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Discovery of A Dual Inhibitor of NQO1 and GSTP1 for Treating Malignant Glioblastoma
­ Application A small molecule compound to treat Malignant Glioblastoma multiforme. Key Benefits Dual inhibition of NQO1 and GSTP1 induces cell death in glioblastoma cells. Inhibition of NQO1 and GSTP1 by MNPC suppresses tumor growth and elongates the life span of the animals with GBM. Market Summary Approximately 30% of patients diagnosed...
Published: 12/20/2022       Contributor(s): Keqiang Ye
Small Molecule Compound to Treat Neurological Diseases
­ Application NMDAR agents for the treatment of various neurological diseases. Key Benefits Exemplary compound EU1180-490 is a potent and selective potentiator of GluN1/GluN3 NMDARs. The compound has excellent Lipinski drug-like properties including low molecular weight and cLogP, as well as water solubility. The initial studies have determined...
Published: 8/26/2022       Contributor(s): Dennis Liotta, Stephen Traynelis, Hongjie Yuan, Matthew Epplin, Samantha Summer, David Menaldino, Leon Jacobs, Adam McCallum
Nonlinear Manifold Alignment Decoding (NoMAD) for Robust Brain-Machine Interfaces
­ Application Nonlinear Manifold Alignment Decoding for Brain-Machine Interface (BMI). Key Benefits Accurate, non-invasive prediction of gallstones in the bile duct. Based on readily available patient information. Market Summary Motor impairment is common in neurological conditions such as cerebral palsy, Parkinson’s disease, stroke,...
Published: 9/29/2022       Contributor(s): Chethan Pandarinath, Mohammadreza Keshtkaran, Lahiru Wimalasena, Yahia Ali, Andrew Sedler, Lee Miller, Josephine Wallner, Xuan Ma, Ali Farshchian, Brianna Karpowicz
Repurposed Treatment for Cocaine Use Disorder
Application Repurposed drug for transcriptomic-driven treatment of cocaine use disorder. Key Benefits FDA-approved drug. Outperformed current targets undergoing clinical trials for CUD at the mRNA level. Market Summary Cocaine abuse is associated with substantial morbidity and mortality, and there are no approved medications for the treatment...
Published: 12/20/2022       Contributor(s): Rohan Palmer, Spencer Huggett
Multimodal Prospective Learning Test
Application Multimodal learning test to assess naming and facial recognition in post-operative epilepsy patients. Key Benefits Provides non-invasive, age-appropriate neuropsychological testing. Allows clinicians to simultaneously assess multiple modalities. Market Summary Epilepsy is a chronic neurological disorder characterized by unpredictable,...
Published: 8/9/2022       Contributor(s): Daniel Drane, Keith Adams
System for Automated Analysis of Sleep and Wake States
Application Algorithm for automatic diagnostic or prognostic monitoring of sleep/wake stages from movement and physiological signals. Key Benefits Device captures and differentiates unbiased sleep or wake information from different physiological signals. 99.8% less data storage space needed over current technology. Capable of use in privacy of...
Published: 1/10/2023       Contributor(s): Gari Clifford, Ayse Cakmak, Adam Willats, Christopher Rozell
SPIRIT Intervention Training Manual And SPIRIT Intervention Guide
Application Training manual and intervention guide designed for care providers of dementia patients to promote patients’ and their family caregivers’ decision-making regarding end-of-life care. Key Benefits Helps patients and their family caregivers prepare for end-of-life decision making. Provides training and intervention guide for...
Published: 8/3/2022       Contributor(s): Mi-Kyung Song
3D-Printed Mouse Headplates for Implantation of EEG, EMG and Depth Electrodes
Application Tool to precisely and reproducibly implant electrode and other instrumentation into the mouse brain for neurophysiology studies. Key Benefits Inexpensive, rapid and efficient reproduction of headplates. Allows consistent and quick surgical implantation. Capable of recording or stimulating multiple sites in the mouse brain. Market...
Published: 8/1/2022       Contributor(s): Nigel Pedersen, Lauren Aiani
Chimeric Molecule for the Treatment of Depression
Application Small molecules for treating depression and/or depression associated with cancer/chemotherapy. Key Benefits Potentially a dual mechanism compound – working via monoamine reuptake inhibition and HDAC inhibition (epigenetic modification). Quicker acting compound compared to current therapies in the market. Works better than the...
Published: 1/10/2023       Contributor(s): Hyunsuk Shim, Huw Davies, Hyun Min Park, Yoon-Hyeun Oum
Strategy to Identify miRNAs for Disease Diagnosis
Application Method to measure precursor and mature miRNA specifically. Key Benefits Unique primers can specifically identify miRNAs and precursor miRNAs by standard qRT-PCR without the requirement for an additional detection probe. Allows for amplification and quantification of both mature miRNA and precursor miRNAs. Potential technology to evaluate...
Published: 7/29/2022       Contributor(s): Wenming Li
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