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Dual Purpose Radiotracer for Renal Imaging
Application
Radioactive tracer with improved plasma clearance for use as either a planar or positron emission tomography (PET) renal imaging agent.
Key Benefits
Rapid renal excretion.
Minimal localization at other body sites.
More rapid blood clearance than current standard.
Can be adapted for either standard planar or positron emission tomography...
Published: 11/20/2024
Contributor(s): Jeffrey Klenc, Malgorzata Lipowska, Andrew Taylor, Jr.
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KIDSCRRT – A Device for Continuous Renal Replacement Therapy in Children
Application
Device that provides continuous renal replacement therapy (CRRT) for neonates and children with acute kidney injury, which is adjustable to treat adults as well.
Key Benefits
Can be used in children - currently no CRRT device is approved for pediatric use.
Improved accuracy over currently available devices due to novel pump and control...
Published: 11/20/2024
Contributor(s): Matthew Paden, Ajit Yoganathan, Lakshmi Prasad Dasi
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Improved Fluid Management System for Continuous Hemofiltration
Application
Device that provides continuous veno-venous hemofiltration for adults and children with kidney failure.
Key Benefits
Used in combination with extracorporeal membrane oxygenation machines.
Improves the accuracy and safety of fluid delivery and extraction compared to existing technology, thereby improving outcomes of critically ill patients.
Can...
Published: 11/20/2024
Contributor(s): Matthew Paden, James Fortenberry, Ajit Yoganathan, Philippe Sucosky, Lakshmi Prasad Dasi
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Tempol-Folate Conjugates to Prevent Oxidative Injury in Tissues
Application
Targeted anti-oxidative therapy for ischemia-reperfusion injury, hemorrhage, major surgery, kidney transplant, or acute renal failure.
Key Benefits
Conjugation of Tempol with Folate does not alter the antioxidant property of Tempol.
Tempol-Folate conjugates are more effective than Tempol alone at preserving kidney structure and function...
Published: 11/20/2024
Contributor(s): Sarah (Knight) Marvar, William Robert Taylor, Niren Murthy, Kousik Kundu
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Renal Imaging Utilizing Tc-99m-NTA Improves Tubular Measurements
Application
Diagnostic imaging of the kidneys for the determination of renal function.
Key Benefits
Renal tracer for measuring the effective renal plasma flow.
99mTc-labeled small molecule has renal clearance characteristics that are superior to currently available tracers.
First-in-man studies have been performed with resulting image quality...
Published: 7/30/2024
Contributor(s): Malgorzata Lipowska, Andrew Taylor, Jr., Luigi Marzilli
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