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Small Molecule TrkB Agonist to Prevent Blindness from Eye Injuries
Application
Small molecule HIOC derivatives as a therapeutic for preventing vision loss in traumatic eye injuries.
Key Benefits
Reduces blindness in a model of traumatic optical injury.
May be administered systemically and penetrates tissues in and adjacent to the brain.
This treatment method has potential for indications outside of retinal injury.
Market...
Published: 5/4/2023
Contributor(s): Frank Mcdonald, Paul Iuvone, Christopher Walker
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Vision Test for Non-Verbal Children
Application
Vision testing for non-verbal children, the hearing impaired, and non English-speaking population.
Key Benefits
Simplifies vision testing for non-verbal children.
Does not require any verbal communication to be used effectively.
Technical Summary
While traditional eye charts are often effective, they rely on verbal communication...
Published: 8/19/2022
Contributor(s): Amy Hutchinson, Caroline Cromelin, Cindy Harrington
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Surgical Device for Eyelid Ptosis Correction
ApplicationSurgical device to perform clamping, incision, and closure for correcting eyelid ptosis.Key BenefitsSimplifies the Müller muscle resection that decreases surgical procedure time.Eliminates the risk of cutting sutures that cause dehiscence and improves the final appearance.Market SummaryPtosis (drooping upper eyelids) is a common condition...
Published: 4/5/2023
Contributor(s): Denise Kim, Jacquelyn Borinski, Andrew Kolpitcke, Mohamad Ali Naja, Drew Padilla
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Knock-In Mouse Model of Oculopharyngeal Muscular Dystrophy
ApplicationConditional knock-in mouse mimicking Oculopharyngeal muscular dystrophy.Technical SummaryOculopharyngeal muscular dystrophy (OPMD) is rare genetic disease caused by a mutation in the PABPN1 gene. In this mutation, the number of GCG trinucleotide repeats at the 5' end of PABPN1 are increased, which leads to an expansion of an alanine repeat...
Published: 9/29/2022
Contributor(s): Grace Pavlath, Anita Corbett, Katherine Vest
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Simplifly (TM): A Fly Genetically Programmed to Identify a Single Scent
ApplicationA fruit fly modified to express only a single odor receptor and therefore only capable of sensing one chemical odorant; used as an animal model for sensory and nervous system studies or as a living biosensor for chemical identification.Key BenefitsNew model for sensory research that simplifies the olfactory system. Insect-based behavioral...
Published: 7/29/2022
Contributor(s): Jessica Eliason, Ichiro Matsumura, Justin Patrick Gallivan, Subhabrata Sanyal
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Questionnaires for Assessing the Effect of Visual Impairment on Quality of Life and Function in Children
Application
A standardized series of questions for the assessment of vision related quality of life and visual function in children and adolescents.
Key Benefits
Provides age-appropriate questions for children from ages 8-18 as an improvement to using currently available assessments geared toward adults.
Allows the subjective assessment of the...
Published: 8/3/2022
Contributor(s): Sheila Angeles-Han
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Cluster Fix: An Eye-Tracking Algorithm for the Measurement of Fixations and Saccades
Application
Software for more precise measurement of fixations and saccades during eye motion tracking.
Key Benefits
Increased precision by combining distance, velocity, acceleration and rotation measurements.
Increased sensitivity by globally and locally evaluating scan paths.
Market Summary
Eye tracking technologies are instrumental for companies...
Published: 8/19/2022
Contributor(s): Seth Koenig, Elizabeth Buffalo
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Treatment of Dry AMD and Other Ophthalmic Diseases
Application
Fulvene and fulvalene compounds that inhibit nicotinamide adenine dinucleotide phosphate (NADPH) oxidases for the treatment of ophthalmic diseases and disorders including the dry form of age-related macular degeneration.
Key Benefits
Lead compound candidate identified.
Demonstrated positive effects in in vivo preclinical ocular models...
Published: 12/6/2022
Contributor(s): Jack Arbiser
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A Porcine Model of Proliferative Vitreoretinopathy
Application
A large animal model of Proliferative Vitreoretinopathy (PVR) in pigs, allows for surgical manipulation and intervention that is not possible in other animal models.
Technical Summary
Proliferative vitreoretinopathy (PVR) is the principle cause for failed retinal detachment (RD) surgery. Currently there is a rabbit model used for research...
Published: 9/29/2022
Contributor(s): Timothy Olsen
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Simulated Vocal Fold and Dry Micrrolaryngeal Surgical Simulator
Application
Training device that simulates the human vocal fold (SVF) is designed to assist in the development of fine manual dexterity and instrument precision necessary for physicians to perform microlaryngeal surgical dissection.
Key Benefits
The SVF housed within a plastic larynx model approximates the both the delicate tissue and limited operating...
Published: 4/5/2023
Contributor(s): Michael Johns Iii, Adam Klein
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