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Biomarker for Clinical Prognosis for Lung Cancer Patients
Application Biomarker to predicting clinical outcome and treatment options for lung cancer patients. Key Benefits Provides early determination of prognosis. Market Summary Upon diagnosis with cancer, there are many different treatment options. While some more aggressive treatment options can be more dangerous to the patient, these aggressiv...
Published: 7/2/2019       Inventor(s): Adam Marcus, Brian Pedro, Jessica Konen
Theranostic Biomarker for Aspirin-Exacerbated Respiratory Disease
Application Biomarkers for a clinical diagnostic tool and non-psychogenic therapy to detect and treat aspirin-exacerbated respiratory disease. Key Benefits Does not rely on aspirin challenge, increasing safety and availability for suspected patients. May be used in patients who have respiratory compromise or are not stable. Minimally-invasiv...
Published: 7/2/2019       Inventor(s): Joshua Levy, Samuel Molina
Combination Therapy for Increasing Venetoclax Sensitivity in Multiple Myeloma
Application Marker and co-therapy that inhibits succinate dehydrogenase to increase patient response to venetoclax. Key Benefits Co-therapy increases MM sensitivity to venetoclax treatment. Identifies patients who will respond to venetoclax therapy. Market Summary Multiple Myeloma (MM) is a cancer of plasma cells responsible for making ant...
Published: 6/18/2019       Inventor(s): Malathy (mala) Shanmugam, Richa Bajpai
Antibodies for Zika and Dengue Viruses
ApplicationsELISAWestern BlotImmunohistochemistrySpecificityHuman monoclonalTechnical SummaryZika Virus (ZIKV) is a mosquito borne filovirus responsible for a 2016-2017 epidemic in North and South America. ZIKV nonstructural protein 1 (NS1) is a pathogenicity factor implicated in virus replication, host interaction and immune invasion. The investig...
Published: 5/9/2019       Inventor(s): Jens Wrammert, Mark Mulligan
Glycoprotein Tetramer for Identifying Antigen-specific B Cells
ApplicationEctodomain of viral glycoprotein tetramers detects antigen-specific memory B Cells.Key BenefitsViral glycoprotein tetramers detect antigen-specific memory B cells in the peripheral blood and tissues.Hepatitis C virus E2 protein triggers immune response, which may yield an effective vaccine against hepatitis C virus.Market SummaryHepatiti...
Published: 5/9/2019       Inventor(s): Arash Grakoui, Joseph Marcotrigiano
Granulin for Treatment of Neurodegeneration
ApplicationGranulin proteins (GRNs) as potential therapeutics for multiple neurodegenerative disorders caused by lysosome dysfunction and inflammation.Key BenefitsNovel pathway and target provides new route for treatment.Granulins shown to rescue lysosomal defects in cell culture models.Market SummaryGranulins are small proteins that are derived by...
Published: 12/18/2018       Inventor(s): Thomas Kukar
Ebola Specific Antibody-Dependent Cell-mediated Cytotoxicity (ADCC) Assay
ApplicationA cell based assay to quantify the titer of circulating Ebola glycoprotein (GP) antibodies that trigger antibody-dependent cell-mediated cytotoxicity (ADCC).Key BenefitsSpecific for detection of ADCC activity of Ebola virus antibodies or antisera.Applicable to all pathogenic strains of Ebola virus.Ebola GP-specific stable reporter cells ...
Published: 11/26/2018       Inventor(s): Paul Spearman, Karnail Singh, Xuemin Chen
Radiotracer for PET Imaging of Brain Tumors
ApplicationRadiolabeled 5-aminolevulinic acid and derivatives for detecting, imaging, and grading tumors.Key BenefitsNoninvasive imaging method for grading brain tumors.Improvement over [18F] FDG, which is less specific and sensitive to brain tumors.110-minute half-life allows radiotracer to be made off site and transported to end site for use.Mark...
Published: 7/25/2018       Inventor(s): Adam Pippin, Mark Goodman, Ronald Voll
Specialized Cell Culturing Media for Enhanced Antibody Secretion and Plasma Cell Survival
ApplicationCell culture media that promotes the survival of human plasma cells and enables immunoglobin (Ig) secretion from such plasma cells.Key BenefitsFacilitates the isolation of antibody-secreting cells (ASCs) found in blood after antigen exposure, which can be used to identify an active antigen or pathogen causing illness.Composed of factors ...
Published: 5/24/2018       Inventor(s): Frances Lee, Ignacio (Inaki) Sanz, Doan Nguyen
TaqMan Array Cards for Pneumococcal Detection and Serotyping
ApplicationDiagnostic for identifying Streptococcus pneumonia serotypes.Key BenefitsAllows for rapid detection and serotype identification of Streptococcus pneumonia infections.Market SummaryStreptococcus pneumonia (Spn) is a gram-positive bacteria and significant human pathogen responsible for most pneumonia cases. Typically, Spn resides asymptoma...
Published: 4/16/2018       Inventor(s): Jorge Vidal, Fuminori Sakai, Lesley Mcgee, Velusamy Srinivasan
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