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Small Molecule Compound to Treat Neurological Diseases
Application
NMDAR agents for the treatment of various neurological diseases.
Key Benefits
Exemplary compound EU1180-490 is a potent and selective potentiator of GluN1/GluN3 NMDARs.
The compound has excellent Lipinski drug-like properties including low molecular weight and cLogP, as well as water solubility.
The initial studies have determined...
Published: 7/30/2024
Contributor(s): Dennis Liotta, Stephen Traynelis, Hongjie Yuan, Matthew Epplin, Samantha Summer, David Menaldino, Leon Jacobs, Adam McCallum
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SPIRIT Intervention Training Manual And SPIRIT Intervention Guide
Application
Training manual and intervention guide designed for care providers of dementia patients to promote patients’ and their family caregivers’ decision-making regarding end-of-life care.
Key Benefits
Helps patients and their family caregivers prepare for end-of-life decision making.
Provides training and intervention guide for...
Published: 7/30/2024
Contributor(s): Mi-Kyung Song
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3D-Printed Mouse Headplates for Implantation of EEG, EMG and Depth Electrodes
Application
Tool to precisely and reproducibly implant electrode and other instrumentation into the mouse brain for neurophysiology studies.
Key Benefits
Inexpensive, rapid and efficient reproduction of headplates.
Allows consistent and quick surgical implantation.
Capable of recording or stimulating multiple sites in the mouse brain.
Market...
Published: 10/28/2024
Contributor(s): Nigel Pedersen, Lauren Aiani
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Strategy to Identify miRNAs for Disease Diagnosis
Application
Method to measure precursor and mature miRNA specifically.
Key Benefits
Unique primers can specifically identify miRNAs and precursor miRNAs by standard qRT-PCR without the requirement for an additional detection probe.
Allows for amplification and quantification of both mature miRNA and precursor miRNAs.
Potential technology to evaluate...
Published: 9/26/2024
Contributor(s): Wenming Li
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Psychosis Prediction Using Speech Patterns
Application
Linguistic software to predict and diagnose psychosis.
Key Benefits
New method of diagnosing psychosis.
Very high accuracy rate (86.7%).
Market Summary
Psychotic disorders are mental illnesses characterized by delusions, hallucinations, and disorganized thinking and speaking. Schizophrenia is an example of a psychotic disorder....
Published: 7/30/2024
Contributor(s): Phillip Wolff, Jinho Choi
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ADGRB3/BAI3 Knockout Mouse
ApplicationKnockout mouse models for adhesion G protein-coupled receptors B3, brain-specific angiogenesis inhibitor-3 (ADGRB3/BAI3) gene study.Technical SummaryEmory University researchers have developed a knockout mouse model for the ADGRB3/BAI3 gene. Mice were generated by CRISP/cas9 technology on C57Bl6 background. These mice can be used to study...
Published: 10/28/2024
Contributor(s): Erwin Van Meir
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3q29 Deletion Mice
Application
Mouse models with the deletion of 3q29 for the study of neurological disorders such as schizophrenia, autism, and anxiety disorders.
Technical Summary
Copy Number Variants (CNV’s) are large genomic deletion or duplications. One of the CNV’s, the 3q29 deletion, confers more than 40 fold increase in risk of schizophrenia. Most...
Published: 9/26/2024
Contributor(s): Tamara Caspary, David Weinshenker, Stephen Theodore Warren
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Human Induced Pluripotent Stem Cells
ApplicationHuman induced pluripotent stem cells useful for human stem cell biology, Lesch-Nyhan disease or DYT1 dystonia.Technical SummaryLesch-Nyhan syndrome (juvenile gout) is a rare, inherited disorder caused by deficiency in hypoxanthine-guanine phosphoribosyltransferase (HGPRT). The disease causes overproduction of uric acid often leading to gout...
Published: 9/26/2024
Contributor(s): Hyder Jinnah
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Dystonia Knock-in Mouse Model
ApplicationKnock-in mouse model for study of L-DOPA responsive dystonia.Useful for other movement disorders like dystonia and Parkinson’s disease.Technical SummaryDystonia is a neurological movement disorder characterized by persistent or intermittent muscle contractions causing abnormal, often repetitive, movements, postures, or both. There are...
Published: 12/4/2024
Contributor(s): Ellen Hess, Hyder Jinnah
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Bioluminescent Ion Indicator Proteins
ApplicationFusion protein for non-invasive assessment of chloride fluctuations in neuronal processes.Key BenefitsEnables a non-invasive method of imaging chloride in animals.Offers high signal-to-noise ratio compared to fluorescent light.Market SummaryNeuronal chloride (Cl-) is involved in many normal neurophysiological activities, including synaptic...
Published: 11/20/2024
Contributor(s): Robert E. Gross, Ken Berglund, Jack Tung
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