Technology Listings


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TGFβR3-based Biomaterial to Treat Bone Damage
Application PEG-MAL (Poly(ethylene glycol) methyl ether maleimide) polymer gel composition containing soluble TGFβ3R or embedded with modified TGFβ3R over-expressing cells for bone growth and repair therapy. Key Benefits Targets a non-BMP2 signaling pathway to improve BMP signaling. •Avoids complications associated with BMP2. Market Summary Whether...
Published: 9/20/2019       Inventor(s): Steven Goudy
Platelet Lysate Gel for Wound Healing and Revascularization Therapy
ApplicationPlatelet lysate (PL) gel for localized growth factor delivery, wound healing and as a delivery vehicle for cellular therapies.Key BenefitsIncreases human mesenchymal stem cell (MSC) expansion capacity compared to fetal bovine serum.Derived from human blood products, reducing risk of contamination from foreign organism.Enables use of lower...
Published: 10/26/2017       Inventor(s): Luke Brewster, Scott Robinson, Ian Copland
Reprogramming of Fibroblasts toward a Three-Dimensional Vascularized Cardiomimetic Tissue (CMT)
Application Fibroblasts reprogrammed into tissue-like patch including functional cardiomyocyte, endothelial, smooth muscle and pericyte cells for treatment of cardiac diseases. Key Benefits Enables simultaneous reprogramming of multi-lineage cells including cardiomyocytes and endothelial cells Increases expression of cardioprotective paracrine factors....
Published: 7/19/2016       Inventor(s): Young-Sup Yoon, Jaeyeaon Cho
Small Molecule Therapeutic for Regeneration of Cartilage
ApplicationSmall molecule therapeutic that can be delivered locally to enhance TGF-beta activity and promote cartilage growth.Key BenefitsIncreases production of protease inhibitors, simultaneously stimulating production and blocking degradation of extracellular matrix (ECM). Potentially reduces or eliminates need for joint replacements by regenerating...
Published: 6/1/2015       Inventor(s): Scott Boden, Sreedhara Sangadala
Clinically Compatible High Efficiency Stem Cell Differentiation Protocol for Endothelial Cell Generation
ApplicationA clinically-compatible protocol for differentiating human stem cells into endothelial cells for cardiovascular tissue regenerative medicine.Key BenefitsProvides a high yield of differentiated endothelial cells, with an efficiency of up to 97%. These endothelial cells are generated using completely clinically compatible system which do not...
Published: 6/21/2013       Inventor(s): Young-Sup Yoon, Shin-Jeong Lee
Enzymatic Treatment to Increase Peripheral Nerve Regeneration
Application Combination treatment of four enzymes to block nerve growth inhibitory molecules in peripheral nerve injury. Key Benefits Enzymes degrade all three families of growth inhibiting molecules in peripheral nerve injury. Combination treatment shows synergistic, not additive effect. Market Summary Peripheral nerve injury can occur in a variety...
Published: 5/24/2013       Inventor(s): Arthur English, Robert Mckeon, Erica Werner
Stem Cell-Based Therapy for Vascular Disease
ApplicationA device and kit for isolating therapeutic quantities of vasculgenic cells from blood that acts as an autologous adult stem cell therapy for the treatment of limb ischemia, ischemic heart disease, and other vascular-related disorders. Key BenefitsReduces complexity and expense of current autologous stem cell therapies. Cells can be isolated...
Published: 3/23/2010       Inventor(s): Young-Sup Yoon, Hyun-Jai Cho