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Beta Blocker Isomers as Angiogenesis Inhibitors
Application β-blocker inactive form of propranolol for treatment of angiogenic disease. Key Benefits Reduced side-effects, such as low blood pressure and low blood sugar. Increased anti-angiogenic activity compared to the active isoform. Market Summary Angiogenesis is the growth of blood vessels from the existing vasculature. While it...
Published: 7/29/2019       Inventor(s): Jack Arbiser
Small Molecule Inhibitors of NADPH Oxidase 4 (NOX4) Signaling
ApplicationSmall molecule inhibitors of NOX4 signaling with a wide array of therapeutic potential.Key BenefitsSmall molecule inhibitors of NOX4 signaling.Low cytotoxicity.Market SummaryThe NADPH oxidase 4 (NOX4) has gained considerable and growing attention during the past years because of its potential key involvement in a variety of diseases, som...
Published: 5/13/2019       Inventor(s): Bernard Lassegue, Kathy Griendling, David Brown, Qian Xu, Osman Guner, J. Phillip Bowen, Amol Kulkarni, E. Blake Watkins
Software for Extended and Accurate Analysis of Biomedical Signals
ApplicationComputational method designed for accurate rhythm sensing with reduced energy consumption of wireless body sensor network (WBSN) medical devices.Key BenefitsCompressed data collection reduces power consumption and addresses power needs of small devices.Addresses power needs of small devices.Increases device longevity.Market SummaryAtrial...
Published: 1/23/2019       Inventor(s): Giulia Da Poian, Roberto Rinaldo, Gari Clifford
Small Molecules for Development of Cardiac Chamber-Specific Myocytes
ApplicationSmall molecule activators and inhibitors of retinoic acid (RA) to create chamber-specific myocytes from pluripotent stem cells without cell sorting.Key BenefitsProduces highly-enriched, subtype-specific populations of cardiac myocytes.Eliminates need for cell-sorting.Does not require transgenic changes to the human stem cells.Market Summ...
Published: 11/16/2018       Inventor(s): Hee Cheol Cho, Pengcheng Han
Biological Pacemakers as Alternatives/Adjuncts to Electronic Pacing Devices
ApplicationNon-viral gene delivery and a small molecule that converts heart muscle cells to pacemaker cells for the device-free treatment of slow heart rhythm.Key BenefitsMinimally invasive procedure provides cardiac pacing without device implant.Restores natural heart rhythm.Eliminates or reduces significant complications such as repeat surgeries ...
Published: 11/16/2018       Inventor(s): Hee Cheol Cho, Jun Li
Cre-Lox PAR1 Conditional Knockout Mouse
Key BenefitsTissue-specific knockout mouse, allowing PAR1 to be inactivated in specific cell types in certain tissue.Inducible knockout mouse, allowing PAR1 to be temporally suppressed at a given time-point in embryonic, post-natal or adult animals.Eliminates drawbacks and side effects of traditional knockout processes that eliminate genes from the...
Published: 6/26/2018       Inventor(s): Stephen Traynelis
Targeting Peptides for Myocarditis
ApplicationTargeting peptide molecule for image-based diagnosis of myocarditis.Key BenefitsEnables noninvasive diagnosis of myocarditis.Targets and binds to biomarker of myocarditis.Market SummaryMyocarditis is an inflammation of the heart muscle (myocardium). Myocarditis can affect your heart muscle and your heart's electrical system, reducing the...
Published: 2/7/2018       Inventor(s): Michael Davis, Mario Martinez
hPSC-Derived Endothelial Cell Generation System
ApplicationClinically compatible cell culture system to generate endothelial cells (EC) from human pluripotent stem cells (hPSC).Key BenefitsProduces hPSC-ECs in high yield.Compatible with clinical applications of hPSC-derived endothelial cells.Engrafted cells survive longer (>10 months) than in prior published research (weeks).Market SummaryAcc...
Published: 12/11/2017       Inventor(s): Young-Sup Yoon, Shin-Jeong Lee, Ho-Wook Jun
RNA Biomarkers for Coronary Artery Disease (CAD)
ApplicationDiagnostic panel to determine severity of coronary artery disease using plasma-based biomarkers of microparticle vesicles and isoforms of specific miRNAs (isomiRs).Key BenefitsPredictive risk diagnostic aids in clinicians' course of treatment decisions.Identifies underlying biological function of biomarkers for potential use of personali...
Published: 11/9/2017       Inventor(s): Charles Searles, Jr., Amanda James
MitraPlug: Transcatheter Mitral Valve Repair
ApplicationRepair of mitral valve regurgitation, using a minimally-invasive transcatheter-based technology.Key BenefitsCan be delivered using a one-shot transcatheter approach via the apex of the heart. Miniature adjustable plug mounts directly on the valve leaflets, closing the gap between the leaflets and eliminating leakage. Designed to be impla...
Published: 6/19/2017       Inventor(s): Sai Muralidhar Padala, Eric Sarin
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