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Strategy to Identify miRNAs for Disease Diagnosis
Application Method to measure precursor and mature miRNA specifically. Key Benefits Unique primers can specifically identify miRNAs and precursor miRNAs by standard qRT-PCR without the requirement for an additional detection probe. Allows for amplification and quantification of both mature miRNA and precursor miRNAs. Potential technology to evaluate...
Published: 1/22/2020       Inventor(s): Wenming Li
Psychosis Prediction Using Speech Patterns
Application Linguistic software to predict and diagnose psychosis. Key Benefits New method of diagnosing psychosis. Very high accuracy rate (86.7%). Market Summary Psychotic disorders are mental illnesses characterized by delusions, hallucinations, and disorganized thinking and speaking. Schizophrenia is an example of a psychotic disorder....
Published: 1/14/2020       Inventor(s): Phillip Wolff, Jinho Choi
Subunit-Selective NMDAR Antagonists for Treatment of Neurological Disorders
Application GluN2C/2D selective inhibitors that modulate N-methyl-D-aspartic acid receptors (NMDAR) in a subunit-selective manner for treatment of neurological disorders. Key Benefits Specifically targets NMDARs that contain the GluN2C/2D subunit. Higher potency and efficacy compared to previously reported GluN2C/2D-selective modulators. Market...
Published: 1/10/2020       Inventor(s): Yao Jing, Stephen Traynelis, Dennis Liotta
Autoencoding Neural Networks with Applications to Brain-machine Interfaces
Application Machine learning software for brain-machine interface and neuro-stimulation device-controlling. Key Benefits Significantly improves machine learning performance by minimizing overfitting. Market Summary In machine learning (ML), autoencoder, a type of unsupervised artificial neural network, attempts to learn efficient data coding....
Published: 11/22/2019       Inventor(s): Chethan Pandarinath, Mohammadreza Keshtkaran
Automated Assessment of Visuospatial Memory as a Screening Tool
Application Visuospatial memory paradigm that passively assesses memory using eye movements, rather than explicit memory judgements, to detect objective memory impairment and to predict Alzheimer’s disease and cognitive status. Key Benefits Does not require verbal or written response for assessment, reducing social and cultural bias. Requires...
Published: 10/11/2019       Inventor(s): Rafi Haque, Allan Levey, Gari Clifford, LaVonda Brown, Cecelia Manzanares
Parent Training Curriculum to Manage Food Selectivity in Children with Autism
Application Parent-mediated intervention, titled the Autism Managing Eating Aversions and Limited variety (MEAL) Plan, to reduce mealtime disruptive behavior and expand dietary diversity in young children with autism spectrum disorders. Key Benefits Hands-on parent training based intervention. Reduces parental stress while developing a child’s...
Published: 8/29/2019       Inventor(s): William Sharp, Teresa (T.) Burrell, Rashelle Berry
Subunit-Selective Modulator for Treatment of Neurological Disorders
Application Subunit-selective GluN2C and GluN2D positive allosteric modulators of N-methyl-D-aspartic acid receptors (NMDAR) for treatment of neurological disorders. Key Benefits Specifically targets GluN2C/D subunits for positive modulation of NMDAR activity. Higher potency compared to non-selective modulators. Improved drug-like properties...
Published: 8/26/2019       Inventor(s): Matthew Epplin, David Menaldino, Stephen Traynelis, Dennis Liotta
PET Tracer for Parkinson’s Disease Diagnostic
Application Small molecule PET tracer for Lewy bodies in the brain for diagnosing Parkinson’s Disease or other Lewy body related diseases. Key Benefits PET tracer to enable quantification of α-Syn. Improves diagnosis of Parkinson’s disease. Allows for earlier treatment. Market Summary Parkinson’s disease is a neurodegenerative disorder that...
Published: 8/26/2019       Inventor(s): Keqiang Ye
ADGRB3/BAI3 Knockout Mouse
ApplicationKnockout mouse models for adhesion G protein-coupled receptors B3, brain-specific angiogenesis inhibitor-3 (ADGRB3/BAI3) gene study.Technical SummaryEmory University researchers have developed a knockout mouse model for the ADGRB3/BAI3 gene. Mice were generated by CRISP/cas9 technology on C57Bl6 background. These mice can be used to study...
Published: 7/9/2019       Inventor(s): Erwin Van Meir
ADGRB1/BAI1 Knockout Mouse
ApplicationKnockout mouse models for adhesion G protein-coupled receptors B1, brain-specific angiogenesis inhibitor-1 (ADGRB1/BAI1) gene study.Technical SummaryEmory University researchers have developed a knockout mouse model for the ADGRB1/BAI1 gene. These mice were developed through homologous recombination and have LacZ gene knock-in. Mice were...
Published: 7/9/2019       Inventor(s): Erwin Van Meir
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