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STAR-Echo: Software to Predict Cardiovascular Disease in Chronic Kidney Disease Patients
Application
A novel software for prognosis of MACE in chronic kidney disease patients using spatiotemporal analysis and transformer-based radiomics models.
Key Benefits
Unique interpretable features – identifies novel features based on longitudinal changes in LVW shape (perimeter & sphericity) and texture (intensity variations) over a...
Published: 2/13/2025
Contributor(s): Rohan Dhamdhere, Sadeer Al-Kindi, Gourav Modanwal, Anant Madabhushi
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Therapeutic Compounds Inhibiting DUSP5 and DUSP6 for Cardiomyocyte Proliferation and Cardiac Regeneration
Application
Therapeutics using siRNAs and small molecules to treat congenital heart defect and myocardial injuries.
Key Benefits
Reactivates cardiomyocyte (CM) cell replication, allowing regeneration of heart muscle after cardiac injuries.
Therapeutic compounds may be administered for transient regeneration/repair of heart muscle after cardiac...
Published: 2/13/2025
Contributor(s): Ahsan Husain, Nawazish Naqvi
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Novel Inhibitors of NOX2/ROS
Applications
Novel therapeutics for treatment of various inflammatory airway conditions including chronic obstructive pulmonary disease (COPD).
Key Benefits
NOX2/ROS inhibitors have potential for use in a wide variety of clinical indications.
Current treatments are weakly effective or provide only symptomatic relief for inflammatory airway diseases.
Technical...
Published: 2/13/2025
Contributor(s): Thota Ganesh, John David Lambeth, Susan Smith, Aiming Sun
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Inhibitors of MicroRNA-miR712/miR205 for the Treatment of Atherosclerosis and Other Vascular Conditions
Application
Antisense oligonucleotide inhibitors of microRNA-miR712/miR205 to prevent or treat atherosclerosis and aortic aneurysm.
Key Benefits
80% reduction on the expression of their microRNA targets.
Reduces atheroma plaque formation in a mouse model of atherosclerosis.
Provides potential non-surgical treatment for aortic aneurysm.
Market...
Published: 2/13/2025
Contributor(s): Hanjoong Jo, Chanwoo Kim, Sandeep Kumar, Dong ju Son, Haiwei Qiu, Wakako Takabe
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