15 Results Sort By:
Method and System for Recording and Recovery and Electrophysiology During Stimulation
­ Application Systems and methods for recording and recovering viable electrophysiological signals and during delivery of stimulation, including deep brain stimulation (DBS). Key Benefits Enables the recording of electrophysiology/neurophysiology during stimulation from the same stimulating contact and adjacent contacts. Enables the potential...
Published: 12/6/2022       Contributor(s): Enrico Opri, Svjetlana Miocinovic
A Predictive Marker and Treatment to Sensitize Multiple Myeloma Patients to Venetoclax (ABT-199)
Application A marker that predicts Venetoclax (ABT-199) sensitivity that can also be targeted with a drug to help multiple myeloma patients. Key Benefits Marker that predicts if venetoclax will be an effective treatment in multiple myeloma patients. A drug that targets venetoclax resistant multiple myeloma cells to improve treatment in patients. Market...
Published: 2/23/2022       Contributor(s): Malathy (mala) Shanmugam, Richa Bajpai
Predicting Treatment Response in Patients with Spinal Muscular Atrophy (SMA)
Application Prognostic model predicts treatment response to nusinersen (Spinraza®) in patients with spinal muscular atrophy. Key Benefits A prediction model using baseline CHOP-INTEND, IL-8, fractalkine, and MCP-1 accurately predicts CHOP-INTEND outcomes in children treated with nusinersen The model can also be incorporated into future therapeutic...
Published: 7/13/2021       Contributor(s): William Hu, Sumit Verma
Theranostic Biomarker for Aspirin-Exacerbated Respiratory Disease
Application Biomarkers for a clinical diagnostic tool and non-psychogenic therapy to detect and treat aspirin-exacerbated respiratory disease. Key Benefits Does not rely on aspirin challenge, increasing safety and availability for suspected patients. May be used in patients who have respiratory compromise or are not stable. Minimally-invasive...
Published: 7/2/2019       Contributor(s): Joshua Levy, Samuel Molina
Combination Therapy for Increasing Venetoclax Sensitivity in Multiple Myeloma
Application Marker and co-therapy that inhibits succinate dehydrogenase to increase patient response to venetoclax. Key Benefits Co-therapy increases MM sensitivity to venetoclax treatment. Identifies patients who will respond to venetoclax therapy. Market Summary Multiple Myeloma (MM) is a cancer of plasma cells responsible for making antibody...
Published: 6/18/2019       Contributor(s): Malathy (mala) Shanmugam, Richa Bajpai
Targeting Peptides for Myocarditis
ApplicationTargeting peptide molecule for image-based diagnosis of myocarditis.Key BenefitsEnables noninvasive diagnosis of myocarditis.Targets and binds to biomarker of myocarditis.Market SummaryMyocarditis is an inflammation of the heart muscle (myocardium). Myocarditis can affect your heart muscle and your heart's electrical system, reducing the...
Published: 2/7/2018       Contributor(s): Michael E. Davis, Mario Martinez
RNA Biomarkers for Coronary Artery Disease (CAD)
ApplicationDiagnostic panel to determine severity of coronary artery disease using plasma-based biomarkers of microparticle vesicles and isoforms of specific miRNAs (isomiRs).Key BenefitsPredictive risk diagnostic aids in clinicians' course of treatment decisions.Identifies underlying biological function of biomarkers for potential use of personalized...
Published: 11/9/2017       Contributor(s): Charles (Charlie) Searles, Jr., Amanda James
Bioluminescent Ion Indicator Proteins
ApplicationFusion protein for non-invasive assessment of chloride fluctuations in neuronal processes.Key BenefitsEnables a non-invasive method of imaging chloride in animals.Offers high signal-to-noise ratio compared to fluorescent light.Market SummaryNeuronal chloride (Cl-) is involved in many normal neurophysiological activities, including synaptic...
Published: 9/26/2017       Contributor(s): Robert Gross, Ken Berglund, Jack Tung
Compound and Method to Explore and Prepare O-Glycans from Living Cells
ApplicationChemical compound and method that enables detection of O-glycans with higher sensitivity than conventional approaches.Key BenefitsHigher accuracy and sensitivity than current β-elimination method.Smaller sample quantities required compared to traditional mass spectrometry.Method promotes the discovery of novel glycans and study of cellular...
Published: 5/25/2017       Contributor(s): Tongzhong Ju, Richard Cummings, Matthew Kudelka
Biomarkers for Diagnosis and Treatment Management of Tuberculosis
Application Biomarkers to diagnose active and latent tuberculosis infection and monitor treatment regimen. Key Benefits Three biomarkers accurately distinguish active tuberculosis (TB) from latent TB infections with 100% specificity and greater than 96% sensitivity. Faster and more accurate test to monitor treatment response among active tuberculosis...
Published: 6/1/2015       Contributor(s): Jyothi Rengarajan, Toidi Adejanbi, Chris Ibegbu
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