Published: 12/20/2022
Contributor(s): Keqiang Ye
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Small Molecule Compound to Treat Neurological Diseases
Application
NMDAR agents for the treatment of various neurological diseases.
Key Benefits
Exemplary compound EU1180-490 is a potent and selective potentiator of GluN1/GluN3 NMDARs.
The compound has excellent Lipinski drug-like properties including low molecular weight and cLogP, as well as water solubility.
The initial studies have determined...
Published: 8/26/2022
Contributor(s): Dennis Liotta, Stephen Traynelis, Hongjie Yuan, Matthew Epplin, Samantha Summer, David Menaldino, Leon Jacobs, Adam McCallum
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Nonlinear Manifold Alignment Decoding (NoMAD) for Robust Brain-Machine Interfaces
Application
Nonlinear Manifold Alignment Decoding for Brain-Machine Interface (BMI).
Key Benefits
Accurate, non-invasive prediction of gallstones in the bile duct.
Based on readily available patient information.
Market Summary
Motor impairment is common in neurological conditions such as cerebral palsy, Parkinson’s disease, stroke,...
Published: 9/29/2022
Contributor(s): Chethan Pandarinath, Mohammadreza Keshtkaran, Lahiru Wimalasena, Yahia Ali, Andrew Sedler, Lee Miller, Josephine Wallner, Xuan Ma, Ali Farshchian, Brianna Karpowicz
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Repurposed Treatment for Cocaine Use Disorder
Application
Repurposed drug for transcriptomic-driven treatment of cocaine use disorder.
Key Benefits
FDA-approved drug.
Outperformed current targets undergoing clinical trials for CUD at the mRNA level.
Market Summary
Cocaine abuse is associated with substantial morbidity and mortality, and there are no approved medications for the treatment...
Published: 12/20/2022
Contributor(s): Rohan Palmer, Spencer Huggett
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Multimodal Prospective Learning Test
Application
Multimodal learning test to assess naming and facial recognition in post-operative epilepsy patients.
Key Benefits
Provides non-invasive, age-appropriate neuropsychological testing.
Allows clinicians to simultaneously assess multiple modalities.
Market Summary
Epilepsy is a chronic neurological disorder characterized by unpredictable,...
Published: 8/9/2022
Contributor(s): Daniel Drane, Keith Adams
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System for Automated Analysis of Sleep and Wake States
Application
Algorithm for automatic diagnostic or prognostic monitoring of sleep/wake stages from movement and physiological signals.
Key Benefits
Device captures and differentiates unbiased sleep or wake information from different physiological signals.
99.8% less data storage space needed over current technology.
Capable of use in privacy of...
Published: 1/10/2023
Contributor(s): Gari Clifford, Ayse Cakmak, Adam Willats, Christopher Rozell
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SPIRIT Intervention Training Manual And SPIRIT Intervention Guide
Application
Training manual and intervention guide designed for care providers of dementia patients to promote patients’ and their family caregivers’ decision-making regarding end-of-life care.
Key Benefits
Helps patients and their family caregivers prepare for end-of-life decision making.
Provides training and intervention guide for...
Published: 8/3/2022
Contributor(s): Mi-Kyung Song
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3D-Printed Mouse Headplates for Implantation of EEG, EMG and Depth Electrodes
Application
Tool to precisely and reproducibly implant electrode and other instrumentation into the mouse brain for neurophysiology studies.
Key Benefits
Inexpensive, rapid and efficient reproduction of headplates.
Allows consistent and quick surgical implantation.
Capable of recording or stimulating multiple sites in the mouse brain.
Market...
Published: 8/1/2022
Contributor(s): Nigel Pedersen, Lauren Aiani
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Chimeric Molecule for the Treatment of Depression
Application
Small molecules for treating depression and/or depression associated with cancer/chemotherapy.
Key Benefits
Potentially a dual mechanism compound – working via monoamine reuptake inhibition and HDAC inhibition (epigenetic modification).
Quicker acting compound compared to current therapies in the market. Works better than the...
Published: 1/10/2023
Contributor(s): Hyunsuk Shim, Huw Davies, Hyun Min Park, Yoon-Hyeun Oum
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Strategy to Identify miRNAs for Disease Diagnosis
Application
Method to measure precursor and mature miRNA specifically.
Key Benefits
Unique primers can specifically identify miRNAs and precursor miRNAs by standard qRT-PCR without the requirement for an additional detection probe.
Allows for amplification and quantification of both mature miRNA and precursor miRNAs.
Potential technology to evaluate...
Published: 7/29/2022
Contributor(s): Wenming Li
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