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Application Simple, low-cost bag-valve-mask (ambu bag) ventilator for treating respiratory challenges associated with COVID-19 and acute respiratory distress syndrome. Key Benefits Enables ventilation of two patients simultaneously or allows alternating tidal volumes for a single patient. Simple, low-cost design. Technical Summary Georgia Tech,...

Published: 2/23/2022 Contributor(s): Susan Margulies, Shannon Yee, Michael Adams, Kentez Craig, Connor Hart, James Hurley, Jordan Kocher, Maxwell Praniewicz, Leon Williams, Christopher (Chris) Saldana

CFTR Modulators for Treating Rare Forms of Cystic Fibrosis

Application Small molecules to treat cystic fibrosis and other pulmonary diseases. Key Benefits Rescue rare variants of CFTR gene. Serve as PDE4 inhibitors with strong anti-inflammatory effects. Market Summary Cystic fibrosis (CF) is a progressive, genetic disorder that arises from mutations in the cystic fibrosis transmembrane conductance...

Published: 11/2/2020 Contributor(s): Eric Sorscher, Jeong Hong, Haian Fu, Yuhong Du, Huw Davies, Andras Rab, Candela Manfredi, Xun Yang, Zhi Ren

Mobile Application for COPD Patients

Application Mobile application for teaching breathing techniques to patients with chronic obstructive pulmonary disease (COPD). Key Benefits Personalized coaching program. Tracks and saves lung performance. Adapts training program to patient’s lung performance. Can be done from the comfort of the patient’s home. Market Summary Chronic...

Published: 1/22/2020 Contributor(s): Weihua Zhang

Virus-Like Particles as RSV Vaccine Candidate

Application Virus-like particle (VLP) vaccine candidate(s) to prevent respiratory syncytial virus (RSV) infection. Key Benefits Candidates may have the most effective anti-viral and anti-inflammatory response. Potentially protects elderly and immunocompromised patients from re-infection with the RSV virus. Efficient, tunable and stable production...

Published: 1/15/2020 Contributor(s): Binh Ha, Larry Anderson, Elizabeth Wright

Theranostic Biomarker for Aspirin-Exacerbated Respiratory Disease

Application Biomarkers for a clinical diagnostic tool and non-psychogenic therapy to detect and treat aspirin-exacerbated respiratory disease. Key Benefits Does not rely on aspirin challenge, increasing safety and availability for suspected patients. May be used in patients who have respiratory compromise or are not stable. Minimally-invasive...

Published: 7/2/2019 Contributor(s): Joshua Levy, Samuel Molina

Peptide Therapeutic for Acute Respiratory Distress Syndrome

ApplicationAnti-claudin 5 peptide to improve lung barrier function for the treatment of alcohol-induced acute respiratory distress syndrome (ARDS).Key BenefitsNew target for treating ARDS.Small inhibitory peptide to specifically target claudin-5.Market SummaryApproximately 200,000 cases of acute respiratory distress syndrome (ARDS) are diagnosed each...

Published: 5/13/2019 Contributor(s): Michael Koval, Barbara Schlingmann-Molina

Alexidine and Analogs to Treat Lung Cancer

ApplicationSmall molecule therapeutic specifically targeting invasive cancer cells for treatment of lung cancer.Key BenefitsInhibits cancer cell invasion.Utilizes a novel mechanism of action.Market SummaryLung cancer is the second most prevalent type of cancer, causing more than 150,000 deaths in the United States per year. One of the main barriers...

Published: 4/12/2019 Contributor(s): Adam Marcus, Jessica Konen, Rachel Commander, Jamie Arnst, Thota Ganesh

Respiratory Syncytial Virus Strain A2-2-20F

ApplicationStrain of respiratory syncytial virus (RSV) for vaccine and therapeutic research and development.Key BenefitsHigher early viral load.Induces greater necrotic airway damage and neurophil infiltration.Market SummaryRSV is a highly contagious and ubiquitous virus that causes respiratory tract infections in individuals of all ages, particularly...

Published: 10/16/2018 Contributor(s): Martin Moore

GeneRegs: Nanoparticles for Treatment of Severe Asthma

Application Gold nanoparticles coated with enzyme which specifically targets and degrades asthma-associated inflammation molecules. Key Benefits Specifically suppresses asthma associated inflammation. Easy self-administration by inhalation. Market Summary Asthma is defined as a chronic inflammatory lung disease with significant worldwide morbidity....

Published: 12/4/2017 Contributor(s): Khalid Salaita, Cherry Wongtrakool, Kornelia Galior

Respiratory Syncytial Virus (RSV) A2 Expressing Firefly Luciferase

ApplicationRecombinant RSV strain expressing firefly luciferase and the F & G genes from clinical strain A2001/2-20 for research and development of vaccines.Key BenefitsF & G proteins included in this strain show different behavior than those of the typical A2 strain proteins.May be adapted in a variety of assays, enabling the identification...

Published: 2/19/2017 Contributor(s): Martin Moore, Christopher Stobart

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