Technology Listings

Huntingtin Associated Protein 1AB (Hap1AB) Mouse Monoclonal Antibodies

  • Western blot
  • Immunoprecipitation
  • Immunocytochemistry

Huntingtin Associated Protein 1A and B isoforms. No detectable cross reactivity to other proteins by Western blot.


Mouse Monoclonal

Technical Summary

Huntington's disease (HD) is an autosomal dominant neurodegenerative disorder caused by an expanded trinucleotide repeat in the IT15 gene. Huntington Associated Protein 1 (Hap1) was initially identified as a protein that interacts with huntingtin, the protein encoded by the gene responsible for the development of HD.

These antibodies can be used to specifically detect Hap-1A and B by immunoblotting or immunocytochemistry. They have been shown to detect Hap-1A and B from mouse, rat, and primate brain tissue. These antibodies can also be used for immunoprecipitation of Hap-1A and B from rat brain tissue.


Chan EY, et al., Hum Mol Genet. 2002 Apr 15; 11(8):945-59
Gutekunst CA, et al., J Histochem Cytochem. 2003 Jun; 51(6):841-52
Torre ER, et al., J Neurosci Methods. 2003 May 30; 125(1-2):27-32
Tang TS, et al., Neuron. 2003 Jul 17; 39(2):227-39

Patent Information
Tech ID: 04017
Published: 3/26/2009
Research Tools

Hyeon (sean) Kim
Licensing Associate
Emory University

Claire-anne Gutekunst