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Optimizing the Engineering of CAR-T Cells
Application
A method for selecting distinct T cell populations in order to generate more effective CAR-T cells.
Key Benefits
The proposed invention focuses on selecting the optimal “starting material” for the engineering CAR-T cells.
This selection method can be utilized for the development of any and all CAR-T therapies, not limited...
Published: 4/11/2024
Contributor(s): Byron Au-Yeung
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Liposome Encapsulated Tyrosine Kinase Inhibitors to Treat Leukemia
Application
Lipid encapsulation of MRX-2843 for the treatment of leukemia.
Key Benefits
Encapsulation of a tyrosine kinase inhibitor called MRX-2843 within a liposome improves its performance in an animal model of acute lymphoblastic leukemia.
Systemic delivery of this therapeutic requires a lower dose and less frequent administration than oral...
Published: 4/23/2024
Contributor(s): Erik Dreaden, James Kelvin, Deborah DeRyckere, Douglas Graham, Juhi Jain
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EF-Tu Targeting Antibody for Infection Treatment
Application
Therapeutic monoclonal antibodies directed to Elongation Factor-Tu (EF-Tu) for the treatment of infections.
Key Benefits
An antibody that targets the protein EF-Tu, which is present on many types of bacteria involved in life-threatening infections.
A research-grade antibody has been developed with animal data showing the ability to...
Published: 10/13/2023
Contributor(s): Joanna Goldberg, Dina Moustafa
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Methods for Enhancing MSC Therapeutic Potential for Treatment of Osteoarthritis by Measuring and Targeting Intracellular Pathways
Application
Highly transformative new strategy to enhance mesenchymal stromal cell consistency and efficacy for taking MSC therapies to clinical stage.
Key Benefits
Currently there is no method to determine if an MSC donor line will be therapeutically effective.
Provides a point of use assay in the clinical setting which can determine MSC efficacy...
Published: 4/23/2024
Contributor(s): Nick Willett, Levi Wood, Jay McKinney
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Quantitative Multi Energy Computed Tomography (MECT) for the Characterization of Composition and Density Maps of Artificial and Human Materials in Proton Therapy
Application
A novel multi-energy computed tomography (MECT) simulation framework to determine the densities of human tissues and material compositions of implant material maps for proton Monte Carlo does performs the calculation.
Key Benefits
Provides a multi-image computer tomography based alternative methodology of providing complete maps...
Published: 7/28/2023
Contributor(s): Liyong Lin, Chih-Wei Chang, Tiezhi Zhang, Shuai Leng, Serdar Charyyev, Xiaofeng Yang, Joseph (Joe) Harms
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Small Molecule Inhibitors for the Treatment of COVID-19 Infection
Application
Small molecule therapy to treat patients infected with COVID-19 virus.
Key Benefits
Current FDA-approved therapeutic can be repurposed to fight COVID-19 infection.
Treatment option for infected COVID-19 patients.
Market Summary
Coronavirus (COVID-19) is an infectious disease that causes severe acute respiratory syndrome coronavirus...
Published: 4/23/2024
Contributor(s): Jack Arbiser, Martijn van Hemert, Melissa Thaler
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An Algorithm for Optimized Patient-Specific Phase Selection During Stereotactic Body Radiation Therapy (SBRT)
Application
An algorithm for optimizing SBRT tumor targeting.
Key Benefits
Reduction in motion errors
Faster treatment planning
Applicable on different treatment modalities such as IMRT and VMAT
Minimize dose delivery to surrounding organs-at-risk
Does not rely on a physician’s subjective judgment
Market Summary
SBRT is a radiation...
Published: 4/24/2024
Contributor(s): Mohammad Khan, Jerome Carl Landry, Lei Zhu
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