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TGFβR3-based Biomaterial to Treat Bone Damage
Application
PEG-MAL (Poly(ethylene glycol) methyl ether maleimide) polymer gel composition containing soluble TGFβ3R or embedded with modified TGFβ3R over-expressing cells for bone growth and repair therapy.
Key Benefits
Targets a non-BMP2 signaling pathway to improve BMP signaling.
Avoids complications associated with BMP2.
Market...
Published: 3/1/2024
Contributor(s): Steven Goudy
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Tool for Measuring Cell Purity and Quality Control of Stem Cell-based Products
Application
Cell-based assay for sensitive and specific detection of undifferentiated cells in stem cell-related research and development.
Key Benefits
Nanotechnology-based assay can detect residual undifferentiated cells and characterize cultures that may be tumorigenic.
Technology is potentially more sensitive method compared to current methods.
Market...
Published: 11/27/2023
Contributor(s): Chunhui Xu, Shuming Nie, Ximei Qian, Jingjia Han
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Reprogramming of Fibroblasts toward a Three-Dimensional Vascularized Cardiomimetic Tissue (CMT)
Application
Fibroblasts reprogrammed into tissue-like patch including functional cardiomyocyte, endothelial, smooth muscle and pericyte cells for treatment of cardiac diseases.
Key Benefits
Enables simultaneous reprogramming of multi-lineage cells including cardiomyocytes and endothelial cells
Increases expression of cardioprotective paracrine...
Published: 11/27/2023
Contributor(s): Young-Sup Yoon, Jaeyeaon Cho
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Small Molecule Therapeutic for Regeneration of Cartilage
ApplicationSmall molecule therapeutic that can be delivered locally to enhance TGF-beta activity and promote cartilage growth.Key BenefitsIncreases production of protease inhibitors, simultaneously stimulating production and blocking degradation of extracellular matrix (ECM). Potentially reduces or eliminates need for joint replacements by regenerating...
Published: 7/28/2023
Contributor(s): Scott Boden, Sreedhara Sangadala
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Enzymatic Treatment to Increase Peripheral Nerve Regeneration
Application
Combination treatment of four enzymes to block nerve growth inhibitory molecules in peripheral nerve injury.
Key Benefits
Enzymes degrade all three families of growth inhibiting molecules in peripheral nerve injury.
Combination treatment shows synergistic, not additive effect.
Market Summary
Peripheral nerve injury can occur in...
Published: 7/28/2023
Contributor(s): Arthur English, Robert Mckeon, Erica Werner
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Noggin Inhibitor: Bone Forming Small Molecule for Use in Spinal Fusion Devices
Application
Bone forming therapeutic for use in spinal fusion devices and treatment of systemic bone diseases and disorders.
Key Benefits
Current devices for bone grafting procedures require high concentrations of bone morphogenetic protein (BMP) which results in a high cost and create a barrier for routine clinical use.
Small molecule therapeutics...
Published: 1/31/2024
Contributor(s): Scott Boden, Sreedhara Sangadala
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Novel Bone Forming Compound for Use in Spinal Fusion Device
Application
Bone forming therapeutic for use in spinal fusion devices and treatment of systemic bone diseases and disorders.
Key Benefits
Current devices for bone grafting procedures require high concentrations of bone morphogenic protein (BMP) which results in a high cost and create a barrier for routine clinical use.
Commercially available small...
Published: 4/8/2024
Contributor(s): Scott Boden, Sreedhara Sangadala
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Device and Kit Isolate Vasculogenic Cells from Blood
Application
A device and kit for isolating therapeutic quantities of vasculgenic cells from blood that acts as an autologous adult stem cell therapy for the treatment of limb ischemia, ischemic heart disease, and other vascular-related disorders.
Key Benefits
Reduces complexity and expense of current autologous stem cell therapies.
Cells can be...
Published: 11/6/2023
Contributor(s): Young-Sup Yoon, Hyun-Jai Cho
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