Software for Predicting Immunotherapy Response in Lung Cancer
Application
Software to predict immunotherapy response and overall survival in patients with non-small cell lung cancer.
Key Benefits
Maps the complex relationships between multiple cell types within the tumor microenvironment to a pathomic signature for predicting immunotherapy outcome.
Interprets these inter- and intra- relationships to predict...
Published: 3/1/2024
Contributor(s): Sara Arabyarmohammadi, Anant Madabhushi, German Corredor Prada, Kurt Schalper, Yufei Zhou, Miguel Lopez de Rodas Gregorio
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RSV Vaccine for Infants and Children
Application
Vaccine for Respiratory Syncytial Virus (RSV) in infants and children.
Key Benefits
A novel vaccine targeting both the F and G proteins of the respiratory syncytial virus (RSV), including its variants.
Preliminary data in in mice show the vaccine induced the production of antibodies associated with preventing disease.
Potential to...
Published: 3/1/2024
Contributor(s): Larry Anderson, Binh Ha, Heying Sun
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Repurposing an FDA-Approved Drug for Treating Age-Associated Lung Fibrosis
Application
New use of an FDA-approved therapeutic, diroximel fumarate (Vumerity), for treating Idiopathic Pulmonary Fibrosis.
Key Benefits
Novel use of an FDA-approved drug, diroximel fumarate - DRF (Vumerity), for treating age-dependent lung fibrosis.
Lung-targeted inhaled delivery of DRF is effective for boosting lung antioxidant responses...
Published: 1/10/2024
Contributor(s): Louise Hecker, Kosuke Kato
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Therapeutic to Treat Age-Dependent Idiopathic Pulmonary Fibrosis
Application
Therapeutic for treating age-associated lung fibrosis.
Key Benefits
Tecfidera (dimethyl fumarate - DMF) is an FDA approved therapy to treat multiple sclerosis via oral administration.
A novel formulation for inhaled delivery demonstrated efficacy for a new indication: Idiopathic Pulmonary Fibrosis (IPF), where it promotes the reversal...
Published: 3/1/2024
Contributor(s): Louise Hecker, Kosuke Kato, Priyadarshini Muralidharan, Heidi Mansour
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Small Molecules for Treating Cystic Fibrosis
ApplicationSmall molecule compounds to potentiate most common type of CFTR mutation in cystic fibrosis patients.Key BenefitsPotentiates ΔF508-hCFTR mutation, addressing more than 60 percent of CF patients. Market SummaryCystic fibrosis transmembrane conductance regulator (CFTR) is a membrane protein and ion channel that malfunctions in the genetic...
Published: 7/28/2023
Contributor(s): Nael McCarty, Guiying Cui, Hanoch Senderowitz, Netaly Khazanov
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Improving Pediatric Asthma Management for Urban Families
Application
Home-based family psychoeducational intervention for low-income children with persistent asthma.
Key Benefits
Medical and psychosocial needs of patients and family members can be addressed simultaneously.
Significantly improved asthma management and caregiver stress in randomized controlled clinical trial.
Market Summary
Asthma...
Published: 7/28/2023
Contributor(s): Marianne Celano, Lisa Kobrynski, Chanda Holsey
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Bag-Valve-Mask (BVM) Ventilator
Application
Simple, low-cost bag-valve-mask (ambu bag) ventilator for treating respiratory challenges associated with COVID-19 and acute respiratory distress syndrome.
Key Benefits
Enables ventilation of two patients simultaneously or allows alternating tidal volumes for a single patient.
Simple, low-cost design.
Technical Summary
Georgia Tech,...
Published: 7/28/2023
Contributor(s): Susan Margulies, Shannon Yee, Michael Adams, Kentez Craig, Connor Hart, James Hurley, Jordan Kocher, Maxwell Praniewicz, Leon Williams, Christopher (Chris) Saldana
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CFTR Modulators for Treating Rare Forms of Cystic Fibrosis
Application
Small molecules to treat cystic fibrosis and other pulmonary diseases.
Key Benefits
Rescue rare variants of CFTR gene.
Serve as PDE4 inhibitors with strong anti-inflammatory effects.
Market Summary
Cystic fibrosis (CF) is a progressive, genetic disorder that arises from mutations in the cystic fibrosis transmembrane conductance...
Published: 3/11/2024
Contributor(s): Eric J. Sorscher, Jeong Hong, Haian Fu, Yuhong Du, Huw Davies, Andras Rab, Candela Manfredi, Xun Yang, Zhi Ren
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Mobile Application for COPD Patients
Application
Mobile application for teaching breathing techniques to patients with chronic obstructive pulmonary disease (COPD).
Key Benefits
Personalized coaching program.
Tracks and saves lung performance.
Adapts training program to patient’s lung performance.
Can be done from the comfort of the patient’s home.
Market Summary
Chronic...
Published: 7/28/2023
Contributor(s): Weihua Zhang
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Virus-Like Particles as RSV Vaccine Candidate
Application
Virus-like particle (VLP) vaccine candidate(s) to prevent respiratory syncytial virus (RSV) infection.
Key Benefits
Candidates may have the most effective anti-viral and anti-inflammatory response.
Potentially protects elderly and immunocompromised patients from re-infection with the RSV virus.
Efficient, tunable and stable production...
Published: 3/11/2024
Contributor(s): Binh Ha, Larry Anderson, Elizabeth Wright
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