Technology Listings


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Small Molecule TrkB Agonist to Prevent Blindness from Eye Injuries
Application Small molecule HIOC derivatives as a therapeutic for preventing vision loss in traumatic eye injuries. Key Benefits Reduces blindness in a model of traumatic optical injury. May be administered systemically and penetrates tissues in and adjacent to the brain. This treatment method has potential for indications outside of retinal injury. Market...
Published: 5/5/2021       Contributor(s): Paul Iuvone, Frank Mcdonald, Christopher Walker
Vision Test for Non-Verbal Children
Application Vision testing for non-verbal children, the hearing impaired, and non English-speaking population. Key Benefits Simplifies vision testing for non-verbal children. Does not require any verbal communication to be used effectively. Technical Summary While traditional eye charts are often effective, they rely on verbal communication...
Published: 2/3/2021       Contributor(s): Amy Hutchinson, Caroline Cromelin, Cindy Harrington
Surgical Device for Eyelid Ptosis Correction
ApplicationSurgical device to perform clamping, incision, and closure for correcting eyelid ptosis.Key BenefitsSimplifies the Müller muscle resection that decreases surgical procedure time.Eliminates the risk of cutting sutures that cause dehiscence and improves the final appearance.Market SummaryPtosis (drooping upper eyelids) is a common condition...
Published: 6/18/2019       Contributor(s): Denise Kim, Jacquelyn Borinski, Andrew Kolpitcke, Mohamad Ali Naja, Drew Padilla
Knock-In Mouse Model of Oculopharyngeal Muscular Dystrophy
ApplicationConditional knock-in mouse mimicking Oculopharyngeal muscular dystrophy.Technical SummaryOculopharyngeal muscular dystrophy (OPMD) is rare genetic disease caused by a mutation in the PABPN1 gene. In this mutation, the number of GCG trinucleotide repeats at the 5' end of PABPN1 are increased, which leads to an expansion of an alanine repeat...
Published: 9/27/2018       Contributor(s): Grace Pavlath, Anita Corbett, Katherine Vest
Simplifly (TM): A Fly Genetically Programmed to Identify a Single Scent
ApplicationA fruit fly modified to express only a single odor receptor and therefore only capable of sensing one chemical odorant; used as an animal model for sensory and nervous system studies or as a living biosensor for chemical identification.Key BenefitsNew model for sensory research that simplifies the olfactory system. Insect-based behavioral...
Published: 2/25/2014       Contributor(s): Jessica Eliason, Ichiro Matsumura, Justin Gallivan, Subhabrata Sanyal
Questionnaires for Assessing the Effect of Visual Impairment on Quality of Life and Function in Children
ApplicationA standardized series of questions for the assessment of vision related quality of life and visual function in children and adolescents.Key BenefitsProvides age-appropriate questions for children from ages 8-18 as an improvement to using currently available assessments geared toward adults. Allows the subjective assessment of the impact of...
Published: 1/3/2014       Contributor(s): Sheila Angeles-Han
Cluster Fix: An Eye-Tracking Algorithm for the Measurement of Fixations and Saccades
Application Software for more precise measurement of fixations and saccades during eye motion tracking. Key Benefits Increased precision by combining distance, velocity, acceleration and rotation measurements. Increased sensitivity by globally and locally evaluating scan paths. Market Summary Eye tracking technologies are instrumental for companies...
Published: 6/7/2013       Contributor(s): Seth Koenig, Elizabeth Buffalo
Surgical Kit for Treating Age-Related Macular Degeneration (AMD)
ApplicationInstruments for surgical treatment of age-related macular degeneration (AMD).Key BenefitsSurgical procedure provides a less costly, curative alternative to expensive drug therapeutics that usually only prevent or slow disease progression. One time surgical treatment applicable to both wet and dry AMD. Specialized instruments allow for precise...
Published: 6/6/2013       Contributor(s): Timothy Olsen, Paul Loftness, David Rosen, Arthur Erdman, Shreyes Melkote, George Koruthu Mathai
Treatment of Dry AMD and Other Ophthalmic Diseases
Application Fulvene and fulvalene compounds that inhibit nicotinamide adenine dinucleotide phosphate (NADPH) oxidases for the treatment of ophthalmic diseases and disorders including the dry form of age-related macular degeneration. Key Benefits Lead compound candidate identified. Demonstrated positive effects in in vivo preclinical ocular models...
Published: 6/4/2012       Contributor(s): Jack Arbiser
A Porcine Model of Proliferative Vitreoretinopathy
Application A large animal model of Proliferative Vitreoretinopathy (PVR) in pigs, allows for surgical manipulation and intervention that is not possible in other animal models. Technical Summary Proliferative vitreoretinopathy (PVR) is the principle cause for failed retinal detachment (RD) surgery. Currently there is a rabbit model used for research...
Published: 10/6/2011       Contributor(s): Timothy Olsen
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