Technology Listings


Huntingtin Associated Protein 1B (Hap1B) Rabbit Polyclonal Antibodies

Applications
  • Western blot
  • Immunoprecipitation
  • Immunocytochemistry
Specificity

Huntingtin Associated Protein 1B isoforms. No detectable cross reactivity to other proteins by Western blot.

Subtype

Rabbit Polyclonal

Technical Summary

Huntington's disease (HD) is an autosomal dominant neurodegenerative disorder caused by an expanded trinucleotide repeat in the IT15 gene. Huntington Associated Protein 1 (Hap1) was initially identified as a protein that interacts with huntingtin, the protein encoded by the gene responsible for the development of HD.

These antibodies can be used to specifically detect Hap-1B by immunoblotting or immunocytochemistry. They have been shown to specifically detect Hap-1B from mouse, and rat brain tissue. These antibodies can also be used for immunoprecipitation of Hap-1B from rat brain tissue.

Publications

Chan EY, et al., Hum Mol Genet. 2002 Apr 15; 11(8):945-59
Gutekunst CA, et al., J Histochem Cytochem. 2003 Jun; 51(6):841-52
Torre ER, et al., J Neurosci Methods. 2003 May 30; 125(1-2):27-32
Tang TS, et al., Neuron. 2003 Jul 17; 39(2):227-39

Patent Information
Tech ID: RT001
Published: 4/15/2010
Category
Research Tools

Contact
Cliff Michaels
Assistant Director
Emory University
404-727-3890
ccmicha@emory.edu

Inventor(s)
Claire-Anne Gutekunst

Keywords
Antibody