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Methioninase Inducing Virus for Anti-Cancer Therapy
Application
A set of viral constructs that induce regulatable expression of methionine degrading enzyme for treatment of brain tumors.
Key Benefits
Built-in Tet-responsive element ensures precise regulation, preventing unwanted enzyme activity.
IL-2 signal directs the enzyme for secretion, optimizing its therapeutic impact.
Specific delivery...
Published: 12/9/2025
Contributor(s): Timothy R. Gershon, Leon McSwain, Andrey Tikunov
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Small Molecule Inhibitors Targeting OTUD4-CD73 Interaction for Immune-Cold Tumors
Application
This technology introduces small molecule inhibitors, ST80 and Z22, to disrupt the protein-protein interaction (PPI) between OTUD4 and CD73. These inhibitors enhance tumor immunogenicity by reducing CD73 stabilization, improving the immune response in triple-negative breast cancer (TNBC) and other immune-cold tumors.
Key Benefits
ST80...
Published: 12/9/2025
Contributor(s): Yong Wan, Yueming Zhu, Ivet Bahar, Anupam Banerjee, Jiyoung Lee
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Protein Biomarkers of Rett Syndrome
Application
Quantifiable protein biomarkers for Rett syndrome.
Key Benefits
Critical protein biomarkers of Rett syndrome identified in brain and cerebrospinal fluid.
Quantifiable biochemical biomarkers of gene therapy effectiveness.
Market Summary
Rett syndrome is a progressive neurodevelopmental disorder that affects approximately one in 10,000...
Published: 10/15/2025
Contributor(s): Victor Faundez, Stephanie Zlatic
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