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Software for Predicting Immunotherapy Response in Lung Cancer
Application Software to predict immunotherapy response and overall survival in patients with non-small cell lung cancer. Key Benefits Maps the complex relationships between multiple cell types within the tumor microenvironment to a pathomic signature for predicting immunotherapy outcome. Interprets these inter- and intra- relationships to predict...
Published: 3/1/2024       Contributor(s): Sara Arabyarmohammadi, Anant Madabhushi, German Corredor Prada, Kurt Schalper, Yufei Zhou, Miguel Lopez de Rodas Gregorio
RSV Vaccine for Infants and Children
Application Vaccine for Respiratory Syncytial Virus (RSV) in infants and children. Key Benefits A novel vaccine targeting both the F and G proteins of the respiratory syncytial virus (RSV), including its variants. Preliminary data in in mice show the vaccine induced the production of antibodies associated with preventing disease. Potential to...
Published: 3/1/2024       Contributor(s): Larry Anderson, Binh Ha, Heying Sun
Repurposing an FDA-Approved Drug for Treating Age-Associated Lung Fibrosis
Application New use of an FDA-approved therapeutic, diroximel fumarate (Vumerity), for treating Idiopathic Pulmonary Fibrosis. Key Benefits Novel use of an FDA-approved drug, diroximel fumarate - DRF (Vumerity), for treating age-dependent lung fibrosis. Lung-targeted inhaled delivery of DRF is effective for boosting lung antioxidant responses...
Published: 1/10/2024       Contributor(s): Louise Hecker, Kosuke Kato
Therapeutic to Treat Age-Dependent Idiopathic Pulmonary Fibrosis
Application Therapeutic for treating age-associated lung fibrosis. Key Benefits Tecfidera (dimethyl fumarate - DMF) is an FDA approved therapy to treat multiple sclerosis via oral administration. A novel formulation for inhaled delivery demonstrated efficacy for a new indication: Idiopathic Pulmonary Fibrosis (IPF), where it promotes the reversal...
Published: 3/1/2024       Contributor(s): Louise Hecker, Kosuke Kato, Priyadarshini Muralidharan, Heidi Mansour
Small Molecules for Treating Cystic Fibrosis
ApplicationSmall molecule compounds to potentiate most common type of CFTR mutation in cystic fibrosis patients.Key BenefitsPotentiates ΔF508-hCFTR mutation, addressing more than 60 percent of CF patients. Market SummaryCystic fibrosis transmembrane conductance regulator (CFTR) is a membrane protein and ion channel that malfunctions in the genetic...
Published: 7/28/2023       Contributor(s): Nael McCarty, Guiying Cui, Hanoch Senderowitz, Netaly Khazanov
Improving Pediatric Asthma Management for Urban Families
Application Home-based family psychoeducational intervention for low-income children with persistent asthma. Key Benefits Medical and psychosocial needs of patients and family members can be addressed simultaneously. Significantly improved asthma management and caregiver stress in randomized controlled clinical trial. Market Summary Asthma...
Published: 7/28/2023       Contributor(s): Marianne Celano, Lisa Kobrynski, Chanda Holsey
Bag-Valve-Mask (BVM) Ventilator
Application Simple, low-cost bag-valve-mask (ambu bag) ventilator for treating respiratory challenges associated with COVID-19 and acute respiratory distress syndrome. Key Benefits Enables ventilation of two patients simultaneously or allows alternating tidal volumes for a single patient. Simple, low-cost design. Technical Summary Georgia Tech,...
Published: 7/28/2023       Contributor(s): Susan Margulies, Shannon Yee, Michael Adams, Kentez Craig, Connor Hart, James Hurley, Jordan Kocher, Maxwell Praniewicz, Leon Williams, Christopher (Chris) Saldana
CFTR Modulators for Treating Rare Forms of Cystic Fibrosis
Application Small molecules to treat cystic fibrosis and other pulmonary diseases. Key Benefits Rescue rare variants of CFTR gene. Serve as PDE4 inhibitors with strong anti-inflammatory effects. Market Summary Cystic fibrosis (CF) is a progressive, genetic disorder that arises from mutations in the cystic fibrosis transmembrane conductance...
Published: 3/11/2024       Contributor(s): Eric J. Sorscher, Jeong Hong, Haian Fu, Yuhong Du, Huw Davies, Andras Rab, Candela Manfredi, Xun Yang, Zhi Ren
Mobile Application for COPD Patients
Application Mobile application for teaching breathing techniques to patients with chronic obstructive pulmonary disease (COPD). Key Benefits Personalized coaching program. Tracks and saves lung performance. Adapts training program to patient’s lung performance. Can be done from the comfort of the patient’s home. Market Summary Chronic...
Published: 7/28/2023       Contributor(s): Weihua Zhang
Virus-Like Particles as RSV Vaccine Candidate
Application Virus-like particle (VLP) vaccine candidate(s) to prevent respiratory syncytial virus (RSV) infection. Key Benefits Candidates may have the most effective anti-viral and anti-inflammatory response. Potentially protects elderly and immunocompromised patients from re-infection with the RSV virus. Efficient, tunable and stable production...
Published: 3/11/2024       Contributor(s): Binh Ha, Larry Anderson, Elizabeth Wright
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