Bag-Valve-Mask (BVM) Ventilator
Application
Simple, low-cost bag-valve-mask (ambu bag) ventilator for treating respiratory challenges associated with COVID-19 and acute respiratory distress syndrome.
Key Benefits
Enables ventilation of two patients simultaneously or allows alternating tidal volumes for a single patient.
Simple, low-cost design.
Technical Summary
Georgia Tech,...
Published: 2/23/2022
Contributor(s): Susan Margulies, Shannon Yee, Michael Adams, Kentez Craig, Connor Hart, James Hurley, Jordan Kocher, Maxwell Praniewicz, Leon Williams, Christopher (Chris) Saldana
|
CFTR Modulators for Treating Rare Forms of Cystic Fibrosis
Application
Small molecules to treat cystic fibrosis and other pulmonary diseases.
Key Benefits
Rescue rare variants of CFTR gene.
Serve as PDE4 inhibitors with strong anti-inflammatory effects.
Market Summary
Cystic fibrosis (CF) is a progressive, genetic disorder that arises from mutations in the cystic fibrosis transmembrane conductance...
Published: 11/2/2020
Contributor(s): Eric Sorscher, Jeong Hong, Haian Fu, Yuhong Du, Huw Davies, Andras Rab, Candela Manfredi, Xun Yang, Zhi Ren
|
Mobile Application for COPD Patients
Application
Mobile application for teaching breathing techniques to patients with chronic obstructive pulmonary disease (COPD).
Key Benefits
Personalized coaching program.
Tracks and saves lung performance.
Adapts training program to patient’s lung performance.
Can be done from the comfort of the patient’s home.
Market Summary
Chronic...
Published: 1/22/2020
Contributor(s): Weihua Zhang
|
Virus-Like Particles as RSV Vaccine Candidate
Application
Virus-like particle (VLP) vaccine candidate(s) to prevent respiratory syncytial virus (RSV) infection.
Key Benefits
Candidates may have the most effective anti-viral and anti-inflammatory response.
Potentially protects elderly and immunocompromised patients from re-infection with the RSV virus.
Efficient, tunable and stable production...
Published: 1/15/2020
Contributor(s): Binh Ha, Larry Anderson, Elizabeth Wright
|
Theranostic Biomarker for Aspirin-Exacerbated Respiratory Disease
Application
Biomarkers for a clinical diagnostic tool and non-psychogenic therapy to detect and treat aspirin-exacerbated respiratory disease.
Key Benefits
Does not rely on aspirin challenge, increasing safety and availability for suspected patients.
May be used in patients who have respiratory compromise or are not stable.
Minimally-invasive...
Published: 7/2/2019
Contributor(s): Joshua Levy, Samuel Molina
|
Peptide Therapeutic for Acute Respiratory Distress Syndrome
ApplicationAnti-claudin 5 peptide to improve lung barrier function for the treatment of alcohol-induced acute respiratory distress syndrome (ARDS).Key BenefitsNew target for treating ARDS.Small inhibitory peptide to specifically target claudin-5.Market SummaryApproximately 200,000 cases of acute respiratory distress syndrome (ARDS) are diagnosed each...
Published: 5/13/2019
Contributor(s): Michael Koval, Barbara Schlingmann-Molina
|
Alexidine and Analogs to Treat Lung Cancer
ApplicationSmall molecule therapeutic specifically targeting invasive cancer cells for treatment of lung cancer.Key BenefitsInhibits cancer cell invasion.Utilizes a novel mechanism of action.Market SummaryLung cancer is the second most prevalent type of cancer, causing more than 150,000 deaths in the United States per year. One of the main barriers...
Published: 4/12/2019
Contributor(s): Adam Marcus, Jessica Konen, Rachel Commander, Jamie Arnst, Thota Ganesh
|
Respiratory Syncytial Virus Strain A2-2-20F
ApplicationStrain of respiratory syncytial virus (RSV) for vaccine and therapeutic research and development.Key BenefitsHigher early viral load.Induces greater necrotic airway damage and neurophil infiltration.Market SummaryRSV is a highly contagious and ubiquitous virus that causes respiratory tract infections in individuals of all ages, particularly...
Published: 10/16/2018
Contributor(s): Martin Moore
|
GeneRegs: Nanoparticles for Treatment of Severe Asthma
Application
Gold nanoparticles coated with enzyme which specifically targets and degrades asthma-associated inflammation molecules.
Key Benefits
Specifically suppresses asthma associated inflammation.
Easy self-administration by inhalation.
Market Summary
Asthma is defined as a chronic inflammatory lung disease with significant worldwide morbidity....
Published: 12/4/2017
Contributor(s): Khalid Salaita, Cherry Wongtrakool, Kornelia Galior
|
Respiratory Syncytial Virus (RSV) A2 Expressing Firefly Luciferase
ApplicationRecombinant RSV strain expressing firefly luciferase and the F & G genes from clinical strain A2001/2-20 for research and development of vaccines.Key BenefitsF & G proteins included in this strain show different behavior than those of the typical A2 strain proteins.May be adapted in a variety of assays, enabling the identification...
Published: 2/19/2017
Contributor(s): Martin Moore, Christopher Stobart
|