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Theranostic Biomarker for Aspirin-Exacerbated Respiratory Disease
Application
Biomarkers for a clinical diagnostic tool and non-psychogenic therapy to detect and treat aspirin-exacerbated respiratory disease.
Key Benefits
Does not rely on aspirin challenge, increasing safety and availability for suspected patients.
May be used in patients who have respiratory compromise or are not stable.
Minimally-invasive...
Published: 9/26/2024
Contributor(s): Joshua Levy, Samuel Molina
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Respiratory Syncytial Virus Strain A2-2-20F
Application
Strain of respiratory syncytial virus (RSV) for vaccine and therapeutic research and development.
Key Benefits
Higher early viral load.
Induces greater necrotic airway damage and neurophil infiltration.
Market Summary
RSV is a highly contagious and ubiquitous virus that causes respiratory tract infections in individuals of all ages,...
Published: 9/26/2024
Contributor(s): Martin Moore
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Respiratory Syncytial Virus (RSV) A2 Expressing Firefly Luciferase
Application
Recombinant RSV strain expressing firefly luciferase and the F & G genes from clinical strain A2001/2-20 for research and development of vaccines.
Key Benefits
F & G proteins included in this strain show different behavior than those of the typical A2 strain proteins.
May be adapted in a variety of assays, enabling the identification...
Published: 9/26/2024
Contributor(s): Martin Moore, Christopher Stobart
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Plasmid for Respiratory Syncytial Virus (RSV) Vaccine Development & Research
Applications
Bacterial artificial chromosome (BAC) plasmid containing the antigenomic sequence A2-BAG-BAF derived from multiple strains of RSV.
Key Benefits
Viral DNA is contained in a BAC, allowing for efficient mutagenesis and recombineering of viral DNA.
BAC is stable and can be used for cloning in common bacteria types like E. coli.
Provides...
Published: 9/26/2024
Contributor(s): Martin Moore, Anne Hotard (Lopez-Ona)
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Recombinant Respiratory Syncytial Virus (RSV) Firefly Luciferase Reporter Strain
Application
Modified recombinant syncytial virus (RSV) strain expressing a bioluminescent reporter protein for high throughput screening and vaccine development.
Key Benefits
Provides a new high throughput screening tool for RSV vaccine development and drug discovery.
Firefly luciferase based assays show better signal-to-noise than fluorescence-based...
Published: 9/26/2024
Contributor(s): Richard Plemper, Martin Moore
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Recombinant RSV Strains Expressing Renilla Luciferase and G & F Proteins
Application
Recombinant respiratory syncytial virus (RSV) strains expressing the G and F Proteins from RSV strains as well as renilla luciferase for use in drug and vaccine screening.
Key Benefits
Provides new and needed tool for screening potential RSV therapies, ensuring they are broadly effective against multiple, distinct strains of the virus....
Published: 9/26/2024
Contributor(s): Martin Moore, Jia Meng
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Recombinant Respiratory Syncytial Viruses (RSVs) Expressing the G and F Proteins from Various Strains
ApplicationRecombinant RSV Strains Expressing the G and F Proteins from various geographically distributed RSV strains for use in drug and vaccine screeningKey BenefitsProvides new and needed tool for screening potential RSV therapies, ensuring they are broadly effective against multiple, geographically distinct strains of the virus Expresses the red...
Published: 9/26/2024
Contributor(s): Martin Moore, Anne Hotard (Lopez-Ona), Christina Rostad, Barney Graham, Syed Moin
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Human Small Airway Cell Culture System for Drug Screening and Research of Airway Diseases and Conditions
Application
Cell culture system that acts as an in vitro model for infection and stress-induced airway inflammation; used for research and drug discovery/screening.
Key Benefits
Improved structure of system offers natural path for neutrophil transepithelial migration, unlike current systems.
More accurately models pathological environment due...
Published: 9/26/2024
Contributor(s): Rabindra Tirouvanziam
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Respiratory Syncytial Virus (RSV) A/2001/2-20 Strain with Enhanced Pathogenesis
Applications
Strain of respiratory syncytial virus (RSV) for use in drug and vaccine development.
Key Benefits
Exhibits increased mucin expression and early epithelial damage in mouse models.
Provides a platform for animal models focused on early airway histopathology.
Market Summary
RSV is the most common cause of severe respiratory illness...
Published: 9/26/2024
Contributor(s): Martin Moore
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